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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Gene

PIGC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi

GO - Molecular functioni

  1. catalytic activity Source: ProtInc
  2. phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. C-terminal protein lipidation Source: Reactome
  3. GPI anchor biosynthetic process Source: ProtInc
  4. post-translational protein modification Source: Reactome
  5. preassembly of GPI anchor in ER membrane Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiREACT_952. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC:2.4.1.198)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name:
PIG-C
Gene namesi
Name:PIGC
Synonyms:GPI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8960. PIGC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33291.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Phosphatidylinositol N-acetylglucosaminyltransferase subunit CPRO_0000058431Add
BLAST

Proteomic databases

MaxQBiQ92535.
PaxDbiQ92535.
PRIDEiQ92535.

PTM databases

PhosphoSiteiQ92535.

Expressioni

Gene expression databases

BgeeiQ92535.
CleanExiHS_PIGC.
GenevestigatoriQ92535.

Organism-specific databases

HPAiHPA036663.

Interactioni

Subunit structurei

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity.

Protein-protein interaction databases

BioGridi111297. 3 interactions.
IntActiQ92535. 2 interactions.
MINTiMINT-1424659.
STRINGi9606.ENSP00000258324.

Structurei

3D structure databases

ProteinModelPortaliQ92535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275923.
GeneTreeiENSGT00390000005496.
HOGENOMiHOG000194668.
HOVERGENiHBG009071.
InParanoidiQ92535.
KOiK03859.
OMAiNIHARKY.
OrthoDBiEOG7KSX8X.
PhylomeDBiQ92535.
TreeFamiTF314325.

Family and domain databases

InterProiIPR009450. Plno_GlcNAc_GPI2.
[Graphical view]
PANTHERiPTHR12982. PTHR12982. 1 hit.
PfamiPF06432. GPI2. 1 hit.
[Graphical view]
PIRSFiPIRSF016104. GPI2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAQPVTNTK EVKWQKVLYE RQPFPDNYVD RRFLEELRKN IHARKYQYWA
60 70 80 90 100
VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APHWLLGTGL ASSLIGYVLF
110 120 130 140 150
DLIDGGEGRK KSGQTRWADL KSALVFITFT YGFSPVLKTL TESVSTDTIY
160 170 180 190 200
AMSVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF
210 220 230 240 250
IMVTFAIQIF ALWPMLQKKL KACTPRSYVG VTLLFAFSAV GGLLSISAVG
260 270 280 290
AVLFALLLMS ISCLCPFYLI RLQLFKENIH GPWDEAEIKE DLSRFLS
Length:297
Mass (Da):33,583
Last modified:February 1, 1997 - v1
Checksum:iBD9584C5D5203A4B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti266 – 2661P → S.1 Publication
Corresponds to variant rs1063412 [ dbSNP | Ensembl ].
VAR_011360

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85418 mRNA. Translation: BAA12812.1.
AB000360 Genomic DNA. Translation: BAA22866.1.
BT006734 mRNA. Translation: AAP35380.1.
CR450292 mRNA. Translation: CAG29288.1.
Z97195 Genomic DNA. Translation: CAB10071.1.
BC006539 mRNA. Translation: AAH06539.1.
CCDSiCCDS1302.1.
PIRiJC4969.
RefSeqiNP_002633.1. NM_002642.3.
NP_714969.1. NM_153747.1.
XP_006711446.1. XM_006711383.1.
UniGeneiHs.188456.

Genome annotation databases

EnsembliENST00000344529; ENSP00000356701; ENSG00000135845.
ENST00000367728; ENSP00000356702; ENSG00000135845.
GeneIDi5279.
KEGGihsa:5279.
UCSCiuc001gin.3. human.

Polymorphism databases

DMDMi14916629.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85418 mRNA. Translation: BAA12812.1.
AB000360 Genomic DNA. Translation: BAA22866.1.
BT006734 mRNA. Translation: AAP35380.1.
CR450292 mRNA. Translation: CAG29288.1.
Z97195 Genomic DNA. Translation: CAB10071.1.
BC006539 mRNA. Translation: AAH06539.1.
CCDSiCCDS1302.1.
PIRiJC4969.
RefSeqiNP_002633.1. NM_002642.3.
NP_714969.1. NM_153747.1.
XP_006711446.1. XM_006711383.1.
UniGeneiHs.188456.

3D structure databases

ProteinModelPortaliQ92535.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111297. 3 interactions.
IntActiQ92535. 2 interactions.
MINTiMINT-1424659.
STRINGi9606.ENSP00000258324.

PTM databases

PhosphoSiteiQ92535.

Polymorphism databases

DMDMi14916629.

Proteomic databases

MaxQBiQ92535.
PaxDbiQ92535.
PRIDEiQ92535.

Protocols and materials databases

DNASUi5279.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344529; ENSP00000356701; ENSG00000135845.
ENST00000367728; ENSP00000356702; ENSG00000135845.
GeneIDi5279.
KEGGihsa:5279.
UCSCiuc001gin.3. human.

Organism-specific databases

CTDi5279.
GeneCardsiGC01M172339.
HGNCiHGNC:8960. PIGC.
HPAiHPA036663.
MIMi601730. gene.
neXtProtiNX_Q92535.
PharmGKBiPA33291.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG275923.
GeneTreeiENSGT00390000005496.
HOGENOMiHOG000194668.
HOVERGENiHBG009071.
InParanoidiQ92535.
KOiK03859.
OMAiNIHARKY.
OrthoDBiEOG7KSX8X.
PhylomeDBiQ92535.
TreeFamiTF314325.

Enzyme and pathway databases

UniPathwayiUPA00196.
ReactomeiREACT_952. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

ChiTaRSiPIGC. human.
GeneWikiiPIGC.
GenomeRNAii5279.
NextBioi20400.
PROiQ92535.
SOURCEiSearch...

Gene expression databases

BgeeiQ92535.
CleanExiHS_PIGC.
GenevestigatoriQ92535.

Family and domain databases

InterProiIPR009450. Plno_GlcNAc_GPI2.
[Graphical view]
PANTHERiPTHR12982. PTHR12982. 1 hit.
PfamiPF06432. GPI2. 1 hit.
[Graphical view]
PIRSFiPIRSF016104. GPI2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2."
    Inoue N., Watanabe R., Takeda J., Kinoshita T.
    Biochem. Biophys. Res. Commun. 226:193-199(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1."
    Hong Y., Ohishi K., Inoue N., Endo Y., Fujita T., Takeda J., Kinoshita T.
    Genomics 44:347-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-266.
    Tissue: Fibroblast.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiPIGC_HUMAN
AccessioniPrimary (citable) accession number: Q92535
Secondary accession number(s): O14491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.