Reviewed, UniProtKB/Swiss-Prot Q92572 (AP3S1_HUMAN)

Names and origin

Protein names

Recommended name:
    AP-3 complex subunit sigma-1
Alternative name(s):
    Adapter-related protein complex 3 sigma-1 subunit
    AP-3 complex sigma-3A subunit
    Sigma-adaptin 3a
    Sigma-3A-adaptin
    Sigma3A-adaptin
    Clathrin-associated/assembly/adapter protein, small 3

Gene names

Name:	AP3S1
Synonyms:	CLAPS3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
Subunit structure	Adaptor protein complex 3 (AP-3) is an heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1 By similarity.
Subcellular location	Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Tissue specificity	Present in all adult tissues examined. Ref.1 Ref.2 Ref.3
Sequence similarities	Belongs to the adaptor complexes small subunit family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasmic vesicle Golgi apparatus Membrane
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	insulin receptor signaling pathway Traceable author statement. Source: ProtInc intracellular protein transport Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	AP-type membrane coat adaptor complex Ref.1 Traceable author statement. Source: ProtInc Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell transport vesicle Ref.3 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	AP-3 complex subunit sigma-1		PRO_0000193815
Natural variations
	Natural variant	158	1	P → L: dbSNP rs7733604.		VAR_059111

Sequences

	Sequence		Length	Mass (Da)
	Q92572-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 1EF17F375881288D	FASTA	193	21,732
	10 20 30 40 50 60 MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD 70 80 90 100 110 120 NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL 130 140 150 160 170 180 AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS EAGLAGAPAR AVSAVKNMNL PEIPRNINIG 190 DISIKVPNLP SFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain." Watanabe T.K., Shimizu F., Nagata M., Takaichi A., Fujiwara T., Nakamura Y., Takahashi E., Hirai Y. Cytogenet. Cell Genet. 73:214-217(1996) [PubMed: 8697810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Characterization of the adaptor-related protein complex, AP-3." Simpson F., Peden A.A., Christopoulou L., Robinson M.S. J. Cell Biol. 137:835-845(1997) [PubMed: 9151686] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Placenta.
[3]	"AP-3: an adaptor-like protein complex with ubiquitous expression." Dell'Angelica E.C., Ohno H., Ooi C.E., Rabinovich E., Roche K.W., Bonifacino J.S. EMBO J. 16:917-928(1997) [PubMed: 9118953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain, Pancreas and Placenta.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D63643 mRNA. Translation: BAA09798.1. U91932 mRNA. Translation: AAD03779.1. X99458 mRNA. Translation: CAA67823.1. BT009833 mRNA. Translation: AAP88835.1. CR450341 mRNA. Translation: CAG29337.1. BC000804 mRNA. Translation: AAH00804.1.
IPI	IPI00014624.
RefSeq	NP_001275.1.
UniGene	Hs.406191
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q92572.
Proteomic databases
PRIDE	Q92572.
Genome annotation databases
Ensembl	ENST00000316788; ENSP00000325369; ENSG00000177879; Homo sapiens. [Genome view]
GeneID	1176.
KEGG	hsa:1176.
UCSC	uc003krl.1. human.
Organism-specific databases
CTD	1176.
GeneCards	GC05P115205.
H-InvDB	HIX0018988.
HGNC	HGNC:2013. AP3S1.
MIM	601507. gene.
PharmGKB	PA24862.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q92572.
HOVERGEN	Q92572.
OMA	RIEEQNK
OrthoDB	EOG9TTK36
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000032040-MON.
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
Bgee	Q92572.
CleanEx	HS_AP3S1.
Genevestigator	Q92572.
GermOnline	ENSG00000177879. Homo sapiens.
Family and domain databases
InterPro	IPR016635. AP_complex_ssu. IPR000804. Clathrin_sigma/coatomer_zeta. IPR011012. Longin-like. [Graphical view]
Pfam	PF01217. Clat_adaptor_s. 1 hit. [Graphical view]
PIRSF	PIRSF015588. AP_complex_sigma. 1 hit.
PROSITE	PS00989. CLAT_ADAPTOR_S. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4862.
SOURCE	Search...

Entry information

Entry name

AP3S1_HUMAN

Accession

Primary (citable) accession number: Q92572
Secondary accession number(s): O00647 , O00676, O00721, O00727, Q53XL4, Q6ICQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	February 1, 1997
Last modified:	November 24, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.