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Q92545

- TM131_HUMAN

UniProt

Q92545 - TM131_HUMAN

Protein

Transmembrane protein 131

Gene

TMEM131

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    May play a role in the immune response to viral infection.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 131
    Alternative name(s):
    Protein RW1
    Gene namesi
    Name:TMEM131
    Synonyms:KIAA0257, RW1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:30366. TMEM131.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485651.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18831883Transmembrane protein 131PRO_0000097538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi300 – 3001N-linked (GlcNAc...)1 Publication
    Modified residuei803 – 8031Phosphoserine1 Publication
    Modified residuei1375 – 13751Phosphoserine1 Publication
    Modified residuei1863 – 18631Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ92545.
    PaxDbiQ92545.
    PRIDEiQ92545.

    PTM databases

    PhosphoSiteiQ92545.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92545.
    BgeeiQ92545.
    CleanExiHS_TMEM131.
    GenevestigatoriQ92545.

    Organism-specific databases

    HPAiHPA017678.
    HPA017682.

    Interactioni

    Protein-protein interaction databases

    BioGridi117052. 3 interactions.
    IntActiQ92545. 1 interaction.
    STRINGi9606.ENSP00000186436.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92545.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1091 – 111121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1118 – 113821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1297 – 133236Pro-richAdd
    BLAST
    Compositional biasi1379 – 147496Lys-richAdd
    BLAST
    Compositional biasi1626 – 16305Poly-Ser
    Compositional biasi1679 – 1815137Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TMEM131 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307029.
    HOGENOMiHOG000168804.
    HOVERGENiHBG017768.
    InParanoidiQ92545.
    OMAiMHIDNNI.
    OrthoDBiEOG77M8MS.
    PhylomeDBiQ92545.
    TreeFamiTF321435.

    Family and domain databases

    Gene3Di2.60.40.360. 1 hit.
    InterProiIPR022113. DUF3651_TMEM131.
    IPR008962. PapD-like.
    [Graphical view]
    PfamiPF12371. DUF3651. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92545-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKRAGGGAT GATTAAVSTS AGAGLEPAAA RSGGPRSAAA GLLGALHLVM     50
    TLVVAAARAE KEAFVQSESI IEVLRFDDGG LLQTETTLGL SSYQQKSISL 100
    YRGNCRPIRF EPPMLDFHEQ PVGMPKMEKV YLHNPSSEET ITLVSISATT 150
    SHFHASFFQN RKILPGGNTS FDVVFLARVV GNVENTLFIN TSNHGVFTYQ 200
    VFGVGVPNPY RLRPFLGARV PVNSSFSPII NIHNPHSEPL QVVEMYSSGG 250
    DLHLELPTGQ QGGTRKLWEI PPYETKGVMR ASFSSREADN HTAFIRIKTN 300
    ASDSTEFIIL PVEVEVTTAP GIYSSTEMLD FGTLRTQDLP KVLNLHLLNS 350
    GTKDVPITSV RPTPQNDAIT VHFKPITLKA SESKYTKVAS ISFDASKAKK 400
    PSQFSGKITV KAKEKSYSKL EIPYQAEVLD GYLGFDHAAT LFHIRDSPAD 450
    PVERPIYLTN TFSFAILIHD VLLPEEAKTM FKVHNFSKPV LILPNESGYI 500
    FTLLFMPSTS SMHIDNNILL ITNASKFHLP VRVYTGFLDY FVLPPKIEER 550
    FIDFGVLSAT EASNILFAII NSNPIELAIK SWHIIGDGLS IELVAVERGN 600
    RTTIISSLPE FEKSSLSDQS SVTLASGYFA VFRVKLTAKK LEGIHDGAIQ 650
    ITTDYEILTI PVKAVIAVGS LTCFPKHVVL PPSFPGKIVH QSLNIMNSFS 700
    QKVKIQQIRS LSEDVRFYYK RLRGNKEDLE PGKKSKIANI YFDPGLQCGD 750
    HCYVGLPFLS KSEPKVQPGV AMQEDMWDAD WDLHQSLFKG WTGIKENSGH 800
    RLSAIFEVNT DLQKNIISKI TAELSWPSIL SSPRHLKFPL TNTNCSSEEE 850
    ITLENPADVP VYVQFIPLAL YSNPSVFVDK LVSRFNLSKV AKIDLRTLEF 900
    QVFRNSAHPL QSSTGFMEGL SRHLILNLIL KPGEKKSVKV KFTPVHNRTV 950
    SSLIIVRNNL TVMDAVMVQG QGTTENLRVA GKLPGPGSSL RFKITEALLK 1000
    DCTDSLKLRE PNFTLKRTFK VENTGQLQIH IETIEISGYS CEGYGFKVVN 1050
    CQEFTLSANA SRDIIILFTP DFTASRVIRE LKFITTSGSE FVFILNASLP 1100
    YHMLATCAEA LPRPNWELAL YIIISGIMSA LFLLVIGTAY LEAQGIWEPF 1150
    RRRLSFEASN PPFDVGRPFD LRRIVGISSE GNLNTLSCDP GHSRGFCGAG 1200
    GSSSRPSAGS HKQCGPSVHP HSSHSNRNSA DVENVRAKNS SSTSSRTSAQ 1250
    AASSQSANKT SPLVLDSNTV TQGHTAGRKS KGAKQSQHGS QHHAHSPLEQ 1300
    HPQPPLPPPV PQPQEPQPER LSPAPLAHPS HPERASSARH SSEDSDITSL 1350
    IEAMDKDFDH HDSPALEVFT EQPPSPLPKS KGKGKPLQRK VKPPKKQEEK 1400
    EKKGKGKPQE DELKDSLADD DSSSTTTETS NPDTEPLLKE DTEKQKGKQA 1450
    MPEKHESEMS QVKQKSKKLL NIKKEIPTDV KPSSLELPYT PPLESKQRRN 1500
    LPSKIPLPTA MTSGSKSRNA QKTKGTSKLV DNRPPALAKF LPNSQELGNT 1550
    SSSEGEKDSP PPEWDSVPVH KPGSSTDSLY KLSLQTLNAD IFLKQRQTSP 1600
    TPASPSPPAA PCPFVARGSY SSIVNSSSSS DPKIKQPNGS KHKLTKAASL 1650
    PGKNGNPTFA AVTAGYDKSP GGNGFAKVSS NKTGFSSSLG ISHAPVDSDG 1700
    SDSSGLWSPV SNPSSPDFTP LNSFSAFGNS FNLTGEVFSK LGLSRSCNQA 1750
    SQRSWNEFNS GPSYLWESPA TDPSPSWPAS SGSPTHTATS VLGNTSGLWS 1800
    TTPFSSSIWS SNLSSALPFT TPANTLASIG LMGTENSPAP HAPSTSSPAD 1850
    DLGQTYNPWR IWSPTIGRRS SDPWSNSHFP HEN 1883
    Length:1,883
    Mass (Da):205,138
    Last modified:April 5, 2011 - v3
    Checksum:iBBC61F6C939A336E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079337 Genomic DNA. No translation available.
    AC016699 Genomic DNA. No translation available.
    D87446 mRNA. Translation: BAA13387.1.
    CCDSiCCDS46368.1.
    RefSeqiNP_056163.1. NM_015348.1.
    UniGeneiHs.469376.

    Genome annotation databases

    EnsembliENST00000186436; ENSP00000186436; ENSG00000075568.
    GeneIDi23505.
    KEGGihsa:23505.
    UCSCiuc002syh.4. human.

    Polymorphism databases

    DMDMi327478552.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC079337 Genomic DNA. No translation available.
    AC016699 Genomic DNA. No translation available.
    D87446 mRNA. Translation: BAA13387.1 .
    CCDSi CCDS46368.1.
    RefSeqi NP_056163.1. NM_015348.1.
    UniGenei Hs.469376.

    3D structure databases

    ProteinModelPortali Q92545.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117052. 3 interactions.
    IntActi Q92545. 1 interaction.
    STRINGi 9606.ENSP00000186436.

    PTM databases

    PhosphoSitei Q92545.

    Polymorphism databases

    DMDMi 327478552.

    Proteomic databases

    MaxQBi Q92545.
    PaxDbi Q92545.
    PRIDEi Q92545.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000186436 ; ENSP00000186436 ; ENSG00000075568 .
    GeneIDi 23505.
    KEGGi hsa:23505.
    UCSCi uc002syh.4. human.

    Organism-specific databases

    CTDi 23505.
    GeneCardsi GC02M098372.
    H-InvDB HIX0002294.
    HGNCi HGNC:30366. TMEM131.
    HPAi HPA017678.
    HPA017682.
    MIMi 615659. gene.
    neXtProti NX_Q92545.
    PharmGKBi PA143485651.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307029.
    HOGENOMi HOG000168804.
    HOVERGENi HBG017768.
    InParanoidi Q92545.
    OMAi MHIDNNI.
    OrthoDBi EOG77M8MS.
    PhylomeDBi Q92545.
    TreeFami TF321435.

    Miscellaneous databases

    ChiTaRSi TMEM131. human.
    GeneWikii TMEM131.
    GenomeRNAii 23505.
    NextBioi 45889.
    PROi Q92545.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92545.
    Bgeei Q92545.
    CleanExi HS_TMEM131.
    Genevestigatori Q92545.

    Family and domain databases

    Gene3Di 2.60.40.360. 1 hit.
    InterProi IPR022113. DUF3651_TMEM131.
    IPR008962. PapD-like.
    [Graphical view ]
    Pfami PF12371. DUF3651. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-1883.
      Tissue: Bone marrow.
    3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1863, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-300.
      Tissue: Liver.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTM131_HUMAN
    AccessioniPrimary (citable) accession number: Q92545
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3