Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Engulfment and cell motility protein 1

Gene

ELMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.2 Publications

GO - Molecular functioni

  • SH3 domain binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • apoptotic process Source: UniProtKB
  • cell migration Source: InterPro
  • Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  • movement of cell or subcellular component Source: UniProtKB
  • phagocytosis, engulfment Source: UniProtKB
  • positive regulation of GTPase activity Source: GOC
  • Rac protein signal transduction Source: UniProtKB
  • regulation of defense response to virus by virus Source: Reactome
  • vascular endothelial growth factor receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Phagocytosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155849-MONOMER.
ReactomeiR-HSA-164944. Nef and signal transduction.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-4420097. VEGFA-VEGFR2 Pathway.
R-HSA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
SIGNORiQ92556.

Names & Taxonomyi

Protein namesi
Recommended name:
Engulfment and cell motility protein 1
Alternative name(s):
Protein ced-12 homolog
Gene namesi
Name:ELMO1
Synonyms:KIAA0281
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16286. ELMO1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • guanyl-nucleotide exchange factor complex Source: WormBase
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9844.
OpenTargetsiENSG00000155849.
PharmGKBiPA27754.

Polymorphism and mutation databases

BioMutaiELMO1.
DMDMi30923321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537121 – 727Engulfment and cell motility protein 1Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Phosphotyrosine; by HCK1 Publication1
Modified residuei100N6-acetyllysineCombined sources1
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei216Phosphotyrosine; by HCK1 Publication1
Modified residuei344PhosphoserineBy similarity1
Modified residuei395Phosphotyrosine; by HCK1 Publication1
Modified residuei511Phosphotyrosine; by HCK1 Publication1
Modified residuei720Phosphotyrosine; by HCK1 Publication1

Post-translational modificationi

Phosphorylated by HCK.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92556.
MaxQBiQ92556.
PaxDbiQ92556.
PeptideAtlasiQ92556.
PRIDEiQ92556.

PTM databases

iPTMnetiQ92556.
PhosphoSitePlusiQ92556.

Expressioni

Tissue specificityi

Widely expressed, with a higher expression in the spleen and placenta.

Gene expression databases

BgeeiENSG00000155849.
CleanExiHS_ELMO1.
ExpressionAtlasiQ92556. baseline and differential.
GenevisibleiQ92556. HS.

Interactioni

Subunit structurei

Interacts with ADGRB1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6. Interacts with HCK (via SH3 domain). Interacts with ADGRB3 (PubMed:24567399).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DOCK1Q1418516EBI-346417,EBI-446740
HCKP086314EBI-346417,EBI-346340
RHOGP840953EBI-346417,EBI-446579
TRIM54Q9BYV23EBI-346417,EBI-2130429
ZNF398Q8TD173EBI-346417,EBI-8643207

GO - Molecular functioni

  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115180. 16 interactors.
DIPiDIP-31095N.
IntActiQ92556. 7 interactors.
MINTiMINT-238417.
STRINGi9606.ENSP00000312185.

Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi532 – 558Combined sources27
Beta strandi560 – 563Combined sources4
Beta strandi569 – 571Combined sources3
Beta strandi573 – 579Combined sources7
Beta strandi583 – 590Combined sources8
Beta strandi607 – 609Combined sources3
Helixi610 – 612Combined sources3
Beta strandi613 – 618Combined sources6
Helixi619 – 621Combined sources3
Helixi623 – 625Combined sources3
Helixi638 – 640Combined sources3
Beta strandi641 – 646Combined sources6
Turni647 – 649Combined sources3
Beta strandi650 – 655Combined sources6
Helixi659 – 672Combined sources14
Helixi680 – 697Combined sources18
Helixi699 – 701Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RQRNMR-A697-722[»]
2VSZX-ray2.30A/B532-675[»]
3A98X-ray2.10B/D532-727[»]
ProteinModelPortaliQ92556.
SMRiQ92556.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92556.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini319 – 492ELMOPROSITE-ProRule annotationAdd BLAST174
Domaini555 – 676PHAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi707 – 714SH3-binding8

Sequence similaritiesi

Contains 1 ELMO domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2999. Eukaryota.
ENOG410XPKN. LUCA.
GeneTreeiENSGT00390000014155.
HOGENOMiHOG000230985.
HOVERGENiHBG055277.
InParanoidiQ92556.
KOiK12366.
OMAiEMSHILA.
OrthoDBiEOG091G03JJ.
PhylomeDBiQ92556.
TreeFamiTF312966.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024574. DUF3361.
IPR030715. ELMO1.
IPR006816. ELMO_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR12771:SF23. PTHR12771:SF23. 1 hit.
PfamiPF11841. DUF3361. 1 hit.
PF04727. ELMO_CED12. 1 hit.
PF16457. PH_12. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92556-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPADIVKV AIEWPGAYPK LMEIDQKKPL SAIIKEVCDG WSLANHEYFA
60 70 80 90 100
LQHADSSNFY ITEKNRNEIK NGTILRLTTS PAQNAQQLHE RIQSSSMDAK
110 120 130 140 150
LEALKDLASL SRDVTFAQEF INLDGISLLT QMVESGTERY QKLQKIMKPC
160 170 180 190 200
FGDMLSFTLT AFVELMDHGI VSWDTFSVAF IKKIASFVNK SAIDISILQR
210 220 230 240 250
SLAILESMVL NSHDLYQKVA QEITIGQLIP HLQGSDQEIQ TYTIAVINAL
260 270 280 290 300
FLKAPDERRQ EMANILAQKQ LRSIILTHVI RAQRAINNEM AHQLYVLQVL
310 320 330 340 350
TFNLLEDRMM TKMDPQDQAQ RDIIFELRRI AFDAESEPNN SSGSMEKRKS
360 370 380 390 400
MYTRDYKKLG FINHVNPAMD FTQTPPGMLA LDNMLYFAKH HQDAYIRIVL
410 420 430 440 450
ENSSREDKHE CPFGRSSIEL TKMLCEILKV GELPSETCND FHPMFFTHDR
460 470 480 490 500
SFEEFFCICI QLLNKTWKEM RATSEDFNKV MQVVKEQVMR ALTTKPSSLD
510 520 530 540 550
QFKSKLQNLS YTEILKIRQS ERMNQEDFQS RPILELKEKI QPEILELIKQ
560 570 580 590 600
QRLNRLVEGT CFRKLNARRR QDKFWYCRLS PNHKVLHYGD LEESPQGEVP
610 620 630 640 650
HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA LKQNKEVLEL AFSILYDSNC
660 670 680 690 700
QLNFIAPDKH EYCIWTDGLN ALLGKDMMSD LTRNDLDTLL SMEIKLRLLD
710 720
LENIQIPDAP PPIPKEPSNY DFVYDCN
Length:727
Mass (Da):83,829
Last modified:May 16, 2003 - v2
Checksum:i053DCA73D2B0A4C6
GO
Isoform 2 (identifier: Q92556-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-480: Missing.

Show »
Length:247
Mass (Da):28,742
Checksum:iD02BCEC8D8A4383F
GO
Isoform 3 (identifier: Q92556-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-298: Missing.
     299-362: VLTFNLLEDR...TRDYKKLGFI → MSEHQKEQTL...GGETNAYCQM

Show »
Length:429
Mass (Da):49,915
Checksum:i36C411CBBE5CA12B
GO

Sequence cautioni

The sequence BAA13397 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti716E → A in CAB66721 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065824362I → S.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0074801 – 480Missing in isoform 2. 2 PublicationsAdd BLAST480
Alternative sequenceiVSP_0385501 – 298Missing in isoform 3. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_038551299 – 362VLTFN…KLGFI → MSEHQKEQTLDTPSLRTVTL TVRVHGFILEVSKTKNPPIP DTFWPPRWDHRPSPGGETNA YCQM in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398885 mRNA. Translation: AAL14466.1.
D87457 mRNA. Translation: BAA13397.2. Different initiation.
AL136787 mRNA. Translation: CAB66721.1.
AK126565 mRNA. Translation: BAC86597.1.
CH236951 Genomic DNA. Translation: EAL23979.1.
CH471073 Genomic DNA. Translation: EAW94076.1.
BC003051 mRNA. Translation: AAH03051.1.
BC064635 mRNA. Translation: AAH64635.1.
BC077074 mRNA. Translation: AAH77074.1.
BC114341 mRNA. Translation: AAI14342.1.
CCDSiCCDS5449.1. [Q92556-1]
CCDS5450.1. [Q92556-2]
RefSeqiNP_001034548.1. NM_001039459.2. [Q92556-2]
NP_001193409.1. NM_001206480.2. [Q92556-1]
NP_001193411.1. NM_001206482.1. [Q92556-1]
NP_055615.8. NM_014800.10. [Q92556-1]
NP_569709.1. NM_130442.3. [Q92556-2]
XP_005249976.1. XM_005249919.2. [Q92556-1]
XP_006715868.1. XM_006715805.1. [Q92556-1]
XP_011513956.1. XM_011515654.1. [Q92556-1]
XP_016868327.1. XM_017012838.1. [Q92556-1]
XP_016868328.1. XM_017012839.1. [Q92556-1]
UniGeneiHs.434989.
Hs.656638.

Genome annotation databases

EnsembliENST00000310758; ENSP00000312185; ENSG00000155849. [Q92556-1]
ENST00000396040; ENSP00000379355; ENSG00000155849. [Q92556-2]
ENST00000396045; ENSP00000379360; ENSG00000155849. [Q92556-2]
ENST00000442504; ENSP00000406952; ENSG00000155849. [Q92556-1]
ENST00000448602; ENSP00000394458; ENSG00000155849. [Q92556-1]
GeneIDi9844.
KEGGihsa:9844.
UCSCiuc003tfi.3. human. [Q92556-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398885 mRNA. Translation: AAL14466.1.
D87457 mRNA. Translation: BAA13397.2. Different initiation.
AL136787 mRNA. Translation: CAB66721.1.
AK126565 mRNA. Translation: BAC86597.1.
CH236951 Genomic DNA. Translation: EAL23979.1.
CH471073 Genomic DNA. Translation: EAW94076.1.
BC003051 mRNA. Translation: AAH03051.1.
BC064635 mRNA. Translation: AAH64635.1.
BC077074 mRNA. Translation: AAH77074.1.
BC114341 mRNA. Translation: AAI14342.1.
CCDSiCCDS5449.1. [Q92556-1]
CCDS5450.1. [Q92556-2]
RefSeqiNP_001034548.1. NM_001039459.2. [Q92556-2]
NP_001193409.1. NM_001206480.2. [Q92556-1]
NP_001193411.1. NM_001206482.1. [Q92556-1]
NP_055615.8. NM_014800.10. [Q92556-1]
NP_569709.1. NM_130442.3. [Q92556-2]
XP_005249976.1. XM_005249919.2. [Q92556-1]
XP_006715868.1. XM_006715805.1. [Q92556-1]
XP_011513956.1. XM_011515654.1. [Q92556-1]
XP_016868327.1. XM_017012838.1. [Q92556-1]
XP_016868328.1. XM_017012839.1. [Q92556-1]
UniGeneiHs.434989.
Hs.656638.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RQRNMR-A697-722[»]
2VSZX-ray2.30A/B532-675[»]
3A98X-ray2.10B/D532-727[»]
ProteinModelPortaliQ92556.
SMRiQ92556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115180. 16 interactors.
DIPiDIP-31095N.
IntActiQ92556. 7 interactors.
MINTiMINT-238417.
STRINGi9606.ENSP00000312185.

PTM databases

iPTMnetiQ92556.
PhosphoSitePlusiQ92556.

Polymorphism and mutation databases

BioMutaiELMO1.
DMDMi30923321.

Proteomic databases

EPDiQ92556.
MaxQBiQ92556.
PaxDbiQ92556.
PeptideAtlasiQ92556.
PRIDEiQ92556.

Protocols and materials databases

DNASUi9844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310758; ENSP00000312185; ENSG00000155849. [Q92556-1]
ENST00000396040; ENSP00000379355; ENSG00000155849. [Q92556-2]
ENST00000396045; ENSP00000379360; ENSG00000155849. [Q92556-2]
ENST00000442504; ENSP00000406952; ENSG00000155849. [Q92556-1]
ENST00000448602; ENSP00000394458; ENSG00000155849. [Q92556-1]
GeneIDi9844.
KEGGihsa:9844.
UCSCiuc003tfi.3. human. [Q92556-1]

Organism-specific databases

CTDi9844.
DisGeNETi9844.
GeneCardsiELMO1.
HGNCiHGNC:16286. ELMO1.
MIMi606420. gene.
neXtProtiNX_Q92556.
OpenTargetsiENSG00000155849.
PharmGKBiPA27754.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2999. Eukaryota.
ENOG410XPKN. LUCA.
GeneTreeiENSGT00390000014155.
HOGENOMiHOG000230985.
HOVERGENiHBG055277.
InParanoidiQ92556.
KOiK12366.
OMAiEMSHILA.
OrthoDBiEOG091G03JJ.
PhylomeDBiQ92556.
TreeFamiTF312966.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155849-MONOMER.
ReactomeiR-HSA-164944. Nef and signal transduction.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-4420097. VEGFA-VEGFR2 Pathway.
R-HSA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
SIGNORiQ92556.

Miscellaneous databases

ChiTaRSiELMO1. human.
EvolutionaryTraceiQ92556.
GeneWikiiELMO1.
GenomeRNAii9844.
PROiQ92556.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155849.
CleanExiHS_ELMO1.
ExpressionAtlasiQ92556. baseline and differential.
GenevisibleiQ92556. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024574. DUF3361.
IPR030715. ELMO1.
IPR006816. ELMO_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR12771:SF23. PTHR12771:SF23. 1 hit.
PfamiPF11841. DUF3361. 1 hit.
PF04727. ELMO_CED12. 1 hit.
PF16457. PH_12. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELMO1_HUMAN
AccessioniPrimary (citable) accession number: Q92556
Secondary accession number(s): A4D1X6
, Q29R79, Q6ZTJ0, Q96PB0, Q9H0I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2003
Last modified: November 30, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.