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Protein

Transmembrane 9 superfamily member 4

Gene

TM9SF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).3 Publications

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • phagocytosis Source: UniProtKB
  • positive regulation of protein exit from endoplasmic reticulum Source: UniProtKB
  • positive regulation of protein localization to cell surface Source: UniProtKB
  • regulation of intracellular pH Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • vacuolar proton-transporting V-type ATPase complex assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101337-MONOMER.

Protein family/group databases

TCDBi8.A.68.1.3. the endomembrane protein-70 (emp70) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 4
Alternative name(s):
Tumor cannibalism associated protein 11 Publication
Gene namesi
Name:TM9SF4
Synonyms:KIAA0255, TUCAP11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:30797. TM9SF4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 281ExtracellularSequence analysisAdd BLAST258
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 346CytoplasmicSequence analysisAdd BLAST44
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 376ExtracellularSequence analysis9
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 416CytoplasmicSequence analysisAdd BLAST19
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 449ExtracellularSequence analysisAdd BLAST12
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 501CytoplasmicSequence analysisAdd BLAST31
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 535ExtracellularSequence analysisAdd BLAST13
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 570CytoplasmicSequence analysisAdd BLAST14
Transmembranei571 – 591HelicalSequence analysisAdd BLAST21
Topological domaini592 – 598ExtracellularSequence analysis7
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 642CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

  • early endosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9777.
OpenTargetsiENSG00000101337.
PharmGKBiPA134937613.

Polymorphism and mutation databases

BioMutaiTM9SF4.
DMDMi172045829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000021017824 – 642Transmembrane 9 superfamily member 4Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei312PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92544.
MaxQBiQ92544.
PaxDbiQ92544.
PeptideAtlasiQ92544.
PRIDEiQ92544.

PTM databases

iPTMnetiQ92544.
PhosphoSitePlusiQ92544.
SwissPalmiQ92544.

Expressioni

Tissue specificityi

Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34+ hematopoietic progenitor cells and during monocyte and granulocyte differentiation. Overexpressed in acute myeloid leukemia, in particular in those displaying granulocytic differentiation (at protein level).2 Publications

Inductioni

Transcriptionally repressed following hypoxia by HIF1A in leukemic cells.1 Publication

Gene expression databases

BgeeiENSG00000101337.
CleanExiHS_TM9SF4.
ExpressionAtlasiQ92544. baseline and differential.
GenevisibleiQ92544. HS.

Organism-specific databases

HPAiHPA064099.

Interactioni

Subunit structurei

Interacts with ATP6V1H in colon cancer cells (PubMed:25659576).1 Publication

Protein-protein interaction databases

BioGridi115121. 47 interactors.
IntActiQ92544. 32 interactors.
MINTiMINT-5006515.
STRINGi9606.ENSP00000381104.

Structurei

3D structure databases

ProteinModelPortaliQ92544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216679.
HOVERGENiHBG054197.
InParanoidiQ92544.
KOiK17086.
OMAiDTRAFYV.
OrthoDBiEOG091G03BD.
PhylomeDBiQ92544.
TreeFamiTF354239.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAMDWLPW SLLLFSLMCE TSAFYVPGVA PINFHQNDPV EIKAVKLTSS
60 70 80 90 100
RTQLPYEYYS LPFCQPSKIT YKAENLGEVL RGDRIVNTPF QVLMNSEKKC
110 120 130 140 150
EVLCSQSNKP VTLTVEQSRL VAERITEDYY VHLIADNLPV ATRLELYSNR
160 170 180 190 200
DSDDKKKEKD VQFEHGYRLG FTDVNKIYLH NHLSFILYYH REDMEEDQEH
210 220 230 240 250
TYRVVRFEVI PQSIRLEDLK ADEKSSCTLP EGTNSSPQEI DPTKENQLYF
260 270 280 290 300
TYSVHWEESD IKWASRWDTY LTMSDVQIHW FSIINSVVVV FFLSGILSMI
310 320 330 340 350
IIRTLRKDIA NYNKEDDIED TMEESGWKLV HGDVFRPPQY PMILSSLLGS
360 370 380 390 400
GIQLFCMILI VIFVAMLGML SPSSRGALMT TACFLFMFMG VFGGFSAGRL
410 420 430 440 450
YRTLKGHRWK KGAFCTATLY PGVVFGICFV LNCFIWGKHS SGAVPFPTMV
460 470 480 490 500
ALLCMWFGIS LPLVYLGYYF GFRKQPYDNP VRTNQIPRQI PEQRWYMNRF
510 520 530 540 550
VGILMAGILP FGAMFIELFF IFSAIWENQF YYLFGFLFLV FIILVVSCSQ
560 570 580 590 600
ISIVMVYFQL CAEDYRWWWR NFLVSGGSAF YVLVYAIFYF VNKLDIVEFI
610 620 630 640
PSLLYFGYTA LMVLSFWLLT GTIGFYAAYM FVRKIYAAVK ID
Length:642
Mass (Da):74,519
Last modified:February 26, 2008 - v2
Checksum:i91E8F925D64A5AE7
GO

Sequence cautioni

The sequence AAH21107 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA13385 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87444 mRNA. Translation: BAA13385.2. Different initiation.
AL049539 Genomic DNA. Translation: CAB75607.2.
AL049539 Genomic DNA. Translation: CAQ09924.1.
CH471077 Genomic DNA. Translation: EAW76391.1.
BC021107 mRNA. Translation: AAH21107.1. Different initiation.
BC022850 mRNA. Translation: AAH22850.2.
CCDSiCCDS13196.2.
RefSeqiNP_055557.2. NM_014742.3.
XP_005260679.1. XM_005260622.4.
UniGeneiHs.654665.

Genome annotation databases

EnsembliENST00000398022; ENSP00000381104; ENSG00000101337.
GeneIDi9777.
KEGGihsa:9777.
UCSCiuc002wxj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87444 mRNA. Translation: BAA13385.2. Different initiation.
AL049539 Genomic DNA. Translation: CAB75607.2.
AL049539 Genomic DNA. Translation: CAQ09924.1.
CH471077 Genomic DNA. Translation: EAW76391.1.
BC021107 mRNA. Translation: AAH21107.1. Different initiation.
BC022850 mRNA. Translation: AAH22850.2.
CCDSiCCDS13196.2.
RefSeqiNP_055557.2. NM_014742.3.
XP_005260679.1. XM_005260622.4.
UniGeneiHs.654665.

3D structure databases

ProteinModelPortaliQ92544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115121. 47 interactors.
IntActiQ92544. 32 interactors.
MINTiMINT-5006515.
STRINGi9606.ENSP00000381104.

Protein family/group databases

TCDBi8.A.68.1.3. the endomembrane protein-70 (emp70) family.

PTM databases

iPTMnetiQ92544.
PhosphoSitePlusiQ92544.
SwissPalmiQ92544.

Polymorphism and mutation databases

BioMutaiTM9SF4.
DMDMi172045829.

Proteomic databases

EPDiQ92544.
MaxQBiQ92544.
PaxDbiQ92544.
PeptideAtlasiQ92544.
PRIDEiQ92544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398022; ENSP00000381104; ENSG00000101337.
GeneIDi9777.
KEGGihsa:9777.
UCSCiuc002wxj.2. human.

Organism-specific databases

CTDi9777.
DisGeNETi9777.
GeneCardsiTM9SF4.
H-InvDBHIX0015722.
HGNCiHGNC:30797. TM9SF4.
HPAiHPA064099.
neXtProtiNX_Q92544.
OpenTargetsiENSG00000101337.
PharmGKBiPA134937613.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1278. Eukaryota.
ENOG410XPIW. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216679.
HOVERGENiHBG054197.
InParanoidiQ92544.
KOiK17086.
OMAiDTRAFYV.
OrthoDBiEOG091G03BD.
PhylomeDBiQ92544.
TreeFamiTF354239.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101337-MONOMER.

Miscellaneous databases

ChiTaRSiTM9SF4. human.
GenomeRNAii9777.
PROiQ92544.

Gene expression databases

BgeeiENSG00000101337.
CleanExiHS_TM9SF4.
ExpressionAtlasiQ92544. baseline and differential.
GenevisibleiQ92544. HS.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM9S4_HUMAN
AccessioniPrimary (citable) accession number: Q92544
Secondary accession number(s): B0QYT7, Q9NUA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.