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Protein

Inositol hexakisphosphate kinase 1

Gene

IP6K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS10997-MONOMER
ReactomeiR-HSA-1855167 Synthesis of pyrophosphates in the cytosol
R-HSA-1855191 Synthesis of IPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene namesi
Name:IP6K1
Synonyms:IHPK1, KIAA0263
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000176095.11
HGNCiHGNC:18360 IP6K1
MIMi606991 gene
neXtProtiNX_Q92551

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9807
OpenTargetsiENSG00000176095
PharmGKBiPA164720982

Polymorphism and mutation databases

BioMutaiIP6K1
DMDMi50400597

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668741 – 441Inositol hexakisphosphate kinase 1Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92551
MaxQBiQ92551
PaxDbiQ92551
PeptideAtlasiQ92551
PRIDEiQ92551

PTM databases

iPTMnetiQ92551
PhosphoSitePlusiQ92551

Expressioni

Gene expression databases

BgeeiENSG00000176095
CleanExiHS_IP6K1
ExpressionAtlasiQ92551 baseline and differential
GenevisibleiQ92551 HS

Organism-specific databases

HPAiHPA040825

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115147, 21 interactors
IntActiQ92551, 8 interactors
STRINGi9606.ENSP00000323780

Structurei

3D structure databases

ProteinModelPortaliQ92551
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 228Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620 Eukaryota
ENOG410YB60 LUCA
GeneTreeiENSGT00390000014381
HOGENOMiHOG000007418
HOVERGENiHBG052140
InParanoidiQ92551
KOiK07756
OMAiIHSDVPF
OrthoDBiEOG091G0JK2
PhylomeDBiQ92551
TreeFamiTF314066

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92551-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP
60 70 80 90 100
LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE
110 120 130 140 150
TVEQDDTTER EQPRRKHSRR SLHRSGSGSD HKEEKASLSL ETSESSQEAK
160 170 180 190 200
SPKVELHSHS EVPFQMLDGN SGLSSEKISH NPWSLRCHKQ QLSRMRSESK
210 220 230 240 250
DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ
260 270 280 290 300
STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
310 320 330 340 350
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRAESCL
360 370 380 390 400
DRRSEMRLKH LDMVLPEVAS SCGPSTSPSN TSPEAGPSSQ PKVDVRMIDF
410 420 430 440
AHSTFKGFRD DPTVHDGPDR GYVFGLENLI SIMEQMRDEN Q
Length:441
Mass (Da):50,236
Last modified:July 19, 2004 - v3
Checksum:i6DFB2F88E1F91EE9
GO
Isoform 2 (identifier: Q92551-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Show »
Length:276
Mass (Da):31,524
Checksum:i90C122582D10BE28
GO

Sequence cautioni

The sequence BAA13393 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0427561 – 165Missing in isoform 2. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87452 mRNA Translation: BAA13393.2 Different initiation.
AK289772 mRNA Translation: BAF82461.1
AK295689 mRNA Translation: BAG58541.1
AC099668 Genomic DNA No translation available.
AC139451 Genomic DNA No translation available.
AC141000 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65016.1
BC012944 mRNA Translation: AAH12944.1
CCDSiCCDS33760.1 [Q92551-1]
CCDS43092.1 [Q92551-2]
RefSeqiNP_001006115.1, NM_001006115.2 [Q92551-2]
NP_001229758.1, NM_001242829.1 [Q92551-1]
NP_695005.1, NM_153273.3 [Q92551-1]
UniGeneiHs.386168

Genome annotation databases

EnsembliENST00000321599; ENSP00000323780; ENSG00000176095 [Q92551-1]
ENST00000395238; ENSP00000378659; ENSG00000176095 [Q92551-2]
ENST00000460540; ENSP00000420762; ENSG00000176095 [Q92551-2]
ENST00000613416; ENSP00000482032; ENSG00000176095 [Q92551-1]
GeneIDi9807
KEGGihsa:9807
UCSCiuc003cxm.2 human [Q92551-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIP6K1_HUMAN
AccessioniPrimary (citable) accession number: Q92551
Secondary accession number(s): A8K157
, A8MUX4, Q7L3I7, Q96E38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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