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Q92572 (AP3S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
AP-3 complex subunit sigma-1
Alternative name(s):
AP-3 complex subunit sigma-3A
Adapter-related protein complex 3 subunit sigma-1
Clathrin-associated/assembly/adapter protein, small 3
Sigma-3A-adaptin
Short name=Sigma3A-adaptin
Sigma-adaptin 3a
Gene names
Name:AP3S1
Synonyms:CLAPS3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Subunit structure

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex By similarity.

Subcellular location

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Tissue specificity

Present in all adult tissues examined. Ref.1 Ref.2 Ref.3

Sequence similarities

Belongs to the adaptor complexes small subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193AP-3 complex subunit sigma-1
PRO_0000193815

Natural variations

Natural variant1581P → L.
Corresponds to variant rs7733604 [ dbSNP | Ensembl ].
VAR_059111

Sequences

Sequence LengthMass (Da)Tools
Q92572 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 1EF17F375881288D

FASTA19321,732
        10         20         30         40         50         60 
MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD 

        70         80         90        100        110        120 
NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL 

       130        140        150        160        170        180 
AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS EAGLAGAPAR AVSAVKNMNL PEIPRNINIG 

       190 
DISIKVPNLP SFK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain."
Watanabe T.K., Shimizu F., Nagata M., Takaichi A., Fujiwara T., Nakamura Y., Takahashi E., Hirai Y.
Cytogenet. Cell Genet. 73:214-217(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"Characterization of the adaptor-related protein complex, AP-3."
Simpson F., Peden A.A., Christopoulou L., Robinson M.S.
J. Cell Biol. 137:835-845(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Placenta.
[3]"AP-3: an adaptor-like protein complex with ubiquitous expression."
Dell'Angelica E.C., Ohno H., Ooi C.E., Rabinovich E., Roche K.W., Bonifacino J.S.
EMBO J. 16:917-928(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain, Pancreas and Placenta.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D63643 mRNA. Translation: BAA09798.1.
U91932 mRNA. Translation: AAD03779.1.
X99458 mRNA. Translation: CAA67823.1.
BT009833 mRNA. Translation: AAP88835.1.
CR450341 mRNA. Translation: CAG29337.1.
BC000804 mRNA. Translation: AAH00804.1.
CCDSCCDS4123.1.
RefSeqNP_001275.1. NM_001284.2.
UniGeneHs.406191.

3D structure databases

ProteinModelPortalQ92572.
SMRQ92572. Positions 1-148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107590. 14 interactions.
IntActQ92572. 1 interaction.
STRING9606.ENSP00000325369.

PTM databases

PhosphoSiteQ92572.

Proteomic databases

MaxQBQ92572.
PaxDbQ92572.
PRIDEQ92572.

Protocols and materials databases

DNASU1176.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316788; ENSP00000325369; ENSG00000177879.
GeneID1176.
KEGGhsa:1176.
UCSCuc003krk.3. human.

Organism-specific databases

CTD1176.
GeneCardsGC05P115177.
HGNCHGNC:2013. AP3S1.
MIM601507. gene.
neXtProtNX_Q92572.
PharmGKBPA24862.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5030.
HOVERGENHBG050517.
InParanoidQ92572.
KOK12399.
OMALSEMIIG.
OrthoDBEOG7W41CZ.
PhylomeDBQ92572.
TreeFamTF300189.

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.

Gene expression databases

ArrayExpressQ92572.
BgeeQ92572.
CleanExHS_AP3S1.
GenevestigatorQ92572.

Family and domain databases

InterProIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERPTHR11753. PTHR11753. 1 hit.
PfamPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMSSF64356. SSF64356. 1 hit.
PROSITEPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAP3S1. human.
GeneWikiAP3S1.
GenomeRNAi1176.
NextBio4862.
PROQ92572.
SOURCESearch...

Entry information

Entry nameAP3S1_HUMAN
AccessionPrimary (citable) accession number: Q92572
Secondary accession number(s): O00647 expand/collapse secondary AC list , O00676, O00721, O00727, Q53XL4, Q6ICQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM