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Protein

Protein FAM168A

Gene

FAM168A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM168A
Alternative name(s):
Tongue cancer chemotherapy resistance-associated protein 1
Gene namesi
Name:FAM168A
Synonyms:KIAA0280, TCRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28999. FAM168A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387077.

Polymorphism and mutation databases

DMDMi46576628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Protein FAM168APRO_0000050742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ92567.
MaxQBiQ92567.
PaxDbiQ92567.
PRIDEiQ92567.

PTM databases

iPTMnetiQ92567.
PhosphoSiteiQ92567.

Expressioni

Gene expression databases

BgeeiQ92567.
CleanExiHS_FAM168A.
GenevisibleiQ92567. HS.

Organism-specific databases

HPAiHPA037580.

Interactioni

Subunit structurei

May interact with FAM168B.

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf94Q6P1W53EBI-7957930,EBI-946029
CALCOCO2Q131373EBI-7957930,EBI-739580
DAB1O755533EBI-7957930,EBI-7875264
DAZAP2Q150383EBI-7957930,EBI-724310
DTX2Q4ZH493EBI-7957930,EBI-10192429
DTX2Q86UW93EBI-7957930,EBI-740376
KLHL42Q9P2K63EBI-7957930,EBI-739890
NAF1Q96HR83EBI-7957930,EBI-2515597
OTUB2Q96DC93EBI-7957930,EBI-746259
OTULINQ96BN83EBI-7957930,EBI-750730
PRR20CP864793EBI-7957930,EBI-10172814
R3HDM2Q9Y2K5-23EBI-7957930,EBI-10326419
RBPMSQ930625EBI-7957930,EBI-740322
SF1Q156373EBI-7957930,EBI-744603
SMAP2Q8WU793EBI-7957930,EBI-2822515
SNRPCQ5TAL43EBI-7957930,EBI-10246938
SS18L1O751774EBI-7957930,EBI-744674
TAX1BP1Q86VP13EBI-7957930,EBI-529518
TNIP1Q150253EBI-7957930,EBI-357849
UBASH3BQ8TF423EBI-7957930,EBI-1380492
UBE2V1Q134043EBI-7957930,EBI-1050671
VPS37CA5D8V63EBI-7957930,EBI-2559305

Protein-protein interaction databases

BioGridi116810. 29 interactions.
IntActiQ92567. 24 interactions.
MINTiMINT-8383567.
STRINGi9606.ENSP00000348852.

Structurei

3D structure databases

ProteinModelPortaliQ92567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM168 family.Curated

Phylogenomic databases

eggNOGiENOG410IHUV. Eukaryota.
ENOG410XR79. LUCA.
GeneTreeiENSGT00390000005140.
HOGENOMiHOG000073527.
HOVERGENiHBG052179.
InParanoidiQ92567.
OMAiCATEGTF.
OrthoDBiEOG7HB5BT.
PhylomeDBiQ92567.
TreeFamiTF331128.

Family and domain databases

InterProiIPR029247. FAM168A/MANI.
[Graphical view]
PfamiPF14944. TCRP1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92567-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPVYSPVQP GAPYGNPKNM AYTGYPTAYP AAAPAYNPSL YPTNSPSYAP
60 70 80 90 100
EFQFLHSAYA TLLMKQAWPQ NSSSCGTEGT FHLPVDTGTE NRTYQASSAA
110 120 130 140 150
FRYTAGTPYK VPPTQSNTAP PPYSPSPNPY QTAMYPIRSA YPQQNLYAQG
160 170 180 190 200
AYYTQPVYAA QPHVIHHTTV VQPNSIPSAI YPAPVAAPRT NGVAMGMVAG
210 220 230 240
TTMAMSAGTL LTTPQHTAIG AHPVSMPTYR AQGTPAYSYV PPHW
Length:244
Mass (Da):26,184
Last modified:April 26, 2004 - v2
Checksum:i60E3E9621665D30C
GO
Isoform 2 (identifier: Q92567-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-59: Missing.

Show »
Length:235
Mass (Da):25,061
Checksum:i8236A41DEBEAC93D
GO
Isoform 3 (identifier: Q92567-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-59: Missing.
     102-208: RYTAGTPYKV...AGTTMAMSAG → S

Show »
Length:129
Mass (Da):13,785
Checksum:i6D2B99442C0475A1
GO

Sequence cautioni

The sequence BAA13408.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei51 – 599Missing in isoform 2 and isoform 3. 3 PublicationsVSP_010095
Alternative sequencei102 – 208107RYTAG…AMSAG → S in isoform 3. 1 PublicationVSP_034630Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF363480 mRNA. Translation: ABM69287.1.
EF197985 mRNA. Translation: ABM69272.1.
D87470 mRNA. Translation: BAA13408.1. Different initiation.
AK292054 mRNA. Translation: BAF84743.1.
BC052341 mRNA. Translation: AAH52341.1.
CCDSiCCDS41689.1. [Q92567-2]
CCDS66165.1. [Q92567-3]
CCDS73346.1. [Q92567-1]
RefSeqiNP_001272979.1. NM_001286050.1. [Q92567-1]
NP_001272980.1. NM_001286051.1. [Q92567-3]
NP_055974.1. NM_015159.2. [Q92567-2]
UniGeneiHs.475334.

Genome annotation databases

EnsembliENST00000064778; ENSP00000064778; ENSG00000054965. [Q92567-1]
ENST00000356467; ENSP00000348852; ENSG00000054965. [Q92567-2]
ENST00000450446; ENSP00000390501; ENSG00000054965. [Q92567-3]
GeneIDi23201.
KEGGihsa:23201.
UCSCiuc001oty.3. human. [Q92567-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF363480 mRNA. Translation: ABM69287.1.
EF197985 mRNA. Translation: ABM69272.1.
D87470 mRNA. Translation: BAA13408.1. Different initiation.
AK292054 mRNA. Translation: BAF84743.1.
BC052341 mRNA. Translation: AAH52341.1.
CCDSiCCDS41689.1. [Q92567-2]
CCDS66165.1. [Q92567-3]
CCDS73346.1. [Q92567-1]
RefSeqiNP_001272979.1. NM_001286050.1. [Q92567-1]
NP_001272980.1. NM_001286051.1. [Q92567-3]
NP_055974.1. NM_015159.2. [Q92567-2]
UniGeneiHs.475334.

3D structure databases

ProteinModelPortaliQ92567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116810. 29 interactions.
IntActiQ92567. 24 interactions.
MINTiMINT-8383567.
STRINGi9606.ENSP00000348852.

PTM databases

iPTMnetiQ92567.
PhosphoSiteiQ92567.

Polymorphism and mutation databases

DMDMi46576628.

Proteomic databases

EPDiQ92567.
MaxQBiQ92567.
PaxDbiQ92567.
PRIDEiQ92567.

Protocols and materials databases

DNASUi23201.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000064778; ENSP00000064778; ENSG00000054965. [Q92567-1]
ENST00000356467; ENSP00000348852; ENSG00000054965. [Q92567-2]
ENST00000450446; ENSP00000390501; ENSG00000054965. [Q92567-3]
GeneIDi23201.
KEGGihsa:23201.
UCSCiuc001oty.3. human. [Q92567-1]

Organism-specific databases

CTDi23201.
GeneCardsiFAM168A.
H-InvDBHIX0009919.
HGNCiHGNC:28999. FAM168A.
HPAiHPA037580.
MIMi616316. gene.
neXtProtiNX_Q92567.
PharmGKBiPA162387077.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUV. Eukaryota.
ENOG410XR79. LUCA.
GeneTreeiENSGT00390000005140.
HOGENOMiHOG000073527.
HOVERGENiHBG052179.
InParanoidiQ92567.
OMAiCATEGTF.
OrthoDBiEOG7HB5BT.
PhylomeDBiQ92567.
TreeFamiTF331128.

Miscellaneous databases

GenomeRNAii23201.
NextBioi44719.
PROiQ92567.
SOURCEiSearch...

Gene expression databases

BgeeiQ92567.
CleanExiHS_FAM168A.
GenevisibleiQ92567. HS.

Family and domain databases

InterProiIPR029247. FAM168A/MANI.
[Graphical view]
PfamiPF14944. TCRP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene TCRP1 associated with tongue cancer chemotherapy resistance."
    He Z., Zhou M., Liu X.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Blood.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Characterizing the neurite outgrowth inhibitory effect of Mani."
    Mishra M., Lee S., Lin M.K., Yamashita T., Heese K.
    FEBS Lett. 586:3018-3023(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FAM168B.

Entry informationi

Entry nameiF168A_HUMAN
AccessioniPrimary (citable) accession number: Q92567
Secondary accession number(s): A2ICY2, A2ID81, Q86UG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: April 13, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.