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Protein

Nuclear receptor subfamily 4 group A member 3

Gene

NR4A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the B1A response-element.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi289 – 36476Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35225NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiQ92570.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 3
Alternative name(s):
Mitogen-induced nuclear orphan receptor
Neuron-derived orphan receptor 1
Nuclear hormone receptor NOR-1
Gene namesi
Name:NR4A3
Synonyms:CHN, CSMF, MINOR, NOR1, TEC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:7982. NR4A3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Ewing sarcoma (ES)

The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.

Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.

See also OMIM:612219

A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi600542. gene+phenotype.
612219. phenotype.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
PharmGKBiPA31763.

Polymorphism and mutation databases

BioMutaiNR4A3.
DMDMi90110039.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Nuclear receptor subfamily 4 group A member 3PRO_0000053722Add
BLAST

Proteomic databases

MaxQBiQ92570.
PaxDbiQ92570.
PRIDEiQ92570.

PTM databases

PhosphoSiteiQ92570.

Expressioni

Tissue specificityi

Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.

Gene expression databases

BgeeiQ92570.
CleanExiHS_NR4A3.
HS_TEC.
ExpressionAtlasiQ92570. baseline and differential.
GenevisibleiQ92570. HS.

Organism-specific databases

HPAiHPA043360.

Interactioni

Subunit structurei

Interacts with SIX3(via homeobox); differentially regulates the transcriptional activities NR4A3.1 Publication

Protein-protein interaction databases

BioGridi113713. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ92570.
SMRiQ92570. Positions 290-626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni440 – 49051Ligand-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 10814Poly-HisAdd
BLAST
Compositional biasi282 – 2876Poly-Ser

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri292 – 31221NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35225NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG245120.
GeneTreeiENSGT00760000118887.
HOVERGENiHBG052663.
InParanoidiQ92570.
KOiK08559.
OMAiHPYGLPL.
OrthoDBiEOG75XGKJ.
PhylomeDBiQ92570.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q92570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCVQAQYSP SPPGSSYAAQ TYSSEYTTEI MNPDYTKLTM DLGSTEITAT
60 70 80 90 100
ATTSLPSIST FVEGYSSNYE LKPSCVYQMQ RPLIKVEEGR APSYHHHHHH
110 120 130 140 150
HHHHHHHHQQ QHQQPSIPPA SSPEDEVLPS TSMYFKQSPP STPTTPAFPP
160 170 180 190 200
QAGALWDEAL PSAPGCIAPG PLLDPPMKAV PTVAGARFPL FHFKPSPPHP
210 220 230 240 250
PAPSPAGGHH LGYDPTAAAA LSLPLGAAAA AGSQAAALES HPYGLPLAKR
260 270 280 290 300
AAPLAFPPLG LTPSPTASSL LGESPSLPSP PSRSSSSGEG TCAVCGDNAA
310 320 330 340 350
CQHYGVRTCE GCKGFFKRTV QKNAKYVCLA NKNCPVDKRR RNRCQYCRFQ
360 370 380 390 400
KCLSVGMVKE VVRTDSLKGR RGRLPSKPKS PLQQEPSQPS PPSPPICMMN
410 420 430 440 450
ALVRALTDST PRDLDYSRYC PTDQAAAGTD AEHVQQFYNL LTASIDVSRS
460 470 480 490 500
WAEKIPGFTD LPKEDQTLLI ESAFLELFVL RLSIRSNTAE DKFVFCNGLV
510 520 530 540 550
LHRLQCLRGF GEWLDSIKDF SLNLQSLNLD IQALACLSAL SMITERHGLK
560 570 580 590 600
EPKRVEELCN KITSSLKDHQ SKGQALEPTE SKVLGALVEL RKICTLGLQR
610 620
IFYLKLEDLV SPPSIIDKLF LDTLPF
Length:626
Mass (Da):68,230
Last modified:March 21, 2006 - v3
Checksum:iFB4A1AB7667D96F6
GO
Isoform Beta (identifier: Q92570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-443: YCPTDQAAAGTDAEHVQQFYNLLTA → VSFMISCFQMNDQGLYLWLLVIRVD
     444-626: Missing.

Show »
Length:443
Mass (Da):47,822
Checksum:i42E97CAE053BA5EF
GO
Isoform 3 (identifier: Q92570-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHDSIRFGNVDM

Note: No experimental confirmation available.
Show »
Length:637
Mass (Da):69,502
Checksum:i584261AA3DAA3AD5
GO

Sequence cautioni

The sequence AAB02581.1 differs from that shown. Reason: Frameshift at positions 4 and 20. Curated
The sequence AAB36006.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2401S → G (PubMed:8809112).Curated
Sequence conflicti240 – 2401S → G (PubMed:8614405).Curated
Sequence conflicti454 – 4541K → R in BAA11419 (PubMed:8809112).Curated
Sequence conflicti579 – 5791T → N in BAA11419 (PubMed:8809112).Curated
Sequence conflicti585 – 5851G → V in BAA11419 (PubMed:8809112).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MHDSIRFGNVDM in isoform 3. CuratedVSP_037877
Alternative sequencei419 – 44325YCPTD…NLLTA → VSFMISCFQMNDQGLYLWLL VIRVD in isoform Beta. 2 PublicationsVSP_003712Add
BLAST
Alternative sequencei444 – 626183Missing in isoform Beta. 2 PublicationsVSP_003713Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78579 mRNA. Translation: BAA11419.1.
U12767 mRNA. Translation: AAB02581.1. Frameshift.
S81243 mRNA. Translation: AAB36006.1. Different initiation.
X89894 mRNA. Translation: CAA61984.1.
AL359710 Genomic DNA. Translation: CAI95139.1.
AL359710, AL358937 Genomic DNA. Translation: CAI95138.1.
AL358937, AL359710 Genomic DNA. Translation: CAI95320.1.
AL359710, AL358937 Genomic DNA. Translation: CAM16648.1.
AL358937, AL359710 Genomic DNA. Translation: CAM22558.1.
CH471105 Genomic DNA. Translation: EAW58915.1.
D85241 mRNA. Translation: BAA28608.1.
D85242 mRNA. Translation: BAA31221.1.
CCDSiCCDS6742.1. [Q92570-3]
CCDS6743.1. [Q92570-1]
CCDS6744.1. [Q92570-2]
PIRiS71930.
RefSeqiNP_008912.2. NM_006981.3. [Q92570-1]
NP_775291.1. NM_173199.2. [Q92570-2]
NP_775292.1. NM_173200.2. [Q92570-3]
UniGeneiHs.279522.

Genome annotation databases

EnsembliENST00000330847; ENSP00000333122; ENSG00000119508. [Q92570-3]
ENST00000338488; ENSP00000340301; ENSG00000119508. [Q92570-2]
ENST00000395097; ENSP00000378531; ENSG00000119508. [Q92570-1]
ENST00000618101; ENSP00000482027; ENSG00000119508. [Q92570-3]
GeneIDi8013.
KEGGihsa:8013.
UCSCiuc004bae.3. human. [Q92570-2]
uc004baf.1. human. [Q92570-1]
uc022bky.1. human. [Q92570-3]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78579 mRNA. Translation: BAA11419.1.
U12767 mRNA. Translation: AAB02581.1. Frameshift.
S81243 mRNA. Translation: AAB36006.1. Different initiation.
X89894 mRNA. Translation: CAA61984.1.
AL359710 Genomic DNA. Translation: CAI95139.1.
AL359710, AL358937 Genomic DNA. Translation: CAI95138.1.
AL358937, AL359710 Genomic DNA. Translation: CAI95320.1.
AL359710, AL358937 Genomic DNA. Translation: CAM16648.1.
AL358937, AL359710 Genomic DNA. Translation: CAM22558.1.
CH471105 Genomic DNA. Translation: EAW58915.1.
D85241 mRNA. Translation: BAA28608.1.
D85242 mRNA. Translation: BAA31221.1.
CCDSiCCDS6742.1. [Q92570-3]
CCDS6743.1. [Q92570-1]
CCDS6744.1. [Q92570-2]
PIRiS71930.
RefSeqiNP_008912.2. NM_006981.3. [Q92570-1]
NP_775291.1. NM_173199.2. [Q92570-2]
NP_775292.1. NM_173200.2. [Q92570-3]
UniGeneiHs.279522.

3D structure databases

ProteinModelPortaliQ92570.
SMRiQ92570. Positions 290-626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113713. 4 interactions.

Chemistry

ChEMBLiCHEMBL1961792.

PTM databases

PhosphoSiteiQ92570.

Polymorphism and mutation databases

BioMutaiNR4A3.
DMDMi90110039.

Proteomic databases

MaxQBiQ92570.
PaxDbiQ92570.
PRIDEiQ92570.

Protocols and materials databases

DNASUi8013.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330847; ENSP00000333122; ENSG00000119508. [Q92570-3]
ENST00000338488; ENSP00000340301; ENSG00000119508. [Q92570-2]
ENST00000395097; ENSP00000378531; ENSG00000119508. [Q92570-1]
ENST00000618101; ENSP00000482027; ENSG00000119508. [Q92570-3]
GeneIDi8013.
KEGGihsa:8013.
UCSCiuc004bae.3. human. [Q92570-2]
uc004baf.1. human. [Q92570-1]
uc022bky.1. human. [Q92570-3]

Organism-specific databases

CTDi8013.
GeneCardsiGC09P102584.
HGNCiHGNC:7982. NR4A3.
HPAiHPA043360.
MIMi600542. gene+phenotype.
612219. phenotype.
neXtProtiNX_Q92570.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
PharmGKBiPA31763.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG245120.
GeneTreeiENSGT00760000118887.
HOVERGENiHBG052663.
InParanoidiQ92570.
KOiK08559.
OMAiHPYGLPL.
OrthoDBiEOG75XGKJ.
PhylomeDBiQ92570.
TreeFamiTF315430.

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiQ92570.

Miscellaneous databases

ChiTaRSiNR4A3. human.
GeneWikiiNeuron-derived_orphan_receptor_1.
GenomeRNAii8013.
NextBioi30567.
PROiQ92570.
SOURCEiSearch...

Gene expression databases

BgeeiQ92570.
CleanExiHS_NR4A3.
HS_TEC.
ExpressionAtlasiQ92570. baseline and differential.
GenevisibleiQ92570. HS.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003072. NOR1_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01286. NORNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family."
    Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
    Biochim. Biophys. Acta 1308:205-214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Fetal brain.
  2. "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor."
    Hedvat C.V., Irving S.G.
    Mol. Endocrinol. 9:1692-1700(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Peripheral blood.
  3. "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma."
    Clark J., Benjamin H., Gill S., Sidhar S., Goodwin G., Crew J., Gusterson B.A., Shipley J., Cooper C.S.
    Oncogene 12:229-235(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Fetal brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), CHROMOSOMAL TRANSLOCATION WITH EWS.
    Tissue: Fetal heart.
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 3).
  7. "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA."
    Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.
    Gene 211:79-85(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-69 AND 301-443 (ISOFORM BETA), ALTERNATIVE SPLICING.
    Tissue: Skeletal muscle.
  8. "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas."
    Laflamme C., Filion C., Bridge J.A., Ladanyi M., Goldring M.B., Labelle Y.
    Cancer Res. 63:449-454(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SIX3.

Entry informationi

Entry nameiNR4A3_HUMAN
AccessioniPrimary (citable) accession number: Q92570
Secondary accession number(s): A2A3I7
, Q12935, Q14979, Q16420, Q4VXA8, Q4VXA9, Q9UEK2, Q9UEK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2006
Last modified: June 24, 2015
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.