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Protein

Sushi domain-containing protein 6

Gene

SUSD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).By similarity2 Publications

GO - Biological processi

  • cell death Source: UniProtKB
  • cellular response to DNA damage stimulus Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 6Imported
Alternative name(s):
Drug-activated gene overexpressed protein1 Publication
Gene namesi
Name:SUSD6Imported
Synonyms:DRAGO1 Publication, KIAA0247Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19956. SUSD6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini40 – 12081ExtracellularSequence analysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Topological domaini142 – 303162CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA128394557.

Polymorphism and mutation databases

BioMutaiKIAA0247.
DMDMi2495723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence analysisAdd
BLAST
Chaini40 – 303264Sushi domain-containing protein 6PRO_0000013985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 89PROSITE-ProRule annotation
Disulfide bondi74 ↔ 102PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ92537.
PaxDbiQ92537.
PRIDEiQ92537.

PTM databases

iPTMnetiQ92537.
PhosphoSiteiQ92537.

Expressioni

Inductioni

Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium.2 Publications

Gene expression databases

BgeeiQ92537.
CleanExiHS_KIAA0247.
GenevisibleiQ92537. HS.

Organism-specific databases

HPAiHPA030464.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-2866213,EBI-10173507
KRTAP10-8P604103EBI-2866213,EBI-10171774

Protein-protein interaction databases

BioGridi115112. 6 interactions.
IntActiQ92537. 3 interactions.
STRINGi9606.ENSP00000344424.

Structurei

3D structure databases

ProteinModelPortaliQ92537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 10465SushiPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYD. Eukaryota.
ENOG410YAB5. LUCA.
GeneTreeiENSGT00530000063768.
HOGENOMiHOG000113143.
HOVERGENiHBG052175.
InParanoidiQ92537.
OMAiLCEAWGS.
OrthoDBiEOG7PVWQF.
PhylomeDBiQ92537.
TreeFamiTF332459.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHGRIAPKS TSVFAVASVG HGVFLPLVIL CTLLGDGLAS VCPLPPEPEN
60 70 80 90 100
GGYICHPRPC RDPLTAGSVI EYLCAEGYML KGDYKYLTCK NGEWKPAMEI
110 120 130 140 150
SCRLNEDKDT HTSLGVPTLS IVASTASSVA LILLLVVLFV LLQPKLKSFH
160 170 180 190 200
HSRRDQGVSG DQVSIMVDGV QVALPSYEEA VYGSSGHCVP PADPRVQIVL
210 220 230 240 250
SEGSGPSGRS VPREQQLPDQ GACSSAGGED EAPGQSGLCE AWGSRASETV
260 270 280 290 300
MVHQATTSSW VAGSGNRQLA HKETADSENS DIQSLLSLTS EEYTDDIPLL

KEA
Length:303
Mass (Da):32,090
Last modified:February 1, 1997 - v1
Checksum:iD5EBDB2F2A8781E1
GO

Sequence cautioni

The sequence BAA13378.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87434 mRNA. Translation: BAA13378.2. Different initiation.
BC064697 mRNA. Translation: AAH64697.1.
CCDSiCCDS9796.1.
RefSeqiNP_055549.1. NM_014734.3.
XP_011535714.1. XM_011537412.1.
UniGeneiHs.440025.

Genome annotation databases

EnsembliENST00000342745; ENSP00000344424; ENSG00000100647.
GeneIDi9766.
KEGGihsa:9766.
UCSCiuc001xlk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87434 mRNA. Translation: BAA13378.2. Different initiation.
BC064697 mRNA. Translation: AAH64697.1.
CCDSiCCDS9796.1.
RefSeqiNP_055549.1. NM_014734.3.
XP_011535714.1. XM_011537412.1.
UniGeneiHs.440025.

3D structure databases

ProteinModelPortaliQ92537.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115112. 6 interactions.
IntActiQ92537. 3 interactions.
STRINGi9606.ENSP00000344424.

PTM databases

iPTMnetiQ92537.
PhosphoSiteiQ92537.

Polymorphism and mutation databases

BioMutaiKIAA0247.
DMDMi2495723.

Proteomic databases

EPDiQ92537.
PaxDbiQ92537.
PRIDEiQ92537.

Protocols and materials databases

DNASUi9766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342745; ENSP00000344424; ENSG00000100647.
GeneIDi9766.
KEGGihsa:9766.
UCSCiuc001xlk.4. human.

Organism-specific databases

CTDi9766.
GeneCardsiSUSD6.
HGNCiHGNC:19956. SUSD6.
HPAiHPA030464.
neXtProtiNX_Q92537.
PharmGKBiPA128394557.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYD. Eukaryota.
ENOG410YAB5. LUCA.
GeneTreeiENSGT00530000063768.
HOGENOMiHOG000113143.
HOVERGENiHBG052175.
InParanoidiQ92537.
OMAiLCEAWGS.
OrthoDBiEOG7PVWQF.
PhylomeDBiQ92537.
TreeFamiTF332459.

Miscellaneous databases

ChiTaRSiKIAA0247. human.
GenomeRNAii9766.
PROiQ92537.

Gene expression databases

BgeeiQ92537.
CleanExiHS_KIAA0247.
GenevisibleiQ92537. HS.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Characterization of SVEP1, KIAA, and SRPX2 in an in vitro cell culture model of endotoxemia."
    Schwanzer-Pfeiffer D., Rossmanith E., Schildberger A., Falkenhagen D.
    Cell. Immunol. 263:65-70(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  4. "DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]."
    Polato F., Rusconi P., Zangrossi S., Morelli F., Boeri M., Musi A., Marchini S., Castiglioni V., Scanziani E., Torri V., Broggini M.
    J. Natl. Cancer Inst. 106:1-10(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiSUSD6_HUMAN
AccessioniPrimary (citable) accession number: Q92537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.