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Q92545

- TM131_HUMAN

UniProt

Q92545 - TM131_HUMAN

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Protein

Transmembrane protein 131

Gene

TMEM131

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the immune response to viral infection.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 131
Alternative name(s):
Protein RW1
Gene namesi
Name:TMEM131
Synonyms:KIAA0257, RW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30366. TMEM131.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18831883Transmembrane protein 131PRO_0000097538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi300 – 3001N-linked (GlcNAc...)1 Publication
Modified residuei803 – 8031Phosphoserine1 Publication
Modified residuei1375 – 13751Phosphoserine1 Publication
Modified residuei1863 – 18631Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ92545.
PaxDbiQ92545.
PRIDEiQ92545.

PTM databases

PhosphoSiteiQ92545.

Expressioni

Gene expression databases

BgeeiQ92545.
CleanExiHS_TMEM131.
ExpressionAtlasiQ92545. baseline and differential.
GenevestigatoriQ92545.

Organism-specific databases

HPAiHPA017678.
HPA017682.

Interactioni

Protein-protein interaction databases

BioGridi117052. 9 interactions.
IntActiQ92545. 1 interaction.
STRINGi9606.ENSP00000186436.

Structurei

3D structure databases

ProteinModelPortaliQ92545.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1091 – 111121HelicalSequence AnalysisAdd
BLAST
Transmembranei1118 – 113821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1297 – 133236Pro-richAdd
BLAST
Compositional biasi1379 – 147496Lys-richAdd
BLAST
Compositional biasi1626 – 16305Poly-Ser
Compositional biasi1679 – 1815137Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM131 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307029.
GeneTreeiENSGT00530000063614.
HOGENOMiHOG000168804.
HOVERGENiHBG017768.
InParanoidiQ92545.
OMAiMHIDNNI.
OrthoDBiEOG77M8MS.
PhylomeDBiQ92545.
TreeFamiTF321435.

Family and domain databases

Gene3Di2.60.40.360. 1 hit.
InterProiIPR022113. DUF3651_TMEM131.
IPR008962. PapD-like.
[Graphical view]
PfamiPF12371. DUF3651. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92545-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKRAGGGAT GATTAAVSTS AGAGLEPAAA RSGGPRSAAA GLLGALHLVM
60 70 80 90 100
TLVVAAARAE KEAFVQSESI IEVLRFDDGG LLQTETTLGL SSYQQKSISL
110 120 130 140 150
YRGNCRPIRF EPPMLDFHEQ PVGMPKMEKV YLHNPSSEET ITLVSISATT
160 170 180 190 200
SHFHASFFQN RKILPGGNTS FDVVFLARVV GNVENTLFIN TSNHGVFTYQ
210 220 230 240 250
VFGVGVPNPY RLRPFLGARV PVNSSFSPII NIHNPHSEPL QVVEMYSSGG
260 270 280 290 300
DLHLELPTGQ QGGTRKLWEI PPYETKGVMR ASFSSREADN HTAFIRIKTN
310 320 330 340 350
ASDSTEFIIL PVEVEVTTAP GIYSSTEMLD FGTLRTQDLP KVLNLHLLNS
360 370 380 390 400
GTKDVPITSV RPTPQNDAIT VHFKPITLKA SESKYTKVAS ISFDASKAKK
410 420 430 440 450
PSQFSGKITV KAKEKSYSKL EIPYQAEVLD GYLGFDHAAT LFHIRDSPAD
460 470 480 490 500
PVERPIYLTN TFSFAILIHD VLLPEEAKTM FKVHNFSKPV LILPNESGYI
510 520 530 540 550
FTLLFMPSTS SMHIDNNILL ITNASKFHLP VRVYTGFLDY FVLPPKIEER
560 570 580 590 600
FIDFGVLSAT EASNILFAII NSNPIELAIK SWHIIGDGLS IELVAVERGN
610 620 630 640 650
RTTIISSLPE FEKSSLSDQS SVTLASGYFA VFRVKLTAKK LEGIHDGAIQ
660 670 680 690 700
ITTDYEILTI PVKAVIAVGS LTCFPKHVVL PPSFPGKIVH QSLNIMNSFS
710 720 730 740 750
QKVKIQQIRS LSEDVRFYYK RLRGNKEDLE PGKKSKIANI YFDPGLQCGD
760 770 780 790 800
HCYVGLPFLS KSEPKVQPGV AMQEDMWDAD WDLHQSLFKG WTGIKENSGH
810 820 830 840 850
RLSAIFEVNT DLQKNIISKI TAELSWPSIL SSPRHLKFPL TNTNCSSEEE
860 870 880 890 900
ITLENPADVP VYVQFIPLAL YSNPSVFVDK LVSRFNLSKV AKIDLRTLEF
910 920 930 940 950
QVFRNSAHPL QSSTGFMEGL SRHLILNLIL KPGEKKSVKV KFTPVHNRTV
960 970 980 990 1000
SSLIIVRNNL TVMDAVMVQG QGTTENLRVA GKLPGPGSSL RFKITEALLK
1010 1020 1030 1040 1050
DCTDSLKLRE PNFTLKRTFK VENTGQLQIH IETIEISGYS CEGYGFKVVN
1060 1070 1080 1090 1100
CQEFTLSANA SRDIIILFTP DFTASRVIRE LKFITTSGSE FVFILNASLP
1110 1120 1130 1140 1150
YHMLATCAEA LPRPNWELAL YIIISGIMSA LFLLVIGTAY LEAQGIWEPF
1160 1170 1180 1190 1200
RRRLSFEASN PPFDVGRPFD LRRIVGISSE GNLNTLSCDP GHSRGFCGAG
1210 1220 1230 1240 1250
GSSSRPSAGS HKQCGPSVHP HSSHSNRNSA DVENVRAKNS SSTSSRTSAQ
1260 1270 1280 1290 1300
AASSQSANKT SPLVLDSNTV TQGHTAGRKS KGAKQSQHGS QHHAHSPLEQ
1310 1320 1330 1340 1350
HPQPPLPPPV PQPQEPQPER LSPAPLAHPS HPERASSARH SSEDSDITSL
1360 1370 1380 1390 1400
IEAMDKDFDH HDSPALEVFT EQPPSPLPKS KGKGKPLQRK VKPPKKQEEK
1410 1420 1430 1440 1450
EKKGKGKPQE DELKDSLADD DSSSTTTETS NPDTEPLLKE DTEKQKGKQA
1460 1470 1480 1490 1500
MPEKHESEMS QVKQKSKKLL NIKKEIPTDV KPSSLELPYT PPLESKQRRN
1510 1520 1530 1540 1550
LPSKIPLPTA MTSGSKSRNA QKTKGTSKLV DNRPPALAKF LPNSQELGNT
1560 1570 1580 1590 1600
SSSEGEKDSP PPEWDSVPVH KPGSSTDSLY KLSLQTLNAD IFLKQRQTSP
1610 1620 1630 1640 1650
TPASPSPPAA PCPFVARGSY SSIVNSSSSS DPKIKQPNGS KHKLTKAASL
1660 1670 1680 1690 1700
PGKNGNPTFA AVTAGYDKSP GGNGFAKVSS NKTGFSSSLG ISHAPVDSDG
1710 1720 1730 1740 1750
SDSSGLWSPV SNPSSPDFTP LNSFSAFGNS FNLTGEVFSK LGLSRSCNQA
1760 1770 1780 1790 1800
SQRSWNEFNS GPSYLWESPA TDPSPSWPAS SGSPTHTATS VLGNTSGLWS
1810 1820 1830 1840 1850
TTPFSSSIWS SNLSSALPFT TPANTLASIG LMGTENSPAP HAPSTSSPAD
1860 1870 1880
DLGQTYNPWR IWSPTIGRRS SDPWSNSHFP HEN
Length:1,883
Mass (Da):205,138
Last modified:April 5, 2011 - v3
Checksum:iBBC61F6C939A336E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079337 Genomic DNA. No translation available.
AC016699 Genomic DNA. No translation available.
D87446 mRNA. Translation: BAA13387.1.
CCDSiCCDS46368.1.
RefSeqiNP_056163.1. NM_015348.1.
UniGeneiHs.469376.

Genome annotation databases

EnsembliENST00000186436; ENSP00000186436; ENSG00000075568.
GeneIDi23505.
KEGGihsa:23505.
UCSCiuc002syh.4. human.

Polymorphism databases

DMDMi327478552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC079337 Genomic DNA. No translation available.
AC016699 Genomic DNA. No translation available.
D87446 mRNA. Translation: BAA13387.1 .
CCDSi CCDS46368.1.
RefSeqi NP_056163.1. NM_015348.1.
UniGenei Hs.469376.

3D structure databases

ProteinModelPortali Q92545.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117052. 9 interactions.
IntActi Q92545. 1 interaction.
STRINGi 9606.ENSP00000186436.

PTM databases

PhosphoSitei Q92545.

Polymorphism databases

DMDMi 327478552.

Proteomic databases

MaxQBi Q92545.
PaxDbi Q92545.
PRIDEi Q92545.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000186436 ; ENSP00000186436 ; ENSG00000075568 .
GeneIDi 23505.
KEGGi hsa:23505.
UCSCi uc002syh.4. human.

Organism-specific databases

CTDi 23505.
GeneCardsi GC02M098372.
H-InvDB HIX0002294.
HGNCi HGNC:30366. TMEM131.
HPAi HPA017678.
HPA017682.
MIMi 615659. gene.
neXtProti NX_Q92545.
PharmGKBi PA143485651.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307029.
GeneTreei ENSGT00530000063614.
HOGENOMi HOG000168804.
HOVERGENi HBG017768.
InParanoidi Q92545.
OMAi MHIDNNI.
OrthoDBi EOG77M8MS.
PhylomeDBi Q92545.
TreeFami TF321435.

Miscellaneous databases

ChiTaRSi TMEM131. human.
GeneWikii TMEM131.
GenomeRNAii 23505.
NextBioi 45889.
PROi Q92545.
SOURCEi Search...

Gene expression databases

Bgeei Q92545.
CleanExi HS_TMEM131.
ExpressionAtlasi Q92545. baseline and differential.
Genevestigatori Q92545.

Family and domain databases

Gene3Di 2.60.40.360. 1 hit.
InterProi IPR022113. DUF3651_TMEM131.
IPR008962. PapD-like.
[Graphical view ]
Pfami PF12371. DUF3651. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-1883.
    Tissue: Bone marrow.
  3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1863, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-300.
    Tissue: Liver.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM131_HUMAN
AccessioniPrimary (citable) accession number: Q92545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3