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Q92563

- TICN2_HUMAN

UniProt

Q92563 - TICN2_HUMAN

Protein

Testican-2

Gene

SPOCK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    May participate in diverse steps of neurogenesis. Binds calcium.

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. extracellular matrix binding Source: Ensembl
    3. glycosaminoglycan binding Source: Ensembl

    GO - Biological processi

    1. extracellular matrix organization Source: UniProtKB
    2. peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
    3. positive regulation of cell-substrate adhesion Source: Ensembl
    4. regulation of cell differentiation Source: UniProtKB
    5. signal transduction Source: InterPro
    6. synapse assembly Source: UniProtKB

    Keywords - Ligandi

    Calcium

    Protein family/group databases

    MEROPSiI31.954.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testican-2
    Alternative name(s):
    SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
    Gene namesi
    Name:SPOCK2
    Synonyms:KIAA0275, TICN2
    ORF Names:UNQ269/PRO306
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:13564. SPOCK2.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394560.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 424402Testican-2PRO_0000026701Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi90 ↔ 101By similarity
    Disulfide bondi95 ↔ 111By similarity
    Disulfide bondi136 ↔ 166By similarity
    Disulfide bondi139 ↔ 159By similarity
    Disulfide bondi148 ↔ 180By similarity
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi313 ↔ 337By similarity
    Disulfide bondi348 ↔ 355By similarity
    Disulfide bondi357 ↔ 376By similarity
    Glycosylationi383 – 3831O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis
    Glycosylationi388 – 3881O-linked (Xyl...) (glycosaminoglycan)Sequence Analysis

    Post-translational modificationi

    Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

    Proteomic databases

    MaxQBiQ92563.
    PaxDbiQ92563.
    PRIDEiQ92563.

    Expressioni

    Tissue specificityi

    Highly expressed in brain. Also found in lung and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ92563.
    BgeeiQ92563.
    CleanExiHS_SPOCK2.
    GenevestigatoriQ92563.

    Organism-specific databases

    HPAiHPA044605.

    Interactioni

    Protein-protein interaction databases

    BioGridi115146. 2 interactions.
    IntActiQ92563. 2 interactions.
    STRINGi9606.ENSP00000321108.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92563.
    SMRiQ92563. Positions 89-306, 330-378.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini130 – 18253Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini310 – 37667Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi393 – 41624Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG244822.
    HOGENOMiHOG000293295.
    HOVERGENiHBG026595.
    InParanoidiQ92563.
    KOiK08136.
    OMAiEHRIKQP.
    PhylomeDBiQ92563.
    TreeFamiTF317779.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002350. Kazal_dom.
    IPR019577. SPARC/Testican_Ca-bd-dom.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PfamiPF07648. Kazal_2. 1 hit.
    PF10591. SPARC_Ca_bdg. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57610. SSF57610. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92563-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ    50
    YSGKIKHWNR FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV 100
    CIAQGYQRAM CISRKKLEHR IKQPTVKLHG NKDSICKPCH MAQLASVCGS 150
    DGHTYSSVCK LEQQACLSSK QLAVRCEGPC PCPTEQAATS TADGKPETCT 200
    GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK SLGASCKDSI 250
    GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA 300
    EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ 350
    SSGDCWCVDQ LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET 400
    EEAGEEAEEE EGEAGEADDG GYIW 424
    Length:424
    Mass (Da):46,779
    Last modified:February 1, 1997 - v1
    Checksum:iB7894E657FC2257F
    GO
    Isoform 2 (identifier: Q92563-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         64-77: EVEDDYIKSWEDNQ → VPSSDPPSTTQATP
         78-424: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:77
    Mass (Da):8,311
    Checksum:i09ACECE0F615B8CC
    GO

    Sequence cautioni

    The sequence BAA13404.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti357 – 3571C → R in AAQ89280. (PubMed:12975309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti353 – 3531G → S.
    Corresponds to variant rs2306322 [ dbSNP | Ensembl ].
    VAR_022020

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei64 – 7714EVEDD…WEDNQ → VPSSDPPSTTQATP in isoform 2. 1 PublicationVSP_045668Add
    BLAST
    Alternative sequencei78 – 424347Missing in isoform 2. 1 PublicationVSP_045669Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001453 mRNA. Translation: CAA04774.1.
    D87465 mRNA. Translation: BAA13404.2. Different initiation.
    AY358921 mRNA. Translation: AAQ89280.1.
    AK307091 mRNA. No translation available.
    AC022392 Genomic DNA. No translation available.
    BC023558 mRNA. Translation: AAH23558.1.
    CCDSiCCDS44431.1. [Q92563-2]
    CCDS7313.1. [Q92563-1]
    RefSeqiNP_001127906.1. NM_001134434.1. [Q92563-2]
    NP_001231879.1. NM_001244950.1. [Q92563-1]
    NP_055582.1. NM_014767.2. [Q92563-1]
    XP_005270359.1. XM_005270302.1. [Q92563-2]
    UniGeneiHs.523009.

    Genome annotation databases

    EnsembliENST00000317376; ENSP00000321108; ENSG00000107742. [Q92563-1]
    ENST00000373109; ENSP00000362201; ENSG00000107742. [Q92563-1]
    ENST00000412663; ENSP00000397715; ENSG00000107742. [Q92563-2]
    GeneIDi9806.
    KEGGihsa:9806.
    UCSCiuc001jso.2. human. [Q92563-1]

    Polymorphism databases

    DMDMi24212500.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001453 mRNA. Translation: CAA04774.1 .
    D87465 mRNA. Translation: BAA13404.2 . Different initiation.
    AY358921 mRNA. Translation: AAQ89280.1 .
    AK307091 mRNA. No translation available.
    AC022392 Genomic DNA. No translation available.
    BC023558 mRNA. Translation: AAH23558.1 .
    CCDSi CCDS44431.1. [Q92563-2 ]
    CCDS7313.1. [Q92563-1 ]
    RefSeqi NP_001127906.1. NM_001134434.1. [Q92563-2 ]
    NP_001231879.1. NM_001244950.1. [Q92563-1 ]
    NP_055582.1. NM_014767.2. [Q92563-1 ]
    XP_005270359.1. XM_005270302.1. [Q92563-2 ]
    UniGenei Hs.523009.

    3D structure databases

    ProteinModelPortali Q92563.
    SMRi Q92563. Positions 89-306, 330-378.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115146. 2 interactions.
    IntActi Q92563. 2 interactions.
    STRINGi 9606.ENSP00000321108.

    Protein family/group databases

    MEROPSi I31.954.

    Polymorphism databases

    DMDMi 24212500.

    Proteomic databases

    MaxQBi Q92563.
    PaxDbi Q92563.
    PRIDEi Q92563.

    Protocols and materials databases

    DNASUi 9806.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317376 ; ENSP00000321108 ; ENSG00000107742 . [Q92563-1 ]
    ENST00000373109 ; ENSP00000362201 ; ENSG00000107742 . [Q92563-1 ]
    ENST00000412663 ; ENSP00000397715 ; ENSG00000107742 . [Q92563-2 ]
    GeneIDi 9806.
    KEGGi hsa:9806.
    UCSCi uc001jso.2. human. [Q92563-1 ]

    Organism-specific databases

    CTDi 9806.
    GeneCardsi GC10M073818.
    HGNCi HGNC:13564. SPOCK2.
    HPAi HPA044605.
    MIMi 607988. gene.
    neXtProti NX_Q92563.
    PharmGKBi PA128394560.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG244822.
    HOGENOMi HOG000293295.
    HOVERGENi HBG026595.
    InParanoidi Q92563.
    KOi K08136.
    OMAi EHRIKQP.
    PhylomeDBi Q92563.
    TreeFami TF317779.

    Miscellaneous databases

    GeneWikii SPOCK2.
    GenomeRNAii 9806.
    NextBioi 36920.
    PROi Q92563.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92563.
    Bgeei Q92563.
    CleanExi HS_SPOCK2.
    Genevestigatori Q92563.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002350. Kazal_dom.
    IPR019577. SPARC/Testican_Ca-bd-dom.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    Pfami PF07648. Kazal_2. 1 hit.
    PF10591. SPARC_Ca_bdg. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57610. SSF57610. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain."
      Vannahme C., Schuebel S., Herud M., Goesling S., Hulsmann H., Paulsson M., Hartmann U., Maurer P.
      J. Neurochem. 73:12-20(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CALCIUM-BINDING.
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Amygdala.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-37.

    Entry informationi

    Entry nameiTICN2_HUMAN
    AccessioniPrimary (citable) accession number: Q92563
    Secondary accession number(s): C9J767, Q6UW87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3