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Q92529

- SHC3_HUMAN

UniProt

Q92529 - SHC3_HUMAN

Protein

SHC-transforming protein 3

Gene

SHC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. signal transducer activity Source: ProtInc

    GO - Biological processi

    1. central nervous system development Source: ProtInc
    2. epidermal growth factor receptor signaling pathway Source: ProtInc
    3. insulin receptor signaling pathway Source: Reactome
    4. learning or memory Source: Ensembl
    5. neurotrophin TRK receptor signaling pathway Source: Reactome
    6. Ras protein signal transduction Source: Reactome
    7. synaptic transmission, glutamatergic Source: Ensembl
    8. transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

    Enzyme and pathway databases

    ReactomeiREACT_12033. Signalling to RAS.
    REACT_508. Signal attenuation.
    REACT_661. SHC-mediated signalling.
    SignaLinkiQ92529.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SHC-transforming protein 3
    Alternative name(s):
    Neuronal Shc
    Short name:
    N-Shc
    Protein Rai
    SHC-transforming protein C
    Src homology 2 domain-containing-transforming protein C3
    Short name:
    SH2 domain protein C3
    Gene namesi
    Name:SHC3
    Synonyms:NSHC, SHCC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18181. SHC3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134913435.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594SHC-transforming protein 3PRO_0000097734Add
    BLAST

    Post-translational modificationi

    Tyrosine phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ92529.
    PRIDEiQ92529.

    PTM databases

    PhosphoSiteiQ92529.

    Expressioni

    Tissue specificityi

    Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.1 Publication

    Gene expression databases

    ArrayExpressiQ92529.
    BgeeiQ92529.
    CleanExiHS_SHC3.
    GenevestigatoriQ92529.

    Organism-specific databases

    HPAiHPA046656.

    Interactioni

    Subunit structurei

    Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPP050672EBI-79084,EBI-77613
    ERBB2P046262EBI-79084,EBI-641062
    ERBB3P218602EBI-79084,EBI-720706
    KITP107213EBI-79084,EBI-1379503

    Protein-protein interaction databases

    BioGridi119752. 10 interactions.
    IntActiQ92529. 9 interactions.
    MINTiMINT-1492377.
    STRINGi9606.ENSP00000364995.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92529.
    SMRiQ92529. Positions 136-310, 492-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini149 – 334186PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini499 – 59092SH2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni335 – 498164CH1Add
    BLAST

    Sequence similaritiesi

    Contains 1 PID domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG315087.
    HOGENOMiHOG000231974.
    HOVERGENiHBG050121.
    InParanoidiQ92529.
    KOiK17448.
    OMAiGSDHPYY.
    OrthoDBiEOG7MD4QK.
    PhylomeDBiQ92529.
    TreeFamiTF315807.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTiSM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform p64 (identifier: Q92529-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG    50
    EALRKAPDDG PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC 100
    SAPSLAAPDG SAPSAPRAPA MSAARKGRPG DEPLPRPPRG APHASDQVLG 150
    PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI TREAISRVCE AVPGAKGAFK 200
    KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD SKQIIANHHM 250
    RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 300
    FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP 350
    PPGGFLDTRL KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ 400
    GSSDIYSTPE GKLHVAPTGE APTYVNTQQI PPQAWPAAVS SAESSPRKDL 450
    FDMKPFEDAL KNQPLGPVLS KAASVECISP VSPRAPDAKM LEELQAETWY 500
    QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE 550
    GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ 594
    Length:594
    Mass (Da):64,056
    Last modified:February 1, 1997 - v1
    Checksum:i047A9D08002E41BF
    GO
    Isoform p52 (identifier: Q92529-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-155: MLPRTKYNRF...DQVLGPGVTY → MHARAAASVMDICRIRLLIRLTIGLERPPGQV

    Show »
    Length:471
    Mass (Da):51,939
    Checksum:iBE74C85B97AF30CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581D → V in AAH26314. (PubMed:15489334)Curated
    Sequence conflicti201 – 2011K → R(PubMed:8760305)Curated
    Sequence conflicti271 – 2711A → T in AAH26314. (PubMed:15489334)Curated
    Sequence conflicti553 – 5531I → E(PubMed:8760305)Curated
    Sequence conflicti554 – 5541R → Q in AAH26314. (PubMed:15489334)Curated
    Sequence conflicti593 – 5942KQ → NE(PubMed:8760305)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 155155MLPRT…PGVTY → MHARAAASVMDICRIRLLIR LTIGLERPPGQV in isoform p52. 2 PublicationsVSP_009805Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D84361 mRNA. Translation: BAA12322.1.
    D84361 mRNA. Translation: BAA12323.1.
    AL353150, AL160054 Genomic DNA. Translation: CAI16865.1.
    AL160054, AL353150 Genomic DNA. Translation: CAI41366.1.
    BC026314 mRNA. Translation: AAH26314.1.
    CCDSiCCDS6681.1. [Q92529-1]
    RefSeqiNP_058544.3. NM_016848.5. [Q92529-1]
    UniGeneiHs.292737.

    Genome annotation databases

    EnsembliENST00000375835; ENSP00000364995; ENSG00000148082. [Q92529-1]
    GeneIDi53358.
    KEGGihsa:53358.
    UCSCiuc004aqf.2. human. [Q92529-1]

    Polymorphism databases

    DMDMi48474922.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D84361 mRNA. Translation: BAA12322.1 .
    D84361 mRNA. Translation: BAA12323.1 .
    AL353150 , AL160054 Genomic DNA. Translation: CAI16865.1 .
    AL160054 , AL353150 Genomic DNA. Translation: CAI41366.1 .
    BC026314 mRNA. Translation: AAH26314.1 .
    CCDSi CCDS6681.1. [Q92529-1 ]
    RefSeqi NP_058544.3. NM_016848.5. [Q92529-1 ]
    UniGenei Hs.292737.

    3D structure databases

    ProteinModelPortali Q92529.
    SMRi Q92529. Positions 136-310, 492-593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119752. 10 interactions.
    IntActi Q92529. 9 interactions.
    MINTi MINT-1492377.
    STRINGi 9606.ENSP00000364995.

    PTM databases

    PhosphoSitei Q92529.

    Polymorphism databases

    DMDMi 48474922.

    Proteomic databases

    PaxDbi Q92529.
    PRIDEi Q92529.

    Protocols and materials databases

    DNASUi 53358.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375835 ; ENSP00000364995 ; ENSG00000148082 . [Q92529-1 ]
    GeneIDi 53358.
    KEGGi hsa:53358.
    UCSCi uc004aqf.2. human. [Q92529-1 ]

    Organism-specific databases

    CTDi 53358.
    GeneCardsi GC09M091628.
    HGNCi HGNC:18181. SHC3.
    HPAi HPA046656.
    MIMi 605263. gene.
    neXtProti NX_Q92529.
    PharmGKBi PA134913435.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315087.
    HOGENOMi HOG000231974.
    HOVERGENi HBG050121.
    InParanoidi Q92529.
    KOi K17448.
    OMAi GSDHPYY.
    OrthoDBi EOG7MD4QK.
    PhylomeDBi Q92529.
    TreeFami TF315807.

    Enzyme and pathway databases

    Reactomei REACT_12033. Signalling to RAS.
    REACT_508. Signal attenuation.
    REACT_661. SHC-mediated signalling.
    SignaLinki Q92529.

    Miscellaneous databases

    GeneWikii SHC3.
    GenomeRNAii 53358.
    NextBioi 56022.
    PROi Q92529.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92529.
    Bgeei Q92529.
    CleanExi HS_SHC3.
    Genevestigatori Q92529.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006019. PID_Shc-like.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00629. SHCPIDOMAIN.
    SMARTi SM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS01179. PID. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway."
      Nakamura T., Sanokawa R., Sasaki Y., Ayusawa D., Oishi M., Mori N.
      Oncogene 13:1111-1121(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P64 AND P52), TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions."
      Pelicci G., Dente L., De Giuseppe A., Verducci-Galletti B., Giuli S., Mele S., Vetriani C., Giorgio M., Pandolfi P.P., Cesareni G., Pelicci P.-G.
      Oncogene 13:633-641(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P52).
      Tissue: Fetal brain.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P64).
      Tissue: Brain.
    5. "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases."
      Liu H.Y., Meakin S.O.
      J. Biol. Chem. 277:26046-26056(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, INTERACTION WITH THE TRK RECEPTORS.

    Entry informationi

    Entry nameiSHC3_HUMAN
    AccessioniPrimary (citable) accession number: Q92529
    Secondary accession number(s): Q5T7I7, Q8TAP2, Q9UCX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3