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Q92540

- SMG7_HUMAN

UniProt

Q92540 - SMG7_HUMAN

Protein

Protein SMG7

Gene

SMG7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein phosphatase 2A binding Source: HGNC

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA export from nucleus Source: HGNC
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: HGNC
    5. regulation of dephosphorylation Source: HGNC
    6. RNA metabolic process Source: Reactome

    Keywords - Biological processi

    Nonsense-mediated mRNA decay

    Enzyme and pathway databases

    ReactomeiREACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SMG7
    Alternative name(s):
    EST1-like protein C
    SMG-7 homolog
    Short name:
    hSMG-7
    Gene namesi
    Name:SMG7
    Synonyms:C1orf16, EST1C, KIAA0250
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:16792. SMG7.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: HGNC
    2. cytosol Source: Reactome
    3. intermediate filament cytoskeleton Source: HPA
    4. nucleus Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi66 – 661K → E: Abolishes interaction with UPF1; when associated with E-163. 1 Publication
    Mutagenesisi163 – 1631R → E: Abolishes interaction with UPF1; when associated with E-66. 1 Publication

    Organism-specific databases

    PharmGKBiPA25605.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 11371136Protein SMG7PRO_0000076324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications
    Modified residuei520 – 5201Phosphoserine1 Publication
    Modified residuei781 – 7811Phosphoserine4 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ92540.
    PaxDbiQ92540.
    PRIDEiQ92540.

    PTM databases

    PhosphoSiteiQ92540.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92540.
    BgeeiQ92540.
    CleanExiHS_SMG7.
    GenevestigatoriQ92540.

    Organism-specific databases

    HPAiHPA029350.

    Interactioni

    Subunit structurei

    Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1.1 Publication

    Protein-protein interaction databases

    BioGridi115218. 7 interactions.
    IntActiQ92540. 6 interactions.
    MINTiMINT-1413681.
    STRINGi9606.ENSP00000340766.

    Structurei

    Secondary structure

    1
    1137
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 1615
    Helixi17 – 193
    Beta strandi22 – 243
    Beta strandi26 – 294
    Helixi30 – 4617
    Helixi48 – 547
    Helixi56 – 649
    Helixi66 – 7611
    Turni82 – 854
    Helixi86 – 10924
    Helixi145 – 16420
    Helixi168 – 18114
    Helixi187 – 19812
    Helixi202 – 21312
    Beta strandi214 – 2174
    Helixi220 – 23314
    Helixi246 – 26217
    Helixi266 – 2683
    Helixi269 – 28517
    Helixi291 – 30818
    Helixi311 – 3144
    Helixi322 – 34726
    Beta strandi356 – 3605
    Helixi361 – 37111
    Helixi375 – 3795
    Helixi381 – 3844
    Turni385 – 3884
    Helixi390 – 3978
    Helixi398 – 4003
    Helixi416 – 4205
    Turni421 – 4233
    Helixi425 – 4273
    Helixi428 – 4314
    Helixi449 – 46921
    Turni471 – 4733
    Beta strandi475 – 4795
    Beta strandi482 – 4865

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YA0X-ray2.55A/B1-497[»]
    ProteinModelPortaliQ92540.
    SMRiQ92540. Positions 1-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92540.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati152 – 18534TPR 11 PublicationAdd
    BLAST
    Repeati187 – 21933TPR 21 PublicationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi648 – 843196Gln/Pro-richAdd
    BLAST
    Compositional biasi922 – 101594Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG302147.
    HOGENOMiHOG000049052.
    HOVERGENiHBG056330.
    KOiK14409.
    OMAiQETSLYS.
    PhylomeDBiQ92540.
    TreeFamiTF327119.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR018834. DNA/RNA-bd_Est1-type.
    IPR019458. EST1.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF10374. EST1. 1 hit.
    PF10373. EST1_DNA_bind. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92540-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY     50
    ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG 100
    FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI 150
    CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG 200
    DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI 250
    KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 300
    NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE 350
    SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF 400
    HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ 450
    QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDPSEA 500
    KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG EKPVVTFKEN 550
    IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL 600
    EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH 650
    HPGAFPPLPS RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA 700
    HSPAGNQVQA GKQSHIPYSQ QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ 750
    PTAQSTSQLQ VQALTQQQQS PTKAVPALGK SPPHHSGFQQ YQQADASKQL 800
    WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM QQQPLEKKMK 850
    PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV 900
    FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF 950
    NEVYGKNLTS SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA 1000
    SQSPHSSNPS SLPSSPPTHN HNSVPFSNFG PIGTPDNRDR RTADRWKTDK 1050
    PAMGGFGIDY LSATSSSESS WHQASTPSGT WTGHGPSMED SSAVLMESLK 1100
    SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH 1137
    Length:1,137
    Mass (Da):127,282
    Last modified:December 20, 2005 - v2
    Checksum:iE152AFAFEF8F3A42
    GO
    Isoform 2 (identifier: Q92540-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         569-614: Missing.

    Show »
    Length:1,091
    Mass (Da):122,020
    Checksum:i2E6B7AFB0201D533
    GO
    Isoform 4 (identifier: Q92540-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         569-614: Missing.
         914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF
         1101-1137: SIWSSSMMHP...RGQGTMNPPH → KQQHGVQQLG...PFWKRRKKGK

    Show »
    Length:1,178
    Mass (Da):131,650
    Checksum:i2087382714FE3D57
    GO
    Isoform 5 (identifier: Q92540-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.
         914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF

    Show »
    Length:1,145
    Mass (Da):127,854
    Checksum:i9F9B61B6384AA0FA
    GO

    Sequence cautioni

    The sequence BAA13381.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti187 – 1871Q → R in BAG61224. (PubMed:14702039)Curated
    Sequence conflicti282 – 2821R → E in BAC53621. (PubMed:14636577)Curated
    Isoform 4 (identifier: Q92540-4)
    Sequence conflicti854 – 8541V → I in AAH36381. (PubMed:16710414)Curated
    Sequence conflicti898 – 8981P → T in AAH36381. (PubMed:16710414)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti627 – 6271S → F.
    Corresponds to variant rs34221194 [ dbSNP | Ensembl ].
    VAR_051363
    Natural varianti900 – 9001V → I.2 Publications
    Corresponds to variant rs2298083 [ dbSNP | Ensembl ].
    VAR_051364

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4242Missing in isoform 5. 1 PublicationVSP_047130Add
    BLAST
    Alternative sequencei569 – 61446Missing in isoform 2 and isoform 4. 2 PublicationsVSP_016574Add
    BLAST
    Alternative sequencei914 – 9141E → EDPKSSPLLPPDLLKSLAAL EEEEELIFSNPPDLYPALLG PLASLPGRSLF in isoform 4 and isoform 5. 2 PublicationsVSP_016575
    Alternative sequencei1101 – 113737SIWSS…MNPPH → KQQHGVQQLGPKRQSEEEGS SSICVAHRGPRPLPSCSLPA STFRVKFKAARTCAHQAQKK TRRRPFWKRRKKGK in isoform 4. 1 PublicationVSP_016576Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085674 mRNA. Translation: BAC53621.1.
    D87437 mRNA. Translation: BAA13381.2. Different initiation.
    AK299178 mRNA. Translation: BAG61224.1.
    AL449223, AL137800 Genomic DNA. Translation: CAI16627.1.
    AL137800, AL449223 Genomic DNA. Translation: CAI19486.1.
    BC036381 mRNA. Translation: AAH36381.1.
    BC052565 mRNA. Translation: AAH52565.1.
    CCDSiCCDS1355.1. [Q92540-1]
    CCDS41445.2. [Q92540-4]
    CCDS53444.1. [Q92540-2]
    CCDS53445.1. [Q92540-5]
    RefSeqiNP_001167532.1. NM_001174061.1. [Q92540-5]
    NP_775179.1. NM_173156.2. [Q92540-1]
    NP_963862.1. NM_201568.2. [Q92540-2]
    NP_963863.2. NM_201569.2. [Q92540-4]
    UniGeneiHs.591463.

    Genome annotation databases

    EnsembliENST00000347615; ENSP00000340766; ENSG00000116698. [Q92540-1]
    ENST00000507469; ENSP00000425133; ENSG00000116698. [Q92540-4]
    ENST00000508461; ENSP00000426915; ENSG00000116698. [Q92540-5]
    ENST00000515829; ENSP00000421358; ENSG00000116698. [Q92540-2]
    GeneIDi9887.
    KEGGihsa:9887.
    UCSCiuc001gqg.3. human. [Q92540-1]
    uc001gqh.3. human. [Q92540-2]

    Polymorphism databases

    DMDMi84028262.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085674 mRNA. Translation: BAC53621.1 .
    D87437 mRNA. Translation: BAA13381.2 . Different initiation.
    AK299178 mRNA. Translation: BAG61224.1 .
    AL449223 , AL137800 Genomic DNA. Translation: CAI16627.1 .
    AL137800 , AL449223 Genomic DNA. Translation: CAI19486.1 .
    BC036381 mRNA. Translation: AAH36381.1 .
    BC052565 mRNA. Translation: AAH52565.1 .
    CCDSi CCDS1355.1. [Q92540-1 ]
    CCDS41445.2. [Q92540-4 ]
    CCDS53444.1. [Q92540-2 ]
    CCDS53445.1. [Q92540-5 ]
    RefSeqi NP_001167532.1. NM_001174061.1. [Q92540-5 ]
    NP_775179.1. NM_173156.2. [Q92540-1 ]
    NP_963862.1. NM_201568.2. [Q92540-2 ]
    NP_963863.2. NM_201569.2. [Q92540-4 ]
    UniGenei Hs.591463.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YA0 X-ray 2.55 A/B 1-497 [» ]
    ProteinModelPortali Q92540.
    SMRi Q92540. Positions 1-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115218. 7 interactions.
    IntActi Q92540. 6 interactions.
    MINTi MINT-1413681.
    STRINGi 9606.ENSP00000340766.

    PTM databases

    PhosphoSitei Q92540.

    Polymorphism databases

    DMDMi 84028262.

    Proteomic databases

    MaxQBi Q92540.
    PaxDbi Q92540.
    PRIDEi Q92540.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347615 ; ENSP00000340766 ; ENSG00000116698 . [Q92540-1 ]
    ENST00000507469 ; ENSP00000425133 ; ENSG00000116698 . [Q92540-4 ]
    ENST00000508461 ; ENSP00000426915 ; ENSG00000116698 . [Q92540-5 ]
    ENST00000515829 ; ENSP00000421358 ; ENSG00000116698 . [Q92540-2 ]
    GeneIDi 9887.
    KEGGi hsa:9887.
    UCSCi uc001gqg.3. human. [Q92540-1 ]
    uc001gqh.3. human. [Q92540-2 ]

    Organism-specific databases

    CTDi 9887.
    GeneCardsi GC01P183441.
    H-InvDB HIX0001408.
    HGNCi HGNC:16792. SMG7.
    HPAi HPA029350.
    MIMi 610964. gene.
    neXtProti NX_Q92540.
    PharmGKBi PA25605.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302147.
    HOGENOMi HOG000049052.
    HOVERGENi HBG056330.
    KOi K14409.
    OMAi QETSLYS.
    PhylomeDBi Q92540.
    TreeFami TF327119.

    Enzyme and pathway databases

    Reactomei REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    ChiTaRSi SMG7. human.
    EvolutionaryTracei Q92540.
    GeneWikii SMG7.
    GenomeRNAii 9887.
    NextBioi 37276.
    PROi Q92540.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92540.
    Bgeei Q92540.
    CleanExi HS_SMG7.
    Genevestigatori Q92540.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR018834. DNA/RNA-bd_Est1-type.
    IPR019458. EST1.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF10374. EST1. 1 hit.
    PF10373. EST1_DNA_bind. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7."
      Ohnishi T., Yamashita A., Kashima I., Schell T., Anders K.R., Grimson A., Hachiya T., Hentze M.W., Anderson P., Ohno S.
      Mol. Cell 12:1187-1200(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX CONTAINING SMG5; SMG7; UPF1; PPP2CA AND UPF3.
    2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-900.
      Tissue: Bone marrow.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT ILE-900.
      Tissue: Testis.
    7. "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay."
      Unterholzner L., Izaurralde E.
      Mol. Cell 16:587-596(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH CYTOPLASMIC MRNA DECAY BODIES.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520 AND SER-781, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-781, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway."
      Fukuhara N., Ebert J., Unterholzner L., Lindner D., Izaurralde E., Conti E.
      Mol. Cell 17:537-547(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 1-497, FUNCTION, INTERACTION WITH SMG5 AND PHOSPHORYLATED RENT1, SUBCELLULAR LOCATION, TPR REPEAT, MUTAGENESIS OF LYS-66 AND ARG-163.

    Entry informationi

    Entry nameiSMG7_HUMAN
    AccessioniPrimary (citable) accession number: Q92540
    Secondary accession number(s): B4DRB2
    , E9PCI0, E9PEH2, Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3