Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92563 (TICN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testican-2
Alternative name(s):
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
Gene names
Name:SPOCK2
Synonyms:KIAA0275, TICN2
ORF Names:UNQ269/PRO306
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May participate in diverse steps of neurogenesis. Binds calcium.

Subcellular location

Secretedextracellular spaceextracellular matrix Probable.

Tissue specificity

Highly expressed in brain. Also found in lung and testis. Ref.1

Post-translational modification

Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides By similarity.

Sequence similarities

Contains 1 Kazal-like domain.

Contains 1 thyroglobulin type-1 domain.

Sequence caution

The sequence BAA13404.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92563-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92563-2)

The sequence of this isoform differs from the canonical sequence as follows:
     64-77: EVEDDYIKSWEDNQ → VPSSDPPSTTQATP
     78-424: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.7
Chain23 – 424402Testican-2
PRO_0000026701

Regions

Domain130 – 18253Kazal-like
Domain310 – 37667Thyroglobulin type-1
Compositional bias393 – 41624Glu-rich

Amino acid modifications

Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation3831O-linked (Xyl...) (glycosaminoglycan) Potential
Glycosylation3881O-linked (Xyl...) (glycosaminoglycan) Potential
Disulfide bond90 ↔ 101 By similarity
Disulfide bond95 ↔ 111 By similarity
Disulfide bond136 ↔ 166 By similarity
Disulfide bond139 ↔ 159 By similarity
Disulfide bond148 ↔ 180 By similarity
Disulfide bond313 ↔ 337 By similarity
Disulfide bond348 ↔ 355 By similarity
Disulfide bond357 ↔ 376 By similarity

Natural variations

Alternative sequence64 – 7714EVEDD…WEDNQ → VPSSDPPSTTQATP in isoform 2.
VSP_045668
Alternative sequence78 – 424347Missing in isoform 2.
VSP_045669
Natural variant3531G → S.
Corresponds to variant rs2306322 [ dbSNP | Ensembl ].
VAR_022020

Experimental info

Sequence conflict3571C → R in AAQ89280. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: B7894E657FC2257F

FASTA42446,779
        10         20         30         40         50         60 
MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ YSGKIKHWNR 

        70         80         90        100        110        120 
FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV CIAQGYQRAM CISRKKLEHR 

       130        140        150        160        170        180 
IKQPTVKLHG NKDSICKPCH MAQLASVCGS DGHTYSSVCK LEQQACLSSK QLAVRCEGPC 

       190        200        210        220        230        240 
PCPTEQAATS TADGKPETCT GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK 

       250        260        270        280        290        300 
SLGASCKDSI GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA 

       310        320        330        340        350        360 
EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ SSGDCWCVDQ 

       370        380        390        400        410        420 
LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET EEAGEEAEEE EGEAGEADDG 


GYIW 

« Hide

Isoform 2 [UniParc].

Checksum: 09ACECE0F615B8CC
Show »

FASTA778,311

References

« Hide 'large scale' references
[1]"Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain."
Vannahme C., Schuebel S., Herud M., Goesling S., Hulsmann H., Paulsson M., Hartmann U., Maurer P.
J. Neurochem. 73:12-20(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CALCIUM-BINDING.
Tissue: Brain.
[2]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Amygdala.
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Muscle.
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-37.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001453 mRNA. Translation: CAA04774.1.
D87465 mRNA. Translation: BAA13404.2. Different initiation.
AY358921 mRNA. Translation: AAQ89280.1.
AK307091 mRNA. No translation available.
AC022392 Genomic DNA. No translation available.
BC023558 mRNA. Translation: AAH23558.1.
RefSeqNP_001127906.1. NM_001134434.1.
NP_001231879.1. NM_001244950.1.
NP_055582.1. NM_014767.2.
XP_005270359.1. XM_005270302.1.
UniGeneHs.523009.

3D structure databases

ProteinModelPortalQ92563.
SMRQ92563. Positions 87-378.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115146. 2 interactions.
IntActQ92563. 2 interactions.
STRING9606.ENSP00000321108.

Protein family/group databases

MEROPSI31.954.

Polymorphism databases

DMDM24212500.

Proteomic databases

PaxDbQ92563.
PRIDEQ92563.

Protocols and materials databases

DNASU9806.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317376; ENSP00000321108; ENSG00000107742. [Q92563-1]
ENST00000373109; ENSP00000362201; ENSG00000107742. [Q92563-1]
ENST00000412663; ENSP00000397715; ENSG00000107742. [Q92563-2]
GeneID9806.
KEGGhsa:9806.
UCSCuc001jso.2. human. [Q92563-1]

Organism-specific databases

CTD9806.
GeneCardsGC10M073818.
HGNCHGNC:13564. SPOCK2.
HPAHPA044605.
MIM607988. gene.
neXtProtNX_Q92563.
PharmGKBPA128394560.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG244822.
HOGENOMHOG000293295.
HOVERGENHBG026595.
InParanoidQ92563.
KOK08136.
OMAEHRIKQP.
PhylomeDBQ92563.
TreeFamTF317779.

Gene expression databases

ArrayExpressQ92563.
BgeeQ92563.
CleanExHS_SPOCK2.
GenevestigatorQ92563.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
4.10.800.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR002350. Kazal_dom.
IPR019577. SPARC/Testican_Ca-bd-dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamPF07648. Kazal_2. 1 hit.
PF10591. SPARC_Ca_bdg. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57610. SSF57610. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSPOCK2.
GenomeRNAi9806.
NextBio36920.
PROQ92563.
SOURCESearch...

Entry information

Entry nameTICN2_HUMAN
AccessionPrimary (citable) accession number: Q92563
Secondary accession number(s): C9J767, Q6UW87
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: February 1, 1997
Last modified: March 19, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM