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Q92545

- TM131_HUMAN

UniProt

Q92545 - TM131_HUMAN

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Protein

Transmembrane protein 131

Gene
TMEM131, KIAA0257, RW1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the immune response to viral infection By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 131
Alternative name(s):
Protein RW1
Gene namesi
Name:TMEM131
Synonyms:KIAA0257, RW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30366. TMEM131.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1091 – 111121Helical; Reviewed predictionAdd
BLAST
Transmembranei1118 – 113821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18831883Transmembrane protein 131PRO_0000097538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi300 – 3001N-linked (GlcNAc...)1 Publication
Modified residuei803 – 8031Phosphoserine1 Publication
Modified residuei1375 – 13751Phosphoserine1 Publication
Modified residuei1863 – 18631Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ92545.
PaxDbiQ92545.
PRIDEiQ92545.

PTM databases

PhosphoSiteiQ92545.

Expressioni

Gene expression databases

ArrayExpressiQ92545.
BgeeiQ92545.
CleanExiHS_TMEM131.
GenevestigatoriQ92545.

Organism-specific databases

HPAiHPA017678.
HPA017682.

Interactioni

Protein-protein interaction databases

BioGridi117052. 3 interactions.
IntActiQ92545. 1 interaction.
STRINGi9606.ENSP00000186436.

Structurei

3D structure databases

ProteinModelPortaliQ92545.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1297 – 133236Pro-richAdd
BLAST
Compositional biasi1379 – 147496Lys-richAdd
BLAST
Compositional biasi1626 – 16305Poly-Ser
Compositional biasi1679 – 1815137Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM131 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307029.
HOGENOMiHOG000168804.
HOVERGENiHBG017768.
InParanoidiQ92545.
OMAiMHIDNNI.
OrthoDBiEOG77M8MS.
PhylomeDBiQ92545.
TreeFamiTF321435.

Family and domain databases

Gene3Di2.60.40.360. 1 hit.
InterProiIPR022113. DUF3651_TMEM131.
IPR008962. PapD-like.
[Graphical view]
PfamiPF12371. DUF3651. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92545-1 [UniParc]FASTAAdd to Basket

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MGKRAGGGAT GATTAAVSTS AGAGLEPAAA RSGGPRSAAA GLLGALHLVM     50
TLVVAAARAE KEAFVQSESI IEVLRFDDGG LLQTETTLGL SSYQQKSISL 100
YRGNCRPIRF EPPMLDFHEQ PVGMPKMEKV YLHNPSSEET ITLVSISATT 150
SHFHASFFQN RKILPGGNTS FDVVFLARVV GNVENTLFIN TSNHGVFTYQ 200
VFGVGVPNPY RLRPFLGARV PVNSSFSPII NIHNPHSEPL QVVEMYSSGG 250
DLHLELPTGQ QGGTRKLWEI PPYETKGVMR ASFSSREADN HTAFIRIKTN 300
ASDSTEFIIL PVEVEVTTAP GIYSSTEMLD FGTLRTQDLP KVLNLHLLNS 350
GTKDVPITSV RPTPQNDAIT VHFKPITLKA SESKYTKVAS ISFDASKAKK 400
PSQFSGKITV KAKEKSYSKL EIPYQAEVLD GYLGFDHAAT LFHIRDSPAD 450
PVERPIYLTN TFSFAILIHD VLLPEEAKTM FKVHNFSKPV LILPNESGYI 500
FTLLFMPSTS SMHIDNNILL ITNASKFHLP VRVYTGFLDY FVLPPKIEER 550
FIDFGVLSAT EASNILFAII NSNPIELAIK SWHIIGDGLS IELVAVERGN 600
RTTIISSLPE FEKSSLSDQS SVTLASGYFA VFRVKLTAKK LEGIHDGAIQ 650
ITTDYEILTI PVKAVIAVGS LTCFPKHVVL PPSFPGKIVH QSLNIMNSFS 700
QKVKIQQIRS LSEDVRFYYK RLRGNKEDLE PGKKSKIANI YFDPGLQCGD 750
HCYVGLPFLS KSEPKVQPGV AMQEDMWDAD WDLHQSLFKG WTGIKENSGH 800
RLSAIFEVNT DLQKNIISKI TAELSWPSIL SSPRHLKFPL TNTNCSSEEE 850
ITLENPADVP VYVQFIPLAL YSNPSVFVDK LVSRFNLSKV AKIDLRTLEF 900
QVFRNSAHPL QSSTGFMEGL SRHLILNLIL KPGEKKSVKV KFTPVHNRTV 950
SSLIIVRNNL TVMDAVMVQG QGTTENLRVA GKLPGPGSSL RFKITEALLK 1000
DCTDSLKLRE PNFTLKRTFK VENTGQLQIH IETIEISGYS CEGYGFKVVN 1050
CQEFTLSANA SRDIIILFTP DFTASRVIRE LKFITTSGSE FVFILNASLP 1100
YHMLATCAEA LPRPNWELAL YIIISGIMSA LFLLVIGTAY LEAQGIWEPF 1150
RRRLSFEASN PPFDVGRPFD LRRIVGISSE GNLNTLSCDP GHSRGFCGAG 1200
GSSSRPSAGS HKQCGPSVHP HSSHSNRNSA DVENVRAKNS SSTSSRTSAQ 1250
AASSQSANKT SPLVLDSNTV TQGHTAGRKS KGAKQSQHGS QHHAHSPLEQ 1300
HPQPPLPPPV PQPQEPQPER LSPAPLAHPS HPERASSARH SSEDSDITSL 1350
IEAMDKDFDH HDSPALEVFT EQPPSPLPKS KGKGKPLQRK VKPPKKQEEK 1400
EKKGKGKPQE DELKDSLADD DSSSTTTETS NPDTEPLLKE DTEKQKGKQA 1450
MPEKHESEMS QVKQKSKKLL NIKKEIPTDV KPSSLELPYT PPLESKQRRN 1500
LPSKIPLPTA MTSGSKSRNA QKTKGTSKLV DNRPPALAKF LPNSQELGNT 1550
SSSEGEKDSP PPEWDSVPVH KPGSSTDSLY KLSLQTLNAD IFLKQRQTSP 1600
TPASPSPPAA PCPFVARGSY SSIVNSSSSS DPKIKQPNGS KHKLTKAASL 1650
PGKNGNPTFA AVTAGYDKSP GGNGFAKVSS NKTGFSSSLG ISHAPVDSDG 1700
SDSSGLWSPV SNPSSPDFTP LNSFSAFGNS FNLTGEVFSK LGLSRSCNQA 1750
SQRSWNEFNS GPSYLWESPA TDPSPSWPAS SGSPTHTATS VLGNTSGLWS 1800
TTPFSSSIWS SNLSSALPFT TPANTLASIG LMGTENSPAP HAPSTSSPAD 1850
DLGQTYNPWR IWSPTIGRRS SDPWSNSHFP HEN 1883
Length:1,883
Mass (Da):205,138
Last modified:April 5, 2011 - v3
Checksum:iBBC61F6C939A336E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079337 Genomic DNA. No translation available.
AC016699 Genomic DNA. No translation available.
D87446 mRNA. Translation: BAA13387.1.
CCDSiCCDS46368.1.
RefSeqiNP_056163.1. NM_015348.1.
UniGeneiHs.469376.

Genome annotation databases

EnsembliENST00000186436; ENSP00000186436; ENSG00000075568.
GeneIDi23505.
KEGGihsa:23505.
UCSCiuc002syh.4. human.

Polymorphism databases

DMDMi327478552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079337 Genomic DNA. No translation available.
AC016699 Genomic DNA. No translation available.
D87446 mRNA. Translation: BAA13387.1 .
CCDSi CCDS46368.1.
RefSeqi NP_056163.1. NM_015348.1.
UniGenei Hs.469376.

3D structure databases

ProteinModelPortali Q92545.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117052. 3 interactions.
IntActi Q92545. 1 interaction.
STRINGi 9606.ENSP00000186436.

PTM databases

PhosphoSitei Q92545.

Polymorphism databases

DMDMi 327478552.

Proteomic databases

MaxQBi Q92545.
PaxDbi Q92545.
PRIDEi Q92545.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000186436 ; ENSP00000186436 ; ENSG00000075568 .
GeneIDi 23505.
KEGGi hsa:23505.
UCSCi uc002syh.4. human.

Organism-specific databases

CTDi 23505.
GeneCardsi GC02M098372.
H-InvDB HIX0002294.
HGNCi HGNC:30366. TMEM131.
HPAi HPA017678.
HPA017682.
MIMi 615659. gene.
neXtProti NX_Q92545.
PharmGKBi PA143485651.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307029.
HOGENOMi HOG000168804.
HOVERGENi HBG017768.
InParanoidi Q92545.
OMAi MHIDNNI.
OrthoDBi EOG77M8MS.
PhylomeDBi Q92545.
TreeFami TF321435.

Miscellaneous databases

ChiTaRSi TMEM131. human.
GeneWikii TMEM131.
GenomeRNAii 23505.
NextBioi 45889.
PROi Q92545.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92545.
Bgeei Q92545.
CleanExi HS_TMEM131.
Genevestigatori Q92545.

Family and domain databases

Gene3Di 2.60.40.360. 1 hit.
InterProi IPR022113. DUF3651_TMEM131.
IPR008962. PapD-like.
[Graphical view ]
Pfami PF12371. DUF3651. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-1883.
    Tissue: Bone marrow.
  3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1863, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-300.
    Tissue: Liver.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM131_HUMAN
AccessioniPrimary (citable) accession number: Q92545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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