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Protein

Protein FAM168A

Gene

FAM168A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.4 Publications

GO - Biological processi

  • positive regulation of base-excision repair Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM168A
Alternative name(s):
Tongue cancer chemotherapy resistance-associated protein 1
Gene namesi
Name:FAM168A
Synonyms:KIAA0280, TCRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000054965.10
HGNCiHGNC:28999 FAM168A
MIMi616316 gene
neXtProtiNX_Q92567

Pathology & Biotechi

Involvement in diseasei

Associated with cisplatin (DDP)-resistance and radioresistance in the treatment of lung cancer as well as oral squamous cell carcinoma and poor clinical outcome in patients.4 Publications

Organism-specific databases

DisGeNETi23201
OpenTargetsiENSG00000054965
PharmGKBiPA162387077

Polymorphism and mutation databases

DMDMi46576628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507421 – 244Protein FAM168AAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei102Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ92567
MaxQBiQ92567
PaxDbiQ92567
PeptideAtlasiQ92567
PRIDEiQ92567
ProteomicsDBi75324
75325 [Q92567-2]
75326 [Q92567-3]

PTM databases

iPTMnetiQ92567
PhosphoSitePlusiQ92567

Expressioni

Gene expression databases

BgeeiENSG00000054965
CleanExiHS_FAM168A
GenevisibleiQ92567 HS

Organism-specific databases

HPAiHPA037580

Interactioni

Subunit structurei

Interacts with POLB (PubMed:25260657). Interacts with AKT1 and MT1X (PubMed:23251525). May interact with FAM168B (PubMed:22771904).3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116810, 86 interactors
IntActiQ92567, 61 interactors
MINTiQ92567
STRINGi9606.ENSP00000348852

Structurei

3D structure databases

ProteinModelPortaliQ92567
SMRiQ92567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM168 family.Curated

Phylogenomic databases

eggNOGiENOG410IHUV Eukaryota
ENOG410XR79 LUCA
GeneTreeiENSGT00390000005140
HOGENOMiHOG000073527
HOVERGENiHBG052179
InParanoidiQ92567
OMAiCATEGTF
OrthoDBiEOG091G0P0L
PhylomeDBiQ92567
TreeFamiTF331128

Family and domain databases

InterProiView protein in InterPro
IPR029247 FAM168A/MANI
PANTHERiPTHR31844 PTHR31844, 1 hit
PfamiView protein in Pfam
PF14944 TCRP1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92567-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPVYSPVQP GAPYGNPKNM AYTGYPTAYP AAAPAYNPSL YPTNSPSYAP
60 70 80 90 100
EFQFLHSAYA TLLMKQAWPQ NSSSCGTEGT FHLPVDTGTE NRTYQASSAA
110 120 130 140 150
FRYTAGTPYK VPPTQSNTAP PPYSPSPNPY QTAMYPIRSA YPQQNLYAQG
160 170 180 190 200
AYYTQPVYAA QPHVIHHTTV VQPNSIPSAI YPAPVAAPRT NGVAMGMVAG
210 220 230 240
TTMAMSAGTL LTTPQHTAIG AHPVSMPTYR AQGTPAYSYV PPHW
Length:244
Mass (Da):26,184
Last modified:April 26, 2004 - v2
Checksum:i60E3E9621665D30C
GO
Isoform 2 (identifier: Q92567-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-59: Missing.

Show »
Length:235
Mass (Da):25,061
Checksum:i8236A41DEBEAC93D
GO
Isoform 3 (identifier: Q92567-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-59: Missing.
     102-208: RYTAGTPYKV...AGTTMAMSAG → S

Show »
Length:129
Mass (Da):13,785
Checksum:i6D2B99442C0475A1
GO

Sequence cautioni

The sequence BAA13408 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01009551 – 59Missing in isoform 2 and isoform 3. 3 Publications9
Alternative sequenceiVSP_034630102 – 208RYTAG…AMSAG → S in isoform 3. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF363480 mRNA Translation: ABM69287.1
EF197985 mRNA Translation: ABM69272.1
D87470 mRNA Translation: BAA13408.1 Different initiation.
AK292054 mRNA Translation: BAF84743.1
BC052341 mRNA Translation: AAH52341.1
CCDSiCCDS41689.1 [Q92567-2]
CCDS66165.1 [Q92567-3]
CCDS73346.1 [Q92567-1]
RefSeqiNP_001272979.1, NM_001286050.1 [Q92567-1]
NP_001272980.1, NM_001286051.1 [Q92567-3]
NP_055974.1, NM_015159.2 [Q92567-2]
UniGeneiHs.475334

Genome annotation databases

EnsembliENST00000064778; ENSP00000064778; ENSG00000054965 [Q92567-1]
ENST00000356467; ENSP00000348852; ENSG00000054965 [Q92567-2]
ENST00000450446; ENSP00000390501; ENSG00000054965 [Q92567-3]
GeneIDi23201
KEGGihsa:23201
UCSCiuc001oty.3 human [Q92567-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiF168A_HUMAN
AccessioniPrimary (citable) accession number: Q92567
Secondary accession number(s): A2ICY2, A2ID81, Q86UG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: June 20, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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