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Q92569 (P55G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase regulatory subunit gamma

Short name=PI3-kinase regulatory subunit gamma
Short name=PI3K regulatory subunit gamma
Short name=PtdIns-3-kinase regulatory subunit gamma
Alternative name(s):
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
Short name=PI3-kinase subunit p55-gamma
Short name=PtdIns-3-kinase regulatory subunit p55-gamma
p55PIK
Gene names
Name:PIK3R3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Subunit structure

Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Ref.6

Tissue specificity

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Sequence similarities

Belongs to the PI3K p85 subunit family.

Contains 2 SH2 domains.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92569-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92569-2)

The sequence of this isoform differs from the canonical sequence as follows:
     256-314: Missing.
Isoform 3 (identifier: Q92569-3)

The sequence of this isoform differs from the canonical sequence as follows:
     36-71: Missing.
     256-314: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Phosphatidylinositol 3-kinase regulatory subunit gamma
PRO_0000080767

Regions

Domain65 – 16096SH2 1
Domain358 – 45295SH2 2
Compositional bias34 – 4411Pro-rich

Amino acid modifications

Modified residue3411Phosphotyrosine By similarity

Natural variations

Alternative sequence36 – 7136Missing in isoform 3.
VSP_004713
Alternative sequence256 – 31459Missing in isoform 2 and isoform 3.
VSP_004714
Natural variant2831N → K. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs785467 [ dbSNP | Ensembl ].
VAR_047153

Experimental info

Sequence conflict211P → L in AAC39696. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 303BCC2F9EEE5364

FASTA46154,448
        10         20         30         40         50         60 
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP NGMKDSSVSL 

        70         80         90        100        110        120 
QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG 

       130        140        150        160        170        180 
KYGFSDPLTF NSVVELINHY HHESLAQYNP KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK 

       190        200        210        220        230        240 
LQEYHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY 

       250        260        270        280        290        300 
IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP 

       310        320        330        340        350        360 
DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDADEN YFINEEDENL PHYDEKTWFV 

       370        380        390        400        410        420 
EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKHCVIYSTA RGYGFAEPYN 

       430        440        450        460 
LYSSLKELVL HYQQTSLVQH NDSLNVRLAY PVHAQMPSLC R 

« Hide

Isoform 2 [UniParc].

Checksum: 054C2111B68F17A6
Show »

FASTA40247,348
Isoform 3 [UniParc].

Checksum: F8B6B90E29AA2DF6
Show »

FASTA36643,465

References

« Hide 'large scale' references
[1]"Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor."
Dey B.R., Furlanetto R.W., Nissley S.P.
Gene 209:175-183(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT LYS-283.
Tissue: Fetal brain.
[2]"Molecular cloning of human p55pik."
Suzuki T.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-283.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-283.
Tissue: Brain.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-283.
[6]"Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."
Hafizi S., Alindri F., Karlsson R., Dahlbaeck B.
Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AXL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF028785 mRNA. Translation: AAC39696.1.
D88532 mRNA. Translation: BAA13636.1.
AK313726 mRNA. Translation: BAG36468.1.
AL358075 Genomic DNA. Translation: CAI21702.1.
AL358075 Genomic DNA. Translation: CAI21703.1.
CH471059 Genomic DNA. Translation: EAX06946.1.
CH471059 Genomic DNA. Translation: EAX06947.1.
CH471059 Genomic DNA. Translation: EAX06944.1.
CH471059 Genomic DNA. Translation: EAX06945.1.
CCDSCCDS529.1. [Q92569-1]
RefSeqNP_001107644.1. NM_001114172.1. [Q92569-1]
NP_003620.3. NM_003629.3. [Q92569-1]
UniGeneHs.655387.

3D structure databases

ProteinModelPortalQ92569.
SMRQ92569. Positions 55-455.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114075. 34 interactions.
IntActQ92569. 40 interactions.
MINTMINT-1490763.
STRING9606.ENSP00000262741.

PTM databases

PhosphoSiteQ92569.

Polymorphism databases

DMDM317373310.

Proteomic databases

MaxQBQ92569.
PaxDbQ92569.
PRIDEQ92569.

Protocols and materials databases

DNASU8503.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262741; ENSP00000262741; ENSG00000117461. [Q92569-1]
ENST00000354242; ENSP00000346188; ENSG00000117461. [Q92569-2]
ENST00000372006; ENSP00000361075; ENSG00000117461. [Q92569-1]
ENST00000420542; ENSP00000412546; ENSG00000117461. [Q92569-1]
ENST00000423209; ENSP00000391431; ENSG00000117461. [Q92569-2]
GeneID8503.
KEGGhsa:8503.
UCSCuc001cpb.4. human. [Q92569-1]
uc009vyb.3. human. [Q92569-2]

Organism-specific databases

CTD8503.
GeneCardsGC01M046505.
H-InvDBHIX0000542.
HGNCHGNC:8981. PIK3R3.
HPAHPA005751.
MIM606076. gene.
neXtProtNX_Q92569.
PharmGKBPA33314.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG263689.
HOVERGENHBG082100.
InParanoidQ92569.
KOK02649.
OrthoDBEOG7BP831.
PhylomeDBQ92569.
TreeFamTF102033.

Enzyme and pathway databases

BioCycMetaCyc:ENSG00000117461-MONOMER.
ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_116125. Disease.
REACT_604. Hemostasis.
REACT_6900. Immune System.
SignaLinkQ92569.

Gene expression databases

ArrayExpressQ92569.
BgeeQ92569.
CleanExHS_PIK3R3.
GenevestigatorQ92569.

Family and domain databases

Gene3D3.30.505.10. 2 hits.
InterProIPR001720. PI3kinase_P85.
IPR000980. SH2.
[Graphical view]
PANTHERPTHR10155. PTHR10155. 1 hit.
PfamPF00017. SH2. 2 hits.
[Graphical view]
PRINTSPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTSM00252. SH2. 2 hits.
[Graphical view]
SUPFAMSSF55550. SSF55550. 2 hits.
PROSITEPS50001. SH2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPIK3R3.
GenomeRNAi8503.
NextBio31821.
PROQ92569.
SOURCESearch...

Entry information

Entry nameP55G_HUMAN
AccessionPrimary (citable) accession number: Q92569
Secondary accession number(s): B2R9C1 expand/collapse secondary AC list , D3DQ12, O60482, Q5T4P1, Q5T4P2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM