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Protein

Protein SMG7

Gene

SMG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.2 Publications

GO - Molecular functioni

  • protein phosphatase 2A binding Source: HGNC
  • ribonuclease activity Source: GO_Central
  • ribonucleoprotein complex binding Source: GO_Central
  • telomerase RNA binding Source: GO_Central
  • telomeric DNA binding Source: BHF-UCL

GO - Biological processi

  • mRNA export from nucleus Source: HGNC
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: HGNC
  • regulation of dephosphorylation Source: HGNC
  • regulation of RNA stability Source: GO_Central
  • telomere maintenance via telomerase Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Nonsense-mediated mRNA decay

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116698-MONOMER.
ReactomeiR-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SMG7
Alternative name(s):
EST1-like protein C
SMG-7 homolog
Short name:
hSMG-7
Gene namesi
Name:SMG7
Synonyms:C1orf16, EST1C, KIAA0250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16792. SMG7.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • cytosol Source: Reactome
  • intermediate filament cytoskeleton Source: HPA
  • nucleus Source: HGNC
  • telomerase holoenzyme complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi66K → E: Abolishes interaction with UPF1; when associated with E-163. 1 Publication1
Mutagenesisi163R → E: Abolishes interaction with UPF1; when associated with E-66. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000116698.
PharmGKBiPA25605.

Polymorphism and mutation databases

BioMutaiSMG7.
DMDMi84028262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000763242 – 1137Protein SMG7Add BLAST1136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei520PhosphoserineCombined sources1
Modified residuei624PhosphothreonineCombined sources1
Modified residuei781PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ92540.
PeptideAtlasiQ92540.
PRIDEiQ92540.

PTM databases

iPTMnetiQ92540.
PhosphoSitePlusiQ92540.

Expressioni

Gene expression databases

BgeeiENSG00000116698.
CleanExiHS_SMG7.
ExpressionAtlasiQ92540. baseline and differential.
GenevisibleiQ92540. HS.

Organism-specific databases

HPAiHPA029350.

Interactioni

Subunit structurei

Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SMG5Q9UPR35EBI-719830,EBI-3400861
UPF1Q929003EBI-719830,EBI-373471

GO - Molecular functioni

  • protein phosphatase 2A binding Source: HGNC

Protein-protein interaction databases

BioGridi115218. 30 interactors.
IntActiQ92540. 21 interactors.
MINTiMINT-1413681.

Structurei

Secondary structure

11137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 16Combined sources15
Helixi17 – 19Combined sources3
Beta strandi22 – 24Combined sources3
Beta strandi26 – 29Combined sources4
Helixi30 – 46Combined sources17
Helixi48 – 54Combined sources7
Helixi56 – 64Combined sources9
Helixi66 – 76Combined sources11
Turni82 – 85Combined sources4
Helixi86 – 109Combined sources24
Helixi145 – 164Combined sources20
Helixi168 – 181Combined sources14
Helixi187 – 198Combined sources12
Helixi202 – 213Combined sources12
Beta strandi214 – 217Combined sources4
Helixi220 – 233Combined sources14
Helixi246 – 262Combined sources17
Helixi266 – 268Combined sources3
Helixi269 – 285Combined sources17
Helixi291 – 308Combined sources18
Helixi311 – 314Combined sources4
Helixi322 – 347Combined sources26
Beta strandi356 – 360Combined sources5
Helixi361 – 371Combined sources11
Helixi375 – 379Combined sources5
Helixi381 – 384Combined sources4
Turni385 – 388Combined sources4
Helixi390 – 397Combined sources8
Helixi398 – 400Combined sources3
Helixi416 – 420Combined sources5
Turni421 – 423Combined sources3
Helixi425 – 427Combined sources3
Helixi428 – 431Combined sources4
Helixi449 – 469Combined sources21
Turni471 – 473Combined sources3
Beta strandi475 – 479Combined sources5
Beta strandi482 – 486Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YA0X-ray2.55A/B1-497[»]
ProteinModelPortaliQ92540.
SMRiQ92540.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92540.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati152 – 185TPR 11 PublicationAdd BLAST34
Repeati187 – 219TPR 21 PublicationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi648 – 843Gln/Pro-richAdd BLAST196
Compositional biasi922 – 1015Ser-richAdd BLAST94

Sequence similaritiesi

Contains 2 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

GeneTreeiENSGT00560000077120.
HOGENOMiHOG000049052.
HOVERGENiHBG056330.
InParanoidiQ92540.
KOiK14409.
OMAiQCENEVG.
OrthoDBiEOG091G04DJ.
PhylomeDBiQ92540.
TreeFamiTF327119.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR018834. DNA/RNA-bd_Est1-type.
IPR019458. EST1.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF10374. EST1. 1 hit.
PF10373. EST1_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92540-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY
60 70 80 90 100
ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG
110 120 130 140 150
FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI
160 170 180 190 200
CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG
210 220 230 240 250
DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI
260 270 280 290 300
KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI
310 320 330 340 350
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE
360 370 380 390 400
SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF
410 420 430 440 450
HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ
460 470 480 490 500
QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDPSEA
510 520 530 540 550
KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG EKPVVTFKEN
560 570 580 590 600
IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL
610 620 630 640 650
EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH
660 670 680 690 700
HPGAFPPLPS RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA
710 720 730 740 750
HSPAGNQVQA GKQSHIPYSQ QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ
760 770 780 790 800
PTAQSTSQLQ VQALTQQQQS PTKAVPALGK SPPHHSGFQQ YQQADASKQL
810 820 830 840 850
WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM QQQPLEKKMK
860 870 880 890 900
PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV
910 920 930 940 950
FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF
960 970 980 990 1000
NEVYGKNLTS SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA
1010 1020 1030 1040 1050
SQSPHSSNPS SLPSSPPTHN HNSVPFSNFG PIGTPDNRDR RTADRWKTDK
1060 1070 1080 1090 1100
PAMGGFGIDY LSATSSSESS WHQASTPSGT WTGHGPSMED SSAVLMESLK
1110 1120 1130
SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH
Length:1,137
Mass (Da):127,282
Last modified:December 20, 2005 - v2
Checksum:iE152AFAFEF8F3A42
GO
Isoform 2 (identifier: Q92540-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.

Show »
Length:1,091
Mass (Da):122,020
Checksum:i2E6B7AFB0201D533
GO
Isoform 4 (identifier: Q92540-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.
     914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF
     1101-1137: SIWSSSMMHP...RGQGTMNPPH → KQQHGVQQLG...PFWKRRKKGK

Show »
Length:1,178
Mass (Da):131,650
Checksum:i2087382714FE3D57
GO
Isoform 5 (identifier: Q92540-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF

Show »
Length:1,145
Mass (Da):127,854
Checksum:i9F9B61B6384AA0FA
GO

Sequence cautioni

The sequence BAA13381 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187Q → R in BAG61224 (PubMed:14702039).Curated1
Sequence conflicti282R → E in BAC53621 (PubMed:14636577).Curated1
Isoform 4 (identifier: Q92540-4)
Sequence conflicti854V → I in AAH36381 (PubMed:16710414).Curated1
Sequence conflicti898P → T in AAH36381 (PubMed:16710414).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051363627S → F.Corresponds to variant rs34221194dbSNPEnsembl.1
Natural variantiVAR_051364900V → I.2 PublicationsCorresponds to variant rs2298083dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471301 – 42Missing in isoform 5. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_016574569 – 614Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_016575914E → EDPKSSPLLPPDLLKSLAAL EEEEELIFSNPPDLYPALLG PLASLPGRSLF in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_0165761101 – 1137SIWSS…MNPPH → KQQHGVQQLGPKRQSEEEGS SSICVAHRGPRPLPSCSLPA STFRVKFKAARTCAHQAQKK TRRRPFWKRRKKGK in isoform 4. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085674 mRNA. Translation: BAC53621.1.
D87437 mRNA. Translation: BAA13381.2. Different initiation.
AK299178 mRNA. Translation: BAG61224.1.
AL449223, AL137800 Genomic DNA. Translation: CAI16627.1.
AL137800, AL449223 Genomic DNA. Translation: CAI19486.1.
BC036381 mRNA. Translation: AAH36381.1.
BC052565 mRNA. Translation: AAH52565.1.
CCDSiCCDS1355.1. [Q92540-1]
CCDS41445.2. [Q92540-4]
CCDS53444.1. [Q92540-2]
CCDS53445.1. [Q92540-5]
RefSeqiNP_001167532.1. NM_001174061.1. [Q92540-5]
NP_775179.1. NM_173156.2. [Q92540-1]
NP_963862.1. NM_201568.2. [Q92540-2]
NP_963863.2. NM_201569.2. [Q92540-4]
UniGeneiHs.591463.

Genome annotation databases

EnsembliENST00000347615; ENSP00000340766; ENSG00000116698. [Q92540-1]
ENST00000507469; ENSP00000425133; ENSG00000116698. [Q92540-4]
ENST00000508461; ENSP00000426915; ENSG00000116698. [Q92540-5]
ENST00000515829; ENSP00000421358; ENSG00000116698. [Q92540-2]
GeneIDi9887.
KEGGihsa:9887.
UCSCiuc001gqf.4. human. [Q92540-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085674 mRNA. Translation: BAC53621.1.
D87437 mRNA. Translation: BAA13381.2. Different initiation.
AK299178 mRNA. Translation: BAG61224.1.
AL449223, AL137800 Genomic DNA. Translation: CAI16627.1.
AL137800, AL449223 Genomic DNA. Translation: CAI19486.1.
BC036381 mRNA. Translation: AAH36381.1.
BC052565 mRNA. Translation: AAH52565.1.
CCDSiCCDS1355.1. [Q92540-1]
CCDS41445.2. [Q92540-4]
CCDS53444.1. [Q92540-2]
CCDS53445.1. [Q92540-5]
RefSeqiNP_001167532.1. NM_001174061.1. [Q92540-5]
NP_775179.1. NM_173156.2. [Q92540-1]
NP_963862.1. NM_201568.2. [Q92540-2]
NP_963863.2. NM_201569.2. [Q92540-4]
UniGeneiHs.591463.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YA0X-ray2.55A/B1-497[»]
ProteinModelPortaliQ92540.
SMRiQ92540.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115218. 30 interactors.
IntActiQ92540. 21 interactors.
MINTiMINT-1413681.

PTM databases

iPTMnetiQ92540.
PhosphoSitePlusiQ92540.

Polymorphism and mutation databases

BioMutaiSMG7.
DMDMi84028262.

Proteomic databases

MaxQBiQ92540.
PeptideAtlasiQ92540.
PRIDEiQ92540.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347615; ENSP00000340766; ENSG00000116698. [Q92540-1]
ENST00000507469; ENSP00000425133; ENSG00000116698. [Q92540-4]
ENST00000508461; ENSP00000426915; ENSG00000116698. [Q92540-5]
ENST00000515829; ENSP00000421358; ENSG00000116698. [Q92540-2]
GeneIDi9887.
KEGGihsa:9887.
UCSCiuc001gqf.4. human. [Q92540-1]

Organism-specific databases

CTDi9887.
GeneCardsiSMG7.
H-InvDBHIX0001408.
HGNCiHGNC:16792. SMG7.
HPAiHPA029350.
MIMi610964. gene.
neXtProtiNX_Q92540.
OpenTargetsiENSG00000116698.
PharmGKBiPA25605.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00560000077120.
HOGENOMiHOG000049052.
HOVERGENiHBG056330.
InParanoidiQ92540.
KOiK14409.
OMAiQCENEVG.
OrthoDBiEOG091G04DJ.
PhylomeDBiQ92540.
TreeFamiTF327119.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116698-MONOMER.
ReactomeiR-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiSMG7. human.
EvolutionaryTraceiQ92540.
GeneWikiiSMG7.
GenomeRNAii9887.
PROiQ92540.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116698.
CleanExiHS_SMG7.
ExpressionAtlasiQ92540. baseline and differential.
GenevisibleiQ92540. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR018834. DNA/RNA-bd_Est1-type.
IPR019458. EST1.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF10374. EST1. 1 hit.
PF10373. EST1_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMG7_HUMAN
AccessioniPrimary (citable) accession number: Q92540
Secondary accession number(s): B4DRB2
, E9PCI0, E9PEH2, Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 20, 2005
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.