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Protein

AP-3 complex subunit sigma-1

Gene

AP3S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

GO - Molecular functioni

  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma-1
Alternative name(s):
AP-3 complex subunit sigma-3A
Adaptor-related protein complex 3 subunit sigma-1
Clathrin-associated/assembly/adaptor protein, small 3
Sigma-3A-adaptin
Short name:
Sigma3A-adaptin
Sigma-adaptin 3a
Gene namesi
Name:AP3S1
Synonyms:CLAPS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000177879.14
HGNCiHGNC:2013 AP3S1
MIMi601507 gene
neXtProtiNX_Q92572

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1176
OpenTargetsiENSG00000177879
PharmGKBiPA24862

Polymorphism and mutation databases

BioMutaiAP3S1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938151 – 193AP-3 complex subunit sigma-1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92572
MaxQBiQ92572
PaxDbiQ92572
PeptideAtlasiQ92572
PRIDEiQ92572
TopDownProteomicsiQ92572

PTM databases

iPTMnetiQ92572
PhosphoSitePlusiQ92572

Expressioni

Tissue specificityi

Present in all adult tissues examined.3 Publications

Gene expression databases

BgeeiENSG00000177879
CleanExiHS_AP3S1
ExpressionAtlasiQ92572 baseline and differential
GenevisibleiQ92572 HS

Organism-specific databases

HPAiHPA049270

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi107590, 63 interactors
CORUMiQ92572
IntActiQ92572, 12 interactors
STRINGi9606.ENSP00000325369

Structurei

3D structure databases

ProteinModelPortaliQ92572
SMRiQ92572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0936 Eukaryota
COG5030 LUCA
GeneTreeiENSGT00550000074761
HOVERGENiHBG050517
InParanoidiQ92572
KOiK12399
OMAiVDAQNKM
OrthoDBiEOG091G0QZV
PhylomeDBiQ92572
TreeFamiTF300189

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequencei

Sequence statusi: Complete.

Q92572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL
60 70 80 90 100
EGGLLIGGSD NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC
110 120 130 140 150
FENVCELDLI FHVDKVHNIL AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS
160 170 180 190
EAGLAGAPAR AVSAVKNMNL PEIPRNINIG DISIKVPNLP SFK
Length:193
Mass (Da):21,732
Last modified:February 1, 1997 - v1
Checksum:i1EF17F375881288D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059111158P → L. Corresponds to variant dbSNP:rs7733604Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63643 mRNA Translation: BAA09798.1
U91932 mRNA Translation: AAD03779.1
X99458 mRNA Translation: CAA67823.1
BT009833 mRNA Translation: AAP88835.1
CR450341 mRNA Translation: CAG29337.1
BC000804 mRNA Translation: AAH00804.1
CCDSiCCDS4123.1
RefSeqiNP_001002924.2, NM_001002924.2
NP_001275.1, NM_001284.3
NP_001305019.1, NM_001318090.1
NP_001305020.1, NM_001318091.1
NP_001305022.1, NM_001318093.1
NP_001305023.1, NM_001318094.1
UniGeneiHs.406191

Genome annotation databases

EnsembliENST00000316788; ENSP00000325369; ENSG00000177879
GeneIDi1176
KEGGihsa:1176
UCSCiuc003krl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAP3S1_HUMAN
AccessioniPrimary (citable) accession number: Q92572
Secondary accession number(s): O00647
, O00676, O00721, O00727, Q53XL4, Q6ICQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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