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Protein

Sorting nexin-19

Gene

SNX19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei582 – 5821Phosphatidylinositol 3-phosphateBy similarity
Binding sitei629 – 6291Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

  • chondrocyte differentiation Source: GO_Central
  • dense core granule maturation Source: GO_Central
  • exocytosis Source: UniProtKB-KW
  • insulin secretion Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-19
Gene namesi
Name:SNX19
Synonyms:KIAA0254
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:21532. SNX19.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • early endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134904352.

Polymorphism and mutation databases

BioMutaiSNX19.
DMDMi296452910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 992992Sorting nexin-19PRO_0000213868Add
BLAST

Proteomic databases

MaxQBiQ92543.
PaxDbiQ92543.
PRIDEiQ92543.

PTM databases

iPTMnetiQ92543.
PhosphoSiteiQ92543.

Expressioni

Gene expression databases

BgeeiQ92543.
CleanExiHS_SNX19.
ExpressionAtlasiQ92543. baseline and differential.
GenevisibleiQ92543. HS.

Organism-specific databases

HPAiHPA013447.

Interactioni

Subunit structurei

Interacts with PTPRN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPRNQ168494EBI-728232,EBI-728153

Protein-protein interaction databases

BioGridi134476. 4 interactions.
IntActiQ92543. 4 interactions.
STRINGi9606.ENSP00000265909.

Structurei

3D structure databases

ProteinModelPortaliQ92543.
SMRiQ92543. Positions 527-659.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 272178PXAPROSITE-ProRule annotationAdd
BLAST
Domaini533 – 663131PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 PXA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH51. Eukaryota.
ENOG410XTBC. LUCA.
GeneTreeiENSGT00730000111038.
HOGENOMiHOG000168459.
HOVERGENiHBG062485.
InParanoidiQ92543.
OMAiPDWINLL.
OrthoDBiEOG7DFXBS.
PhylomeDBiQ92543.
TreeFamiTF324055.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTETVPPFQ ETPAGSSCHL NNLLSSRKLM AVGVLLGWLL VIHLLVNVWL
60 70 80 90 100
LCLLSALLVV LGGWLGSSLA GVASGRLHLE RFIPLATCPP CPEAERQLER
110 120 130 140 150
EINRTIQMII RDFVLSWYRS VSQEPAFEEE MEAAMKGLVQ ELRRRMSVMD
160 170 180 190 200
SHAVAQSVLT LCGCHLQSYI QAKEATAGKN GPVEPSHLWE AYCRATAPHP
210 220 230 240 250
AVHSPSAEVT YTRGVVNLLL QGLVPKPHLE TRTGRHVVVE LITCNVILPL
260 270 280 290 300
ISRLSDPDWI HLVLVGIFSK ARDPAPCPAS APEQPSVPTS LPLIAEVEQL
310 320 330 340 350
PEGRASPVAA PVFLSYSEPE GSAGPSPEVE EGHEAVEGDL GGMCEERKVG
360 370 380 390 400
NNSSHFLQPN VRGPLFLCED SELESPLSEL GKETIMLMTP GSFLSDRIQD
410 420 430 440 450
ALCALESSQA LEPKDGEASE GAEAEEGPGT ETETGLPVST LNSCPEIHID
460 470 480 490 500
TADKEIEQGD VTASVTALLE GPEKTCPSRP SCLEKDLTND VSSLDPTLPP
510 520 530 540 550
VLLSSSPPGP LSSATFSFEP LSSPDGPVII QNLRITGTIT AREHSGTGFH
560 570 580 590 600
PYTLYTVKYE TALDGENSSG LQQLAYHTVN RRYREFLNLQ TRLEEKPDLR
610 620 630 640 650
KFIKNVKGPK KLFPDLPLGN MDSDRVEARK SLLESFLKQL CAIPEIANSE
660 670 680 690 700
EVQEFLALNT DARIAFVKKP FMVSRIDKMV VSAIVDTLKT AFPRSEPQSP
710 720 730 740 750
TEELSEAETE SKPQTEGKKA SKSRLRFSSS KISPALSVTE AQDKILYCLQ
760 770 780 790 800
EGNVESETLS MSAMESFIEK QTKLLEMQPT KAPEKDPEQP PKGRVDSCVS
810 820 830 840 850
DAAVPAQDPS NSDPGTETEL ADTALDLLLL LLTEQWKWLC TENMQKFLRL
860 870 880 890 900
IFGTLVQRWL EVQVANLTSP QRWVQYLLLL QESIWPGGVL PKFPRPVRTQ
910 920 930 940 950
EQKLAAEKQA LQSLMGVLPD LVVEILGVNK CRLSWGLVLE SLQQPLINRH
960 970 980 990
LIYCLGDIIL EFLDLSASVE ESAATTSASD TPGNSKRMGV SS
Length:992
Mass (Da):108,598
Last modified:May 18, 2010 - v2
Checksum:i0540670530743C6B
GO
Isoform 2 (identifier: Q92543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     755-771: Missing.
     815-820: GTETEL → AEHAMC
     821-992: Missing.

Note: No experimental confirmation available.
Show »
Length:803
Mass (Da):87,343
Checksum:iFA52A230597FCBA0
GO

Sequence cautioni

The sequence BAA13384.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti361 – 3611V → L.3 Publications
Corresponds to variant rs3751037 [ dbSNP | Ensembl ].
VAR_060288
Natural varianti396 – 3961D → E.
Corresponds to variant rs52802589 [ dbSNP | Ensembl ].
VAR_060289
Natural varianti407 – 4071S → G.
Corresponds to variant rs3190345 [ dbSNP | Ensembl ].
VAR_057334
Natural varianti618 – 6181L → F.3 Publications
Corresponds to variant rs681982 [ dbSNP | Ensembl ].
VAR_060290
Natural varianti753 – 7531N → S.3 Publications
Corresponds to variant rs4414223 [ dbSNP | Ensembl ].
VAR_060291
Natural varianti878 – 8781L → R.2 Publications
Corresponds to variant rs2298566 [ dbSNP | Ensembl ].
VAR_060292

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei755 – 77117Missing in isoform 2. 1 PublicationVSP_057153Add
BLAST
Alternative sequencei815 – 8206GTETEL → AEHAMC in isoform 2. 1 PublicationVSP_057154
Alternative sequencei821 – 992172Missing in isoform 2. 1 PublicationVSP_057155Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395843 mRNA. Translation: AAK73124.1.
D87443 mRNA. Translation: BAA13384.2. Different initiation.
AP000824 Genomic DNA. No translation available.
AP001093 Genomic DNA. No translation available.
BC031620 mRNA. Translation: AAH31620.1.
CCDSiCCDS31721.1. [Q92543-1]
RefSeqiNP_055573.2. NM_014758.2.
UniGeneiHs.444024.

Genome annotation databases

EnsembliENST00000265909; ENSP00000265909; ENSG00000120451. [Q92543-1]
ENST00000533214; ENSP00000435390; ENSG00000120451. [Q92543-2]
GeneIDi399979.
UCSCiuc001qgk.5. human. [Q92543-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395843 mRNA. Translation: AAK73124.1.
D87443 mRNA. Translation: BAA13384.2. Different initiation.
AP000824 Genomic DNA. No translation available.
AP001093 Genomic DNA. No translation available.
BC031620 mRNA. Translation: AAH31620.1.
CCDSiCCDS31721.1. [Q92543-1]
RefSeqiNP_055573.2. NM_014758.2.
UniGeneiHs.444024.

3D structure databases

ProteinModelPortaliQ92543.
SMRiQ92543. Positions 527-659.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134476. 4 interactions.
IntActiQ92543. 4 interactions.
STRINGi9606.ENSP00000265909.

PTM databases

iPTMnetiQ92543.
PhosphoSiteiQ92543.

Polymorphism and mutation databases

BioMutaiSNX19.
DMDMi296452910.

Proteomic databases

MaxQBiQ92543.
PaxDbiQ92543.
PRIDEiQ92543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265909; ENSP00000265909; ENSG00000120451. [Q92543-1]
ENST00000533214; ENSP00000435390; ENSG00000120451. [Q92543-2]
GeneIDi399979.
UCSCiuc001qgk.5. human. [Q92543-1]

Organism-specific databases

CTDi399979.
GeneCardsiSNX19.
HGNCiHGNC:21532. SNX19.
HPAiHPA013447.
neXtProtiNX_Q92543.
PharmGKBiPA134904352.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH51. Eukaryota.
ENOG410XTBC. LUCA.
GeneTreeiENSGT00730000111038.
HOGENOMiHOG000168459.
HOVERGENiHBG062485.
InParanoidiQ92543.
OMAiPDWINLL.
OrthoDBiEOG7DFXBS.
PhylomeDBiQ92543.
TreeFamiTF324055.

Miscellaneous databases

ChiTaRSiSNX19. human.
GenomeRNAii399979.
NextBioi105721.
PROiQ92543.

Gene expression databases

BgeeiQ92543.
CleanExiHS_SNX19.
ExpressionAtlasiQ92543. baseline and differential.
GenevisibleiQ92543. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Kiaa0254 as a new member (SNX19) of sorting nexin family."
    Hong W.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS LEU-361; PHE-618; SER-753 AND ARG-878.
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-361; PHE-618; SER-753 AND ARG-878.
    Tissue: Bone marrow.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-361; PHE-618 AND SER-753.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: INTERACTION WITH PTPRN.
  6. "Sorting nexin 19 regulates the number of dense core vesicles in pancreatic beta-cells."
    Harashima S., Horiuchi T., Wang Y., Notkins A.L., Seino Y., Inagaki N.
    J. Diabetes Investig. 3:52-61(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSNX19_HUMAN
AccessioniPrimary (citable) accession number: Q92543
Secondary accession number(s): E9PKB9, Q8IV55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.