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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Gene

PIGC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

  • catalytic activity Source: ProtInc
  • phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  • GPI anchor biosynthetic process Source: ProtInc
  • preassembly of GPI anchor in ER membrane Source: Reactome

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-162710. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC:2.4.1.198)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name:
PIG-C
Gene namesi
Name:PIGC
Synonyms:GPI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000135845.9.
HGNCiHGNC:8960. PIGC.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei227 – 244HelicalSequence analysisAdd BLAST18
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135845.
PharmGKBiPA33291.

Polymorphism and mutation databases

BioMutaiPIGC.
DMDMi14916629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584311 – 297Phosphatidylinositol N-acetylglucosaminyltransferase subunit CAdd BLAST297

Proteomic databases

EPDiQ92535.
MaxQBiQ92535.
PaxDbiQ92535.
PeptideAtlasiQ92535.
PRIDEiQ92535.

PTM databases

iPTMnetiQ92535.
PhosphoSitePlusiQ92535.

Expressioni

Gene expression databases

BgeeiENSG00000135845.
CleanExiHS_PIGC.
GenevisibleiQ92535. HS.

Organism-specific databases

HPAiHPA036663.

Interactioni

Subunit structurei

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity.

Protein-protein interaction databases

BioGridi111297. 3 interactors.
CORUMiQ92535.
IntActiQ92535. 2 interactors.
MINTiMINT-1424659.
STRINGi9606.ENSP00000258324.

Structurei

3D structure databases

ProteinModelPortaliQ92535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3059. Eukaryota.
ENOG41112YY. LUCA.
GeneTreeiENSGT00390000005496.
HOGENOMiHOG000194668.
HOVERGENiHBG009071.
InParanoidiQ92535.
KOiK03859.
OMAiSYHAFVL.
OrthoDBiEOG091G0M0J.
PhylomeDBiQ92535.
TreeFamiTF314325.

Family and domain databases

InterProiView protein in InterPro
IPR009450. Plno_GlcNAc_GPI2.
PANTHERiPTHR12982. PTHR12982. 1 hit.
PfamiView protein in Pfam
PF06432. GPI2. 1 hit.
PIRSFiPIRSF016104. GPI2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAQPVTNTK EVKWQKVLYE RQPFPDNYVD RRFLEELRKN IHARKYQYWA
60 70 80 90 100
VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APHWLLGTGL ASSLIGYVLF
110 120 130 140 150
DLIDGGEGRK KSGQTRWADL KSALVFITFT YGFSPVLKTL TESVSTDTIY
160 170 180 190 200
AMSVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF
210 220 230 240 250
IMVTFAIQIF ALWPMLQKKL KACTPRSYVG VTLLFAFSAV GGLLSISAVG
260 270 280 290
AVLFALLLMS ISCLCPFYLI RLQLFKENIH GPWDEAEIKE DLSRFLS
Length:297
Mass (Da):33,583
Last modified:February 1, 1997 - v1
Checksum:iBD9584C5D5203A4B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011360266P → S1 PublicationCorresponds to variant dbSNP:rs1063412Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85418 mRNA. Translation: BAA12812.1.
AB000360 Genomic DNA. Translation: BAA22866.1.
BT006734 mRNA. Translation: AAP35380.1.
CR450292 mRNA. Translation: CAG29288.1.
Z97195 Genomic DNA. No translation available.
BC006539 mRNA. Translation: AAH06539.1.
CCDSiCCDS1302.1.
PIRiJC4969.
RefSeqiNP_002633.1. NM_002642.3.
NP_714969.1. NM_153747.1.
UniGeneiHs.188456.

Genome annotation databases

EnsembliENST00000344529; ENSP00000356701; ENSG00000135845.
ENST00000367728; ENSP00000356702; ENSG00000135845.
GeneIDi5279.
KEGGihsa:5279.
UCSCiuc001gio.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPIGC_HUMAN
AccessioniPrimary (citable) accession number: Q92535
Secondary accession number(s): O14491
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families