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Protein

Sushi domain-containing protein 6

Gene

SUSD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).By similarity2 Publications

GO - Biological processi

  • cell death Source: UniProtKB
  • cellular response to DNA damage stimulus Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 6Imported
Alternative name(s):
Drug-activated gene overexpressed protein1 Publication
Gene namesi
Name:SUSD6Imported
Synonyms:DRAGO1 Publication, KIAA0247Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100647.7
HGNCiHGNC:19956 SUSD6
neXtProtiNX_Q92537

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini40 – 120ExtracellularSequence analysisAdd BLAST81
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 303CytoplasmicSequence analysisAdd BLAST162

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi9766
OpenTargetsiENSG00000100647
PharmGKBiPA128394557

Polymorphism and mutation databases

BioMutaiKIAA0247
DMDMi2495723

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000001398540 – 303Sushi domain-containing protein 6Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 89PROSITE-ProRule annotation
Disulfide bondi74 ↔ 102PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ92537
PeptideAtlasiQ92537
PRIDEiQ92537

PTM databases

iPTMnetiQ92537
PhosphoSitePlusiQ92537

Expressioni

Inductioni

Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium.2 Publications

Gene expression databases

BgeeiENSG00000100647
CleanExiHS_KIAA0247
GenevisibleiQ92537 HS

Organism-specific databases

HPAiHPA030464

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi1151127 interactors.
IntActiQ92537 4 interactors.
MINTiQ92537

Structurei

3D structure databases

ProteinModelPortaliQ92537
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 104SushiPROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYD Eukaryota
ENOG410YAB5 LUCA
GeneTreeiENSGT00530000063768
HOGENOMiHOG000113143
HOVERGENiHBG052175
InParanoidiQ92537
OMAiLCEAWGS
OrthoDBiEOG091G0E24
PhylomeDBiQ92537
TreeFamiTF332459

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SUPFAMiSSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHGRIAPKS TSVFAVASVG HGVFLPLVIL CTLLGDGLAS VCPLPPEPEN
60 70 80 90 100
GGYICHPRPC RDPLTAGSVI EYLCAEGYML KGDYKYLTCK NGEWKPAMEI
110 120 130 140 150
SCRLNEDKDT HTSLGVPTLS IVASTASSVA LILLLVVLFV LLQPKLKSFH
160 170 180 190 200
HSRRDQGVSG DQVSIMVDGV QVALPSYEEA VYGSSGHCVP PADPRVQIVL
210 220 230 240 250
SEGSGPSGRS VPREQQLPDQ GACSSAGGED EAPGQSGLCE AWGSRASETV
260 270 280 290 300
MVHQATTSSW VAGSGNRQLA HKETADSENS DIQSLLSLTS EEYTDDIPLL

KEA
Length:303
Mass (Da):32,090
Last modified:February 1, 1997 - v1
Checksum:iD5EBDB2F2A8781E1
GO

Sequence cautioni

The sequence BAA13378 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87434 mRNA Translation: BAA13378.2 Different initiation.
BC064697 mRNA Translation: AAH64697.1
CCDSiCCDS9796.1
RefSeqiNP_055549.1, NM_014734.3
XP_011535714.1, XM_011537412.1
XP_016877327.1, XM_017021838.1
XP_016877328.1, XM_017021839.1
UniGeneiHs.440025

Genome annotation databases

EnsembliENST00000342745; ENSP00000344424; ENSG00000100647
GeneIDi9766
KEGGihsa:9766
UCSCiuc001xlk.4 human

Similar proteinsi

Entry informationi

Entry nameiSUSD6_HUMAN
AccessioniPrimary (citable) accession number: Q92537
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome