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Q92551

- IP6K1_HUMAN

UniProt

Q92551 - IP6K1_HUMAN

Protein

Inositol hexakisphosphate kinase 1

Gene

IP6K1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

    Catalytic activityi

    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
    ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
    3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
    4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
    5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. inositol phosphate metabolic process Source: Reactome
    2. phosphatidylinositol phosphorylation Source: UniProtKB
    3. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS10997-MONOMER.
    ReactomeiREACT_150188. Synthesis of pyrophosphates in the cytosol.
    REACT_150275. Synthesis of IPs in the nucleus.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
    Short name:
    InsP6 kinase 1
    Alternative name(s):
    Inositol hexaphosphate kinase 1
    Gene namesi
    Name:IP6K1
    Synonyms:IHPK1, KIAA0263
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:18360. IP6K1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleolus Source: HPA
    3. nucleoplasm Source: Reactome
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164720982.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Inositol hexakisphosphate kinase 1PRO_0000066874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ92551.
    PaxDbiQ92551.
    PRIDEiQ92551.

    PTM databases

    PhosphoSiteiQ92551.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92551.
    BgeeiQ92551.
    CleanExiHS_IP6K1.
    GenevestigatoriQ92551.

    Organism-specific databases

    HPAiHPA040825.

    Interactioni

    Protein-protein interaction databases

    BioGridi115147. 5 interactions.
    IntActiQ92551. 2 interactions.
    MINTiMINT-1457443.
    STRINGi9606.ENSP00000323780.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92551.
    SMRiQ92551. Positions 206-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni220 – 2289Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG274869.
    HOGENOMiHOG000007418.
    HOVERGENiHBG052140.
    InParanoidiQ92551.
    KOiK07756.
    OMAiQTMEVGK.
    OrthoDBiEOG747PHX.
    PhylomeDBiQ92551.
    TreeFamiTF314066.

    Family and domain databases

    InterProiIPR005522. IPK.
    [Graphical view]
    PANTHERiPTHR12400. PTHR12400. 1 hit.
    PfamiPF03770. IPK. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92551-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP    50
    LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE 100
    TVEQDDTTER EQPRRKHSRR SLHRSGSGSD HKEEKASLSL ETSESSQEAK 150
    SPKVELHSHS EVPFQMLDGN SGLSSEKISH NPWSLRCHKQ QLSRMRSESK 200
    DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ 250
    STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG 300
    LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRAESCL 350
    DRRSEMRLKH LDMVLPEVAS SCGPSTSPSN TSPEAGPSSQ PKVDVRMIDF 400
    AHSTFKGFRD DPTVHDGPDR GYVFGLENLI SIMEQMRDEN Q 441
    Length:441
    Mass (Da):50,236
    Last modified:July 19, 2004 - v3
    Checksum:i6DFB2F88E1F91EE9
    GO
    Isoform 2 (identifier: Q92551-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-165: Missing.

    Show »
    Length:276
    Mass (Da):31,524
    Checksum:i90C122582D10BE28
    GO

    Sequence cautioni

    The sequence BAA13393.2 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 165165Missing in isoform 2. 1 PublicationVSP_042756Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87452 mRNA. Translation: BAA13393.2. Different initiation.
    AK289772 mRNA. Translation: BAF82461.1.
    AK295689 mRNA. Translation: BAG58541.1.
    AC099668 Genomic DNA. No translation available.
    AC139451 Genomic DNA. No translation available.
    AC141000 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65016.1.
    BC012944 mRNA. Translation: AAH12944.1.
    CCDSiCCDS33760.1. [Q92551-1]
    CCDS43092.1. [Q92551-2]
    RefSeqiNP_001006115.1. NM_001006115.2. [Q92551-2]
    NP_001229758.1. NM_001242829.1. [Q92551-1]
    NP_695005.1. NM_153273.3. [Q92551-1]
    UniGeneiHs.386168.

    Genome annotation databases

    EnsembliENST00000321599; ENSP00000323780; ENSG00000176095. [Q92551-1]
    ENST00000395238; ENSP00000378659; ENSG00000176095. [Q92551-2]
    ENST00000460540; ENSP00000420762; ENSG00000176095. [Q92551-2]
    GeneIDi9807.
    KEGGihsa:9807.
    UCSCiuc003cxm.1. human. [Q92551-1]

    Polymorphism databases

    DMDMi50400597.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87452 mRNA. Translation: BAA13393.2 . Different initiation.
    AK289772 mRNA. Translation: BAF82461.1 .
    AK295689 mRNA. Translation: BAG58541.1 .
    AC099668 Genomic DNA. No translation available.
    AC139451 Genomic DNA. No translation available.
    AC141000 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65016.1 .
    BC012944 mRNA. Translation: AAH12944.1 .
    CCDSi CCDS33760.1. [Q92551-1 ]
    CCDS43092.1. [Q92551-2 ]
    RefSeqi NP_001006115.1. NM_001006115.2. [Q92551-2 ]
    NP_001229758.1. NM_001242829.1. [Q92551-1 ]
    NP_695005.1. NM_153273.3. [Q92551-1 ]
    UniGenei Hs.386168.

    3D structure databases

    ProteinModelPortali Q92551.
    SMRi Q92551. Positions 206-432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115147. 5 interactions.
    IntActi Q92551. 2 interactions.
    MINTi MINT-1457443.
    STRINGi 9606.ENSP00000323780.

    PTM databases

    PhosphoSitei Q92551.

    Polymorphism databases

    DMDMi 50400597.

    Proteomic databases

    MaxQBi Q92551.
    PaxDbi Q92551.
    PRIDEi Q92551.

    Protocols and materials databases

    DNASUi 9807.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321599 ; ENSP00000323780 ; ENSG00000176095 . [Q92551-1 ]
    ENST00000395238 ; ENSP00000378659 ; ENSG00000176095 . [Q92551-2 ]
    ENST00000460540 ; ENSP00000420762 ; ENSG00000176095 . [Q92551-2 ]
    GeneIDi 9807.
    KEGGi hsa:9807.
    UCSCi uc003cxm.1. human. [Q92551-1 ]

    Organism-specific databases

    CTDi 9807.
    GeneCardsi GC03M049737.
    HGNCi HGNC:18360. IP6K1.
    HPAi HPA040825.
    MIMi 606991. gene.
    neXtProti NX_Q92551.
    PharmGKBi PA164720982.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274869.
    HOGENOMi HOG000007418.
    HOVERGENi HBG052140.
    InParanoidi Q92551.
    KOi K07756.
    OMAi QTMEVGK.
    OrthoDBi EOG747PHX.
    PhylomeDBi Q92551.
    TreeFami TF314066.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS10997-MONOMER.
    Reactomei REACT_150188. Synthesis of pyrophosphates in the cytosol.
    REACT_150275. Synthesis of IPs in the nucleus.

    Miscellaneous databases

    GeneWikii IHPK1.
    GenomeRNAii 9807.
    NextBioi 36924.
    PROi Q92551.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92551.
    Bgeei Q92551.
    CleanExi HS_IP6K1.
    Genevestigatori Q92551.

    Family and domain databases

    InterProi IPR005522. IPK.
    [Graphical view ]
    PANTHERi PTHR12400. PTHR12400. 1 hit.
    Pfami PF03770. IPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    6. "Identification and characterization of a novel inositol hexakisphosphate kinase."
      Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H.
      J. Biol. Chem. 276:39179-39185(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIP6K1_HUMAN
    AccessioniPrimary (citable) accession number: Q92551
    Secondary accession number(s): A8K157
    , A8MUX4, Q7L3I7, Q96E38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3