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Protein

AP-3 complex subunit sigma-1

Gene

AP3S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

GO - Molecular functioni

  • protein transporter activity Source: InterPro
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma-1
Alternative name(s):
AP-3 complex subunit sigma-3A
Adaptor-related protein complex 3 subunit sigma-1
Clathrin-associated/assembly/adaptor protein, small 3
Sigma-3A-adaptin
Short name:
Sigma3A-adaptin
Sigma-adaptin 3a
Gene namesi
Name:AP3S1
Synonyms:CLAPS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000177879.14.
HGNCiHGNC:2013. AP3S1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1176.
OpenTargetsiENSG00000177879.
PharmGKBiPA24862.

Polymorphism and mutation databases

BioMutaiAP3S1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938151 – 193AP-3 complex subunit sigma-1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92572.
MaxQBiQ92572.
PaxDbiQ92572.
PeptideAtlasiQ92572.
PRIDEiQ92572.
TopDownProteomicsiQ92572.

PTM databases

iPTMnetiQ92572.
PhosphoSitePlusiQ92572.

Expressioni

Tissue specificityi

Present in all adult tissues examined.3 Publications

Gene expression databases

BgeeiENSG00000177879.
CleanExiHS_AP3S1.
ExpressionAtlasiQ92572. baseline and differential.
GenevisibleiQ92572. HS.

Organism-specific databases

HPAiHPA049270.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi107590. 62 interactors.
CORUMiQ92572.
IntActiQ92572. 11 interactors.
STRINGi9606.ENSP00000325369.

Structurei

3D structure databases

ProteinModelPortaliQ92572.
SMRiQ92572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0936. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00550000074761.
HOVERGENiHBG050517.
InParanoidiQ92572.
KOiK12399.
OMAiVDAQNKM.
OrthoDBiEOG091G0QZV.
PhylomeDBiQ92572.
TreeFamiTF300189.

Family and domain databases

InterProiView protein in InterPro
IPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiView protein in Pfam
PF01217. Clat_adaptor_s. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiView protein in PROSITE
PS00989. CLAT_ADAPTOR_S. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL
60 70 80 90 100
EGGLLIGGSD NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC
110 120 130 140 150
FENVCELDLI FHVDKVHNIL AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS
160 170 180 190
EAGLAGAPAR AVSAVKNMNL PEIPRNINIG DISIKVPNLP SFK
Length:193
Mass (Da):21,732
Last modified:February 1, 1997 - v1
Checksum:i1EF17F375881288D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059111158P → L. Corresponds to variant dbSNP:rs7733604Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63643 mRNA. Translation: BAA09798.1.
U91932 mRNA. Translation: AAD03779.1.
X99458 mRNA. Translation: CAA67823.1.
BT009833 mRNA. Translation: AAP88835.1.
CR450341 mRNA. Translation: CAG29337.1.
BC000804 mRNA. Translation: AAH00804.1.
CCDSiCCDS4123.1.
RefSeqiNP_001002924.2. NM_001002924.2.
NP_001275.1. NM_001284.3.
NP_001305019.1. NM_001318090.1.
NP_001305020.1. NM_001318091.1.
NP_001305022.1. NM_001318093.1.
NP_001305023.1. NM_001318094.1.
UniGeneiHs.406191.

Genome annotation databases

EnsembliENST00000316788; ENSP00000325369; ENSG00000177879.
GeneIDi1176.
KEGGihsa:1176.
UCSCiuc003krl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAP3S1_HUMAN
AccessioniPrimary (citable) accession number: Q92572
Secondary accession number(s): O00647
, O00676, O00721, O00727, Q53XL4, Q6ICQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families