Q92564 (DCNL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DCN1-like protein 4

Alternative name(s):
DCUN1 domain-containing protein 4
Defective in cullin neddylation protein 1-like protein 4

Gene names

Name:	DCUN1D4
Synonyms:	KIAA0276

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Contains 1 DCUN1 domain.
Sequence caution	The sequence BAA13405.1 differs from that shown. Reason: Erroneous initiation. The sequence CAD97912.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92564-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92564-2)

The sequence of this isoform differs from the canonical sequence as follows:
     206-240: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	DCN1-like protein 4		PRO_0000129503
Regions
	Domain	101 – 287	187	DCUN1
Natural variations
	Alternative sequence	206 – 240	35	Missing in isoform 2.		VSP_016016

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 25, 2005. Version 2. Checksum: 1927AA612E075E9C	FASTA	292	34,068
	10 20 30 40 50 60 MHSDAAAVNF QLNSHLSTLA NIHKIYHTLN KLNLTEDIGQ DDHQTGSLRS CSSSDCFNKV 70 80 90 100 110 120 MPPRKKRRPA SGDDLSAKKS RHDSMYRKYD STRIKTEEEA FSSKRCLEWF YEYAGTDDVV 130 140 150 160 170 180 GPEGMEKFCE DIGVEPENVV MLVLAWKLDA QNMGYFTLQE WLKGMTSLQC DTTEKLRNTL 190 200 210 220 230 240 DYLRSFLNDS TNFKLIYRYA FDFAREKDQR SLDINTAKCM LGLLLGKIWP LFPVFHQFLE 250 260 270 280 290 QSKYKVINKD QWCNVLEFSR TINLDLSNYD EDGAWPVLLD EFVEWYKDKQ MS
	Isoform 2 [UniParc]. Checksum: 0090D4A1D4E7314C	FASTA	257	29,984
	10 20 30 40 50 60 MHSDAAAVNF QLNSHLSTLA NIHKIYHTLN KLNLTEDIGQ DDHQTGSLRS CSSSDCFNKV 70 80 90 100 110 120 MPPRKKRRPA SGDDLSAKKS RHDSMYRKYD STRIKTEEEA FSSKRCLEWF YEYAGTDDVV 130 140 150 160 170 180 GPEGMEKFCE DIGVEPENVV MLVLAWKLDA QNMGYFTLQE WLKGMTSLQC DTTEKLRNTL 190 200 210 220 230 240 DYLRSFLNDS TNFKLIYRYA FDFARQSKYK VINKDQWCNV LEFSRTINLD LSNYDEDGAW 250 PVLLDEFVEW YKDKQMS

References

[1]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Retina.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Uterus.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D87466 mRNA. Translation: BAA13405.1. Different initiation. BX537944 mRNA. Translation: CAD97912.1. Different initiation. BC053897 mRNA. Translation: AAH53897.2.
IPI	IPI00385380. IPI00941798.
RefSeq	NP_001035492.1. NM_001040402.1. NP_055930.2. NM_015115.2.
UniGene	Hs.605388.
3D structure databases
ProteinModelPortal	Q92564.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92564. 1 interaction.
STRING	9606.ENSP00000334625.
Polymorphism databases
DMDM	78099237.
Proteomic databases
PaxDb	Q92564.
PRIDE	Q92564.
Protocols and materials databases
DNASU	23142.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334635; ENSP00000334625; ENSG00000109184. ENST00000381441; ENSP00000370850; ENSG00000109184.
GeneID	23142.
KEGG	hsa:23142.
UCSC	uc003gze.3. human. uc003gzf.3. human.
Organism-specific databases
CTD	23142.
GeneCards	GC04P052709.
HGNC	HGNC:28998. DCUN1D4.
HPA	HPA036483. HPA036484.
MIM	612977. gene.
neXtProt	NX_Q92564.
PharmGKB	PA142672010.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279481.
HOGENOM	HOG000241761.
HOVERGEN	HBG106637.
InParanoid	Q92564.
OrthoDB	EOG4X97HX.
Gene expression databases
ArrayExpress	Q92564.
Bgee	Q92564.
CleanEx	HS_DCUN1D4.
Genevestigator	Q92564.
GermOnline	ENSG00000109184. Homo sapiens.
Family and domain databases
InterPro	IPR014764. DCN-prot. IPR005176. PONY_dom. [Graphical view]
PANTHER	PTHR12281. PTHR12281. 1 hit.
Pfam	PF03556. Cullin_binding. 1 hit. [Graphical view]
PROSITE	PS51229. DCUN1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DCUN1D4. human.
GenomeRNAi	23142.
NextBio	44424.
SOURCE	Search...

Entry information

Entry name

DCNL4_HUMAN

Accession

Primary (citable) accession number: Q92564
Secondary accession number(s): Q7Z3F3, Q7Z6B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.