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Q92570

- NR4A3_HUMAN

UniProt

Q92570 - NR4A3_HUMAN

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Protein
Nuclear receptor subfamily 4 group A member 3
Gene
NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to the B1A response-element.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi289 – 36476Nuclear receptor
Add
BLAST
Zinc fingeri292 – 31221NR C4-type
Add
BLAST
Zinc fingeri328 – 35225NR C4-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl
  4. steroid hormone receptor activity Source: ProtInc
  5. thyroid hormone receptor activity Source: ProtInc
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. axon guidance Source: Ensembl
  3. gene expression Source: Reactome
  4. hippocampus development Source: Ensembl
  5. intracellular receptor signaling pathway Source: GOC
  6. mesoderm formation Source: Ensembl
  7. negative regulation of neuron apoptotic process Source: Ensembl
  8. neuromuscular process controlling balance Source: Ensembl
  9. organ regeneration Source: Ensembl
  10. positive regulation of cell cycle Source: Ensembl
  11. positive regulation of leukocyte apoptotic process Source: Ensembl
  12. response to hydrogen peroxide Source: Ensembl
  13. response to peptide hormone Source: Ensembl
  14. semicircular canal morphogenesis Source: Ensembl
  15. transcription initiation from RNA polymerase II promoter Source: Reactome
  16. vestibular reflex Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiQ92570.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 3
Alternative name(s):
Mitogen-induced nuclear orphan receptor
Neuron-derived orphan receptor 1
Nuclear hormone receptor NOR-1
Gene namesi
Name:NR4A3
Synonyms:CHN, CSMF, MINOR, NOR1, TEC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:7982. NR4A3.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi600542. gene+phenotype.
612219. phenotype.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
PharmGKBiPA31763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Nuclear receptor subfamily 4 group A member 3
PRO_0000053722Add
BLAST

Proteomic databases

MaxQBiQ92570.
PaxDbiQ92570.
PRIDEiQ92570.

PTM databases

PhosphoSiteiQ92570.

Expressioni

Tissue specificityi

Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.

Gene expression databases

BgeeiQ92570.
CleanExiHS_NR4A3.
HS_TEC.
GenevestigatoriQ92570.

Organism-specific databases

HPAiHPA043360.

Interactioni

Protein-protein interaction databases

BioGridi113713. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ92570.
SMRiQ92570. Positions 290-626.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni440 – 49051Ligand-binding Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 10814Poly-His
Add
BLAST
Compositional biasi282 – 2876Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG245120.
HOVERGENiHBG052663.
InParanoidiQ92570.
KOiK08559.
OMAiCMMNALV.
OrthoDBiEOG75XGKJ.
PhylomeDBiQ92570.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q92570-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPCVQAQYSP SPPGSSYAAQ TYSSEYTTEI MNPDYTKLTM DLGSTEITAT    50
ATTSLPSIST FVEGYSSNYE LKPSCVYQMQ RPLIKVEEGR APSYHHHHHH 100
HHHHHHHHQQ QHQQPSIPPA SSPEDEVLPS TSMYFKQSPP STPTTPAFPP 150
QAGALWDEAL PSAPGCIAPG PLLDPPMKAV PTVAGARFPL FHFKPSPPHP 200
PAPSPAGGHH LGYDPTAAAA LSLPLGAAAA AGSQAAALES HPYGLPLAKR 250
AAPLAFPPLG LTPSPTASSL LGESPSLPSP PSRSSSSGEG TCAVCGDNAA 300
CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKNCPVDKRR RNRCQYCRFQ 350
KCLSVGMVKE VVRTDSLKGR RGRLPSKPKS PLQQEPSQPS PPSPPICMMN 400
ALVRALTDST PRDLDYSRYC PTDQAAAGTD AEHVQQFYNL LTASIDVSRS 450
WAEKIPGFTD LPKEDQTLLI ESAFLELFVL RLSIRSNTAE DKFVFCNGLV 500
LHRLQCLRGF GEWLDSIKDF SLNLQSLNLD IQALACLSAL SMITERHGLK 550
EPKRVEELCN KITSSLKDHQ SKGQALEPTE SKVLGALVEL RKICTLGLQR 600
IFYLKLEDLV SPPSIIDKLF LDTLPF 626
Length:626
Mass (Da):68,230
Last modified:March 21, 2006 - v3
Checksum:iFB4A1AB7667D96F6
GO
Isoform Beta (identifier: Q92570-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-443: YCPTDQAAAGTDAEHVQQFYNLLTA → VSFMISCFQMNDQGLYLWLLVIRVD
     444-626: Missing.

Show »
Length:443
Mass (Da):47,822
Checksum:i42E97CAE053BA5EF
GO
Isoform 3 (identifier: Q92570-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHDSIRFGNVDM

Note: No experimental confirmation available.

Show »
Length:637
Mass (Da):69,502
Checksum:i584261AA3DAA3AD5
GO

Sequence cautioni

The sequence AAB02581.1 differs from that shown. Reason: Frameshift at positions 4 and 20.
The sequence AAB36006.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MHDSIRFGNVDM in isoform 3.
VSP_037877
Alternative sequencei419 – 44325YCPTD…NLLTA → VSFMISCFQMNDQGLYLWLL VIRVD in isoform Beta.
VSP_003712Add
BLAST
Alternative sequencei444 – 626183Missing in isoform Beta.
VSP_003713Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2401S → G1 Publication
Sequence conflicti240 – 2401S → G1 Publication
Sequence conflicti454 – 4541K → R in BAA11419. 1 Publication
Sequence conflicti579 – 5791T → N in BAA11419. 1 Publication
Sequence conflicti585 – 5851G → V in BAA11419. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78579 mRNA. Translation: BAA11419.1.
U12767 mRNA. Translation: AAB02581.1. Frameshift.
S81243 mRNA. Translation: AAB36006.1. Different initiation.
X89894 mRNA. Translation: CAA61984.1.
AL359710 Genomic DNA. Translation: CAI95139.1.
AL359710, AL358937 Genomic DNA. Translation: CAI95138.1.
AL358937, AL359710 Genomic DNA. Translation: CAI95320.1.
AL359710, AL358937 Genomic DNA. Translation: CAM16648.1.
AL358937, AL359710 Genomic DNA. Translation: CAM22558.1.
CH471105 Genomic DNA. Translation: EAW58915.1.
D85241 mRNA. Translation: BAA28608.1.
D85242 mRNA. Translation: BAA31221.1.
CCDSiCCDS6742.1. [Q92570-3]
CCDS6743.1. [Q92570-1]
CCDS6744.1. [Q92570-2]
PIRiS71930.
RefSeqiNP_008912.2. NM_006981.3. [Q92570-1]
NP_775291.1. NM_173199.2. [Q92570-2]
NP_775292.1. NM_173200.2. [Q92570-3]
UniGeneiHs.279522.

Genome annotation databases

EnsembliENST00000330847; ENSP00000333122; ENSG00000119508. [Q92570-3]
ENST00000338488; ENSP00000340301; ENSG00000119508. [Q92570-2]
ENST00000395097; ENSP00000378531; ENSG00000119508. [Q92570-1]
GeneIDi8013.
KEGGihsa:8013.
UCSCiuc004bae.3. human. [Q92570-2]
uc004baf.1. human. [Q92570-1]
uc022bky.1. human. [Q92570-3]

Polymorphism databases

DMDMi90110039.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78579 mRNA. Translation: BAA11419.1 .
U12767 mRNA. Translation: AAB02581.1 . Frameshift.
S81243 mRNA. Translation: AAB36006.1 . Different initiation.
X89894 mRNA. Translation: CAA61984.1 .
AL359710 Genomic DNA. Translation: CAI95139.1 .
AL359710 , AL358937 Genomic DNA. Translation: CAI95138.1 .
AL358937 , AL359710 Genomic DNA. Translation: CAI95320.1 .
AL359710 , AL358937 Genomic DNA. Translation: CAM16648.1 .
AL358937 , AL359710 Genomic DNA. Translation: CAM22558.1 .
CH471105 Genomic DNA. Translation: EAW58915.1 .
D85241 mRNA. Translation: BAA28608.1 .
D85242 mRNA. Translation: BAA31221.1 .
CCDSi CCDS6742.1. [Q92570-3 ]
CCDS6743.1. [Q92570-1 ]
CCDS6744.1. [Q92570-2 ]
PIRi S71930.
RefSeqi NP_008912.2. NM_006981.3. [Q92570-1 ]
NP_775291.1. NM_173199.2. [Q92570-2 ]
NP_775292.1. NM_173200.2. [Q92570-3 ]
UniGenei Hs.279522.

3D structure databases

ProteinModelPortali Q92570.
SMRi Q92570. Positions 290-626.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113713. 4 interactions.

Chemistry

ChEMBLi CHEMBL1961792.

PTM databases

PhosphoSitei Q92570.

Polymorphism databases

DMDMi 90110039.

Proteomic databases

MaxQBi Q92570.
PaxDbi Q92570.
PRIDEi Q92570.

Protocols and materials databases

DNASUi 8013.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330847 ; ENSP00000333122 ; ENSG00000119508 . [Q92570-3 ]
ENST00000338488 ; ENSP00000340301 ; ENSG00000119508 . [Q92570-2 ]
ENST00000395097 ; ENSP00000378531 ; ENSG00000119508 . [Q92570-1 ]
GeneIDi 8013.
KEGGi hsa:8013.
UCSCi uc004bae.3. human. [Q92570-2 ]
uc004baf.1. human. [Q92570-1 ]
uc022bky.1. human. [Q92570-3 ]

Organism-specific databases

CTDi 8013.
GeneCardsi GC09P102584.
HGNCi HGNC:7982. NR4A3.
HPAi HPA043360.
MIMi 600542. gene+phenotype.
612219. phenotype.
neXtProti NX_Q92570.
Orphaneti 209916. Extraskeletal myxoid chondrosarcoma.
PharmGKBi PA31763.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245120.
HOVERGENi HBG052663.
InParanoidi Q92570.
KOi K08559.
OMAi CMMNALV.
OrthoDBi EOG75XGKJ.
PhylomeDBi Q92570.
TreeFami TF315430.

Enzyme and pathway databases

Reactomei REACT_15525. Nuclear Receptor transcription pathway.
SignaLinki Q92570.

Miscellaneous databases

ChiTaRSi NR4A3. human.
GeneWikii Neuron-derived_orphan_receptor_1.
GenomeRNAii 8013.
NextBioi 30567.
PROi Q92570.
SOURCEi Search...

Gene expression databases

Bgeei Q92570.
CleanExi HS_NR4A3.
HS_TEC.
Genevestigatori Q92570.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family."
    Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
    Biochim. Biophys. Acta 1308:205-214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Fetal brain.
  2. "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor."
    Hedvat C.V., Irving S.G.
    Mol. Endocrinol. 9:1692-1700(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Peripheral blood.
  3. "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma."
    Clark J., Benjamin H., Gill S., Sidhar S., Goodwin G., Crew J., Gusterson B.A., Shipley J., Cooper C.S.
    Oncogene 12:229-235(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Fetal brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), CHROMOSOMAL TRANSLOCATION WITH EWS.
    Tissue: Fetal heart.
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 3).
  7. "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA."
    Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
    Gene 211:79-85(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-69 AND 301-443 (ISOFORM BETA), ALTERNATIVE SPLICING.
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiNR4A3_HUMAN
AccessioniPrimary (citable) accession number: Q92570
Secondary accession number(s): A2A3I7
, Q12935, Q14979, Q16420, Q4VXA8, Q4VXA9, Q9UEK2, Q9UEK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi