Q92570 (NR4A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear receptor subfamily 4 group A member 3

Alternative name(s):
Mitogen-induced nuclear orphan receptor
Neuron-derived orphan receptor 1
Nuclear hormone receptor NOR-1

Gene names

Name:	NR4A3
Synonyms:	CHN, CSMF, MINOR, NOR1, TEC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to the B1A response-element.
Subcellular location	Nucleus Potential.
Tissue specificity	Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.
Involvement in disease	Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1. A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Sequence caution	The sequence AAB02581.1 differs from that shown. Reason: Frameshift at positions 4 and 20. The sequence AAB36006.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult behavior Inferred from electronic annotation. Source: Compara axon guidance Inferred from electronic annotation. Source: Compara cellular response to stress Inferred from electronic annotation. Source: Compara hippocampus development Inferred from electronic annotation. Source: Compara mesoderm formation Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara neuromuscular process controlling balance Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara positive regulation of cell cycle Inferred from electronic annotation. Source: Compara positive regulation of leukocyte apoptotic process Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara semicircular canal morphogenesis Inferred from electronic annotation. Source: Compara transcription initiation from RNA polymerase II promoter Traceable author statement. Source: Reactome vestibular reflex Inferred from electronic annotation. Source: Compara
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Non-traceable author statement Ref.4. Source: UniProtKB RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: Compara steroid hormone receptor activity Traceable author statement Ref.3. Source: ProtInc thyroid hormone receptor activity Traceable author statement Ref.3. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha (identifier: Q92570-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: Q92570-2)

The sequence of this isoform differs from the canonical sequence as follows:
     419-443: YCPTDQAAAGTDAEHVQQFYNLLTA → VSFMISCFQMNDQGLYLWLLVIRVD
     444-626: Missing.

Isoform 3 (identifier: Q92570-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHDSIRFGNVDM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 626	626	Nuclear receptor subfamily 4 group A member 3		PRO_0000053722
Regions
	DNA binding	289 – 364	76	Nuclear receptor
	Zinc finger	292 – 312	21	NR C4-type
	Zinc finger	328 – 352	25	NR C4-type
	Region	440 – 490	51	Ligand-binding Potential
	Compositional bias	95 – 108	14	Poly-His
	Compositional bias	282 – 287	6	Poly-Ser
Natural variations
	Alternative sequence	1	1	M → MHDSIRFGNVDM in isoform 3.		VSP_037877
	Alternative sequence	419 – 443	25	YCPTD…NLLTA → VSFMISCFQMNDQGLYLWLL VIRVD in isoform Beta.		VSP_003712
	Alternative sequence	444 – 626	183	Missing in isoform Beta.		VSP_003713
Experimental info
	Sequence conflict	240	1	S → G Ref.1
	Sequence conflict	240	1	S → G Ref.2
	Sequence conflict	454	1	K → R in BAA11419. Ref.1
	Sequence conflict	579	1	T → N in BAA11419. Ref.1
	Sequence conflict	585	1	G → V in BAA11419. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified March 21, 2006. Version 3. Checksum: FB4A1AB7667D96F6	FASTA	626	68,230
	10 20 30 40 50 60 MPCVQAQYSP SPPGSSYAAQ TYSSEYTTEI MNPDYTKLTM DLGSTEITAT ATTSLPSIST 70 80 90 100 110 120 FVEGYSSNYE LKPSCVYQMQ RPLIKVEEGR APSYHHHHHH HHHHHHHHQQ QHQQPSIPPA 130 140 150 160 170 180 SSPEDEVLPS TSMYFKQSPP STPTTPAFPP QAGALWDEAL PSAPGCIAPG PLLDPPMKAV 190 200 210 220 230 240 PTVAGARFPL FHFKPSPPHP PAPSPAGGHH LGYDPTAAAA LSLPLGAAAA AGSQAAALES 250 260 270 280 290 300 HPYGLPLAKR AAPLAFPPLG LTPSPTASSL LGESPSLPSP PSRSSSSGEG TCAVCGDNAA 310 320 330 340 350 360 CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKNCPVDKRR RNRCQYCRFQ KCLSVGMVKE 370 380 390 400 410 420 VVRTDSLKGR RGRLPSKPKS PLQQEPSQPS PPSPPICMMN ALVRALTDST PRDLDYSRYC 430 440 450 460 470 480 PTDQAAAGTD AEHVQQFYNL LTASIDVSRS WAEKIPGFTD LPKEDQTLLI ESAFLELFVL 490 500 510 520 530 540 RLSIRSNTAE DKFVFCNGLV LHRLQCLRGF GEWLDSIKDF SLNLQSLNLD IQALACLSAL 550 560 570 580 590 600 SMITERHGLK EPKRVEELCN KITSSLKDHQ SKGQALEPTE SKVLGALVEL RKICTLGLQR 610 620 IFYLKLEDLV SPPSIIDKLF LDTLPF
	Isoform Beta [UniParc]. Checksum: 42E97CAE053BA5EF	FASTA	443	47,822
	10 20 30 40 50 60 MPCVQAQYSP SPPGSSYAAQ TYSSEYTTEI MNPDYTKLTM DLGSTEITAT ATTSLPSIST 70 80 90 100 110 120 FVEGYSSNYE LKPSCVYQMQ RPLIKVEEGR APSYHHHHHH HHHHHHHHQQ QHQQPSIPPA 130 140 150 160 170 180 SSPEDEVLPS TSMYFKQSPP STPTTPAFPP QAGALWDEAL PSAPGCIAPG PLLDPPMKAV 190 200 210 220 230 240 PTVAGARFPL FHFKPSPPHP PAPSPAGGHH LGYDPTAAAA LSLPLGAAAA AGSQAAALES 250 260 270 280 290 300 HPYGLPLAKR AAPLAFPPLG LTPSPTASSL LGESPSLPSP PSRSSSSGEG TCAVCGDNAA 310 320 330 340 350 360 CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKNCPVDKRR RNRCQYCRFQ KCLSVGMVKE 370 380 390 400 410 420 VVRTDSLKGR RGRLPSKPKS PLQQEPSQPS PPSPPICMMN ALVRALTDST PRDLDYSRVS 430 440 FMISCFQMND QGLYLWLLVI RVD
	Isoform 3 [UniParc]. Checksum: 584261AA3DAA3AD5	FASTA	637	69,502
	10 20 30 40 50 60 MHDSIRFGNV DMPCVQAQYS PSPPGSSYAA QTYSSEYTTE IMNPDYTKLT MDLGSTEITA 70 80 90 100 110 120 TATTSLPSIS TFVEGYSSNY ELKPSCVYQM QRPLIKVEEG RAPSYHHHHH HHHHHHHHHQ 130 140 150 160 170 180 QQHQQPSIPP ASSPEDEVLP STSMYFKQSP PSTPTTPAFP PQAGALWDEA LPSAPGCIAP 190 200 210 220 230 240 GPLLDPPMKA VPTVAGARFP LFHFKPSPPH PPAPSPAGGH HLGYDPTAAA ALSLPLGAAA 250 260 270 280 290 300 AAGSQAAALE SHPYGLPLAK RAAPLAFPPL GLTPSPTASS LLGESPSLPS PPSRSSSSGE 310 320 330 340 350 360 GTCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF 370 380 390 400 410 420 QKCLSVGMVK EVVRTDSLKG RRGRLPSKPK SPLQQEPSQP SPPSPPICMM NALVRALTDS 430 440 450 460 470 480 TPRDLDYSRY CPTDQAAAGT DAEHVQQFYN LLTASIDVSR SWAEKIPGFT DLPKEDQTLL 490 500 510 520 530 540 IESAFLELFV LRLSIRSNTA EDKFVFCNGL VLHRLQCLRG FGEWLDSIKD FSLNLQSLNL 550 560 570 580 590 600 DIQALACLSA LSMITERHGL KEPKRVEELC NKITSSLKDH QSKGQALEPT ESKVLGALVE 610 620 630 LRKICTLGLQ RIFYLKLEDL VSPPSIIDKL FLDTLPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family." Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K. Biochim. Biophys. Acta 1308:205-214(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA). Tissue: Fetal brain.
[2]	"The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor." Hedvat C.V., Irving S.G. Mol. Endocrinol. 9:1692-1700(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA). Tissue: Peripheral blood.
[3]	"Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma." Clark J., Benjamin H., Gill S., Sidhar S., Goodwin G., Crew J., Gusterson B.A., Shipley J., Cooper C.S. Oncogene 12:229-235(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA). Tissue: Fetal brain.
[4]	"Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation." Labelle Y., Zucman J., Stenman G., Kindblom L.-G., Knight J., Turc-Carel C., Dockhorn-Dworniczak B., Mandahl N., Desmaze C., Peter M., Aurias A., Delattre O., Thomas G. Hum. Mol. Genet. 4:2219-2226(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), CHROMOSOMAL TRANSLOCATION WITH EWS. Tissue: Fetal heart.
[5]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 3).
[7]	"Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA." Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K. Gene 211:79-85(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-69 AND 301-443 (ISOFORM BETA), ALTERNATIVE SPLICING. Tissue: Skeletal muscle.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	D78579 mRNA. Translation: BAA11419.1. U12767 mRNA. Translation: AAB02581.1. Frameshift. S81243 mRNA. Translation: AAB36006.1. Different initiation. X89894 mRNA. Translation: CAA61984.1. AL359710 Genomic DNA. Translation: CAI95139.1. AL359710, AL358937 Genomic DNA. Translation: CAI95138.1. AL358937, AL359710 Genomic DNA. Translation: CAI95320.1. AL359710, AL358937 Genomic DNA. Translation: CAM16648.1. AL358937, AL359710 Genomic DNA. Translation: CAM22558.1. CH471105 Genomic DNA. Translation: EAW58915.1. D85241 mRNA. Translation: BAA28608.1. D85242 mRNA. Translation: BAA31221.1.
IPI	IPI00293038. IPI00328269. IPI00334557.
PIR	S71930.
RefSeq	NP_008912.2. NM_006981.3. NP_775291.1. NM_173199.2. NP_775292.1. NM_173200.2.
UniGene	Hs.279522.
3D structure databases
ProteinModelPortal	Q92570.
ModBase	Search...
PTM databases
PhosphoSite	Q92570.
Polymorphism databases
DMDM	90110039.
Proteomic databases
PaxDb	Q92570.
PRIDE	Q92570.
Protocols and materials databases
DNASU	8013.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330847; ENSP00000333122; ENSG00000119508. ENST00000338488; ENSP00000340301; ENSG00000119508. ENST00000395097; ENSP00000378531; ENSG00000119508.
GeneID	8013.
KEGG	hsa:8013.
UCSC	uc004bae.3. human. uc004baf.1. human. uc022bky.1. human.
Organism-specific databases
CTD	8013.
GeneCards	GC09P102584.
HGNC	HGNC:7982. NR4A3.
HPA	HPA043360.
MIM	600542. gene+phenotype. 612219. phenotype.
neXtProt	NX_Q92570.
PharmGKB	PA31763.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG245120.
HOVERGEN	HBG052663.
InParanoid	Q92570.
KO	K08559.
OMA	PSTSMYF.
OrthoDB	EOG4894MB.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q92570.
CleanEx	HS_NR4A3. HS_TEC.
Genevestigator	Q92570.
GermOnline	ENSG00000119508. Homo sapiens.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR003072. NOR1_rcpt. IPR003070. Nuc_orph_rcpt. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01286. NORNUCRECPTR. PR01284. NUCLEARECPTR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1961792.
ChiTaRS	NR4A3. human.
GenomeRNAi	8013.
NextBio	30567.
SOURCE	Search...

Entry information

Entry name

NR4A3_HUMAN

Accession

Primary (citable) accession number: Q92570
Secondary accession number(s): A2A3I7 , Q12935, Q14979, Q16420, Q4VXA8, Q4VXA9, Q9UEK2, Q9UEK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 134 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.