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Protein

Testican-2

Gene

SPOCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in diverse steps of neurogenesis. Binds calcium.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • extracellular matrix binding Source: Ensembl
  • glycosaminoglycan binding Source: Ensembl
  • metalloendopeptidase inhibitor activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • extracellular matrix organization Source: UniProtKB
  • negative regulation of endopeptidase activity Source: ParkinsonsUK-UCL
  • peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
  • positive regulation of cell motility Source: ParkinsonsUK-UCL
  • positive regulation of cell-substrate adhesion Source: Ensembl
  • regulation of cell differentiation Source: UniProtKB
  • signal transduction Source: InterPro
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107742-MONOMER.

Protein family/group databases

MEROPSiI31.954.

Names & Taxonomyi

Protein namesi
Recommended name:
Testican-2
Alternative name(s):
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
Gene namesi
Name:SPOCK2
Synonyms:KIAA0275, TICN2
ORF Names:UNQ269/PRO306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13564. SPOCK2.

Subcellular locationi

GO - Cellular componenti

  • proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9806.
OpenTargetsiENSG00000107742.
PharmGKBiPA128394560.

Polymorphism and mutation databases

BioMutaiSPOCK2.
DMDMi24212500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002670123 – 424Testican-2Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72Phosphoserine; by FAM20C1 Publication1
Disulfide bondi90 ↔ 101By similarity
Disulfide bondi95 ↔ 111By similarity
Disulfide bondi136 ↔ 166By similarity
Disulfide bondi139 ↔ 159By similarity
Disulfide bondi148 ↔ 180By similarity
Glycosylationi225N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi313 ↔ 337By similarity
Disulfide bondi348 ↔ 355By similarity
Disulfide bondi357 ↔ 376By similarity
Glycosylationi383O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi388O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1

Post-translational modificationi

Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ92563.
PaxDbiQ92563.
PeptideAtlasiQ92563.
PRIDEiQ92563.

PTM databases

iPTMnetiQ92563.
PhosphoSitePlusiQ92563.

Expressioni

Tissue specificityi

Highly expressed in brain. Also found in lung and testis.1 Publication

Gene expression databases

BgeeiENSG00000107742.
CleanExiHS_SPOCK2.
ExpressionAtlasiQ92563. baseline and differential.
GenevisibleiQ92563. HS.

Organism-specific databases

HPAiHPA044605.

Interactioni

Protein-protein interaction databases

BioGridi115146. 2 interactors.
IntActiQ92563. 2 interactors.
STRINGi9606.ENSP00000321108.

Structurei

3D structure databases

ProteinModelPortaliQ92563.
SMRiQ92563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 182Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini310 – 376Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi393 – 416Glu-richAdd BLAST24

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3555. Eukaryota.
ENOG410Y6A8. LUCA.
GeneTreeiENSGT00510000046429.
HOGENOMiHOG000293295.
HOVERGENiHBG026595.
InParanoidiQ92563.
KOiK08136.
OMAiDYIKSWE.
OrthoDBiEOG091G086I.
PhylomeDBiQ92563.
TreeFamiTF317779.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
3.40.50.1820. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR011992. EF-hand-dom_pair.
IPR002350. Kazal_dom.
IPR019577. SPARC/Testican_Ca-bd-dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
PF10591. SPARC_Ca_bdg. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ
60 70 80 90 100
YSGKIKHWNR FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV
110 120 130 140 150
CIAQGYQRAM CISRKKLEHR IKQPTVKLHG NKDSICKPCH MAQLASVCGS
160 170 180 190 200
DGHTYSSVCK LEQQACLSSK QLAVRCEGPC PCPTEQAATS TADGKPETCT
210 220 230 240 250
GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK SLGASCKDSI
260 270 280 290 300
GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA
310 320 330 340 350
EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ
360 370 380 390 400
SSGDCWCVDQ LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET
410 420
EEAGEEAEEE EGEAGEADDG GYIW
Length:424
Mass (Da):46,779
Last modified:February 1, 1997 - v1
Checksum:iB7894E657FC2257F
GO
Isoform 2 (identifier: Q92563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-77: EVEDDYIKSWEDNQ → VPSSDPPSTTQATP
     78-424: Missing.

Note: No experimental confirmation available.
Show »
Length:77
Mass (Da):8,311
Checksum:i09ACECE0F615B8CC
GO

Sequence cautioni

The sequence BAA13404 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357C → R in AAQ89280 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022020353G → S.Corresponds to variant rs2306322dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04566864 – 77EVEDD…WEDNQ → VPSSDPPSTTQATP in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_04566978 – 424Missing in isoform 2. 1 PublicationAdd BLAST347

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001453 mRNA. Translation: CAA04774.1.
D87465 mRNA. Translation: BAA13404.2. Different initiation.
AY358921 mRNA. Translation: AAQ89280.1.
AK307091 mRNA. No translation available.
AC022392 Genomic DNA. No translation available.
BC023558 mRNA. Translation: AAH23558.1.
CCDSiCCDS44431.1. [Q92563-2]
CCDS7313.1. [Q92563-1]
RefSeqiNP_001127906.1. NM_001134434.1. [Q92563-2]
NP_001231879.1. NM_001244950.1. [Q92563-1]
NP_055582.1. NM_014767.2. [Q92563-1]
XP_016872474.1. XM_017016985.1. [Q92563-2]
UniGeneiHs.523009.

Genome annotation databases

EnsembliENST00000317376; ENSP00000321108; ENSG00000107742. [Q92563-1]
ENST00000373109; ENSP00000362201; ENSG00000107742. [Q92563-1]
ENST00000412663; ENSP00000397715; ENSG00000107742. [Q92563-2]
GeneIDi9806.
KEGGihsa:9806.
UCSCiuc001jso.3. human. [Q92563-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001453 mRNA. Translation: CAA04774.1.
D87465 mRNA. Translation: BAA13404.2. Different initiation.
AY358921 mRNA. Translation: AAQ89280.1.
AK307091 mRNA. No translation available.
AC022392 Genomic DNA. No translation available.
BC023558 mRNA. Translation: AAH23558.1.
CCDSiCCDS44431.1. [Q92563-2]
CCDS7313.1. [Q92563-1]
RefSeqiNP_001127906.1. NM_001134434.1. [Q92563-2]
NP_001231879.1. NM_001244950.1. [Q92563-1]
NP_055582.1. NM_014767.2. [Q92563-1]
XP_016872474.1. XM_017016985.1. [Q92563-2]
UniGeneiHs.523009.

3D structure databases

ProteinModelPortaliQ92563.
SMRiQ92563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115146. 2 interactors.
IntActiQ92563. 2 interactors.
STRINGi9606.ENSP00000321108.

Protein family/group databases

MEROPSiI31.954.

PTM databases

iPTMnetiQ92563.
PhosphoSitePlusiQ92563.

Polymorphism and mutation databases

BioMutaiSPOCK2.
DMDMi24212500.

Proteomic databases

MaxQBiQ92563.
PaxDbiQ92563.
PeptideAtlasiQ92563.
PRIDEiQ92563.

Protocols and materials databases

DNASUi9806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317376; ENSP00000321108; ENSG00000107742. [Q92563-1]
ENST00000373109; ENSP00000362201; ENSG00000107742. [Q92563-1]
ENST00000412663; ENSP00000397715; ENSG00000107742. [Q92563-2]
GeneIDi9806.
KEGGihsa:9806.
UCSCiuc001jso.3. human. [Q92563-1]

Organism-specific databases

CTDi9806.
DisGeNETi9806.
GeneCardsiSPOCK2.
HGNCiHGNC:13564. SPOCK2.
HPAiHPA044605.
MIMi607988. gene.
neXtProtiNX_Q92563.
OpenTargetsiENSG00000107742.
PharmGKBiPA128394560.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3555. Eukaryota.
ENOG410Y6A8. LUCA.
GeneTreeiENSGT00510000046429.
HOGENOMiHOG000293295.
HOVERGENiHBG026595.
InParanoidiQ92563.
KOiK08136.
OMAiDYIKSWE.
OrthoDBiEOG091G086I.
PhylomeDBiQ92563.
TreeFamiTF317779.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107742-MONOMER.

Miscellaneous databases

GeneWikiiSPOCK2.
GenomeRNAii9806.
PROiQ92563.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107742.
CleanExiHS_SPOCK2.
ExpressionAtlasiQ92563. baseline and differential.
GenevisibleiQ92563. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
3.40.50.1820. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR011992. EF-hand-dom_pair.
IPR002350. Kazal_dom.
IPR019577. SPARC/Testican_Ca-bd-dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF07648. Kazal_2. 1 hit.
PF10591. SPARC_Ca_bdg. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTICN2_HUMAN
AccessioniPrimary (citable) accession number: Q92563
Secondary accession number(s): C9J767, Q6UW87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.