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Q92535 (PIGC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

EC=2.4.1.198
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name=PIG-C
Gene names
Name:PIGC
Synonyms:GPI2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Catalytic activity

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subunit structure

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the PIGC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
PRO_0000058431

Regions

Transmembrane51 – 7121Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane239 – 25921Helical; Potential

Natural variations

Natural variant2661P → S. Ref.2
Corresponds to variant rs1063412 [ dbSNP | Ensembl ].
VAR_011360

Sequences

Sequence LengthMass (Da)Tools
Q92535 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: BD9584C5D5203A4B

FASTA29733,583
        10         20         30         40         50         60 
MYAQPVTNTK EVKWQKVLYE RQPFPDNYVD RRFLEELRKN IHARKYQYWA VVFESSVVIQ 

        70         80         90        100        110        120 
QLCSVCVFVV IWWYMDEGLL APHWLLGTGL ASSLIGYVLF DLIDGGEGRK KSGQTRWADL 

       130        140        150        160        170        180 
KSALVFITFT YGFSPVLKTL TESVSTDTIY AMSVFMLLGH LIFFDYGANA AIVSSTLSLN 

       190        200        210        220        230        240 
MAIFASVCLA SRLPRSLHAF IMVTFAIQIF ALWPMLQKKL KACTPRSYVG VTLLFAFSAV 

       250        260        270        280        290 
GGLLSISAVG AVLFALLLMS ISCLCPFYLI RLQLFKENIH GPWDEAEIKE DLSRFLS 

« Hide

References

« Hide 'large scale' references
[1]"PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2."
Inoue N., Watanabe R., Takeda J., Kinoshita T.
Biochem. Biophys. Res. Commun. 226:193-199(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1."
Hong Y., Ohishi K., Inoue N., Endo Y., Fujita T., Takeda J., Kinoshita T.
Genomics 44:347-349(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-266.
Tissue: Fibroblast.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - GTase

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C8

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D85418 mRNA. Translation: BAA12812.1.
AB000360 Genomic DNA. Translation: BAA22866.1.
BT006734 mRNA. Translation: AAP35380.1.
CR450292 mRNA. Translation: CAG29288.1.
Z97195 Genomic DNA. Translation: CAB10071.1.
BC006539 mRNA. Translation: AAH06539.1.
CCDSCCDS1302.1.
PIRJC4969.
RefSeqNP_002633.1. NM_002642.3.
NP_714969.1. NM_153747.1.
XP_006711446.1. XM_006711383.1.
UniGeneHs.188456.

3D structure databases

ProteinModelPortalQ92535.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111297. 3 interactions.
IntActQ92535. 2 interactions.
MINTMINT-1424659.
STRING9606.ENSP00000258324.

PTM databases

PhosphoSiteQ92535.

Polymorphism databases

DMDM14916629.

Proteomic databases

MaxQBQ92535.
PaxDbQ92535.
PRIDEQ92535.

Protocols and materials databases

DNASU5279.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258324; ENSP00000258324; ENSG00000135845.
ENST00000344529; ENSP00000356701; ENSG00000135845.
ENST00000367728; ENSP00000356702; ENSG00000135845.
GeneID5279.
KEGGhsa:5279.
UCSCuc001gin.3. human.

Organism-specific databases

CTD5279.
GeneCardsGC01M172339.
HGNCHGNC:8960. PIGC.
HPAHPA036663.
MIM601730. gene.
neXtProtNX_Q92535.
PharmGKBPA33291.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG275923.
HOGENOMHOG000194668.
HOVERGENHBG009071.
InParanoidQ92535.
KOK03859.
OMANIHARKY.
OrthoDBEOG7KSX8X.
PhylomeDBQ92535.
TreeFamTF314325.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.
UniPathwayUPA00196.

Gene expression databases

BgeeQ92535.
CleanExHS_PIGC.
GenevestigatorQ92535.

Family and domain databases

InterProIPR009450. Plno_GlcNAc_GPI2.
[Graphical view]
PANTHERPTHR12982. PTHR12982. 1 hit.
PfamPF06432. GPI2. 1 hit.
[Graphical view]
PIRSFPIRSF016104. GPI2. 1 hit.
ProtoNetSearch...

Other

GeneWikiPIGC.
GenomeRNAi5279.
NextBio20400.
PROQ92535.
SOURCESearch...

Entry information

Entry namePIGC_HUMAN
AccessionPrimary (citable) accession number: Q92535
Secondary accession number(s): O14491
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM