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Protein

Inositol hexakisphosphate kinase 1

Gene

IP6K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
  3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. inositol phosphate metabolic process Source: Reactome
  2. phosphatidylinositol phosphorylation Source: UniProtKB
  3. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS10997-MONOMER.
ReactomeiREACT_150188. Synthesis of pyrophosphates in the cytosol.
REACT_150275. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene namesi
Name:IP6K1
Synonyms:IHPK1, KIAA0263
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18360. IP6K1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleolus Source: HPA
  3. nucleoplasm Source: Reactome
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Inositol hexakisphosphate kinase 1PRO_0000066874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92551.
PaxDbiQ92551.
PRIDEiQ92551.

PTM databases

PhosphoSiteiQ92551.

Expressioni

Gene expression databases

BgeeiQ92551.
CleanExiHS_IP6K1.
ExpressionAtlasiQ92551. baseline and differential.
GenevestigatoriQ92551.

Organism-specific databases

HPAiHPA040825.

Interactioni

Protein-protein interaction databases

BioGridi115147. 10 interactions.
IntActiQ92551. 2 interactions.
MINTiMINT-1457443.
STRINGi9606.ENSP00000323780.

Structurei

3D structure databases

ProteinModelPortaliQ92551.
SMRiQ92551. Positions 206-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni220 – 2289Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ92551.
KOiK07756.
OMAiQTMEVGK.
OrthoDBiEOG747PHX.
PhylomeDBiQ92551.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92551-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP
60 70 80 90 100
LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE
110 120 130 140 150
TVEQDDTTER EQPRRKHSRR SLHRSGSGSD HKEEKASLSL ETSESSQEAK
160 170 180 190 200
SPKVELHSHS EVPFQMLDGN SGLSSEKISH NPWSLRCHKQ QLSRMRSESK
210 220 230 240 250
DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ
260 270 280 290 300
STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
310 320 330 340 350
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRAESCL
360 370 380 390 400
DRRSEMRLKH LDMVLPEVAS SCGPSTSPSN TSPEAGPSSQ PKVDVRMIDF
410 420 430 440
AHSTFKGFRD DPTVHDGPDR GYVFGLENLI SIMEQMRDEN Q
Length:441
Mass (Da):50,236
Last modified:July 19, 2004 - v3
Checksum:i6DFB2F88E1F91EE9
GO
Isoform 2 (identifier: Q92551-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Show »
Length:276
Mass (Da):31,524
Checksum:i90C122582D10BE28
GO

Sequence cautioni

The sequence BAA13393.2 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 165165Missing in isoform 2. 1 PublicationVSP_042756Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87452 mRNA. Translation: BAA13393.2. Different initiation.
AK289772 mRNA. Translation: BAF82461.1.
AK295689 mRNA. Translation: BAG58541.1.
AC099668 Genomic DNA. No translation available.
AC139451 Genomic DNA. No translation available.
AC141000 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65016.1.
BC012944 mRNA. Translation: AAH12944.1.
CCDSiCCDS33760.1. [Q92551-1]
CCDS43092.1. [Q92551-2]
RefSeqiNP_001006115.1. NM_001006115.2. [Q92551-2]
NP_001229758.1. NM_001242829.1. [Q92551-1]
NP_695005.1. NM_153273.3. [Q92551-1]
UniGeneiHs.386168.

Genome annotation databases

EnsembliENST00000321599; ENSP00000323780; ENSG00000176095. [Q92551-1]
ENST00000395238; ENSP00000378659; ENSG00000176095. [Q92551-2]
ENST00000460540; ENSP00000420762; ENSG00000176095. [Q92551-2]
ENST00000613416; ENSP00000482032; ENSG00000176095. [Q92551-1]
GeneIDi9807.
KEGGihsa:9807.
UCSCiuc003cxm.1. human. [Q92551-1]

Polymorphism databases

DMDMi50400597.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87452 mRNA. Translation: BAA13393.2. Different initiation.
AK289772 mRNA. Translation: BAF82461.1.
AK295689 mRNA. Translation: BAG58541.1.
AC099668 Genomic DNA. No translation available.
AC139451 Genomic DNA. No translation available.
AC141000 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65016.1.
BC012944 mRNA. Translation: AAH12944.1.
CCDSiCCDS33760.1. [Q92551-1]
CCDS43092.1. [Q92551-2]
RefSeqiNP_001006115.1. NM_001006115.2. [Q92551-2]
NP_001229758.1. NM_001242829.1. [Q92551-1]
NP_695005.1. NM_153273.3. [Q92551-1]
UniGeneiHs.386168.

3D structure databases

ProteinModelPortaliQ92551.
SMRiQ92551. Positions 206-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115147. 10 interactions.
IntActiQ92551. 2 interactions.
MINTiMINT-1457443.
STRINGi9606.ENSP00000323780.

PTM databases

PhosphoSiteiQ92551.

Polymorphism databases

DMDMi50400597.

Proteomic databases

MaxQBiQ92551.
PaxDbiQ92551.
PRIDEiQ92551.

Protocols and materials databases

DNASUi9807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321599; ENSP00000323780; ENSG00000176095. [Q92551-1]
ENST00000395238; ENSP00000378659; ENSG00000176095. [Q92551-2]
ENST00000460540; ENSP00000420762; ENSG00000176095. [Q92551-2]
ENST00000613416; ENSP00000482032; ENSG00000176095. [Q92551-1]
GeneIDi9807.
KEGGihsa:9807.
UCSCiuc003cxm.1. human. [Q92551-1]

Organism-specific databases

CTDi9807.
GeneCardsiGC03M049761.
HGNCiHGNC:18360. IP6K1.
HPAiHPA040825.
MIMi606991. gene.
neXtProtiNX_Q92551.
PharmGKBiPA164720982.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ92551.
KOiK07756.
OMAiQTMEVGK.
OrthoDBiEOG747PHX.
PhylomeDBiQ92551.
TreeFamiTF314066.

Enzyme and pathway databases

BioCyciMetaCyc:HS10997-MONOMER.
ReactomeiREACT_150188. Synthesis of pyrophosphates in the cytosol.
REACT_150275. Synthesis of IPs in the nucleus.

Miscellaneous databases

GeneWikiiIHPK1.
GenomeRNAii9807.
NextBioi36924.
PROiQ92551.
SOURCEiSearch...

Gene expression databases

BgeeiQ92551.
CleanExiHS_IP6K1.
ExpressionAtlasiQ92551. baseline and differential.
GenevestigatoriQ92551.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. "Identification and characterization of a novel inositol hexakisphosphate kinase."
    Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H.
    J. Biol. Chem. 276:39179-39185(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiIP6K1_HUMAN
AccessioniPrimary (citable) accession number: Q92551
Secondary accession number(s): A8K157
, A8MUX4, Q7L3I7, Q96E38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: March 4, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.