##gff-version 3 Q92538 UniProtKB Chain 1 1860 . . . ID=PRO_0000120210;Note=Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 Q92538 UniProtKB Domain 693 883 . . . Note=SEC7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00189 Q92538 UniProtKB Region 1 381 . . . Note=Interaction with RAB1B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17429068;Dbxref=PMID:17429068 Q92538 UniProtKB Region 1 211 . . . Note=DCB%3B DCB:DCB domain and DCB:HUS domain interaction;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R1D7 Q92538 UniProtKB Region 215 266 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Region 281 372 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Region 531 551 . . . Note=HUS%3B DCB:HUS domain interaction;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R1D7 Q92538 UniProtKB Region 620 666 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Region 887 1371 . . . Note=Phosphatidylinositol-phosphate binding%3B required for translocation to the leading edge and for ARF1 activation upon GPCR signaling;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22573891;Dbxref=PMID:22573891 Q92538 UniProtKB Region 1285 1336 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Region 1351 1371 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Region 1431 1484 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Region 1726 1809 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Compositional bias 246 265 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Compositional bias 281 326 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Compositional bias 1301 1319 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Compositional bias 1320 1336 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Compositional bias 1775 1794 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Compositional bias 1795 1809 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92538 UniProtKB Modified residue 350 350 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q92538 UniProtKB Modified residue 353 353 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q92538 UniProtKB Modified residue 508 508 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18088087;Dbxref=PMID:18088087 Q92538 UniProtKB Modified residue 663 663 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q92538 UniProtKB Modified residue 1299 1299 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:24275569 Q92538 UniProtKB Modified residue 1317 1317 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q92538 UniProtKB Modified residue 1319 1319 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q92538 UniProtKB Modified residue 1321 1321 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q92538 UniProtKB Modified residue 1336 1336 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q92538 UniProtKB Modified residue 1338 1338 . . . Note=Phosphothreonine%3B by AMPK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18063581;Dbxref=PMID:18063581 Q92538 UniProtKB Modified residue 1476 1476 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q92538 UniProtKB Modified residue 1774 1774 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q92538 UniProtKB Modified residue 1785 1785 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569 Q92538 UniProtKB Alternative sequence 337 338 . . . ID=VSP_062172;Note=In isoform 4 and isoform 3. QQ->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:9039502,ECO:0000269|PubMed:9828135;Dbxref=PMID:9039502,PMID:9828135 Q92538 UniProtKB Alternative sequence 1495 1498 . . . ID=VSP_057523;Note=In isoform 2 and isoform 3. Missing Q92538 UniProtKB Natural variant 983 983 . . . ID=VAR_088570;Note=In CMT2GG%3B uncertain significance. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32937143;Dbxref=dbSNP:rs2060050669,PMID:32937143 Q92538 UniProtKB Natural variant 1138 1138 . . . ID=VAR_088571;Note=In CMT2GG%3B uncertain significance. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32937143;Dbxref=dbSNP:rs1299997613,PMID:32937143 Q92538 UniProtKB Natural variant 1176 1860 . . . ID=VAR_088572;Note=In CMT2GG%3B likely pathogenic. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32937143;Dbxref=dbSNP:rs2060161763,PMID:32937143 Q92538 UniProtKB Natural variant 1462 1462 . . . ID=VAR_088573;Note=In CMT2GG%3B uncertain significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32937143;Dbxref=dbSNP:rs2060541274,PMID:32937143 Q92538 UniProtKB Natural variant 1694 1694 . . . ID=VAR_051926;Note=G->S;Dbxref=dbSNP:rs11191274 Q92538 UniProtKB Mutagenesis 544 544 . . . Note=Increases interaction with COPG1 and PNPLA2. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19039328,ECO:0000269|PubMed:21789191;Dbxref=PMID:19039328,PMID:21789191 Q92538 UniProtKB Mutagenesis 795 795 . . . Note=Inhibits Golgi membrane recruitment of GGA1%2C GGA2 and GGA3%3B generates misprocessing of PSAP. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17666033;Dbxref=PMID:17666033 Q92538 UniProtKB Mutagenesis 795 795 . . . Note=Arrests retrograde ERGIC/cis-Golgi-to-ER transport at an early step and causes disassembly of the Golgi and disassociation of COP1 from membranes. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12808027;Dbxref=PMID:12808027 Q92538 UniProtKB Mutagenesis 833 833 . . . Note=Confers BFA tolerance. M->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15616190;Dbxref=PMID:15616190 Q92538 UniProtKB Mutagenesis 1338 1338 . . . Note=Prevents 2-DG-induced Golgi disassembly. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18063581;Dbxref=PMID:18063581 Q92538 UniProtKB Sequence conflict 24 24 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92538 UniProtKB Sequence conflict 460 460 . . . Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92538 UniProtKB Sequence conflict 531 531 . . . Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92538 UniProtKB Sequence conflict 1812 1812 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305