Q92543 (SNX19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorting nexin-19

Gene names

Name:	SNX19
Synonyms:	KIAA0254

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	992 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in several stages of intracellular trafficking By similarity.
Subcellular location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Domain	The PX domain mediates specific binding to membranes enriched in phosphatidylinositol-3-phosphate (PtdIns(P3)) By similarity.
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain. Contains 1 PXA domain.
Sequence caution	The sequence BAA13384.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasmic vesicle Membrane
Coding sequence diversity	Polymorphism
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell communication Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PTPRN	Q16849	4	EBI-728232,EBI-728153

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 992	992	Sorting nexin-19		PRO_0000213868
Regions
	Domain	95 – 272	178	PXA
	Domain	533 – 663	131	PX
Sites
	Binding site	582	1	Phosphatidylinositol 3-phosphate By similarity
	Binding site	629	1	Phosphatidylinositol 3-phosphate By similarity
Natural variations
	Natural variant	361	1	V → L. Ref.1 Ref.2 Corresponds to variant rs3751037 [ dbSNP | Ensembl ].		VAR_060288
	Natural variant	396	1	D → E. Corresponds to variant rs52802589 [ dbSNP | Ensembl ].		VAR_060289
	Natural variant	407	1	S → G. Corresponds to variant rs3190345 [ dbSNP | Ensembl ].		VAR_057334
	Natural variant	618	1	L → F. Ref.1 Ref.2 Corresponds to variant rs681982 [ dbSNP | Ensembl ].		VAR_060290
	Natural variant	753	1	N → S. Ref.1 Ref.2 Corresponds to variant rs4414223 [ dbSNP | Ensembl ].		VAR_060291
	Natural variant	878	1	L → R. Ref.1 Ref.2 Corresponds to variant rs2298566 [ dbSNP | Ensembl ].		VAR_060292

Sequences

	Sequence		Length	Mass (Da)
	Q92543 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 0540670530743C6B	FASTA	992	108,598
	10 20 30 40 50 60 MKTETVPPFQ ETPAGSSCHL NNLLSSRKLM AVGVLLGWLL VIHLLVNVWL LCLLSALLVV 70 80 90 100 110 120 LGGWLGSSLA GVASGRLHLE RFIPLATCPP CPEAERQLER EINRTIQMII RDFVLSWYRS 130 140 150 160 170 180 VSQEPAFEEE MEAAMKGLVQ ELRRRMSVMD SHAVAQSVLT LCGCHLQSYI QAKEATAGKN 190 200 210 220 230 240 GPVEPSHLWE AYCRATAPHP AVHSPSAEVT YTRGVVNLLL QGLVPKPHLE TRTGRHVVVE 250 260 270 280 290 300 LITCNVILPL ISRLSDPDWI HLVLVGIFSK ARDPAPCPAS APEQPSVPTS LPLIAEVEQL 310 320 330 340 350 360 PEGRASPVAA PVFLSYSEPE GSAGPSPEVE EGHEAVEGDL GGMCEERKVG NNSSHFLQPN 370 380 390 400 410 420 VRGPLFLCED SELESPLSEL GKETIMLMTP GSFLSDRIQD ALCALESSQA LEPKDGEASE 430 440 450 460 470 480 GAEAEEGPGT ETETGLPVST LNSCPEIHID TADKEIEQGD VTASVTALLE GPEKTCPSRP 490 500 510 520 530 540 SCLEKDLTND VSSLDPTLPP VLLSSSPPGP LSSATFSFEP LSSPDGPVII QNLRITGTIT 550 560 570 580 590 600 AREHSGTGFH PYTLYTVKYE TALDGENSSG LQQLAYHTVN RRYREFLNLQ TRLEEKPDLR 610 620 630 640 650 660 KFIKNVKGPK KLFPDLPLGN MDSDRVEARK SLLESFLKQL CAIPEIANSE EVQEFLALNT 670 680 690 700 710 720 DARIAFVKKP FMVSRIDKMV VSAIVDTLKT AFPRSEPQSP TEELSEAETE SKPQTEGKKA 730 740 750 760 770 780 SKSRLRFSSS KISPALSVTE AQDKILYCLQ EGNVESETLS MSAMESFIEK QTKLLEMQPT 790 800 810 820 830 840 KAPEKDPEQP PKGRVDSCVS DAAVPAQDPS NSDPGTETEL ADTALDLLLL LLTEQWKWLC 850 860 870 880 890 900 TENMQKFLRL IFGTLVQRWL EVQVANLTSP QRWVQYLLLL QESIWPGGVL PKFPRPVRTQ 910 920 930 940 950 960 EQKLAAEKQA LQSLMGVLPD LVVEILGVNK CRLSWGLVLE SLQQPLINRH LIYCLGDIIL 970 980 990 EFLDLSASVE ESAATTSASD TPGNSKRMGV SS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Kiaa0254 as a new member (SNX19) of sorting nexin family." Hong W. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-361; PHE-618; SER-753 AND ARG-878.
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed: 9039502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-361; PHE-618; SER-753 AND ARG-878. Tissue: Bone marrow.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF395843 mRNA. Translation: AAK73124.1. D87443 mRNA. Translation: BAA13384.2. Different initiation. AP000824 Genomic DNA. No translation available. AP001093 Genomic DNA. No translation available.
IPI	IPI00021984.
RefSeq	NP_055573.2. NM_014758.2.
UniGene	Hs.444024.
3D structure databases
ProteinModelPortal	Q92543.
SMR	Q92543. Positions 547-661.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92543. 2 interactions.
STRING	Q92543.
Polymorphism databases
DMDM	296452910.
Proteomic databases
PRIDE	Q92543.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265909; ENSP00000265909; ENSG00000120451.
GeneID	399979.
KEGG	hsa:399979.
UCSC	uc001qgk.2. human.
Organism-specific databases
CTD	399979.
GeneCards	GC11M130779.
H-InvDB	HIX0010276.
HGNC	HGNC:21532. SNX19.
HPA	HPA013447.
neXtProt	NX_Q92543.
PharmGKB	PA134904352.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG444265.
HOVERGEN	HBG062485.
InParanoid	Q92543.
OMA	MLMTPGN.
OrthoDB	EOG4FXR71.
PhylomeDB	Q92543.
Gene expression databases
ArrayExpress	Q92543.
Bgee	Q92543.
CleanEx	HS_SNX19.
Genevestigator	Q92543.
GermOnline	ENSG00000120451. Homo sapiens.
Family and domain databases
InterPro	IPR001683. Phox. IPR003114. Phox_assoc. IPR013996. PX_assoc_Snx13. IPR013937. Sorting_nexin_C. [Graphical view]
Gene3D	G3DSA:3.30.1520.10. PX. 1 hit.
Pfam	PF08628. Nexin_C. 1 hit. PF00787. PX. 1 hit. PF02194. PXA. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. SM00313. PXA. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit.
PROSITE	PS50195. PX. 1 hit. PS51207. PXA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	105721.

Entry information

Entry name

SNX19_HUMAN

Accession

Primary (citable) accession number: Q92543

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.