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Q92529 (SHC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name=N-Shc
Protein Rai
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name=SH2 domain protein C3
Gene names
Name:SHC3
Synonyms:NSHC, SHCC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Subunit structure

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Ref.5

Tissue specificity

Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. Ref.1

Post-translational modification

Tyrosine phosphorylated. Ref.5

Sequence similarities

Contains 1 PID domain.

Contains 1 SH2 domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform p64 (identifier: Q92529-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform p52 (identifier: Q92529-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: MLPRTKYNRF...DQVLGPGVTY → MHARAAASVMDICRIRLLIRLTIGLERPPGQV

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594SHC-transforming protein 3
PRO_0000097734

Regions

Domain149 – 334186PID
Domain499 – 59092SH2
Region335 – 498164CH1

Natural variations

Alternative sequence1 – 155155MLPRT…PGVTY → MHARAAASVMDICRIRLLIR LTIGLERPPGQV in isoform p52.
VSP_009805

Experimental info

Sequence conflict581D → V in AAH26314. Ref.4
Sequence conflict2011K → R Ref.2
Sequence conflict2711A → T in AAH26314. Ref.4
Sequence conflict5531I → E Ref.2
Sequence conflict5541R → Q in AAH26314. Ref.4
Sequence conflict593 – 5942KQ → NE Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform p64 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 047A9D08002E41BF

FASTA59464,056
        10         20         30         40         50         60 
MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG EALRKAPDDG 

        70         80         90        100        110        120 
PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC SAPSLAAPDG SAPSAPRAPA 

       130        140        150        160        170        180 
MSAARKGRPG DEPLPRPPRG APHASDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI 

       190        200        210        220        230        240 
TREAISRVCE AVPGAKGAFK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 

       250        260        270        280        290        300 
SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 

       310        320        330        340        350        360 
FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP PPGGFLDTRL 

       370        380        390        400        410        420 
KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ GSSDIYSTPE GKLHVAPTGE 

       430        440        450        460        470        480 
APTYVNTQQI PPQAWPAAVS SAESSPRKDL FDMKPFEDAL KNQPLGPVLS KAASVECISP 

       490        500        510        520        530        540 
VSPRAPDAKM LEELQAETWY QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ 

       550        560        570        580        590 
AKHLLLVDPE GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ 

« Hide

Isoform p52 [UniParc].

Checksum: BE74C85B97AF30CE
Show »

FASTA47151,939

References

« Hide 'large scale' references
[1]"N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway."
Nakamura T., Sanokawa R., Sasaki Y., Ayusawa D., Oishi M., Mori N.
Oncogene 13:1111-1121(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P64 AND P52), TISSUE SPECIFICITY.
Tissue: Brain.
[2]"A family of Shc related proteins with conserved PTB, CH1 and SH2 regions."
Pelicci G., Dente L., De Giuseppe A., Verducci-Galletti B., Giuli S., Mele S., Vetriani C., Giorgio M., Pandolfi P.P., Cesareni G., Pelicci P.-G.
Oncogene 13:633-641(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P52).
Tissue: Fetal brain.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P64).
Tissue: Brain.
[5]"ShcB and ShcC activation by the Trk family of receptor tyrosine kinases."
Liu H.Y., Meakin S.O.
J. Biol. Chem. 277:26046-26056(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, INTERACTION WITH THE TRK RECEPTORS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D84361 mRNA. Translation: BAA12322.1.
D84361 mRNA. Translation: BAA12323.1.
AL353150, AL160054 Genomic DNA. Translation: CAI16865.1.
AL160054, AL353150 Genomic DNA. Translation: CAI41366.1.
BC026314 mRNA. Translation: AAH26314.1.
CCDSCCDS6681.1. [Q92529-1]
RefSeqNP_058544.3. NM_016848.5. [Q92529-1]
UniGeneHs.292737.

3D structure databases

ProteinModelPortalQ92529.
SMRQ92529. Positions 136-310, 492-593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119752. 10 interactions.
IntActQ92529. 9 interactions.
MINTMINT-1492377.
STRING9606.ENSP00000364995.

PTM databases

PhosphoSiteQ92529.

Polymorphism databases

DMDM48474922.

Proteomic databases

PaxDbQ92529.
PRIDEQ92529.

Protocols and materials databases

DNASU53358.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375835; ENSP00000364995; ENSG00000148082. [Q92529-1]
GeneID53358.
KEGGhsa:53358.
UCSCuc004aqf.2. human. [Q92529-1]

Organism-specific databases

CTD53358.
GeneCardsGC09M091628.
HGNCHGNC:18181. SHC3.
HPAHPA046656.
MIM605263. gene.
neXtProtNX_Q92529.
PharmGKBPA134913435.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315087.
HOGENOMHOG000231974.
HOVERGENHBG050121.
InParanoidQ92529.
KOK17448.
OMAGSDHPYY.
OrthoDBEOG7MD4QK.
PhylomeDBQ92529.
TreeFamTF315807.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkQ92529.

Gene expression databases

ArrayExpressQ92529.
BgeeQ92529.
CleanExHS_SHC3.
GenevestigatorQ92529.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSHC3.
GenomeRNAi53358.
NextBio56022.
PROQ92529.
SOURCESearch...

Entry information

Entry nameSHC3_HUMAN
AccessionPrimary (citable) accession number: Q92529
Secondary accession number(s): Q5T7I7, Q8TAP2, Q9UCX5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM