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Protein

Y+L amino acid transporter 2

Gene

SLC7A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.8 Publications

Enzyme regulationi

Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and histidine, in the presence of Na+. Also inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA). Mutual inhibition is observed when leucine or glutamine is used as substrate. Inhibition of arginine and leucine uptake also occurs when SLC3A2/4F2hc is either truncated at its C-terminus or mutated at critical residues within the terminal 15 amino acids.

Kineticsi

  1. KM=295 µM for glutamine (in the presence of NaCl)1 Publication
  2. KM=236 µM for leucine (in the presence of NaCl)1 Publication
  3. KM=120 µM for arginine (in the presence of NaCl)1 Publication
  4. KM=138 µM for arginine (in the absence of NaCl)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • cellular amino acid metabolic process Source: ProtInc
    • leukocyte migration Source: Reactome
    • protein-containing complex assembly Source: ProtInc

    Keywordsi

    Biological processAmino-acid transport, Antiport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000103064-MONOMER
    ReactomeiR-HSA-210991 Basigin interactions
    R-HSA-352230 Amino acid transport across the plasma membrane
    SABIO-RKiQ92536

    Protein family/group databases

    TCDBi2.A.3.8.23 the amino acid-polyamine-organocation (apc) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Y+L amino acid transporter 2
    Alternative name(s):
    Cationic amino acid transporter, y+ system
    Solute carrier family 7 member 6
    y(+)L-type amino acid transporter 2
    Short name:
    Y+LAT2
    Short name:
    y+LAT-2
    Gene namesi
    Name:SLC7A6Imported
    Synonyms:KIAA0245Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 16

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000103064.13
    HGNCiHGNC:11064 SLC7A6
    MIMi605641 gene
    neXtProtiNX_Q92536

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
    Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
    Topological domaini66 – 78ExtracellularSequence analysisAdd BLAST13
    Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
    Topological domaini100 – 114CytoplasmicSequence analysisAdd BLAST15
    Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
    Topological domaini136 – 167ExtracellularSequence analysisAdd BLAST32
    Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
    Topological domaini189 – 194CytoplasmicSequence analysis6
    Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
    Topological domaini216 – 235ExtracellularSequence analysisAdd BLAST20
    Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
    Topological domaini257 – 266CytoplasmicSequence analysis10
    Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
    Topological domaini288 – 311ExtracellularSequence analysisAdd BLAST24
    Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
    Topological domaini333 – 363CytoplasmicSequence analysisAdd BLAST31
    Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
    Topological domaini385ExtracellularSequence analysis1
    Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
    Topological domaini407 – 425CytoplasmicSequence analysisAdd BLAST19
    Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
    Topological domaini447 – 451ExtracellularSequence analysis5
    Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
    Topological domaini473 – 515CytoplasmicSequence analysisAdd BLAST43

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi9057
    OpenTargetsiENSG00000103064
    PharmGKBiPA35924

    Polymorphism and mutation databases

    BioMutaiSLC7A6
    DMDMi190462822

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003414771 – 515Y+L amino acid transporter 2Add BLAST515

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei30PhosphoserineBy similarity1

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    EPDiQ92536
    MaxQBiQ92536
    PaxDbiQ92536
    PeptideAtlasiQ92536
    PRIDEiQ92536

    PTM databases

    iPTMnetiQ92536
    PhosphoSitePlusiQ92536

    Expressioni

    Tissue specificityi

    Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.6 Publications

    Gene expression databases

    BgeeiENSG00000103064
    CleanExiHS_SLC7A6
    ExpressionAtlasiQ92536 baseline and differential
    GenevisibleiQ92536 HS

    Organism-specific databases

    HPAiHPA050713

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.2 Publications

    Protein-protein interaction databases

    BioGridi114519, 6 interactors
    IntActiQ92536, 2 interactors
    STRINGi9606.ENSP00000219343

    Structurei

    3D structure databases

    ProteinModelPortaliQ92536
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1287 Eukaryota
    COG0531 LUCA
    GeneTreeiENSGT00760000119037
    HOGENOMiHOG000098892
    HOVERGENiHBG000476
    InParanoidiQ92536
    KOiK13872
    OMAiPFKAWLP
    OrthoDBiEOG091G07EM
    PhylomeDBiQ92536
    TreeFamiTF313355

    Family and domain databases

    InterProiView protein in InterPro
    IPR002293 AA/rel_permease1
    PfamiView protein in Pfam
    PF13520 AA_permease_2, 1 hit
    PIRSFiPIRSF006060 AA_transporter, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q92536-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MEAREPGRPT PTYHLVPNTS QSQVEEDVSS PPQRSSETMQ LKKEISLLNG
    60 70 80 90 100
    VSLVVGNMIG SGIFVSPKGV LVHTASYGMS LIVWAIGGLF SVVGALCYAE
    110 120 130 140 150
    LGTTITKSGA SYAYILEAFG GFIAFIRLWV SLLVVEPTGQ AIIAITFANY
    160 170 180 190 200
    IIQPSFPSCD PPYLACRLLA AACICLLTFV NCAYVKWGTR VQDTFTYAKV
    210 220 230 240 250
    VALIAIIVMG LVKLCQGHSE HFQDAFEGSS WDMGNLSLAL YSALFSYSGW
    260 270 280 290 300
    DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNISDVLS
    310 320 330 340 350
    SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG
    360 370 380 390 400
    HLPDLLSMIH IERFTPIPAL LFNCTMALIY LIVEDVFQLI NYFSFSYWFF
    410 420 430 440 450
    VGLSVVGQLY LRWKEPKRPR PLKLSVFFPI VFCICSVFLV IVPLFTDTIN
    460 470 480 490 500
    SLIGIGIALS GVPFYFMGVY LPESRRPLFI RNVLAAITRG TQQLCFCVLT
    510
    ELDVAEEKKD ERKTD
    Length:515
    Mass (Da):56,828
    Last modified:June 10, 2008 - v3
    Checksum:i4E92F6E1972351A9
    GO

    Sequence cautioni

    The sequence BAA13376 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti8R → G in CAH18146 (PubMed:17974005).Curated1
    Sequence conflicti388Q → R in CAH18146 (PubMed:17974005).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D87432 mRNA Translation: BAA13376.2 Different initiation.
    CR749291 mRNA Translation: CAH18146.1
    CH471092 Genomic DNA Translation: EAW83219.1
    BC028216 mRNA Translation: AAH28216.1
    CCDSiCCDS32470.1
    RefSeqiNP_001070253.1, NM_001076785.2
    NP_003974.3, NM_003983.5
    XP_011521735.1, XM_011523433.1
    XP_011521736.1, XM_011523434.1
    XP_011521740.1, XM_011523438.1
    UniGeneiHs.679580

    Genome annotation databases

    EnsembliENST00000219343; ENSP00000219343; ENSG00000103064
    ENST00000566454; ENSP00000455064; ENSG00000103064
    GeneIDi9057
    KEGGihsa:9057
    UCSCiuc002evt.3 human

    Similar proteinsi

    Entry informationi

    Entry nameiYLAT2_HUMAN
    AccessioniPrimary (citable) accession number: Q92536
    Secondary accession number(s): Q68DS4, Q7L1N3
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: May 23, 2018
    This is version 142 of the entry and version 3 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

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