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Q92570 (NR4A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor subfamily 4 group A member 3
Alternative name(s):
Mitogen-induced nuclear orphan receptor
Neuron-derived orphan receptor 1
Nuclear hormone receptor NOR-1
Gene names
Name:NR4A3
Synonyms:CHN, CSMF, MINOR, NOR1, TEC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the B1A response-element.

Subcellular location

Nucleus Potential.

Tissue specificity

Isoform alphais highly expressed in skeletal muscle. Isoform betais highly expressed in skeletal muscle and low expressed in fetal brain and placenta.

Involvement in disease

Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.

A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR4 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence caution

The sequence AAB02581.1 differs from that shown. Reason: Frameshift at positions 4 and 20.

The sequence AAB36006.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Chromosomal rearrangement
   DiseaseProto-oncogene
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult behavior

Inferred from electronic annotation. Source: Ensembl

axon guidance

Inferred from electronic annotation. Source: Ensembl

gene expression

Traceable author statement. Source: Reactome

hippocampus development

Inferred from electronic annotation. Source: Ensembl

intracellular receptor signaling pathway

Traceable author statement Ref.3. Source: GOC

mesoderm formation

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neuromuscular process controlling balance

Inferred from electronic annotation. Source: Ensembl

organ regeneration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte apoptotic process

Inferred from electronic annotation. Source: Ensembl

response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

semicircular canal morphogenesis

Inferred from electronic annotation. Source: Ensembl

transcription initiation from RNA polymerase II promoter

Traceable author statement. Source: Reactome

vestibular reflex

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleoplasm

Traceable author statement. Source: Reactome

nucleus

Non-traceable author statement Ref.4. Source: UniProtKB

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Non-traceable author statement Ref.4. Source: UniProtKB

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

steroid hormone receptor activity

Traceable author statement Ref.3. Source: ProtInc

thyroid hormone receptor activity

Traceable author statement Ref.3. Source: ProtInc

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q92570-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q92570-2)

The sequence of this isoform differs from the canonical sequence as follows:
     419-443: YCPTDQAAAGTDAEHVQQFYNLLTA → VSFMISCFQMNDQGLYLWLLVIRVD
     444-626: Missing.
Isoform 3 (identifier: Q92570-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHDSIRFGNVDM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 626626Nuclear receptor subfamily 4 group A member 3
PRO_0000053722

Regions

DNA binding289 – 36476Nuclear receptor
Zinc finger292 – 31221NR C4-type
Zinc finger328 – 35225NR C4-type
Region440 – 49051Ligand-binding Potential
Compositional bias95 – 10814Poly-His
Compositional bias282 – 2876Poly-Ser

Natural variations

Alternative sequence11M → MHDSIRFGNVDM in isoform 3.
VSP_037877
Alternative sequence419 – 44325YCPTD…NLLTA → VSFMISCFQMNDQGLYLWLL VIRVD in isoform Beta.
VSP_003712
Alternative sequence444 – 626183Missing in isoform Beta.
VSP_003713

Experimental info

Sequence conflict2401S → G Ref.1
Sequence conflict2401S → G Ref.2
Sequence conflict4541K → R in BAA11419. Ref.1
Sequence conflict5791T → N in BAA11419. Ref.1
Sequence conflict5851G → V in BAA11419. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified March 21, 2006. Version 3.
Checksum: FB4A1AB7667D96F6

FASTA62668,230
        10         20         30         40         50         60 
MPCVQAQYSP SPPGSSYAAQ TYSSEYTTEI MNPDYTKLTM DLGSTEITAT ATTSLPSIST 

        70         80         90        100        110        120 
FVEGYSSNYE LKPSCVYQMQ RPLIKVEEGR APSYHHHHHH HHHHHHHHQQ QHQQPSIPPA 

       130        140        150        160        170        180 
SSPEDEVLPS TSMYFKQSPP STPTTPAFPP QAGALWDEAL PSAPGCIAPG PLLDPPMKAV 

       190        200        210        220        230        240 
PTVAGARFPL FHFKPSPPHP PAPSPAGGHH LGYDPTAAAA LSLPLGAAAA AGSQAAALES 

       250        260        270        280        290        300 
HPYGLPLAKR AAPLAFPPLG LTPSPTASSL LGESPSLPSP PSRSSSSGEG TCAVCGDNAA 

       310        320        330        340        350        360 
CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKNCPVDKRR RNRCQYCRFQ KCLSVGMVKE 

       370        380        390        400        410        420 
VVRTDSLKGR RGRLPSKPKS PLQQEPSQPS PPSPPICMMN ALVRALTDST PRDLDYSRYC 

       430        440        450        460        470        480 
PTDQAAAGTD AEHVQQFYNL LTASIDVSRS WAEKIPGFTD LPKEDQTLLI ESAFLELFVL 

       490        500        510        520        530        540 
RLSIRSNTAE DKFVFCNGLV LHRLQCLRGF GEWLDSIKDF SLNLQSLNLD IQALACLSAL 

       550        560        570        580        590        600 
SMITERHGLK EPKRVEELCN KITSSLKDHQ SKGQALEPTE SKVLGALVEL RKICTLGLQR 

       610        620 
IFYLKLEDLV SPPSIIDKLF LDTLPF 

« Hide

Isoform Beta [UniParc].

Checksum: 42E97CAE053BA5EF
Show »

FASTA44347,822
Isoform 3 [UniParc].

Checksum: 584261AA3DAA3AD5
Show »

FASTA63769,502

References

« Hide 'large scale' references
[1]"Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family."
Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
Biochim. Biophys. Acta 1308:205-214(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
Tissue: Fetal brain.
[2]"The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor."
Hedvat C.V., Irving S.G.
Mol. Endocrinol. 9:1692-1700(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
Tissue: Peripheral blood.
[3]"Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma."
Clark J., Benjamin H., Gill S., Sidhar S., Goodwin G., Crew J., Gusterson B.A., Shipley J., Cooper C.S.
Oncogene 12:229-235(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
Tissue: Fetal brain.
[4]"Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation."
Labelle Y., Zucman J., Stenman G., Kindblom L.-G., Knight J., Turc-Carel C., Dockhorn-Dworniczak B., Mandahl N., Desmaze C., Peter M., Aurias A., Delattre O., Thomas G.
Hum. Mol. Genet. 4:2219-2226(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), CHROMOSOMAL TRANSLOCATION WITH EWS.
Tissue: Fetal heart.
[5]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 3).
[7]"Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA."
Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
Gene 211:79-85(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-69 AND 301-443 (ISOFORM BETA), ALTERNATIVE SPLICING.
Tissue: Skeletal muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D78579 mRNA. Translation: BAA11419.1.
U12767 mRNA. Translation: AAB02581.1. Frameshift.
S81243 mRNA. Translation: AAB36006.1. Different initiation.
X89894 mRNA. Translation: CAA61984.1.
AL359710 Genomic DNA. Translation: CAI95139.1.
AL359710, AL358937 Genomic DNA. Translation: CAI95138.1.
AL358937, AL359710 Genomic DNA. Translation: CAI95320.1.
AL359710, AL358937 Genomic DNA. Translation: CAM16648.1.
AL358937, AL359710 Genomic DNA. Translation: CAM22558.1.
CH471105 Genomic DNA. Translation: EAW58915.1.
D85241 mRNA. Translation: BAA28608.1.
D85242 mRNA. Translation: BAA31221.1.
CCDSCCDS6742.1. [Q92570-3]
CCDS6743.1. [Q92570-1]
CCDS6744.1. [Q92570-2]
PIRS71930.
RefSeqNP_008912.2. NM_006981.3. [Q92570-1]
NP_775291.1. NM_173199.2. [Q92570-2]
NP_775292.1. NM_173200.2. [Q92570-3]
UniGeneHs.279522.

3D structure databases

ProteinModelPortalQ92570.
SMRQ92570. Positions 290-626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113713. 4 interactions.

Chemistry

ChEMBLCHEMBL1961792.

PTM databases

PhosphoSiteQ92570.

Polymorphism databases

DMDM90110039.

Proteomic databases

MaxQBQ92570.
PaxDbQ92570.
PRIDEQ92570.

Protocols and materials databases

DNASU8013.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330847; ENSP00000333122; ENSG00000119508. [Q92570-3]
ENST00000338488; ENSP00000340301; ENSG00000119508. [Q92570-2]
ENST00000395097; ENSP00000378531; ENSG00000119508. [Q92570-1]
GeneID8013.
KEGGhsa:8013.
UCSCuc004bae.3. human. [Q92570-2]
uc004baf.1. human. [Q92570-1]
uc022bky.1. human. [Q92570-3]

Organism-specific databases

CTD8013.
GeneCardsGC09P102584.
HGNCHGNC:7982. NR4A3.
HPAHPA043360.
MIM600542. gene+phenotype.
612219. phenotype.
neXtProtNX_Q92570.
Orphanet209916. Extraskeletal myxoid chondrosarcoma.
PharmGKBPA31763.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245120.
HOVERGENHBG052663.
InParanoidQ92570.
KOK08559.
OMACMMNALV.
OrthoDBEOG75XGKJ.
PhylomeDBQ92570.
TreeFamTF315430.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.
SignaLinkQ92570.

Gene expression databases

BgeeQ92570.
CleanExHS_NR4A3.
HS_TEC.
GenevestigatorQ92570.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNR4A3. human.
GeneWikiNeuron-derived_orphan_receptor_1.
GenomeRNAi8013.
NextBio30567.
PROQ92570.
SOURCESearch...

Entry information

Entry nameNR4A3_HUMAN
AccessionPrimary (citable) accession number: Q92570
Secondary accession number(s): A2A3I7 expand/collapse secondary AC list , Q12935, Q14979, Q16420, Q4VXA8, Q4VXA9, Q9UEK2, Q9UEK3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM