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Protein

Phosphatidylinositol 3-kinase regulatory subunit gamma

Gene

PIK3R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: ProtInc
  • 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117461-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-388841. Costimulation by the CD28 family.
R-HSA-389357. CD28 dependent PI3K/Akt signaling.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8853659. RET signaling.
R-HSA-912526. Interleukin receptor SHC signaling.
R-HSA-912631. Regulation of signaling by CBL.
SignaLinkiQ92569.
SIGNORiQ92569.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Short name:
PI3-kinase regulatory subunit gamma
Short name:
PI3K regulatory subunit gamma
Short name:
PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name:
PI3-kinase subunit p55-gamma
Short name:
PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
Gene namesi
Name:PIK3R3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8981. PIK3R3.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi8503.
OpenTargetsiENSG00000117461.
PharmGKBiPA33314.

Chemistry databases

ChEMBLiCHEMBL3559703.
DrugBankiDB01064. Isoprenaline.
DB05210. SF1126.

Polymorphism and mutation databases

BioMutaiPIK3R3.
DMDMi317373310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000807671 – 461Phosphatidylinositol 3-kinase regulatory subunit gammaAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei341PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92569.
MaxQBiQ92569.
PaxDbiQ92569.
PeptideAtlasiQ92569.
PRIDEiQ92569.

PTM databases

iPTMnetiQ92569.
PhosphoSitePlusiQ92569.

Expressioni

Tissue specificityi

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Gene expression databases

BgeeiENSG00000117461.
CleanExiHS_PIK3R3.
ExpressionAtlasiQ92569. baseline and differential.
GenevisibleiQ92569. HS.

Organism-specific databases

HPAiHPA005751.
HPA071988.

Interactioni

Subunit structurei

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114075. 117 interactors.
DIPiDIP-30925N.
IntActiQ92569. 131 interactors.
MINTiMINT-1490763.
STRINGi9606.ENSP00000262741.

Structurei

3D structure databases

ProteinModelPortaliQ92569.
SMRiQ92569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 160SH2 1PROSITE-ProRule annotationAdd BLAST96
Domaini358 – 452SH2 2PROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 44Pro-richAdd BLAST11

Sequence similaritiesi

Belongs to the PI3K p85 subunit family.Curated

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
GeneTreeiENSGT00390000010431.
HOVERGENiHBG082100.
InParanoidiQ92569.
KOiK02649.
OrthoDBiEOG091G0C3Z.
PhylomeDBiQ92569.
TreeFamiTF102033.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiView protein in InterPro
IPR032498. PI3K_P85_iSH2.
IPR001720. PI3kinase_P85.
IPR000980. SH2.
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiView protein in Pfam
PF16454. PI3K_P85_iSH2. 1 hit.
PF00017. SH2. 2 hits.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 2 hits.
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92569-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP
60 70 80 90 100
NGMKDSSVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY
110 120 130 140 150
TLTLRKGGNN KLIKIYHRDG KYGFSDPLTF NSVVELINHY HHESLAQYNP
160 170 180 190 200
KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK LQEYHSQYQE KSKEYDRLYE
210 220 230 240 250
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY IERFRREGNE
260 270 280 290 300
KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP
310 320 330 340 350
DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDADEN YFINEEDENL
360 370 380 390 400
PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE
410 420 430 440 450
VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY
460
PVHAQMPSLC R
Length:461
Mass (Da):54,448
Last modified:January 11, 2011 - v2
Checksum:i303BCC2F9EEE5364
GO
Isoform 2 (identifier: Q92569-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-314: Missing.

Show »
Length:402
Mass (Da):47,348
Checksum:i054C2111B68F17A6
GO
Isoform 3 (identifier: Q92569-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-71: Missing.
     256-314: Missing.

Show »
Length:366
Mass (Da):43,465
Checksum:iF8B6B90E29AA2DF6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21P → L in AAC39696 (PubMed:9524259).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047153283N → K4 PublicationsCorresponds to variant dbSNP:rs785467Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00471336 – 71Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_004714256 – 314Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028785 mRNA. Translation: AAC39696.1.
D88532 mRNA. Translation: BAA13636.1.
AK313726 mRNA. Translation: BAG36468.1.
AL358075 Genomic DNA. Translation: CAI21702.1.
AL358075 Genomic DNA. Translation: CAI21703.1.
CH471059 Genomic DNA. Translation: EAX06946.1.
CH471059 Genomic DNA. Translation: EAX06947.1.
CH471059 Genomic DNA. Translation: EAX06944.1.
CH471059 Genomic DNA. Translation: EAX06945.1.
CCDSiCCDS529.1. [Q92569-1]
CCDS76154.1. [Q92569-2]
RefSeqiNP_001107644.1. NM_001114172.1. [Q92569-1]
NP_001290358.1. NM_001303429.1. [Q92569-2]
NP_003620.3. NM_003629.3. [Q92569-1]
XP_016858103.1. XM_017002614.1. [Q92569-1]
UniGeneiHs.655387.

Genome annotation databases

EnsembliENST00000262741; ENSP00000262741; ENSG00000117461. [Q92569-1]
ENST00000372006; ENSP00000361075; ENSG00000117461. [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461. [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461. [Q92569-2]
GeneIDi8503.
KEGGihsa:8503.
UCSCiuc001cpb.5. human. [Q92569-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028785 mRNA. Translation: AAC39696.1.
D88532 mRNA. Translation: BAA13636.1.
AK313726 mRNA. Translation: BAG36468.1.
AL358075 Genomic DNA. Translation: CAI21702.1.
AL358075 Genomic DNA. Translation: CAI21703.1.
CH471059 Genomic DNA. Translation: EAX06946.1.
CH471059 Genomic DNA. Translation: EAX06947.1.
CH471059 Genomic DNA. Translation: EAX06944.1.
CH471059 Genomic DNA. Translation: EAX06945.1.
CCDSiCCDS529.1. [Q92569-1]
CCDS76154.1. [Q92569-2]
RefSeqiNP_001107644.1. NM_001114172.1. [Q92569-1]
NP_001290358.1. NM_001303429.1. [Q92569-2]
NP_003620.3. NM_003629.3. [Q92569-1]
XP_016858103.1. XM_017002614.1. [Q92569-1]
UniGeneiHs.655387.

3D structure databases

ProteinModelPortaliQ92569.
SMRiQ92569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114075. 117 interactors.
DIPiDIP-30925N.
IntActiQ92569. 131 interactors.
MINTiMINT-1490763.
STRINGi9606.ENSP00000262741.

Chemistry databases

ChEMBLiCHEMBL3559703.
DrugBankiDB01064. Isoprenaline.
DB05210. SF1126.

PTM databases

iPTMnetiQ92569.
PhosphoSitePlusiQ92569.

Polymorphism and mutation databases

BioMutaiPIK3R3.
DMDMi317373310.

Proteomic databases

EPDiQ92569.
MaxQBiQ92569.
PaxDbiQ92569.
PeptideAtlasiQ92569.
PRIDEiQ92569.

Protocols and materials databases

DNASUi8503.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262741; ENSP00000262741; ENSG00000117461. [Q92569-1]
ENST00000372006; ENSP00000361075; ENSG00000117461. [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461. [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461. [Q92569-2]
GeneIDi8503.
KEGGihsa:8503.
UCSCiuc001cpb.5. human. [Q92569-1]

Organism-specific databases

CTDi8503.
DisGeNETi8503.
GeneCardsiPIK3R3.
H-InvDBiHIX0000542.
HGNCiHGNC:8981. PIK3R3.
HPAiHPA005751.
HPA071988.
MIMi606076. gene.
neXtProtiNX_Q92569.
OpenTargetsiENSG00000117461.
PharmGKBiPA33314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
GeneTreeiENSGT00390000010431.
HOVERGENiHBG082100.
InParanoidiQ92569.
KOiK02649.
OrthoDBiEOG091G0C3Z.
PhylomeDBiQ92569.
TreeFamiTF102033.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117461-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-1433557. Signaling by SCF-KIT.
R-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-388841. Costimulation by the CD28 family.
R-HSA-389357. CD28 dependent PI3K/Akt signaling.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8853659. RET signaling.
R-HSA-912526. Interleukin receptor SHC signaling.
R-HSA-912631. Regulation of signaling by CBL.
SignaLinkiQ92569.
SIGNORiQ92569.

Miscellaneous databases

ChiTaRSiPIK3R3. human.
GeneWikiiPIK3R3.
GenomeRNAii8503.
PROiPR:Q92569.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117461.
CleanExiHS_PIK3R3.
ExpressionAtlasiQ92569. baseline and differential.
GenevisibleiQ92569. HS.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiView protein in InterPro
IPR032498. PI3K_P85_iSH2.
IPR001720. PI3kinase_P85.
IPR000980. SH2.
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiView protein in Pfam
PF16454. PI3K_P85_iSH2. 1 hit.
PF00017. SH2. 2 hits.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 2 hits.
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiP55G_HUMAN
AccessioniPrimary (citable) accession number: Q92569
Secondary accession number(s): B2R9C1
, D3DQ12, O60482, Q5T4P1, Q5T4P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 11, 2011
Last modified: March 15, 2017
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.