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Q92569

- P55G_HUMAN

UniProt

Q92569 - P55G_HUMAN

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Protein
Phosphatidylinositol 3-kinase regulatory subunit gamma
Gene
PIK3R3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: ProtInc
  2. phosphatidylinositol 3-kinase regulator activity Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. insulin receptor signaling pathway Source: ProtInc
  2. phosphatidylinositol biosynthetic process Source: Reactome
  3. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  4. phospholipid metabolic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117461-MONOMER.
ReactomeiREACT_111040. Signaling by SCF-KIT.
REACT_115529. Interleukin-7 signaling.
REACT_121025. Synthesis of PIPs at the plasma membrane.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_1695. GPVI-mediated activation cascade.
REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.
REACT_19344. Costimulation by the CD28 family.
REACT_19358. CD28 dependent PI3K/Akt signaling.
REACT_23787. Regulation of signaling by CBL.
REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
REACT_23891. Interleukin receptor SHC signaling.
REACT_75829. PIP3 activates AKT signaling.
SignaLinkiQ92569.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Short name:
PI3-kinase regulatory subunit gamma
Short name:
PI3K regulatory subunit gamma
Short name:
PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name:
PI3-kinase subunit p55-gamma
Short name:
PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
Gene namesi
Name:PIK3R3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8981. PIK3R3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. phosphatidylinositol 3-kinase complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gamma
PRO_0000080767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92569.
PaxDbiQ92569.
PRIDEiQ92569.

PTM databases

PhosphoSiteiQ92569.

Expressioni

Tissue specificityi

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Gene expression databases

ArrayExpressiQ92569.
BgeeiQ92569.
CleanExiHS_PIK3R3.
GenevestigatoriQ92569.

Organism-specific databases

HPAiHPA005751.

Interactioni

Subunit structurei

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI1Q8IZP02EBI-79893,EBI-375446
ARP1027537EBI-79893,EBI-608057
EGFRP005334EBI-79893,EBI-297353
ERBB2P046269EBI-79893,EBI-641062
ERBB3P2186022EBI-79893,EBI-720706
GAB1Q1348036EBI-79893,EBI-517684
HTTP428586EBI-79893,EBI-466029
KITP1072131EBI-79893,EBI-1379503
METP0858111EBI-79893,EBI-1039152

Protein-protein interaction databases

BioGridi114075. 34 interactions.
IntActiQ92569. 40 interactions.
MINTiMINT-1490763.
STRINGi9606.ENSP00000262741.

Structurei

3D structure databases

ProteinModelPortaliQ92569.
SMRiQ92569. Positions 55-455.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 16096SH2 1
Add
BLAST
Domaini358 – 45295SH2 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 4411Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the PI3K p85 subunit family.
Contains 2 SH2 domains.

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiNOG263689.
HOVERGENiHBG082100.
InParanoidiQ92569.
KOiK02649.
OrthoDBiEOG7BP831.
PhylomeDBiQ92569.
TreeFamiTF102033.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92569-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP    50
NGMKDSSVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY 100
TLTLRKGGNN KLIKIYHRDG KYGFSDPLTF NSVVELINHY HHESLAQYNP 150
KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK LQEYHSQYQE KSKEYDRLYE 200
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY IERFRREGNE 250
KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP 300
DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDADEN YFINEEDENL 350
PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE 400
VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY 450
PVHAQMPSLC R 461
Length:461
Mass (Da):54,448
Last modified:January 11, 2011 - v2
Checksum:i303BCC2F9EEE5364
GO
Isoform 2 (identifier: Q92569-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-314: Missing.

Show »
Length:402
Mass (Da):47,348
Checksum:i054C2111B68F17A6
GO
Isoform 3 (identifier: Q92569-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-71: Missing.
     256-314: Missing.

Show »
Length:366
Mass (Da):43,465
Checksum:iF8B6B90E29AA2DF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti283 – 2831N → K.4 Publications
Corresponds to variant rs785467 [ dbSNP | Ensembl ].
VAR_047153

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei36 – 7136Missing in isoform 3.
VSP_004713Add
BLAST
Alternative sequencei256 – 31459Missing in isoform 2 and isoform 3.
VSP_004714Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211P → L in AAC39696. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF028785 mRNA. Translation: AAC39696.1.
D88532 mRNA. Translation: BAA13636.1.
AK313726 mRNA. Translation: BAG36468.1.
AL358075 Genomic DNA. Translation: CAI21702.1.
AL358075 Genomic DNA. Translation: CAI21703.1.
CH471059 Genomic DNA. Translation: EAX06946.1.
CH471059 Genomic DNA. Translation: EAX06947.1.
CH471059 Genomic DNA. Translation: EAX06944.1.
CH471059 Genomic DNA. Translation: EAX06945.1.
CCDSiCCDS529.1. [Q92569-1]
RefSeqiNP_001107644.1. NM_001114172.1. [Q92569-1]
NP_003620.3. NM_003629.3. [Q92569-1]
UniGeneiHs.655387.

Genome annotation databases

EnsembliENST00000262741; ENSP00000262741; ENSG00000117461. [Q92569-1]
ENST00000354242; ENSP00000346188; ENSG00000117461. [Q92569-2]
ENST00000372006; ENSP00000361075; ENSG00000117461. [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461. [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461. [Q92569-2]
GeneIDi8503.
KEGGihsa:8503.
UCSCiuc001cpb.4. human. [Q92569-1]
uc009vyb.3. human. [Q92569-2]

Polymorphism databases

DMDMi317373310.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF028785 mRNA. Translation: AAC39696.1 .
D88532 mRNA. Translation: BAA13636.1 .
AK313726 mRNA. Translation: BAG36468.1 .
AL358075 Genomic DNA. Translation: CAI21702.1 .
AL358075 Genomic DNA. Translation: CAI21703.1 .
CH471059 Genomic DNA. Translation: EAX06946.1 .
CH471059 Genomic DNA. Translation: EAX06947.1 .
CH471059 Genomic DNA. Translation: EAX06944.1 .
CH471059 Genomic DNA. Translation: EAX06945.1 .
CCDSi CCDS529.1. [Q92569-1 ]
RefSeqi NP_001107644.1. NM_001114172.1. [Q92569-1 ]
NP_003620.3. NM_003629.3. [Q92569-1 ]
UniGenei Hs.655387.

3D structure databases

ProteinModelPortali Q92569.
SMRi Q92569. Positions 55-455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114075. 34 interactions.
IntActi Q92569. 40 interactions.
MINTi MINT-1490763.
STRINGi 9606.ENSP00000262741.

PTM databases

PhosphoSitei Q92569.

Polymorphism databases

DMDMi 317373310.

Proteomic databases

MaxQBi Q92569.
PaxDbi Q92569.
PRIDEi Q92569.

Protocols and materials databases

DNASUi 8503.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262741 ; ENSP00000262741 ; ENSG00000117461 . [Q92569-1 ]
ENST00000354242 ; ENSP00000346188 ; ENSG00000117461 . [Q92569-2 ]
ENST00000372006 ; ENSP00000361075 ; ENSG00000117461 . [Q92569-1 ]
ENST00000420542 ; ENSP00000412546 ; ENSG00000117461 . [Q92569-1 ]
ENST00000423209 ; ENSP00000391431 ; ENSG00000117461 . [Q92569-2 ]
GeneIDi 8503.
KEGGi hsa:8503.
UCSCi uc001cpb.4. human. [Q92569-1 ]
uc009vyb.3. human. [Q92569-2 ]

Organism-specific databases

CTDi 8503.
GeneCardsi GC01M046505.
H-InvDB HIX0000542.
HGNCi HGNC:8981. PIK3R3.
HPAi HPA005751.
MIMi 606076. gene.
neXtProti NX_Q92569.
PharmGKBi PA33314.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263689.
HOVERGENi HBG082100.
InParanoidi Q92569.
KOi K02649.
OrthoDBi EOG7BP831.
PhylomeDBi Q92569.
TreeFami TF102033.

Enzyme and pathway databases

BioCyci MetaCyc:ENSG00000117461-MONOMER.
Reactomei REACT_111040. Signaling by SCF-KIT.
REACT_115529. Interleukin-7 signaling.
REACT_121025. Synthesis of PIPs at the plasma membrane.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_1695. GPVI-mediated activation cascade.
REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.
REACT_19344. Costimulation by the CD28 family.
REACT_19358. CD28 dependent PI3K/Akt signaling.
REACT_23787. Regulation of signaling by CBL.
REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
REACT_23891. Interleukin receptor SHC signaling.
REACT_75829. PIP3 activates AKT signaling.
SignaLinki Q92569.

Miscellaneous databases

GeneWikii PIK3R3.
GenomeRNAii 8503.
NextBioi 31821.
PROi Q92569.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92569.
Bgeei Q92569.
CleanExi HS_PIK3R3.
Genevestigatori Q92569.

Family and domain databases

Gene3Di 3.30.505.10. 2 hits.
InterProi IPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view ]
PANTHERi PTHR10155. PTHR10155. 1 hit.
Pfami PF00017. SH2. 2 hits.
[Graphical view ]
PRINTSi PR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTi SM00252. SH2. 2 hits.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 2 hits.
PROSITEi PS50001. SH2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor."
    Dey B.R., Furlanetto R.W., Nissley S.P.
    Gene 209:175-183(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT LYS-283.
    Tissue: Fetal brain.
  2. "Molecular cloning of human p55pik."
    Suzuki T.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-283.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-283.
    Tissue: Brain.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-283.
  6. "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."
    Hafizi S., Alindri F., Karlsson R., Dahlbaeck B.
    Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXL.

Entry informationi

Entry nameiP55G_HUMAN
AccessioniPrimary (citable) accession number: Q92569
Secondary accession number(s): B2R9C1
, D3DQ12, O60482, Q5T4P1, Q5T4P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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