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Reviewed, UniProtKB/Swiss-Prot Q92570 (NR4A3_HUMAN)

Last modified November 3, 2009. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Nuclear receptor subfamily 4 group A member 3
Alternative name(s):
    Nuclear hormone receptor NOR-1
    Neuron-derived orphan receptor 1
    Mitogen-induced nuclear orphan receptor
Gene names
Name: NR4A3
Synonyms: CHN, CSMF, MINOR, NOR1, TEC
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Binds to the B1A response-element.

Subcellular location

Nucleus Potential.

Tissue specificity

High expression of isoform alpha in skeletal muscle. High expression of isoform beta in skeletal muscle and low expression in fetal brain and placenta.

Involvement in disease

A chromosomal aberration involving NR4A3 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(9;22)(q22-31;q11-12) with EWS.

A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR4 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence caution

The sequence AAB02581.1 differs from that shown. Reason: Frameshift at positions 4 and 20.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Chromosomal rearrangement
   DiseaseProto-oncogene
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionReceptor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtranscription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus Ref.4

Non-traceable author statement. Source: UniProtKB

   Molecular functionsteroid hormone receptor activity Ref.3

Traceable author statement. Source: ProtInc

thyroid hormone receptor activity Ref.3

Traceable author statement. Source: ProtInc

transcription factor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q92570-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q92570-2)

The sequence of this isoform differs from the canonical sequence as follows:
     419-443: YCPTDQAAAGTDAEHVQQFYNLLTA → VSFMISCFQMNDQGLYLWLLVIRVD
     444-626: Missing.
Isoform 3 (identifier: Q92570-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHDSIRFGNVDM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 626626Nuclear receptor subfamily 4 group A member 3
PRO_0000053722

Regions

DNA binding289 – 36476Nuclear receptor
Zinc finger292 – 31221NR C4-type
Zinc finger328 – 35225NR C4-type
Region440 – 49051Ligand-binding Potential
Compositional bias95 – 10814Poly-His
Compositional bias282 – 2876Poly-Ser

Natural variations

Alternative sequence11M → MHDSIRFGNVDM in isoform 3.
VSP_037877
Alternative sequence419 – 44325YCPTD…NLLTA → VSFMISCFQMNDQGLYLWLL VIRVD in isoform Beta.
VSP_003712
Alternative sequence444 – 626183Missing in isoform Beta.
VSP_003713

Experimental info

Sequence conflict2401S → G Ref.1
Sequence conflict2401S → G Ref.2
Sequence conflict4541K → R in BAA11419. Ref.1
Sequence conflict5791T → N in BAA11419. Ref.1
Sequence conflict5851G → V in BAA11419. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified March 21, 2006. Version 3.
Checksum: FB4A1AB7667D96F6

FASTA62668,230
        10         20         30         40         50         60 
MPCVQAQYSP SPPGSSYAAQ TYSSEYTTEI MNPDYTKLTM DLGSTEITAT ATTSLPSIST 

        70         80         90        100        110        120 
FVEGYSSNYE LKPSCVYQMQ RPLIKVEEGR APSYHHHHHH HHHHHHHHQQ QHQQPSIPPA 

       130        140        150        160        170        180 
SSPEDEVLPS TSMYFKQSPP STPTTPAFPP QAGALWDEAL PSAPGCIAPG PLLDPPMKAV 

       190        200        210        220        230        240 
PTVAGARFPL FHFKPSPPHP PAPSPAGGHH LGYDPTAAAA LSLPLGAAAA AGSQAAALES 

       250        260        270        280        290        300 
HPYGLPLAKR AAPLAFPPLG LTPSPTASSL LGESPSLPSP PSRSSSSGEG TCAVCGDNAA 

       310        320        330        340        350        360 
CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKNCPVDKRR RNRCQYCRFQ KCLSVGMVKE 

       370        380        390        400        410        420 
VVRTDSLKGR RGRLPSKPKS PLQQEPSQPS PPSPPICMMN ALVRALTDST PRDLDYSRYC 

       430        440        450        460        470        480 
PTDQAAAGTD AEHVQQFYNL LTASIDVSRS WAEKIPGFTD LPKEDQTLLI ESAFLELFVL 

       490        500        510        520        530        540 
RLSIRSNTAE DKFVFCNGLV LHRLQCLRGF GEWLDSIKDF SLNLQSLNLD IQALACLSAL 

       550        560        570        580        590        600 
SMITERHGLK EPKRVEELCN KITSSLKDHQ SKGQALEPTE SKVLGALVEL RKICTLGLQR 

       610        620 
IFYLKLEDLV SPPSIIDKLF LDTLPF 

« Hide

Isoform Beta.

Checksum: 42E97CAE053BA5EF
Show »

FASTA44347,822
Isoform 3.

Checksum: 584261AA3DAA3AD5
Show »

FASTA63769,502

References

« Hide 'large scale' references
[1]"Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family."
Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
Biochim. Biophys. Acta 1308:205-214(1996) [PubMed: 8809112] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
Tissue: Fetal brain.
[2]"The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor."
Hedvat C.V., Irving S.G.
Mol. Endocrinol. 9:1692-1700(1995) [PubMed: 8614405] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
Tissue: Peripheral blood.
[3]"Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma."
Clark J., Benjamin H., Gill S., Sidhar S., Goodwin G., Crew J., Gusterson B.A., Shipley J., Cooper C.S.
Oncogene 12:229-235(1996) [PubMed: 8570200] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
Tissue: Fetal brain.
[4]"Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation."
Labelle Y., Zucman J., Stenman G., Kindblom L.-G., Knight J., Turc-Carel C., Dockhorn-Dworniczak B., Mandahl N., Desmaze C., Peter M., Aurias A., Delattre O., Thomas G.
Hum. Mol. Genet. 4:2219-2226(1995) [PubMed: 8634690] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), CHROMOSOMAL TRANSLOCATION WITH EWS.
Tissue: Fetal heart.
[5]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 3).
[7]"Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA."
Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
Gene 211:79-85(1998) [PubMed: 9573341] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-69 AND 301-443 (ISOFORM BETA), ALTERNATIVE SPLICING.
Tissue: Skeletal muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

D78579 mRNA. Translation: BAA11419.1.
U12767 mRNA. Translation: AAB02581.1. Frameshift.
S81243 mRNA. Translation: AAB36006.1. Different initiation.
X89894 mRNA. Translation: CAA61984.1.
AL359710 Genomic DNA. Translation: CAI95139.1.
AL359710, AL358937 Genomic DNA. Translation: CAI95138.1.
AL358937, AL359710 Genomic DNA. Translation: CAI95320.1.
AL359710, AL358937 Genomic DNA. Translation: CAM16648.1.
AL358937, AL359710 Genomic DNA. Translation: CAM22558.1.
CH471105 Genomic DNA. Translation: EAW58915.1.
D85241 mRNA. Translation: BAA28608.1.
D85242 mRNA. Translation: BAA31221.1.
IPIIPI00293038.
IPI00328269.
IPI00334557.
PIRS71930.
RefSeqNP_008912.2.
NP_775290.1.
NP_775291.1.
NP_775292.1.
UniGeneHs.279522

3D structure databases

HSSPHSSP built from PDB template 1OVL based on UniProtKB P43354.
SMRQ92570. Positions 290-378.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ92570.

PTM databases

PhosphoSiteQ92570.

Proteomic databases

PRIDEQ92570.

Genome annotation databases

EnsemblENST00000238459; ENSP00000238459; ENSG00000119508; Homo sapiens. [Genome view]
ENST00000330847; ENSP00000333122; ENSG00000119508; Homo sapiens. [Genome view]
ENST00000338488; ENSP00000340301; ENSG00000119508; Homo sapiens. [Genome view]
ENST00000395096; ENSP00000378530; ENSG00000119508; Homo sapiens. [Genome view]
ENST00000395097; ENSP00000378531; ENSG00000119508; Homo sapiens. [Genome view]
GeneID8013.
KEGGhsa:8013.
UCSCuc004bae.1. human.
uc004baf.1. human.

Organism-specific databases

CTD8013.
GeneCardsGC09P101623.
H-InvDBHIX0025751.
HGNCHGNC:7982. NR4A3.
MIM133450. gene+phenotype.
600542. gene+phenotype.
Orphanet1957. Esthesioneuroblastoma.
319. Ewing sarcoma.
PharmGKBPA31763.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ92570.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ92570.
BgeeQ92570.
CleanExHS_NR4A3.
HS_TEC.
GenevestigatorQ92570.
GermOnlineENSG00000119508. Homo sapiens.

Family and domain databases

InterProIPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
Gene3DG3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit.
G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
ProDomPD000035. Znf_C4steroid. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio30567.
SOURCESearch...

Entry information

Entry nameNR4A3_HUMAN
AccessionPrimary (citable) accession number: Q92570
Secondary accession number(s): A2A3I7 expand/collapse secondary AC list , Q12935, Q14979, Q16420, Q4VXA8, Q4VXA9, Q9UEK2, Q9UEK3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2006
Last modified: November 3, 2009
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents