Q92527 (ANKR7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 7

Alternative name(s):
Testis-specific protein TSA806

Gene names

Name:

ANKRD7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Testis specific.
Sequence similarities	Contains 5 ANK repeats.
Sequence caution	The sequence AAH32799.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	male gonad development Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92527-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92527-2)

The sequence of this isoform differs from the canonical sequence as follows:
     59-59: Y → YSVVQSSRWLLSYTTPLNDFI

Note: Gene prediction based on EST data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Ankyrin repeat domain-containing protein 7		PRO_0000066902
Regions
	Repeat	58 – 87	30	ANK 1
	Repeat	91 – 120	30	ANK 2
	Repeat	124 – 153	30	ANK 3
	Repeat	157 – 186	30	ANK 4
	Repeat	190 – 219	30	ANK 5
Natural variations
	Alternative sequence	59	1	Y → YSVVQSSRWLLSYTTPLNDF I in isoform 2.		VSP_037160
Experimental info
	Sequence conflict	104 – 108	5	NEDCA → MRIVP in BAA11348. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: F4DC8875BD348C39	FASTA	254	29,029
	10 20 30 40 50 60 MNKLFSFWKR KNETRSQGYN LREKDLKKLH RAASVGDLKK LKEYLQIKKY DVNMQDKKYR 70 80 90 100 110 120 TPLHLACANG HTDVVLFLIE QQCKINVRDS ENKSPLIKAV QCQNEDCATI LLNFGADPDL 130 140 150 160 170 180 RDIRYNTVLH YAVCGQSLSL VEKLLEYEAD LEAKNKDGYT PLLVAVINNN PKMVKFLLEK 190 200 210 220 230 240 GADVNASDNY QRTALILAVS GEPPCLVKLL LQQGVELCYE GIVDSQLRNM FISMVLLHRY 250 PQFTASHGKK KHAK
	Isoform 2 [UniParc]. Checksum: 9B53A06FC2DF54C6	FASTA	274	31,337
	10 20 30 40 50 60 MNKLFSFWKR KNETRSQGYN LREKDLKKLH RAASVGDLKK LKEYLQIKKY DVNMQDKKYS 70 80 90 100 110 120 VVQSSRWLLS YTTPLNDFIR TPLHLACANG HTDVVLFLIE QQCKINVRDS ENKSPLIKAV 130 140 150 160 170 180 QCQNEDCATI LLNFGADPDL RDIRYNTVLH YAVCGQSLSL VEKLLEYEAD LEAKNKDGYT 190 200 210 220 230 240 PLLVAVINNN PKMVKFLLEK GADVNASDNY QRTALILAVS GEPPCLVKLL LQQGVELCYE 250 260 270 GIVDSQLRNM FISMVLLHRY PQFTASHGKK KHAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-254 (ISOFORM 1). Tissue: Brain and Testis.
[4]	"Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method." Ozaki K., Kuroki T., Hayashi S., Nakamura Y. Genomics 36:316-319(1996) [PubMed: 8812458] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-191 (ISOFORMS 1/2). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK302407 mRNA. Translation: BAG63717.1. AC004029 Genomic DNA. No translation available. AC006389 Genomic DNA. No translation available. AC007874 Genomic DNA. Translation: AAF19231.1. BC032799 mRNA. Translation: AAH32799.1. Different initiation. BC007020 mRNA. Translation: AAH07020.2. D78334 mRNA. Translation: BAA11348.1.
IPI	IPI00816206. IPI00926356.
RefSeq	NP_062618.2. NM_019644.3.
UniGene	Hs.729340.
3D structure databases
ProteinModelPortal	Q92527.
SMR	Q92527. Positions 22-253.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92527. 1 interaction.
MINT	MINT-1395362.
STRING	Q92527.
Polymorphism databases
DMDM	229462988.
Proteomic databases
PRIDE	Q92527.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265224; ENSP00000265224; ENSG00000106013.
GeneID	56311.
KEGG	hsa:56311.
UCSC	uc003vjh.1. human.
Organism-specific databases
CTD	56311.
GeneCards	GC07P117854.
H-InvDB	HIX0007026.
HGNC	HGNC:18588. ANKRD7.
HPA	HPA043489.
MIM	610731. gene.
neXtProt	NX_Q92527.
PharmGKB	PA38591.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20382.
HOVERGEN	HBG108744.
OMA	QEVDLSC.
OrthoDB	EOG4933K0.
PhylomeDB	Q92527.
Gene expression databases
ArrayExpress	Q92527.
Bgee	Q92527.
CleanEx	HS_ANKRD7.
Genevestigator	Q92527.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 2 hits. PF12796. Ank_2. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 5 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	61975.
SOURCE	Search...

Entry information

Entry name

ANKR7_HUMAN

Accession

Primary (citable) accession number: Q92527
Secondary accession number(s): B4DYF5, Q96QN1, Q9UDM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.