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Protein

Ankyrin repeat domain-containing protein 7

Gene

ANKRD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • male gonad development Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 7
Alternative name(s):
Testis-specific protein TSA806
Gene namesi
Name:ANKRD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18588. ANKRD7.

Pathology & Biotechi

Organism-specific databases

DisGeNETi56311.
OpenTargetsiENSG00000106013.
PharmGKBiPA38591.

Polymorphism and mutation databases

BioMutaiANKRD7.
DMDMi229462988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669021 – 254Ankyrin repeat domain-containing protein 7Add BLAST254

Proteomic databases

PaxDbiQ92527.
PeptideAtlasiQ92527.
PRIDEiQ92527.

PTM databases

iPTMnetiQ92527.
PhosphoSitePlusiQ92527.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000106013.
CleanExiHS_ANKRD7.
ExpressionAtlasiQ92527. baseline and differential.
GenevisibleiQ92527. HS.

Organism-specific databases

HPAiHPA043489.

Interactioni

Protein-protein interaction databases

BioGridi121138. 1 interactor.
IntActiQ92527. 2 interactors.
MINTiMINT-1395362.
STRINGi9606.ENSP00000265224.

Structurei

3D structure databases

ProteinModelPortaliQ92527.
SMRiQ92527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 87ANK 1Add BLAST30
Repeati91 – 120ANK 2Add BLAST30
Repeati124 – 153ANK 3Add BLAST30
Repeati157 – 186ANK 4Add BLAST30
Repeati190 – 219ANK 5Add BLAST30

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000013154.
HOVERGENiHBG108744.
InParanoidiQ92527.
OMAiNPKMVKF.
OrthoDBiEOG091G077A.
PhylomeDBiQ92527.
TreeFamiTF337879.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92527-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKLFSFWKR KNETRSQGYN LREKDLKKLH RAASVGDLKK LKEYLQIKKY
60 70 80 90 100
DVNMQDKKYR TPLHLACANG HTDVVLFLIE QQCKINVRDS ENKSPLIKAV
110 120 130 140 150
QCQNEDCATI LLNFGADPDL RDIRYNTVLH YAVCGQSLSL VEKLLEYEAD
160 170 180 190 200
LEAKNKDGYT PLLVAVINNN PKMVKFLLEK GADVNASDNY QRTALILAVS
210 220 230 240 250
GEPPCLVKLL LQQGVELCYE GIVDSQLRNM FISMVLLHRY PQFTASHGKK

KHAK
Length:254
Mass (Da):29,029
Last modified:May 5, 2009 - v3
Checksum:iF4DC8875BD348C39
GO
Isoform 2 (identifier: Q92527-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-59: Y → YSVVQSSRWLLSYTTPLNDFI

Note: Gene prediction based on EST data.
Show »
Length:274
Mass (Da):31,337
Checksum:i9B53A06FC2DF54C6
GO

Sequence cautioni

The sequence AAH32799 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104 – 108NEDCA → MRIVP in BAA11348 (PubMed:8812458).Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03716059Y → YSVVQSSRWLLSYTTPLNDF I in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302407 mRNA. Translation: BAG63717.1.
AC004029 Genomic DNA. No translation available.
AC006389 Genomic DNA. No translation available.
AC007874 Genomic DNA. Translation: AAF19231.1.
BC032799 mRNA. Translation: AAH32799.1. Different initiation.
BC007020 mRNA. Translation: AAH07020.2.
D78334 mRNA. Translation: BAA11348.1.
CCDSiCCDS43638.1. [Q92527-1]
RefSeqiNP_062618.2. NM_019644.3. [Q92527-1]
UniGeneiHs.729340.

Genome annotation databases

EnsembliENST00000265224; ENSP00000265224; ENSG00000106013. [Q92527-1]
GeneIDi56311.
KEGGihsa:56311.
UCSCiuc003vji.4. human. [Q92527-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302407 mRNA. Translation: BAG63717.1.
AC004029 Genomic DNA. No translation available.
AC006389 Genomic DNA. No translation available.
AC007874 Genomic DNA. Translation: AAF19231.1.
BC032799 mRNA. Translation: AAH32799.1. Different initiation.
BC007020 mRNA. Translation: AAH07020.2.
D78334 mRNA. Translation: BAA11348.1.
CCDSiCCDS43638.1. [Q92527-1]
RefSeqiNP_062618.2. NM_019644.3. [Q92527-1]
UniGeneiHs.729340.

3D structure databases

ProteinModelPortaliQ92527.
SMRiQ92527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121138. 1 interactor.
IntActiQ92527. 2 interactors.
MINTiMINT-1395362.
STRINGi9606.ENSP00000265224.

PTM databases

iPTMnetiQ92527.
PhosphoSitePlusiQ92527.

Polymorphism and mutation databases

BioMutaiANKRD7.
DMDMi229462988.

Proteomic databases

PaxDbiQ92527.
PeptideAtlasiQ92527.
PRIDEiQ92527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265224; ENSP00000265224; ENSG00000106013. [Q92527-1]
GeneIDi56311.
KEGGihsa:56311.
UCSCiuc003vji.4. human. [Q92527-1]

Organism-specific databases

CTDi56311.
DisGeNETi56311.
GeneCardsiANKRD7.
H-InvDBHIX0007026.
HGNCiHGNC:18588. ANKRD7.
HPAiHPA043489.
MIMi610731. gene.
neXtProtiNX_Q92527.
OpenTargetsiENSG00000106013.
PharmGKBiPA38591.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000013154.
HOVERGENiHBG108744.
InParanoidiQ92527.
OMAiNPKMVKF.
OrthoDBiEOG091G077A.
PhylomeDBiQ92527.
TreeFamiTF337879.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106013-MONOMER.

Miscellaneous databases

GenomeRNAii56311.
PROiQ92527.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106013.
CleanExiHS_ANKRD7.
ExpressionAtlasiQ92527. baseline and differential.
GenevisibleiQ92527. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANKR7_HUMAN
AccessioniPrimary (citable) accession number: Q92527
Secondary accession number(s): B4DYF5, Q96QN1, Q9UDM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.