Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q92572

- AP3S1_HUMAN

UniProt

Q92572 - AP3S1_HUMAN

Protein

AP-3 complex subunit sigma-1

Gene

AP3S1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein transporter activity Source: InterPro
    3. transporter activity Source: ProtInc

    GO - Biological processi

    1. anterograde axon cargo transport Source: UniProtKB
    2. anterograde synaptic vesicle transport Source: UniProtKB
    3. insulin receptor signaling pathway Source: ProtInc
    4. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-3 complex subunit sigma-1
    Alternative name(s):
    AP-3 complex subunit sigma-3A
    Adaptor-related protein complex 3 subunit sigma-1
    Clathrin-associated/assembly/adaptor protein, small 3
    Sigma-3A-adaptin
    Short name:
    Sigma3A-adaptin
    Sigma-adaptin 3a
    Gene namesi
    Name:AP3S1
    Synonyms:CLAPS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:2013. AP3S1.

    Subcellular locationi

    Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side
    Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

    GO - Cellular componenti

    1. AP-3 adaptor complex Source: FlyBase
    2. AP-type membrane coat adaptor complex Source: ProtInc
    3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    4. Golgi apparatus Source: UniProtKB-SubCell
    5. transport vesicle Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24862.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193AP-3 complex subunit sigma-1PRO_0000193815Add
    BLAST

    Proteomic databases

    MaxQBiQ92572.
    PaxDbiQ92572.
    PRIDEiQ92572.

    PTM databases

    PhosphoSiteiQ92572.

    Expressioni

    Tissue specificityi

    Present in all adult tissues examined.3 Publications

    Gene expression databases

    ArrayExpressiQ92572.
    BgeeiQ92572.
    CleanExiHS_AP3S1.
    GenevestigatoriQ92572.

    Interactioni

    Subunit structurei

    Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107590. 13 interactions.
    IntActiQ92572. 1 interaction.
    STRINGi9606.ENSP00000325369.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92572.
    SMRiQ92572. Positions 1-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5030.
    HOVERGENiHBG050517.
    InParanoidiQ92572.
    KOiK12399.
    OMAiLSEMIIG.
    OrthoDBiEOG7W41CZ.
    PhylomeDBiQ92572.
    TreeFamiTF300189.

    Family and domain databases

    InterProiIPR016635. AP_complex_ssu.
    IPR022775. AP_mu_sigma_su.
    IPR000804. Clathrin_sm-chain_CS.
    IPR011012. Longin-like_dom.
    [Graphical view]
    PANTHERiPTHR11753. PTHR11753. 1 hit.
    PfamiPF01217. Clat_adaptor_s. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
    SUPFAMiSSF64356. SSF64356. 1 hit.
    PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92572-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL    50
    EGGLLIGGSD NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC 100
    FENVCELDLI FHVDKVHNIL AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS 150
    EAGLAGAPAR AVSAVKNMNL PEIPRNINIG DISIKVPNLP SFK 193
    Length:193
    Mass (Da):21,732
    Last modified:February 1, 1997 - v1
    Checksum:i1EF17F375881288D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti158 – 1581P → L.
    Corresponds to variant rs7733604 [ dbSNP | Ensembl ].
    VAR_059111

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63643 mRNA. Translation: BAA09798.1.
    U91932 mRNA. Translation: AAD03779.1.
    X99458 mRNA. Translation: CAA67823.1.
    BT009833 mRNA. Translation: AAP88835.1.
    CR450341 mRNA. Translation: CAG29337.1.
    BC000804 mRNA. Translation: AAH00804.1.
    CCDSiCCDS4123.1.
    RefSeqiNP_001275.1. NM_001284.2.
    UniGeneiHs.406191.

    Genome annotation databases

    EnsembliENST00000316788; ENSP00000325369; ENSG00000177879.
    GeneIDi1176.
    KEGGihsa:1176.
    UCSCiuc003krk.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63643 mRNA. Translation: BAA09798.1 .
    U91932 mRNA. Translation: AAD03779.1 .
    X99458 mRNA. Translation: CAA67823.1 .
    BT009833 mRNA. Translation: AAP88835.1 .
    CR450341 mRNA. Translation: CAG29337.1 .
    BC000804 mRNA. Translation: AAH00804.1 .
    CCDSi CCDS4123.1.
    RefSeqi NP_001275.1. NM_001284.2.
    UniGenei Hs.406191.

    3D structure databases

    ProteinModelPortali Q92572.
    SMRi Q92572. Positions 1-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107590. 13 interactions.
    IntActi Q92572. 1 interaction.
    STRINGi 9606.ENSP00000325369.

    PTM databases

    PhosphoSitei Q92572.

    Proteomic databases

    MaxQBi Q92572.
    PaxDbi Q92572.
    PRIDEi Q92572.

    Protocols and materials databases

    DNASUi 1176.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316788 ; ENSP00000325369 ; ENSG00000177879 .
    GeneIDi 1176.
    KEGGi hsa:1176.
    UCSCi uc003krk.3. human.

    Organism-specific databases

    CTDi 1176.
    GeneCardsi GC05P115177.
    HGNCi HGNC:2013. AP3S1.
    MIMi 601507. gene.
    neXtProti NX_Q92572.
    PharmGKBi PA24862.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5030.
    HOVERGENi HBG050517.
    InParanoidi Q92572.
    KOi K12399.
    OMAi LSEMIIG.
    OrthoDBi EOG7W41CZ.
    PhylomeDBi Q92572.
    TreeFami TF300189.

    Enzyme and pathway databases

    Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

    Miscellaneous databases

    ChiTaRSi AP3S1. human.
    GeneWikii AP3S1.
    GenomeRNAii 1176.
    NextBioi 4862.
    PROi Q92572.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92572.
    Bgeei Q92572.
    CleanExi HS_AP3S1.
    Genevestigatori Q92572.

    Family and domain databases

    InterProi IPR016635. AP_complex_ssu.
    IPR022775. AP_mu_sigma_su.
    IPR000804. Clathrin_sm-chain_CS.
    IPR011012. Longin-like_dom.
    [Graphical view ]
    PANTHERi PTHR11753. PTHR11753. 1 hit.
    Pfami PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015588. AP_complex_sigma. 1 hit.
    SUPFAMi SSF64356. SSF64356. 1 hit.
    PROSITEi PS00989. CLAT_ADAPTOR_S. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain."
      Watanabe T.K., Shimizu F., Nagata M., Takaichi A., Fujiwara T., Nakamura Y., Takahashi E., Hirai Y.
      Cytogenet. Cell Genet. 73:214-217(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Characterization of the adaptor-related protein complex, AP-3."
      Simpson F., Peden A.A., Christopoulou L., Robinson M.S.
      J. Cell Biol. 137:835-845(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Placenta.
    3. "AP-3: an adaptor-like protein complex with ubiquitous expression."
      Dell'Angelica E.C., Ohno H., Ooi C.E., Rabinovich E., Roche K.W., Bonifacino J.S.
      EMBO J. 16:917-928(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain, Pancreas and Placenta.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAP3S1_HUMAN
    AccessioniPrimary (citable) accession number: Q92572
    Secondary accession number(s): O00647
    , O00676, O00721, O00727, Q53XL4, Q6ICQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3