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Protein

28S ribosomal protein S27, mitochondrial

Gene

MRPS27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S27, mitochondrial
Short name:
MRP-S27
Short name:
S27mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein mS271 Publication
Gene namesi
Name:MRPS27
Synonyms:KIAA0264
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14512. MRPS27.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113048.
PharmGKBiPA31015.

Polymorphism and mutation databases

BioMutaiMRPS27.
DMDMi209572725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000877121 – 41428S ribosomal protein S27, mitochondrialAdd BLAST414

Proteomic databases

EPDiQ92552.
MaxQBiQ92552.
PaxDbiQ92552.
PeptideAtlasiQ92552.
PRIDEiQ92552.

PTM databases

iPTMnetiQ92552.
PhosphoSitePlusiQ92552.
SwissPalmiQ92552.

Expressioni

Gene expression databases

BgeeiENSG00000113048.
CleanExiHS_MRPS27.
ExpressionAtlasiQ92552. baseline and differential.
GenevisibleiQ92552. HS.

Organism-specific databases

HPAiHPA071751.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25838379). Interacts with NOA1 (PubMed:19103604).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NECAB2H3BTW23EBI-10278573,EBI-10172876

Protein-protein interaction databases

BioGridi116731. 90 interactors.
DIPiDIP-44136N.
IntActiQ92552. 34 interactors.
MINTiMINT-3048759.
STRINGi9606.ENSP00000261413.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AV1-414[»]
ProteinModelPortaliQ92552.
SMRiQ92552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati105 – 139PPR 1Add BLAST35
Repeati140 – 175PPR 2Add BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili368 – 414Sequence analysisAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG4570. Eukaryota.
ENOG4110AQE. LUCA.
GeneTreeiENSGT00390000007246.
HOGENOMiHOG000070071.
HOVERGENiHBG006970.
InParanoidiQ92552.
KOiK17406.
OMAiNCWYLRD.
OrthoDBiEOG091G07XC.
PhylomeDBiQ92552.
TreeFamiTF316446.

Family and domain databases

InterProiView protein in InterPro
IPR019266. MRPS27.
IPR034913. MRPS27/PTCD2.
IPR002885. Pentatricopeptide_repeat.
PANTHERiPTHR21393. PTHR21393. 1 hit.
PfamiView protein in Pfam
PF10037. MRP-S27. 1 hit.
PROSITEiView protein in PROSITE
PS51375. PPR. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92552-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASIVRRGM LLARQVVLPQ LSPAGKRYLL SSAYVDSHKW EAREKEHYCL
60 70 80 90 100
ADLASLMDKT FERKLPVSSL TISRLIDNIS SREEIDHAEY YLYKFRHSPN
110 120 130 140 150
CWYLRNWTIH TWIRQCLKYD AQDKALYTLV NKVQYGIFPD NFTFNLLMDS
160 170 180 190 200
FIKKENYKDA LSVVFEVMMQ EAFEVPSTQL LSLYVLFHCL AKKTDFSWEE
210 220 230 240 250
ERNFGASLLL PGLKQKNSVG FSSQLYGYAL LGKVELQQGL RAVYHNMPLI
260 270 280 290 300
WKPGYLDRAL QVMEKVAASP EDIKLCREAL DVLGAVLKAL TSADGASEEQ
310 320 330 340 350
SQNDEDNQGS EKLVEQLDIE ETEQSKLPQY LERFKALHSK LQALGKIESE
360 370 380 390 400
GLLSLTTQLV KEKLSTCEAE DIATYEQNLQ QWHLDLVQLI QREQQQREQA
410
KQEYQAQKAA KASA
Length:414
Mass (Da):47,611
Last modified:October 14, 2008 - v3
Checksum:iAF8E8D6FC738AA77
GO
Isoform 2 (identifier: Q92552-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-94: K → KKGECSSSNPQNYSR

Note: No experimental confirmation available.
Show »
Length:428
Mass (Da):49,150
Checksum:iB50C5CEC6BB5A8E0
GO

Sequence cautioni

The sequence BAA13394 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047026284G → D Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs3209157Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05488294K → KKGECSSSNPQNYSR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87453 mRNA. Translation: BAA13394.1. Different initiation.
AK299412 mRNA. Translation: BAG61394.1.
AC012609 Genomic DNA. No translation available.
AC026406 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95701.1.
BC064902 mRNA. Translation: AAH64902.1.
CCDSiCCDS4013.1. [Q92552-1]
CCDS68890.1. [Q92552-2]
RefSeqiNP_001273677.1. NM_001286748.1. [Q92552-2]
NP_055899.2. NM_015084.2. [Q92552-1]
UniGeneiHs.482491.

Genome annotation databases

EnsembliENST00000261413; ENSP00000261413; ENSG00000113048. [Q92552-1]
ENST00000513900; ENSP00000426941; ENSG00000113048. [Q92552-2]
GeneIDi23107.
KEGGihsa:23107.
UCSCiuc003kbz.5. human. [Q92552-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87453 mRNA. Translation: BAA13394.1. Different initiation.
AK299412 mRNA. Translation: BAG61394.1.
AC012609 Genomic DNA. No translation available.
AC026406 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95701.1.
BC064902 mRNA. Translation: AAH64902.1.
CCDSiCCDS4013.1. [Q92552-1]
CCDS68890.1. [Q92552-2]
RefSeqiNP_001273677.1. NM_001286748.1. [Q92552-2]
NP_055899.2. NM_015084.2. [Q92552-1]
UniGeneiHs.482491.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AV1-414[»]
ProteinModelPortaliQ92552.
SMRiQ92552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116731. 90 interactors.
DIPiDIP-44136N.
IntActiQ92552. 34 interactors.
MINTiMINT-3048759.
STRINGi9606.ENSP00000261413.

PTM databases

iPTMnetiQ92552.
PhosphoSitePlusiQ92552.
SwissPalmiQ92552.

Polymorphism and mutation databases

BioMutaiMRPS27.
DMDMi209572725.

Proteomic databases

EPDiQ92552.
MaxQBiQ92552.
PaxDbiQ92552.
PeptideAtlasiQ92552.
PRIDEiQ92552.

Protocols and materials databases

DNASUi23107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261413; ENSP00000261413; ENSG00000113048. [Q92552-1]
ENST00000513900; ENSP00000426941; ENSG00000113048. [Q92552-2]
GeneIDi23107.
KEGGihsa:23107.
UCSCiuc003kbz.5. human. [Q92552-1]

Organism-specific databases

CTDi23107.
GeneCardsiMRPS27.
HGNCiHGNC:14512. MRPS27.
HPAiHPA071751.
MIMi611989. gene.
neXtProtiNX_Q92552.
OpenTargetsiENSG00000113048.
PharmGKBiPA31015.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4570. Eukaryota.
ENOG4110AQE. LUCA.
GeneTreeiENSGT00390000007246.
HOGENOMiHOG000070071.
HOVERGENiHBG006970.
InParanoidiQ92552.
KOiK17406.
OMAiNCWYLRD.
OrthoDBiEOG091G07XC.
PhylomeDBiQ92552.
TreeFamiTF316446.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS27. human.
GenomeRNAii23107.
PROiPR:Q92552.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113048.
CleanExiHS_MRPS27.
ExpressionAtlasiQ92552. baseline and differential.
GenevisibleiQ92552. HS.

Family and domain databases

InterProiView protein in InterPro
IPR019266. MRPS27.
IPR034913. MRPS27/PTCD2.
IPR002885. Pentatricopeptide_repeat.
PANTHERiPTHR21393. PTHR21393. 1 hit.
PfamiView protein in Pfam
PF10037. MRP-S27. 1 hit.
PROSITEiView protein in PROSITE
PS51375. PPR. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT27_HUMAN
AccessioniPrimary (citable) accession number: Q92552
Secondary accession number(s): B4DRT2, Q6P1S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 14, 2008
Last modified: June 7, 2017
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.