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Q92540

- SMG7_HUMAN

UniProt

Q92540 - SMG7_HUMAN

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Protein

Protein SMG7

Gene

SMG7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.2 Publications

GO - Molecular functioni

  1. protein phosphatase 2A binding Source: HGNC

GO - Biological processi

  1. gene expression Source: Reactome
  2. mRNA export from nucleus Source: HGNC
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: HGNC
  5. regulation of dephosphorylation Source: HGNC
  6. RNA metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Nonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiREACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SMG7
Alternative name(s):
EST1-like protein C
SMG-7 homolog
Short name:
hSMG-7
Gene namesi
Name:SMG7
Synonyms:C1orf16, EST1C, KIAA0250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:16792. SMG7.

Subcellular locationi

Cytoplasm. Nucleus
Note: Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: HGNC
  2. cytosol Source: Reactome
  3. intermediate filament cytoskeleton Source: HPA
  4. nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi66 – 661K → E: Abolishes interaction with UPF1; when associated with E-163. 1 Publication
Mutagenesisi163 – 1631R → E: Abolishes interaction with UPF1; when associated with E-66. 1 Publication

Organism-specific databases

PharmGKBiPA25605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 11371136Protein SMG7PRO_0000076324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications
Modified residuei520 – 5201Phosphoserine1 Publication
Modified residuei781 – 7811Phosphoserine4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ92540.
PaxDbiQ92540.
PRIDEiQ92540.

PTM databases

PhosphoSiteiQ92540.

Expressioni

Gene expression databases

BgeeiQ92540.
CleanExiHS_SMG7.
ExpressionAtlasiQ92540. baseline and differential.
GenevestigatoriQ92540.

Organism-specific databases

HPAiHPA029350.

Interactioni

Subunit structurei

Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1.1 Publication

Protein-protein interaction databases

BioGridi115218. 10 interactions.
IntActiQ92540. 6 interactions.
MINTiMINT-1413681.
STRINGi9606.ENSP00000340766.

Structurei

Secondary structure

1
1137
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1615
Helixi17 – 193
Beta strandi22 – 243
Beta strandi26 – 294
Helixi30 – 4617
Helixi48 – 547
Helixi56 – 649
Helixi66 – 7611
Turni82 – 854
Helixi86 – 10924
Helixi145 – 16420
Helixi168 – 18114
Helixi187 – 19812
Helixi202 – 21312
Beta strandi214 – 2174
Helixi220 – 23314
Helixi246 – 26217
Helixi266 – 2683
Helixi269 – 28517
Helixi291 – 30818
Helixi311 – 3144
Helixi322 – 34726
Beta strandi356 – 3605
Helixi361 – 37111
Helixi375 – 3795
Helixi381 – 3844
Turni385 – 3884
Helixi390 – 3978
Helixi398 – 4003
Helixi416 – 4205
Turni421 – 4233
Helixi425 – 4273
Helixi428 – 4314
Helixi449 – 46921
Turni471 – 4733
Beta strandi475 – 4795
Beta strandi482 – 4865

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YA0X-ray2.55A/B1-497[»]
ProteinModelPortaliQ92540.
SMRiQ92540. Positions 1-497.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92540.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati152 – 18534TPR 11 PublicationAdd
BLAST
Repeati187 – 21933TPR 21 PublicationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi648 – 843196Gln/Pro-richAdd
BLAST
Compositional biasi922 – 101594Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG302147.
GeneTreeiENSGT00560000077120.
HOGENOMiHOG000049052.
HOVERGENiHBG056330.
InParanoidiQ92540.
KOiK14409.
OMAiQETSLYS.
PhylomeDBiQ92540.
TreeFamiTF327119.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR018834. DNA/RNA-bd_Est1-type.
IPR019458. EST1.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF10374. EST1. 1 hit.
PF10373. EST1_DNA_bind. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92540) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY
60 70 80 90 100
ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG
110 120 130 140 150
FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI
160 170 180 190 200
CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG
210 220 230 240 250
DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI
260 270 280 290 300
KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI
310 320 330 340 350
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE
360 370 380 390 400
SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF
410 420 430 440 450
HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ
460 470 480 490 500
QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDPSEA
510 520 530 540 550
KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG EKPVVTFKEN
560 570 580 590 600
IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL
610 620 630 640 650
EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH
660 670 680 690 700
HPGAFPPLPS RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA
710 720 730 740 750
HSPAGNQVQA GKQSHIPYSQ QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ
760 770 780 790 800
PTAQSTSQLQ VQALTQQQQS PTKAVPALGK SPPHHSGFQQ YQQADASKQL
810 820 830 840 850
WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM QQQPLEKKMK
860 870 880 890 900
PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV
910 920 930 940 950
FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF
960 970 980 990 1000
NEVYGKNLTS SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA
1010 1020 1030 1040 1050
SQSPHSSNPS SLPSSPPTHN HNSVPFSNFG PIGTPDNRDR RTADRWKTDK
1060 1070 1080 1090 1100
PAMGGFGIDY LSATSSSESS WHQASTPSGT WTGHGPSMED SSAVLMESLK
1110 1120 1130
SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH
Length:1,137
Mass (Da):127,282
Last modified:December 20, 2005 - v2
Checksum:iE152AFAFEF8F3A42
GO
Isoform 2 (identifier: Q92540-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.

Show »
Length:1,091
Mass (Da):122,020
Checksum:i2E6B7AFB0201D533
GO
Isoform 4 (identifier: Q92540-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.
     914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF
     1101-1137: SIWSSSMMHP...RGQGTMNPPH → KQQHGVQQLG...PFWKRRKKGK

Show »
Length:1,178
Mass (Da):131,650
Checksum:i2087382714FE3D57
GO
Isoform 5 (identifier: Q92540-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF

Show »
Length:1,145
Mass (Da):127,854
Checksum:i9F9B61B6384AA0FA
GO

Sequence cautioni

The sequence BAA13381.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871Q → R in BAG61224. (PubMed:14702039)Curated
Sequence conflicti282 – 2821R → E in BAC53621. (PubMed:14636577)Curated
Isoform 4 (identifier: Q92540-4)
Sequence conflicti854 – 8541V → I in AAH36381. (PubMed:16710414)Curated
Sequence conflicti898 – 8981P → T in AAH36381. (PubMed:16710414)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti627 – 6271S → F.
Corresponds to variant rs34221194 [ dbSNP | Ensembl ].
VAR_051363
Natural varianti900 – 9001V → I.2 Publications
Corresponds to variant rs2298083 [ dbSNP | Ensembl ].
VAR_051364

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 5. 1 PublicationVSP_047130Add
BLAST
Alternative sequencei569 – 61446Missing in isoform 2 and isoform 4. 2 PublicationsVSP_016574Add
BLAST
Alternative sequencei914 – 9141E → EDPKSSPLLPPDLLKSLAAL EEEEELIFSNPPDLYPALLG PLASLPGRSLF in isoform 4 and isoform 5. 2 PublicationsVSP_016575
Alternative sequencei1101 – 113737SIWSS…MNPPH → KQQHGVQQLGPKRQSEEEGS SSICVAHRGPRPLPSCSLPA STFRVKFKAARTCAHQAQKK TRRRPFWKRRKKGK in isoform 4. 1 PublicationVSP_016576Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB085674 mRNA. Translation: BAC53621.1.
D87437 mRNA. Translation: BAA13381.2. Different initiation.
AK299178 mRNA. Translation: BAG61224.1.
AL449223, AL137800 Genomic DNA. Translation: CAI16627.1.
AL137800, AL449223 Genomic DNA. Translation: CAI19486.1.
BC036381 mRNA. Translation: AAH36381.1.
BC052565 mRNA. Translation: AAH52565.1.
CCDSiCCDS1355.1. [Q92540-1]
CCDS41445.2. [Q92540-4]
CCDS53444.1. [Q92540-2]
CCDS53445.1. [Q92540-5]
RefSeqiNP_001167532.1. NM_001174061.1. [Q92540-5]
NP_775179.1. NM_173156.2. [Q92540-1]
NP_963862.1. NM_201568.2. [Q92540-2]
NP_963863.2. NM_201569.2. [Q92540-4]
UniGeneiHs.591463.

Genome annotation databases

EnsembliENST00000347615; ENSP00000340766; ENSG00000116698. [Q92540-1]
ENST00000507469; ENSP00000425133; ENSG00000116698. [Q92540-4]
ENST00000508461; ENSP00000426915; ENSG00000116698. [Q92540-5]
ENST00000515829; ENSP00000421358; ENSG00000116698. [Q92540-2]
GeneIDi9887.
KEGGihsa:9887.
UCSCiuc001gqg.3. human. [Q92540-1]
uc001gqh.3. human. [Q92540-2]

Polymorphism databases

DMDMi84028262.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB085674 mRNA. Translation: BAC53621.1 .
D87437 mRNA. Translation: BAA13381.2 . Different initiation.
AK299178 mRNA. Translation: BAG61224.1 .
AL449223 , AL137800 Genomic DNA. Translation: CAI16627.1 .
AL137800 , AL449223 Genomic DNA. Translation: CAI19486.1 .
BC036381 mRNA. Translation: AAH36381.1 .
BC052565 mRNA. Translation: AAH52565.1 .
CCDSi CCDS1355.1. [Q92540-1 ]
CCDS41445.2. [Q92540-4 ]
CCDS53444.1. [Q92540-2 ]
CCDS53445.1. [Q92540-5 ]
RefSeqi NP_001167532.1. NM_001174061.1. [Q92540-5 ]
NP_775179.1. NM_173156.2. [Q92540-1 ]
NP_963862.1. NM_201568.2. [Q92540-2 ]
NP_963863.2. NM_201569.2. [Q92540-4 ]
UniGenei Hs.591463.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YA0 X-ray 2.55 A/B 1-497 [» ]
ProteinModelPortali Q92540.
SMRi Q92540. Positions 1-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115218. 10 interactions.
IntActi Q92540. 6 interactions.
MINTi MINT-1413681.
STRINGi 9606.ENSP00000340766.

PTM databases

PhosphoSitei Q92540.

Polymorphism databases

DMDMi 84028262.

Proteomic databases

MaxQBi Q92540.
PaxDbi Q92540.
PRIDEi Q92540.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347615 ; ENSP00000340766 ; ENSG00000116698 . [Q92540-1 ]
ENST00000507469 ; ENSP00000425133 ; ENSG00000116698 . [Q92540-4 ]
ENST00000508461 ; ENSP00000426915 ; ENSG00000116698 . [Q92540-5 ]
ENST00000515829 ; ENSP00000421358 ; ENSG00000116698 . [Q92540-2 ]
GeneIDi 9887.
KEGGi hsa:9887.
UCSCi uc001gqg.3. human. [Q92540-1 ]
uc001gqh.3. human. [Q92540-2 ]

Organism-specific databases

CTDi 9887.
GeneCardsi GC01P183441.
H-InvDB HIX0001408.
HGNCi HGNC:16792. SMG7.
HPAi HPA029350.
MIMi 610964. gene.
neXtProti NX_Q92540.
PharmGKBi PA25605.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302147.
GeneTreei ENSGT00560000077120.
HOGENOMi HOG000049052.
HOVERGENi HBG056330.
InParanoidi Q92540.
KOi K14409.
OMAi QETSLYS.
PhylomeDBi Q92540.
TreeFami TF327119.

Enzyme and pathway databases

Reactomei REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSi SMG7. human.
EvolutionaryTracei Q92540.
GeneWikii SMG7.
GenomeRNAii 9887.
NextBioi 37276.
PROi Q92540.
SOURCEi Search...

Gene expression databases

Bgeei Q92540.
CleanExi HS_SMG7.
ExpressionAtlasi Q92540. baseline and differential.
Genevestigatori Q92540.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR018834. DNA/RNA-bd_Est1-type.
IPR019458. EST1.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF10374. EST1. 1 hit.
PF10373. EST1_DNA_bind. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7."
    Ohnishi T., Yamashita A., Kashima I., Schell T., Anders K.R., Grimson A., Hachiya T., Hentze M.W., Anderson P., Ohno S.
    Mol. Cell 12:1187-1200(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX CONTAINING SMG5; SMG7; UPF1; PPP2CA AND UPF3.
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-900.
    Tissue: Bone marrow.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT ILE-900.
    Tissue: Testis.
  7. "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay."
    Unterholzner L., Izaurralde E.
    Mol. Cell 16:587-596(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH CYTOPLASMIC MRNA DECAY BODIES.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520 AND SER-781, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway."
    Fukuhara N., Ebert J., Unterholzner L., Lindner D., Izaurralde E., Conti E.
    Mol. Cell 17:537-547(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1-497, FUNCTION, INTERACTION WITH SMG5 AND PHOSPHORYLATED RENT1, SUBCELLULAR LOCATION, TPR REPEAT, MUTAGENESIS OF LYS-66 AND ARG-163.

Entry informationi

Entry nameiSMG7_HUMAN
AccessioniPrimary (citable) accession number: Q92540
Secondary accession number(s): B4DRB2
, E9PCI0, E9PEH2, Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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