Q92540 (SMG7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SMG7

Alternative name(s):
EST1-like protein C
SMG-7 homolog
Short name=hSMG-7

Gene names

Name:	SMG7
Synonyms:	C1orf16, EST1C, KIAA0250

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1137 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Ref.6 Ref.13
Subunit structure	Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1. Ref.1
Subcellular location	Cytoplasm. Nucleus. Note: Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Ref.1 Ref.6 Ref.13
Sequence similarities	Contains 2 TPR repeats.
Sequence caution	The sequence BAA13381.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Nonsense-mediated mRNA decay
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat TPR repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gene expression Traceable author statement. Source: Reactome mRNA export from nucleus Traceable author statement PubMed 16488880. Source: HGNC nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement PubMed 16488880. Source: HGNC regulation of dephosphorylation Traceable author statement Ref.13. Source: HGNC
Cellular_component	cytosol Traceable author statement. Source: Reactome intermediate filament cytoskeleton Inferred from direct assay. Source: HPA nucleus Inferred from direct assay Ref.1. Source: HGNC
Molecular_function	protein phosphatase 2A binding Inferred from direct assay Ref.1. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92540-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92540-2)

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.

Isoform 4 (identifier: Q92540-4)

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.
     914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNTPDLYPALLGPLASLPGRSLF
     1101-1137: SIWSSSMMHP...RGQGTMNPPH → KQQHGVQQLG...PFWKRRKKGK

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1137

1137

Protein SMG7

PRO_0000076324

Regions

Repeat

152 – 185

34

TPR 1

Repeat

187 – 219

33

TPR 2

Compositional bias

648 – 843

196

Gln/Pro-rich

Compositional bias

922 – 1015

94

Ser-rich

Amino acid modifications

Modified residue

520

1

Phosphoserine Ref.8

Modified residue

781

1

Phosphoserine Ref.7 Ref.8 Ref.10 Ref.12

Natural variations

Alternative sequence

569 – 614

46

Missing in isoform 2 and isoform 4.

VSP_016574

Alternative sequence

914

1

E → EDPKSSPLLPPDLLKSLAAL EEEEELIFSNTPDLYPALLG PLASLPGRSLF in isoform 4.

VSP_016575

Alternative sequence

1101 – 1137

37

SIWSS…MNPPH → KQQHGVQQLGPKRQSEEEGS SSICVAHRGPRPLPSCSLPA STFRVKFKAARTCAHQAQKK TRRRPFWKRRKKGK in isoform 4.

VSP_016576

Natural variant

627

1

S → F.
Corresponds to variant rs34221194 [ dbSNP | Ensembl ].

VAR_051363

Natural variant

900

1

V → I. Ref.2 Ref.5
Corresponds to variant rs2298083 [ dbSNP | Ensembl ].

VAR_051364

Experimental info

Mutagenesis

66

1

K → E: Abolishes interaction with UPF1; when associated with E-163. Ref.13

Mutagenesis

163

1

R → E: Abolishes interaction with UPF1; when associated with E-66. Ref.13

Sequence conflict

282

1

R → E in BAC53621. Ref.1

Secondary structure

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1137

Helix Strand Turn

Details...

Helix

2 – 16

15

Helix

17 – 19

3

Beta strand

22 – 24

3

Beta strand

26 – 29

4

Helix

30 – 46

17

Helix

48 – 54

7

Helix

56 – 64

9

Helix

66 – 76

11

Turn

82 – 85

4

Helix

86 – 109

24

Helix

145 – 164

20

Helix

168 – 181

14

Helix

187 – 198

12

Helix

202 – 213

12

Beta strand

214 – 217

4

Helix

220 – 233

14

Helix

246 – 262

17

Helix

266 – 268

3

Helix

269 – 285

17

Helix

291 – 308

18

Helix

311 – 314

4

Helix

322 – 347

26

Beta strand

356 – 360

5

Helix

361 – 371

11

Helix

375 – 379

5

Helix

381 – 384

4

Turn

385 – 388

4

Helix

390 – 397

8

Helix

398 – 400

3

Helix

416 – 420

5

Turn

421 – 423

3

Helix

425 – 427

3

Helix

428 – 431

4

Helix

449 – 469

21

Turn

471 – 473

3

Beta strand

475 – 479

5

Beta strand

482 – 486

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: E152AFAFEF8F3A42	FASTA	1,137	127,282
	10 20 30 40 50 60 MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL 70 80 90 100 110 120 WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR 130 140 150 160 170 180 VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ 190 200 210 220 230 240 LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV 250 260 270 280 290 300 KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 310 320 330 340 350 360 NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE SQEESYNAYP 370 380 390 400 410 420 LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSSI SATPLPEEFE 430 440 450 460 470 480 LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRRIRQQRLI SIGKWIADNQ PRLIQCENEV 490 500 510 520 530 540 GKLLFITEIP ELILEDPSEA KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG 550 560 570 580 590 600 EKPVVTFKEN IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL 610 620 630 640 650 660 EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH HPGAFPPLPS 670 680 690 700 710 720 RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA HSPAGNQVQA GKQSHIPYSQ 730 740 750 760 770 780 QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ PTAQSTSQLQ VQALTQQQQS PTKAVPALGK 790 800 810 820 830 840 SPPHHSGFQQ YQQADASKQL WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM 850 860 870 880 890 900 QQQPLEKKMK PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV 910 920 930 940 950 960 FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF NEVYGKNLTS 970 980 990 1000 1010 1020 SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA SQSPHSSNPS SLPSSPPTHN 1030 1040 1050 1060 1070 1080 HNSVPFSNFG PIGTPDNRDR RTADRWKTDK PAMGGFGIDY LSATSSSESS WHQASTPSGT 1090 1100 1110 1120 1130 WTGHGPSMED SSAVLMESLK SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH
	Isoform 2 [UniParc]. Checksum: 2E6B7AFB0201D533	FASTA	1,091	122,020
	10 20 30 40 50 60 MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL 70 80 90 100 110 120 WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR 130 140 150 160 170 180 VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ 190 200 210 220 230 240 LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV 250 260 270 280 290 300 KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 310 320 330 340 350 360 NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE SQEESYNAYP 370 380 390 400 410 420 LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSSI SATPLPEEFE 430 440 450 460 470 480 LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRRIRQQRLI SIGKWIADNQ PRLIQCENEV 490 500 510 520 530 540 GKLLFITEIP ELILEDPSEA KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG 550 560 570 580 590 600 EKPVVTFKEN IKTREVNRDQ GRSFPPKEVK SQTELRKTPV SEARKTPVTQ TPTQASNSQF 610 620 630 640 650 660 IPIHHPGAFP PLPSRPGFPP PTYVIPPPVA FSMGSGYTFP AGVSVPGTFL QPTAHSPAGN 670 680 690 700 710 720 QVQAGKQSHI PYSQQRPSGP GPMNQGPQQS QPPSQQPLTS LPAQPTAQST SQLQVQALTQ 730 740 750 760 770 780 QQQSPTKAVP ALGKSPPHHS GFQQYQQADA SKQLWNPPQV QGPLGKIMPV KQPYYLQTQD 790 800 810 820 830 840 PIKLFEPSLQ PPVMQQQPLE KKMKPFPMEP YNHNPSEVKV PEFYWDSSYS MADNRSVMAQ 850 860 870 880 890 900 QANIDRRGKR SPGVFRPEQD PVPRMPFEKS LLEKPSELMS HSSSFLSLTG FSLNQERYPN 910 920 930 940 950 960 NSMFNEVYGK NLTSSSKAEL SPSMAPQETS LYSLFEGTPW SPSLPASSDH STPASQSPHS 970 980 990 1000 1010 1020 SNPSSLPSSP PTHNHNSVPF SNFGPIGTPD NRDRRTADRW KTDKPAMGGF GIDYLSATSS 1030 1040 1050 1060 1070 1080 SESSWHQAST PSGTWTGHGP SMEDSSAVLM ESLKSIWSSS MMHPGPSALE QLLMQQKQKQ 1090 QRGQGTMNPP H
	Isoform 4 [UniParc]. Checksum: 2182687316121397	FASTA	1,178	131,654
	10 20 30 40 50 60 MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL 70 80 90 100 110 120 WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR 130 140 150 160 170 180 VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ 190 200 210 220 230 240 LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV 250 260 270 280 290 300 KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 310 320 330 340 350 360 NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE SQEESYNAYP 370 380 390 400 410 420 LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSSI SATPLPEEFE 430 440 450 460 470 480 LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRRIRQQRLI SIGKWIADNQ PRLIQCENEV 490 500 510 520 530 540 GKLLFITEIP ELILEDPSEA KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG 550 560 570 580 590 600 EKPVVTFKEN IKTREVNRDQ GRSFPPKEVK SQTELRKTPV SEARKTPVTQ TPTQASNSQF 610 620 630 640 650 660 IPIHHPGAFP PLPSRPGFPP PTYVIPPPVA FSMGSGYTFP AGVSVPGTFL QPTAHSPAGN 670 680 690 700 710 720 QVQAGKQSHI PYSQQRPSGP GPMNQGPQQS QPPSQQPLTS LPAQPTAQST SQLQVQALTQ 730 740 750 760 770 780 QQQSPTKAVP ALGKSPPHHS GFQQYQQADA SKQLWNPPQV QGPLGKIMPV KQPYYLQTQD 790 800 810 820 830 840 PIKLFEPSLQ PPVMQQQPLE KKMKPFPMEP YNHNPSEVKV PEFYWDSSYS MADNRSVMAQ 850 860 870 880 890 900 QANIDRRGKR SPGVFRPEQD PVPRMPFEDP KSSPLLPPDL LKSLAALEEE EELIFSNTPD 910 920 930 940 950 960 LYPALLGPLA SLPGRSLFKS LLEKPSELMS HSSSFLSLTG FSLNQERYPN NSMFNEVYGK 970 980 990 1000 1010 1020 NLTSSSKAEL SPSMAPQETS LYSLFEGTPW SPSLPASSDH STPASQSPHS SNPSSLPSSP 1030 1040 1050 1060 1070 1080 PTHNHNSVPF SNFGPIGTPD NRDRRTADRW KTDKPAMGGF GIDYLSATSS SESSWHQAST 1090 1100 1110 1120 1130 1140 PSGTWTGHGP SMEDSSAVLM ESLKKQQHGV QQLGPKRQSE EEGSSSICVA HRGPRPLPSC 1150 1160 1170 SLPASTFRVK FKAARTCAHQ AQKKTRRRPF WKRRKKGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7." Ohnishi T., Yamashita A., Kashima I., Schell T., Anders K.R., Grimson A., Hachiya T., Hentze M.W., Anderson P., Ohno S. Mol. Cell 12:1187-1200(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX CONTAINING SMG5; SMG7; UPF1; PPP2CA AND UPF3.
[2]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-900. Tissue: Bone marrow.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT ILE-900. Tissue: Testis.
[6]	"SMG7 acts as a molecular link between mRNA surveillance and mRNA decay." Unterholzner L., Izaurralde E. Mol. Cell 16:587-596(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH CYTOPLASMIC MRNA DECAY BODIES.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520 AND SER-781, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, MASS SPECTROMETRY.
[13]	"SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway." Fukuhara N., Ebert J., Unterholzner L., Lindner D., Izaurralde E., Conti E. Mol. Cell 17:537-547(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1-497, FUNCTION, INTERACTION WITH SMG5 AND PHOSPHORYLATED RENT1, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-66 AND ARG-163.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB085674 mRNA. Translation: BAC53621.1.
D87437 mRNA. Translation: BAA13381.2. Different initiation.
AL449223, AL137800 Genomic DNA. Translation: CAI16627.1.
AL137800, AL449223 Genomic DNA. Translation: CAI19486.1.
BC036381 mRNA. Translation: AAH36381.1.
BC052565 mRNA. Translation: AAH52565.1.

IPI

IPI00217494.
IPI00448672.
IPI00657821.

RefSeq

NP_001167532.1. NM_001174061.1.
NP_775179.1. NM_173156.2.
NP_963862.1. NM_201568.2.
NP_963863.2. NM_201569.2.

UniGene

Hs.591463.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YA0	X-ray	2.55	A/B	1-497	[»]

ProteinModelPortal

Q92540.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q92540. 5 interactions.

MINT

MINT-1413681.

STRING

9606.ENSP00000340766.

PTM databases

PhosphoSite

Q92540.

Polymorphism databases

DMDM

84028262.

Proteomic databases

PaxDb

Q92540.

PRIDE

Q92540.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000347615; ENSP00000340766; ENSG00000116698.
ENST00000515829; ENSP00000421358; ENSG00000116698.

GeneID

9887.

KEGG

hsa:9887.

UCSC

uc001gqg.3. human.
uc001gqh.3. human.

Organism-specific databases

CTD

9887.

GeneCards

GC01P183441.

H-InvDB

HIX0001408.

HGNC

HGNC:16792. SMG7.

HPA

HPA029350.

MIM

610964. gene.

neXtProt

NX_Q92540.

PharmGKB

PA25605.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG302147.

HOGENOM

HOG000049052.

HOVERGEN

HBG056330.

KO

K14409.

PhylomeDB

Q92540.

Enzyme and pathway databases

Reactome

REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

Q92540.

Bgee

Q92540.

CleanEx

HS_SMG7.

Genevestigator

Q92540.

GermOnline

ENSG00000116698. Homo sapiens.

Family and domain databases

Gene3D

1.25.40.10. 2 hits.

InterPro

IPR018834. DNA/RNA-bd_Est1-type.
IPR019458. EST1.
IPR011990. TPR-like_helical.
[Graphical view]

Pfam

PF10374. EST1. 1 hit.
PF10373. EST1_DNA_bind. 1 hit.
[Graphical view]

PROSITE

PS50005. TPR. False negative.
PS50293. TPR_REGION. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

SMG7. human.

EvolutionaryTrace

Q92540.

GenomeRNAi

9887.

NextBio

37276.

SOURCE

Search...

Entry information

Entry name

SMG7_HUMAN

Accession

Primary (citable) accession number: Q92540
Secondary accession number(s): Q5T1Q0 , Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.