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Protein

Phosphatidylinositol 3-kinase regulatory subunit gamma

Gene

PIK3R3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: ProtInc
  2. phosphatidylinositol 3-kinase regulator activity Source: InterPro

GO - Biological processi

  1. insulin receptor signaling pathway Source: ProtInc
  2. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  3. phosphatidylinositol biosynthetic process Source: Reactome
  4. phospholipid metabolic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117461-MONOMER.
ReactomeiREACT_111040. Signaling by SCF-KIT.
REACT_115529. Interleukin-7 signaling.
REACT_121025. Synthesis of PIPs at the plasma membrane.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_1695. GPVI-mediated activation cascade.
REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19344. Costimulation by the CD28 family.
REACT_19358. CD28 dependent PI3K/Akt signaling.
REACT_23787. Regulation of signaling by CBL.
REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
REACT_23891. Interleukin receptor SHC signaling.
REACT_75829. PIP3 activates AKT signaling.
SignaLinkiQ92569.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma
Short name:
PI3-kinase regulatory subunit gamma
Short name:
PI3K regulatory subunit gamma
Short name:
PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name:
PI3-kinase subunit p55-gamma
Short name:
PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
Gene namesi
Name:PIK3R3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8981. PIK3R3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. phosphatidylinositol 3-kinase complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gammaPRO_0000080767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei341 – 3411PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92569.
PaxDbiQ92569.
PRIDEiQ92569.

PTM databases

PhosphoSiteiQ92569.

Expressioni

Tissue specificityi

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Gene expression databases

BgeeiQ92569.
CleanExiHS_PIK3R3.
ExpressionAtlasiQ92569. baseline and differential.
GenevestigatoriQ92569.

Organism-specific databases

HPAiHPA005751.

Interactioni

Subunit structurei

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI1Q8IZP02EBI-79893,EBI-375446
ARP1027537EBI-79893,EBI-608057
EGFRP005336EBI-79893,EBI-297353
ERBB2P046269EBI-79893,EBI-641062
ERBB3P2186022EBI-79893,EBI-720706
GAB1Q1348036EBI-79893,EBI-517684
HTTP428586EBI-79893,EBI-466029
KITP1072131EBI-79893,EBI-1379503
METP0858111EBI-79893,EBI-1039152

Protein-protein interaction databases

BioGridi114075. 46 interactions.
DIPiDIP-30925N.
IntActiQ92569. 43 interactions.
MINTiMINT-1490763.
STRINGi9606.ENSP00000262741.

Structurei

3D structure databases

ProteinModelPortaliQ92569.
SMRiQ92569. Positions 55-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 16096SH2 1PROSITE-ProRule annotationAdd
BLAST
Domaini358 – 45295SH2 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 4411Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PI3K p85 subunit family.Curated
Contains 2 SH2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiNOG263689.
GeneTreeiENSGT00390000010431.
HOVERGENiHBG082100.
InParanoidiQ92569.
KOiK02649.
OrthoDBiEOG7BP831.
PhylomeDBiQ92569.
TreeFamiTF102033.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92569-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP
60 70 80 90 100
NGMKDSSVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY
110 120 130 140 150
TLTLRKGGNN KLIKIYHRDG KYGFSDPLTF NSVVELINHY HHESLAQYNP
160 170 180 190 200
KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK LQEYHSQYQE KSKEYDRLYE
210 220 230 240 250
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY IERFRREGNE
260 270 280 290 300
KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP
310 320 330 340 350
DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDADEN YFINEEDENL
360 370 380 390 400
PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE
410 420 430 440 450
VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY
460
PVHAQMPSLC R
Length:461
Mass (Da):54,448
Last modified:January 10, 2011 - v2
Checksum:i303BCC2F9EEE5364
GO
Isoform 2 (identifier: Q92569-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-314: Missing.

Show »
Length:402
Mass (Da):47,348
Checksum:i054C2111B68F17A6
GO
Isoform 3 (identifier: Q92569-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-71: Missing.
     256-314: Missing.

Show »
Length:366
Mass (Da):43,465
Checksum:iF8B6B90E29AA2DF6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211P → L in AAC39696 (PubMed:9524259).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti283 – 2831N → K.4 Publications
Corresponds to variant rs785467 [ dbSNP | Ensembl ].
VAR_047153

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei36 – 7136Missing in isoform 3. 1 PublicationVSP_004713Add
BLAST
Alternative sequencei256 – 31459Missing in isoform 2 and isoform 3. 1 PublicationVSP_004714Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028785 mRNA. Translation: AAC39696.1.
D88532 mRNA. Translation: BAA13636.1.
AK313726 mRNA. Translation: BAG36468.1.
AL358075 Genomic DNA. Translation: CAI21702.1.
AL358075 Genomic DNA. Translation: CAI21703.1.
CH471059 Genomic DNA. Translation: EAX06946.1.
CH471059 Genomic DNA. Translation: EAX06947.1.
CH471059 Genomic DNA. Translation: EAX06944.1.
CH471059 Genomic DNA. Translation: EAX06945.1.
CCDSiCCDS529.1. [Q92569-1]
RefSeqiNP_001107644.1. NM_001114172.1. [Q92569-1]
NP_001290358.1. NM_001303429.1. [Q92569-2]
NP_003620.3. NM_003629.3. [Q92569-1]
UniGeneiHs.655387.

Genome annotation databases

EnsembliENST00000262741; ENSP00000262741; ENSG00000117461. [Q92569-1]
ENST00000372006; ENSP00000361075; ENSG00000117461. [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461. [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461. [Q92569-2]
GeneIDi8503.
KEGGihsa:8503.
UCSCiuc001cpb.4. human. [Q92569-1]
uc009vyb.3. human. [Q92569-2]

Polymorphism databases

DMDMi317373310.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028785 mRNA. Translation: AAC39696.1.
D88532 mRNA. Translation: BAA13636.1.
AK313726 mRNA. Translation: BAG36468.1.
AL358075 Genomic DNA. Translation: CAI21702.1.
AL358075 Genomic DNA. Translation: CAI21703.1.
CH471059 Genomic DNA. Translation: EAX06946.1.
CH471059 Genomic DNA. Translation: EAX06947.1.
CH471059 Genomic DNA. Translation: EAX06944.1.
CH471059 Genomic DNA. Translation: EAX06945.1.
CCDSiCCDS529.1. [Q92569-1]
RefSeqiNP_001107644.1. NM_001114172.1. [Q92569-1]
NP_001290358.1. NM_001303429.1. [Q92569-2]
NP_003620.3. NM_003629.3. [Q92569-1]
UniGeneiHs.655387.

3D structure databases

ProteinModelPortaliQ92569.
SMRiQ92569. Positions 55-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114075. 46 interactions.
DIPiDIP-30925N.
IntActiQ92569. 43 interactions.
MINTiMINT-1490763.
STRINGi9606.ENSP00000262741.

Chemistry

DrugBankiDB01064. Isoprenaline.

PTM databases

PhosphoSiteiQ92569.

Polymorphism databases

DMDMi317373310.

Proteomic databases

MaxQBiQ92569.
PaxDbiQ92569.
PRIDEiQ92569.

Protocols and materials databases

DNASUi8503.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262741; ENSP00000262741; ENSG00000117461. [Q92569-1]
ENST00000372006; ENSP00000361075; ENSG00000117461. [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461. [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461. [Q92569-2]
GeneIDi8503.
KEGGihsa:8503.
UCSCiuc001cpb.4. human. [Q92569-1]
uc009vyb.3. human. [Q92569-2]

Organism-specific databases

CTDi8503.
GeneCardsiGC01M046505.
H-InvDBHIX0000542.
HGNCiHGNC:8981. PIK3R3.
HPAiHPA005751.
MIMi606076. gene.
neXtProtiNX_Q92569.
PharmGKBiPA33314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG263689.
GeneTreeiENSGT00390000010431.
HOVERGENiHBG082100.
InParanoidiQ92569.
KOiK02649.
OrthoDBiEOG7BP831.
PhylomeDBiQ92569.
TreeFamiTF102033.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117461-MONOMER.
ReactomeiREACT_111040. Signaling by SCF-KIT.
REACT_115529. Interleukin-7 signaling.
REACT_121025. Synthesis of PIPs at the plasma membrane.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_1695. GPVI-mediated activation cascade.
REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19344. Costimulation by the CD28 family.
REACT_19358. CD28 dependent PI3K/Akt signaling.
REACT_23787. Regulation of signaling by CBL.
REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
REACT_23891. Interleukin receptor SHC signaling.
REACT_75829. PIP3 activates AKT signaling.
SignaLinkiQ92569.

Miscellaneous databases

ChiTaRSiPIK3R3. human.
GeneWikiiPIK3R3.
GenomeRNAii8503.
NextBioi31821.
PROiQ92569.
SOURCEiSearch...

Gene expression databases

BgeeiQ92569.
CleanExiHS_PIK3R3.
ExpressionAtlasiQ92569. baseline and differential.
GenevestigatoriQ92569.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00017. SH2. 2 hits.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor."
    Dey B.R., Furlanetto R.W., Nissley S.P.
    Gene 209:175-183(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT LYS-283.
    Tissue: Fetal brain.
  2. "Molecular cloning of human p55pik."
    Suzuki T.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-283.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-283.
    Tissue: Brain.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-283.
  6. "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."
    Hafizi S., Alindri F., Karlsson R., Dahlbaeck B.
    Biochem. Biophys. Res. Commun. 299:793-800(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXL.

Entry informationi

Entry nameiP55G_HUMAN
AccessioniPrimary (citable) accession number: Q92569
Secondary accession number(s): B2R9C1
, D3DQ12, O60482, Q5T4P1, Q5T4P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2000
Last sequence update: January 10, 2011
Last modified: March 31, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.