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Protein

Testican-2

Gene

SPOCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in diverse steps of neurogenesis. Binds calcium.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • extracellular matrix binding Source: Ensembl
  • glycosaminoglycan binding Source: Ensembl
  • metalloendopeptidase inhibitor activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: Ensembl
  • extracellular matrix organization Source: UniProtKB
  • negative regulation of endopeptidase activity Source: ParkinsonsUK-UCL
  • peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
  • positive regulation of cell motility Source: ParkinsonsUK-UCL
  • positive regulation of cell-substrate adhesion Source: Ensembl
  • regulation of cell differentiation Source: UniProtKB
  • signal transduction Source: InterPro
  • synapse assembly Source: UniProtKB

Keywordsi

LigandCalcium

Protein family/group databases

MEROPSiI31.954

Names & Taxonomyi

Protein namesi
Recommended name:
Testican-2
Alternative name(s):
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
Gene namesi
Name:SPOCK2
Synonyms:KIAA0275, TICN2
ORF Names:UNQ269/PRO306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107742.12
HGNCiHGNC:13564 SPOCK2
MIMi607988 gene
neXtProtiNX_Q92563

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9806
OpenTargetsiENSG00000107742
PharmGKBiPA128394560

Polymorphism and mutation databases

BioMutaiSPOCK2
DMDMi24212500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002670123 – 424Testican-2Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72Phosphoserine; by FAM20C1 Publication1
Disulfide bondi90 ↔ 101By similarity
Disulfide bondi95 ↔ 111By similarity
Disulfide bondi136 ↔ 166By similarity
Disulfide bondi139 ↔ 159By similarity
Disulfide bondi148 ↔ 180By similarity
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 337By similarity
Disulfide bondi348 ↔ 355By similarity
Disulfide bondi357 ↔ 376By similarity
Glycosylationi383O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi388O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1

Post-translational modificationi

Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ92563
PaxDbiQ92563
PeptideAtlasiQ92563
PRIDEiQ92563
ProteomicsDBi75319

PTM databases

iPTMnetiQ92563
PhosphoSitePlusiQ92563

Expressioni

Tissue specificityi

Highly expressed in brain. Also found in lung and testis.1 Publication

Gene expression databases

BgeeiENSG00000107742
CleanExiHS_SPOCK2
ExpressionAtlasiQ92563 baseline and differential
GenevisibleiQ92563 HS

Organism-specific databases

HPAiHPA044605

Interactioni

Protein-protein interaction databases

BioGridi115146, 2 interactors
IntActiQ92563, 2 interactors
STRINGi9606.ENSP00000321108

Structurei

3D structure databases

ProteinModelPortaliQ92563
SMRiQ92563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 182Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini310 – 376Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi393 – 416Glu-richAdd BLAST24

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3555 Eukaryota
ENOG410Y6A8 LUCA
GeneTreeiENSGT00510000046429
HOGENOMiHOG000293295
HOVERGENiHBG026595
InParanoidiQ92563
KOiK08136
OMAiSTAEWCF
OrthoDBiEOG091G086I
PhylomeDBiQ92563
TreeFamiTF317779

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ
60 70 80 90 100
YSGKIKHWNR FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV
110 120 130 140 150
CIAQGYQRAM CISRKKLEHR IKQPTVKLHG NKDSICKPCH MAQLASVCGS
160 170 180 190 200
DGHTYSSVCK LEQQACLSSK QLAVRCEGPC PCPTEQAATS TADGKPETCT
210 220 230 240 250
GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK SLGASCKDSI
260 270 280 290 300
GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA
310 320 330 340 350
EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ
360 370 380 390 400
SSGDCWCVDQ LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET
410 420
EEAGEEAEEE EGEAGEADDG GYIW
Length:424
Mass (Da):46,779
Last modified:February 1, 1997 - v1
Checksum:iB7894E657FC2257F
GO
Isoform 2 (identifier: Q92563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-77: EVEDDYIKSWEDNQ → VPSSDPPSTTQATP
     78-424: Missing.

Note: No experimental confirmation available.
Show »
Length:77
Mass (Da):8,311
Checksum:i09ACECE0F615B8CC
GO

Sequence cautioni

The sequence BAA13404 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357C → R in AAQ89280 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022020353G → S. Corresponds to variant dbSNP:rs2306322Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04566864 – 77EVEDD…WEDNQ → VPSSDPPSTTQATP in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_04566978 – 424Missing in isoform 2. 1 PublicationAdd BLAST347

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001453 mRNA Translation: CAA04774.1
D87465 mRNA Translation: BAA13404.2 Different initiation.
AY358921 mRNA Translation: AAQ89280.1
AK307091 mRNA No translation available.
AC022392 Genomic DNA No translation available.
BC023558 mRNA Translation: AAH23558.1
CCDSiCCDS44431.1 [Q92563-2]
CCDS7313.1 [Q92563-1]
RefSeqiNP_001127906.1, NM_001134434.1 [Q92563-2]
NP_001231879.1, NM_001244950.1 [Q92563-1]
NP_055582.1, NM_014767.2 [Q92563-1]
XP_016872474.1, XM_017016985.1 [Q92563-2]
UniGeneiHs.523009

Genome annotation databases

EnsembliENST00000317376; ENSP00000321108; ENSG00000107742 [Q92563-1]
ENST00000373109; ENSP00000362201; ENSG00000107742 [Q92563-1]
ENST00000412663; ENSP00000397715; ENSG00000107742 [Q92563-2]
GeneIDi9806
KEGGihsa:9806
UCSCiuc001jso.3 human [Q92563-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTICN2_HUMAN
AccessioniPrimary (citable) accession number: Q92563
Secondary accession number(s): C9J767, Q6UW87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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