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Protein

DNA topoisomerase 2-binding protein 1

Gene

TOPBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.6 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • protein C-terminus binding Source: ProtInc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • DNA metabolic process Source: ProtInc
  • DNA repair Source: UniProtKB
  • DNA replication Source: Reactome
  • DNA replication initiation Source: GO_Central
  • mitotic DNA replication checkpoint Source: GO_Central
  • mitotic G2 DNA damage checkpoint Source: GO_Central
  • regulation of signal transduction by p53 class mediator Source: Reactome
  • response to ionizing radiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163781-MONOMER.
ReactomeiR-HSA-5685938. HDR through Single Strand Annealing (SSA).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-69473. G2/M DNA damage checkpoint.
SignaLinkiQ92547.
SIGNORiQ92547.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 2-binding protein 1
Alternative name(s):
DNA topoisomerase II-beta-binding protein 1
Short name:
TopBP1
DNA topoisomerase II-binding protein 1
Gene namesi
Name:TOPBP1
Synonyms:KIAA0259
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17008. TOPBP1.

Subcellular locationi

  • Nucleus
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
  • Cytoplasmcytoskeletonspindle pole
  • Chromosome

  • Note: Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner.By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • centrosome Source: HPA
  • chromosome Source: UniProtKB
  • condensed nuclear chromosome Source: Ensembl
  • cytoplasm Source: HPA
  • Golgi apparatus Source: HPA
  • male germ cell nucleus Source: Ensembl
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
  • PML body Source: UniProtKB
  • spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11073.
OpenTargetsiENSG00000163781.
PharmGKBiPA134934073.

Chemistry databases

ChEMBLiCHEMBL3175.

Polymorphism and mutation databases

BioMutaiTOPBP1.
DMDMi296453012.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726311 – 1522DNA topoisomerase 2-binding protein 1Add BLAST1522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298PhosphothreonineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei779PhosphothreonineCombined sources1
Modified residuei848PhosphothreonineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei861PhosphothreonineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei886PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1
Modified residuei1002PhosphoserineCombined sources1
Modified residuei1064PhosphothreonineCombined sources1
Modified residuei1504PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on serine and threonine residues in response to X-ray irradiation.2 Publications
Ubiquitinated and degraded by the proteasome. X-ray irradiation reduces ubiquitination.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92547.
MaxQBiQ92547.
PaxDbiQ92547.
PeptideAtlasiQ92547.
PRIDEiQ92547.

PTM databases

iPTMnetiQ92547.
PhosphoSitePlusiQ92547.

Expressioni

Tissue specificityi

Highly expressed in heart, brain, placenta, lung and kidney.1 Publication

Inductioni

Up-regulated during the S phase of the cell cycle. Up-regulated by E2F1 and interferon.1 Publication

Gene expression databases

BgeeiENSG00000163781.
CleanExiHS_TOPBP1.
ExpressionAtlasiQ92547. baseline and differential.
GenevisibleiQ92547. HS.

Organism-specific databases

HPAiCAB022451.
HPA036738.
HPA063020.
HPA064566.

Interactioni

Subunit structurei

Interacts with POLE (PubMed:11395493). Interacts with RAD9A (PubMed:11395493). Interacts with UBR5 (PubMed:11714696). Interacts with E2F1 (PubMed:12697828, PubMed:15075294). Interacts with PML (PubMed:12773567). Interacts with SMARCA2 (PubMed:15075294). Interacts with SMARCA4 (PubMed:15075294). Interacts with RHNO1 (PubMed:21659603). May interact with TOP2B (PubMed:9461304). Interacts with TICRR (PubMed:20080954). Interacts with HELB (PubMed:25933514).9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-308302,EBI-308302
AKT1P317492EBI-308302,EBI-296087
CDC45O754196EBI-308302,EBI-374969
E2P031202EBI-308302,EBI-1779322From a different organism.
E2F1Q010943EBI-308302,EBI-448924
ZBTB17Q131052EBI-308302,EBI-372156

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein C-terminus binding Source: ProtInc

Protein-protein interaction databases

BioGridi116256. 55 interactors.
DIPiDIP-24263N.
IntActiQ92547. 20 interactors.
MINTiMINT-275958.
STRINGi9606.ENSP00000260810.

Chemistry databases

BindingDBiQ92547.

Structurei

Secondary structure

11522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 15Combined sources5
Helixi21 – 33Combined sources13
Helixi36 – 38Combined sources3
Beta strandi39 – 43Combined sources5
Helixi44 – 47Combined sources4
Beta strandi57 – 59Combined sources3
Beta strandi61 – 63Combined sources3
Helixi66 – 74Combined sources9
Beta strandi77 – 79Combined sources3
Helixi81 – 89Combined sources9
Turni105 – 108Combined sources4
Beta strandi110 – 115Combined sources6
Helixi118 – 130Combined sources13
Beta strandi145 – 151Combined sources7
Helixi154 – 161Combined sources8
Helixi169 – 180Combined sources12
Turni181 – 183Combined sources3
Helixi187 – 189Combined sources3
Helixi192 – 195Combined sources4
Turni199 – 202Combined sources4
Beta strandi204 – 207Combined sources4
Helixi212 – 224Combined sources13
Turni235 – 237Combined sources3
Beta strandi240 – 242Combined sources3
Beta strandi244 – 246Combined sources3
Helixi249 – 256Combined sources8
Beta strandi260 – 262Combined sources3
Helixi264 – 273Combined sources10
Helixi279 – 281Combined sources3
Beta strandi282 – 284Combined sources3
Beta strandi333 – 335Combined sources3
Helixi341 – 343Combined sources3
Helixi349 – 351Combined sources3
Turni356 – 361Combined sources6
Beta strandi363 – 368Combined sources6
Helixi372 – 383Combined sources12
Beta strandi387 – 391Combined sources5
Beta strandi398 – 403Combined sources6
Helixi407 – 414Combined sources8
Beta strandi421 – 423Combined sources3
Helixi424 – 433Combined sources10
Helixi440 – 442Combined sources3
Turni552 – 555Combined sources4
Beta strandi557 – 560Combined sources4
Helixi565 – 577Combined sources13
Beta strandi591 – 596Combined sources6
Beta strandi607 – 612Combined sources6
Helixi613 – 621Combined sources9
Helixi628 – 630Combined sources3
Helixi632 – 634Combined sources3
Turni645 – 648Combined sources4
Beta strandi650 – 653Combined sources4
Helixi658 – 670Combined sources13
Turni685 – 688Combined sources4
Beta strandi693 – 696Combined sources4
Beta strandi698 – 700Combined sources3
Helixi703 – 710Combined sources8
Helixi718 – 727Combined sources10
Helixi733 – 735Combined sources3
Helixi738 – 740Combined sources3
Turni904 – 907Combined sources4
Beta strandi909 – 912Combined sources4
Helixi914 – 919Combined sources6
Helixi920 – 929Combined sources10
Beta strandi933 – 937Combined sources5
Beta strandi943 – 946Combined sources4
Helixi956 – 963Combined sources8
Beta strandi967 – 969Combined sources3
Helixi971 – 980Combined sources10
Helixi986 – 988Combined sources3
Beta strandi1269 – 1274Combined sources6
Helixi1277 – 1289Combined sources13
Beta strandi1297 – 1299Combined sources3
Beta strandi1306 – 1311Combined sources6
Helixi1316 – 1323Combined sources8
Beta strandi1327 – 1329Combined sources3
Helixi1332 – 1340Combined sources9
Helixi1347 – 1349Combined sources3
Helixi1354 – 1357Combined sources4
Helixi1365 – 1385Combined sources21
Turni1386 – 1388Combined sources3
Turni1393 – 1396Combined sources4
Beta strandi1398 – 1402Combined sources5
Helixi1405 – 1417Combined sources13
Helixi1428 – 1433Combined sources6
Beta strandi1435 – 1439Combined sources5
Helixi1453 – 1458Combined sources6
Beta strandi1462 – 1465Combined sources4
Helixi1467 – 1474Combined sources8
Helixi1481 – 1484Combined sources4
Helixi1487 – 1492Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF6NMR-A326-444[»]
2XNHX-ray2.80A1-287[»]
2XNKX-ray2.60A/B/C/D1-290[»]
3AL2X-ray2.00A1264-1493[»]
3AL3X-ray2.15A1264-1493[»]
3JVEX-ray1.34A893-996[»]
3OLCX-ray2.40X1-290[»]
3PD7X-ray1.26A/B893-994[»]
3UENX-ray1.90A549-746[»]
3UEOX-ray2.60A/B/C/D549-746[»]
ProteinModelPortaliQ92547.
SMRiQ92547.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92547.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 189BRCT 1PROSITE-ProRule annotationAdd BLAST89
Domaini195 – 284BRCT 2PROSITE-ProRule annotationAdd BLAST90
Domaini354 – 444BRCT 3PROSITE-ProRule annotationAdd BLAST91
Domaini548 – 633BRCT 4PROSITE-ProRule annotationAdd BLAST86
Domaini641 – 738BRCT 5PROSITE-ProRule annotationAdd BLAST98
Domaini900 – 991BRCT 6PROSITE-ProRule annotationAdd BLAST92
Domaini1259 – 1351BRCT 7PROSITE-ProRule annotationAdd BLAST93
Domaini1389 – 1486BRCT 8PROSITE-ProRule annotationAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi852 – 858Nuclear localization signalSequence analysis7
Motifi1517 – 1520Nuclear localization signalSequence analysis4

Sequence similaritiesi

Contains 8 BRCT domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1929. Eukaryota.
ENOG410XPFH. LUCA.
GeneTreeiENSGT00840000129846.
HOGENOMiHOG000154662.
HOVERGENiHBG067053.
InParanoidiQ92547.
KOiK10728.
OMAiCAQEYKH.
OrthoDBiEOG091G02MY.
PhylomeDBiQ92547.
TreeFamiTF326403.

Family and domain databases

CDDicd00027. BRCT. 6 hits.
Gene3Di3.40.50.10190. 6 hits.
InterProiIPR001357. BRCT_dom.
IPR016126. Secretoglobin.
IPR026993. Topbp1.
[Graphical view]
PANTHERiPTHR13561:SF32. PTHR13561:SF32. 3 hits.
PfamiPF00533. BRCT. 4 hits.
PF12738. PTCB-BRCT. 2 hits.
[Graphical view]
SMARTiSM00292. BRCT. 7 hits.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
SSF52113. SSF52113. 6 hits.
PROSITEiPS50172. BRCT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRNDKEPFF VKFLKSSDNS KCFFKALESI KEFQSEEYLQ IITEEEALKI
60 70 80 90 100
KENDRSLYIC DPFSGVVFDH LKKLGCRIVG PQVVIFCMHH QRCVPRAEHP
110 120 130 140 150
VYNMVMSDVT ISCTSLEKEK REEVHKYVQM MGGRVYRDLN VSVTHLIAGE
160 170 180 190 200
VGSKKYLVAA NLKKPILLPS WIKTLWEKSQ EKKITRYTDI NMEDFKCPIF
210 220 230 240 250
LGCIICVTGL CGLDRKEVQQ LTVKHGGQYM GQLKMNECTH LIVQEPKGQK
260 270 280 290 300
YECAKRWNVH CVTTQWFFDS IEKGFCQDES IYKTEPRPEA KTMPNSSTPT
310 320 330 340 350
SQINTIDSRT LSDVSNISNI NASCVSESIC NSLNSKLEPT LENLENLDVS
360 370 380 390 400
AFQAPEDLLD GCRIYLCGFS GRKLDKLRRL INSGGGVRFN QLNEDVTHVI
410 420 430 440 450
VGDYDDELKQ FWNKSAHRPH VVGAKWLLEC FSKGYMLSEE PYIHANYQPV
460 470 480 490 500
EIPVSHKPES KAALLKKKNS SFSKKDFAPS EKHEQADEDL LSQYENGSST
510 520 530 540 550
VVEAKTSEAR PFNDSTHAEP LNDSTHISLQ EENQSSVSHC VPDVSTITEE
560 570 580 590 600
GLFSQKSFLV LGFSNENESN IANIIKENAG KIMSLLSRTV ADYAVVPLLG
610 620 630 640 650
CEVEATVGEV VTNTWLVTCI DYQTLFDPKS NPLFTPVPVM TGMTPLEDCV
660 670 680 690 700
ISFSQCAGAE KESLTFLANL LGASVQEYFV RKSNAKKGMF ASTHLILKER
710 720 730 740 750
GGSKYEAAKK WNLPAVTIAW LLETARTGKR ADESHFLIEN STKEERSLET
760 770 780 790 800
EITNGINLNS DTAEHPGTRL QTHRKTVVTP LDMNRFQSKA FRAVVSQHAR
810 820 830 840 850
QVAASPAVGQ PLQKEPSLHL DTPSKFLSKD KLFKPSFDVK DALAALETPG
860 870 880 890 900
RPSQQKRKPS TPLSEVIVKN LQLALANSSR NAVALSASPQ LKEAQSEKEE
910 920 930 940 950
APKPLHKVVV CVSKKLSKKQ SELNGIAASL GADYRWSFDE TVTHFIYQGR
960 970 980 990 1000
PNDTNREYKS VKERGVHIVS EHWLLDCAQE CKHLPESLYP HTYNPKMSLD
1010 1020 1030 1040 1050
ISAVQDGRLC NSRLLSAVSS TKDDEPDPLI LEENDVDNMA TNNKESAPSN
1060 1070 1080 1090 1100
GSGKNDSKGV LTQTLEMREN FQKQLQEIMS ATSIVKPQGQ RTSLSRSGCN
1110 1120 1130 1140 1150
SASSTPDSTR SARSGRSRVL EALRQSRQTV PDVNTEPSQN EQIIWDDPTA
1160 1170 1180 1190 1200
REERARLASN LQWPSCPTQY SELQVDIQNL EDSPFQKPLH DSEIAKQAVC
1210 1220 1230 1240 1250
DPGNIRVTEA PKHPISEELE TPIKDSHLIP TPQAPSIAFP LANPPVAPHP
1260 1270 1280 1290 1300
REKIITIEET HEELKKQYIF QLSSLNPQER IDYCHLIEKL GGLVIEKQCF
1310 1320 1330 1340 1350
DPTCTHIVVG HPLRNEKYLA SVAAGKWVLH RSYLEACRTA GHFVQEEDYE
1360 1370 1380 1390 1400
WGSSSILDVL TGINVQQRRL ALAAMRWRKK IQQRQESGIV EGAFSGWKVI
1410 1420 1430 1440 1450
LHVDQSREAG FKRLLQSGGA KVLPGHSVPL FKEATHLFSD LNKLKPDDSG
1460 1470 1480 1490 1500
VNIAEAAAQN VYCLRTEYIA DYLMQESPPH VENYCLPEAI SFIQNNKELG
1510 1520
TGLSQKRKAP TEKNKIKRPR VH
Length:1,522
Mass (Da):170,679
Last modified:May 18, 2010 - v3
Checksum:i02C25880EDCD6AC7
GO

Sequence cautioni

The sequence BAA13389 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA34202 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti457K → Q in BAA34202 (PubMed:9461304).Curated1
Sequence conflicti457K → Q in BAA13389 (PubMed:9039502).Curated1
Sequence conflicti911C → R in BAH13754 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059733817S → L.Corresponds to variant rs17301766dbSNPEnsembl.1
Natural variantiVAR_057007955N → S.Corresponds to variant rs10935070dbSNPEnsembl.1
Natural variantiVAR_0597341042N → S.Corresponds to variant rs10935070dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019397 mRNA. Translation: BAA34202.1. Different initiation.
D87448 mRNA. Translation: BAA13389.1. Different initiation.
AK302584 mRNA. Translation: BAH13754.1.
AC016255 Genomic DNA. No translation available.
AC083905 Genomic DNA. No translation available.
CCDSiCCDS46919.1.
RefSeqiNP_008958.2. NM_007027.3.
XP_016861125.1. XM_017005636.1.
UniGeneiHs.593379.

Genome annotation databases

EnsembliENST00000260810; ENSP00000260810; ENSG00000163781.
GeneIDi11073.
KEGGihsa:11073.
UCSCiuc003eps.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019397 mRNA. Translation: BAA34202.1. Different initiation.
D87448 mRNA. Translation: BAA13389.1. Different initiation.
AK302584 mRNA. Translation: BAH13754.1.
AC016255 Genomic DNA. No translation available.
AC083905 Genomic DNA. No translation available.
CCDSiCCDS46919.1.
RefSeqiNP_008958.2. NM_007027.3.
XP_016861125.1. XM_017005636.1.
UniGeneiHs.593379.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF6NMR-A326-444[»]
2XNHX-ray2.80A1-287[»]
2XNKX-ray2.60A/B/C/D1-290[»]
3AL2X-ray2.00A1264-1493[»]
3AL3X-ray2.15A1264-1493[»]
3JVEX-ray1.34A893-996[»]
3OLCX-ray2.40X1-290[»]
3PD7X-ray1.26A/B893-994[»]
3UENX-ray1.90A549-746[»]
3UEOX-ray2.60A/B/C/D549-746[»]
ProteinModelPortaliQ92547.
SMRiQ92547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116256. 55 interactors.
DIPiDIP-24263N.
IntActiQ92547. 20 interactors.
MINTiMINT-275958.
STRINGi9606.ENSP00000260810.

Chemistry databases

BindingDBiQ92547.
ChEMBLiCHEMBL3175.

PTM databases

iPTMnetiQ92547.
PhosphoSitePlusiQ92547.

Polymorphism and mutation databases

BioMutaiTOPBP1.
DMDMi296453012.

Proteomic databases

EPDiQ92547.
MaxQBiQ92547.
PaxDbiQ92547.
PeptideAtlasiQ92547.
PRIDEiQ92547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260810; ENSP00000260810; ENSG00000163781.
GeneIDi11073.
KEGGihsa:11073.
UCSCiuc003eps.4. human.

Organism-specific databases

CTDi11073.
DisGeNETi11073.
GeneCardsiTOPBP1.
H-InvDBHIX0003693.
HGNCiHGNC:17008. TOPBP1.
HPAiCAB022451.
HPA036738.
HPA063020.
HPA064566.
MIMi607760. gene.
neXtProtiNX_Q92547.
OpenTargetsiENSG00000163781.
PharmGKBiPA134934073.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1929. Eukaryota.
ENOG410XPFH. LUCA.
GeneTreeiENSGT00840000129846.
HOGENOMiHOG000154662.
HOVERGENiHBG067053.
InParanoidiQ92547.
KOiK10728.
OMAiCAQEYKH.
OrthoDBiEOG091G02MY.
PhylomeDBiQ92547.
TreeFamiTF326403.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163781-MONOMER.
ReactomeiR-HSA-5685938. HDR through Single Strand Annealing (SSA).
R-HSA-5693607. Processing of DNA double-strand break ends.
R-HSA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-69473. G2/M DNA damage checkpoint.
SignaLinkiQ92547.
SIGNORiQ92547.

Miscellaneous databases

ChiTaRSiTOPBP1. human.
EvolutionaryTraceiQ92547.
GeneWikiiTOPBP1.
GenomeRNAii11073.
PROiQ92547.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163781.
CleanExiHS_TOPBP1.
ExpressionAtlasiQ92547. baseline and differential.
GenevisibleiQ92547. HS.

Family and domain databases

CDDicd00027. BRCT. 6 hits.
Gene3Di3.40.50.10190. 6 hits.
InterProiIPR001357. BRCT_dom.
IPR016126. Secretoglobin.
IPR026993. Topbp1.
[Graphical view]
PANTHERiPTHR13561:SF32. PTHR13561:SF32. 3 hits.
PfamiPF00533. BRCT. 4 hits.
PF12738. PTCB-BRCT. 2 hits.
[Graphical view]
SMARTiSM00292. BRCT. 7 hits.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
SSF52113. SSF52113. 6 hits.
PROSITEiPS50172. BRCT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOPB1_HUMAN
AccessioniPrimary (citable) accession number: Q92547
Secondary accession number(s): B7Z7W8, Q7LGC1, Q9UEB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.