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Protein

28S ribosomal protein S27, mitochondrial

Gene

MRPS27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S27, mitochondrial
Short name:
MRP-S27
Short name:
S27mt
Gene namesi
Name:MRPS27
Synonyms:KIAA0264
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14512. MRPS27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31015.

Polymorphism and mutation databases

BioMutaiMRPS27.
DMDMi209572725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 41441428S ribosomal protein S27, mitochondrialPRO_0000087712Add
BLAST

Proteomic databases

EPDiQ92552.
MaxQBiQ92552.
PaxDbiQ92552.
PeptideAtlasiQ92552.
PRIDEiQ92552.

PTM databases

iPTMnetiQ92552.
PhosphoSiteiQ92552.
SwissPalmiQ92552.

Expressioni

Gene expression databases

BgeeiENSG00000113048.
CleanExiHS_MRPS27.
ExpressionAtlasiQ92552. baseline and differential.
GenevisibleiQ92552. HS.

Organism-specific databases

HPAiCAB055509.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with NOA1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NECAB2H3BTW23EBI-10278573,EBI-10172876

Protein-protein interaction databases

BioGridi116731. 90 interactions.
DIPiDIP-44136N.
IntActiQ92552. 34 interactions.
MINTiMINT-3048759.
STRINGi9606.ENSP00000261413.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AV1-414[»]
ProteinModelPortaliQ92552.
SMRiQ92552. Positions 107-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati105 – 13935PPR 1Add
BLAST
Repeati140 – 17536PPR 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili368 – 41447Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG4570. Eukaryota.
ENOG4110AQE. LUCA.
GeneTreeiENSGT00390000007246.
HOGENOMiHOG000070071.
HOVERGENiHBG006970.
InParanoidiQ92552.
KOiK17406.
OMAiIHSWIRQ.
OrthoDBiEOG091G07XC.
PhylomeDBiQ92552.
TreeFamiTF316446.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
IPR019266. Ribosomal_S27_mit.
[Graphical view]
PfamiPF10037. MRP-S27. 1 hit.
[Graphical view]
PROSITEiPS51375. PPR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92552-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASIVRRGM LLARQVVLPQ LSPAGKRYLL SSAYVDSHKW EAREKEHYCL
60 70 80 90 100
ADLASLMDKT FERKLPVSSL TISRLIDNIS SREEIDHAEY YLYKFRHSPN
110 120 130 140 150
CWYLRNWTIH TWIRQCLKYD AQDKALYTLV NKVQYGIFPD NFTFNLLMDS
160 170 180 190 200
FIKKENYKDA LSVVFEVMMQ EAFEVPSTQL LSLYVLFHCL AKKTDFSWEE
210 220 230 240 250
ERNFGASLLL PGLKQKNSVG FSSQLYGYAL LGKVELQQGL RAVYHNMPLI
260 270 280 290 300
WKPGYLDRAL QVMEKVAASP EDIKLCREAL DVLGAVLKAL TSADGASEEQ
310 320 330 340 350
SQNDEDNQGS EKLVEQLDIE ETEQSKLPQY LERFKALHSK LQALGKIESE
360 370 380 390 400
GLLSLTTQLV KEKLSTCEAE DIATYEQNLQ QWHLDLVQLI QREQQQREQA
410
KQEYQAQKAA KASA
Length:414
Mass (Da):47,611
Last modified:October 14, 2008 - v3
Checksum:iAF8E8D6FC738AA77
GO
Isoform 2 (identifier: Q92552-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-94: K → KKGECSSSNPQNYSR

Note: No experimental confirmation available.
Show »
Length:428
Mass (Da):49,150
Checksum:iB50C5CEC6BB5A8E0
GO

Sequence cautioni

The sequence BAA13394 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti284 – 2841G → D Polymorphism; confirmed at protein level. 2 Publications
Corresponds to variant rs3209157 [ dbSNP | Ensembl ].
VAR_047026

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 941K → KKGECSSSNPQNYSR in isoform 2. 1 PublicationVSP_054882

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87453 mRNA. Translation: BAA13394.1. Different initiation.
AK299412 mRNA. Translation: BAG61394.1.
AC012609 Genomic DNA. No translation available.
AC026406 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95701.1.
BC064902 mRNA. Translation: AAH64902.1.
CCDSiCCDS4013.1. [Q92552-1]
CCDS68890.1. [Q92552-2]
RefSeqiNP_001273677.1. NM_001286748.1. [Q92552-2]
NP_055899.2. NM_015084.2. [Q92552-1]
UniGeneiHs.482491.

Genome annotation databases

EnsembliENST00000261413; ENSP00000261413; ENSG00000113048. [Q92552-1]
ENST00000513900; ENSP00000426941; ENSG00000113048. [Q92552-2]
GeneIDi23107.
KEGGihsa:23107.
UCSCiuc003kbz.5. human. [Q92552-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87453 mRNA. Translation: BAA13394.1. Different initiation.
AK299412 mRNA. Translation: BAG61394.1.
AC012609 Genomic DNA. No translation available.
AC026406 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95701.1.
BC064902 mRNA. Translation: AAH64902.1.
CCDSiCCDS4013.1. [Q92552-1]
CCDS68890.1. [Q92552-2]
RefSeqiNP_001273677.1. NM_001286748.1. [Q92552-2]
NP_055899.2. NM_015084.2. [Q92552-1]
UniGeneiHs.482491.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AV1-414[»]
ProteinModelPortaliQ92552.
SMRiQ92552. Positions 107-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116731. 90 interactions.
DIPiDIP-44136N.
IntActiQ92552. 34 interactions.
MINTiMINT-3048759.
STRINGi9606.ENSP00000261413.

PTM databases

iPTMnetiQ92552.
PhosphoSiteiQ92552.
SwissPalmiQ92552.

Polymorphism and mutation databases

BioMutaiMRPS27.
DMDMi209572725.

Proteomic databases

EPDiQ92552.
MaxQBiQ92552.
PaxDbiQ92552.
PeptideAtlasiQ92552.
PRIDEiQ92552.

Protocols and materials databases

DNASUi23107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261413; ENSP00000261413; ENSG00000113048. [Q92552-1]
ENST00000513900; ENSP00000426941; ENSG00000113048. [Q92552-2]
GeneIDi23107.
KEGGihsa:23107.
UCSCiuc003kbz.5. human. [Q92552-1]

Organism-specific databases

CTDi23107.
GeneCardsiMRPS27.
HGNCiHGNC:14512. MRPS27.
HPAiCAB055509.
MIMi611989. gene.
neXtProtiNX_Q92552.
PharmGKBiPA31015.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4570. Eukaryota.
ENOG4110AQE. LUCA.
GeneTreeiENSGT00390000007246.
HOGENOMiHOG000070071.
HOVERGENiHBG006970.
InParanoidiQ92552.
KOiK17406.
OMAiIHSWIRQ.
OrthoDBiEOG091G07XC.
PhylomeDBiQ92552.
TreeFamiTF316446.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS27. human.
GenomeRNAii23107.
PROiQ92552.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113048.
CleanExiHS_MRPS27.
ExpressionAtlasiQ92552. baseline and differential.
GenevisibleiQ92552. HS.

Family and domain databases

InterProiIPR002885. Pentatricopeptide_repeat.
IPR019266. Ribosomal_S27_mit.
[Graphical view]
PfamiPF10037. MRP-S27. 1 hit.
[Graphical view]
PROSITEiPS51375. PPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT27_HUMAN
AccessioniPrimary (citable) accession number: Q92552
Secondary accession number(s): B4DRT2, Q6P1S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.