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Q92564 (DCNL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DCN1-like protein 4
Alternative name(s):
DCUN1 domain-containing protein 4
Defective in cullin neddylation protein 1-like protein 4
Gene names
Name:DCUN1D4
Synonyms:KIAA0276
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 DCUN1 domain.

Sequence caution

The sequence BAA13405.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAD97912.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

P299913EBI-2654610,EBI-8826488From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92564-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92564-2)

The sequence of this isoform differs from the canonical sequence as follows:
     206-240: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292DCN1-like protein 4
PRO_0000129503

Regions

Domain101 – 287187DCUN1

Natural variations

Alternative sequence206 – 24035Missing in isoform 2.
VSP_016016

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 25, 2005. Version 2.
Checksum: 1927AA612E075E9C

FASTA29234,068
        10         20         30         40         50         60 
MHSDAAAVNF QLNSHLSTLA NIHKIYHTLN KLNLTEDIGQ DDHQTGSLRS CSSSDCFNKV 

        70         80         90        100        110        120 
MPPRKKRRPA SGDDLSAKKS RHDSMYRKYD STRIKTEEEA FSSKRCLEWF YEYAGTDDVV 

       130        140        150        160        170        180 
GPEGMEKFCE DIGVEPENVV MLVLAWKLDA QNMGYFTLQE WLKGMTSLQC DTTEKLRNTL 

       190        200        210        220        230        240 
DYLRSFLNDS TNFKLIYRYA FDFAREKDQR SLDINTAKCM LGLLLGKIWP LFPVFHQFLE 

       250        260        270        280        290 
QSKYKVINKD QWCNVLEFSR TINLDLSNYD EDGAWPVLLD EFVEWYKDKQ MS 

« Hide

Isoform 2 [UniParc].

Checksum: 0090D4A1D4E7314C
Show »

FASTA25729,984

References

[1]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Retina.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87466 mRNA. Translation: BAA13405.1. Different initiation.
BX537944 mRNA. Translation: CAD97912.1. Different initiation.
BC053897 mRNA. Translation: AAH53897.2.
RefSeqNP_001035492.1. NM_001040402.2.
NP_001274684.1. NM_001287755.1.
NP_001274686.1. NM_001287757.1.
NP_055930.2. NM_015115.3.
UniGeneHs.605388.

3D structure databases

ProteinModelPortalQ92564.
SMRQ92564. Positions 104-287.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116759. 9 interactions.
IntActQ92564. 2 interactions.
MINTMINT-4720144.
STRING9606.ENSP00000334625.

Polymorphism databases

DMDM78099237.

Proteomic databases

PaxDbQ92564.
PRIDEQ92564.

Protocols and materials databases

DNASU23142.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334635; ENSP00000334625; ENSG00000109184. [Q92564-1]
ENST00000381441; ENSP00000370850; ENSG00000109184. [Q92564-2]
GeneID23142.
KEGGhsa:23142.
UCSCuc003gze.3. human. [Q92564-1]
uc003gzf.3. human. [Q92564-2]

Organism-specific databases

CTD23142.
GeneCardsGC04P052709.
HGNCHGNC:28998. DCUN1D4.
HPAHPA036483.
HPA036484.
MIM612977. gene.
neXtProtNX_Q92564.
PharmGKBPA142672010.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279481.
HOGENOMHOG000241761.
HOVERGENHBG106637.
InParanoidQ92564.
KOK17824.
PhylomeDBQ92564.
TreeFamTF354270.

Gene expression databases

ArrayExpressQ92564.
BgeeQ92564.
CleanExHS_DCUN1D4.
GenevestigatorQ92564.

Family and domain databases

InterProIPR014764. DCN-prot.
IPR005176. PONY_dom.
[Graphical view]
PANTHERPTHR12281. PTHR12281. 1 hit.
PfamPF03556. Cullin_binding. 1 hit.
[Graphical view]
PROSITEPS51229. DCUN1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDCUN1D4. human.
GeneWikiDCUN1D4.
GenomeRNAi23142.
NextBio44424.
PROQ92564.
SOURCESearch...

Entry information

Entry nameDCNL4_HUMAN
AccessionPrimary (citable) accession number: Q92564
Secondary accession number(s): Q7Z3F3, Q7Z6B8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM