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Protein

T-complex protein 1 subunit zeta-2

Gene

CCT6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

Caution

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein complex assembly Source: ProtInc
  • chaperone-mediated protein folding Source: GO_Central
  • protein folding Source: ProtInc
  • spermatogenesis Source: ProtInc
  • toxin transport Source: Ensembl

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta-2
Short name:
TCP-1-zeta-2
Alternative name(s):
CCT-zeta-2
CCT-zeta-like
TCP-1-zeta-like
Testis-specific Tcp20
Testis-specific protein TSA303
Gene namesi
Name:CCT6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000132141.13
HGNCiHGNC:1621 CCT6B
MIMi610730 gene
neXtProtiNX_Q92526

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10693
OpenTargetsiENSG00000132141
PharmGKBiPA26184

Polymorphism and mutation databases

BioMutaiCCT6B
DMDMi327478610

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283631 – 530T-complex protein 1 subunit zeta-2Add BLAST530

Proteomic databases

EPDiQ92526
MaxQBiQ92526
PaxDbiQ92526
PeptideAtlasiQ92526
PRIDEiQ92526

2D gel databases

REPRODUCTION-2DPAGEiIPI00220656

PTM databases

iPTMnetiQ92526
PhosphoSitePlusiQ92526
SwissPalmiQ92526

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000132141
CleanExiHS_CCT6B
ExpressionAtlasiQ92526 baseline and differential
GenevisibleiQ92526 HS

Organism-specific databases

HPAiHPA042996
HPA045576
HPA049949

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115932127 interactors.
DIPiDIP-53269N
IntActiQ92526 14 interactors.
MINTiQ92526
STRINGi9606.ENSP00000327191

Structurei

3D structure databases

ProteinModelPortaliQ92526
SMRiQ92526
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359 Eukaryota
ENOG410XQ3Q LUCA
GeneTreeiENSGT00550000074743
HOGENOMiHOG000226733
HOVERGENiHBG103725
InParanoidiQ92526
KOiK09498
OMAiCINPRSV
OrthoDBiEOG091G07CE
PhylomeDBiQ92526
TreeFamiTF106333

Family and domain databases

CDDicd03342 TCP1_zeta, 1 hit
Gene3Di1.10.560.102 hits
3.50.7.101 hit
InterProiView protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353 PTHR11353, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02347 chap_CCT_zeta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92526-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIA EGFEAAKIKA LEVLEEVKVT KEMKRKILLD
160 170 180 190 200
VARTSLQTKV HAELADVLTE VVVDSVLAVR RPGYPIDLFM VEIMEMKHKL
210 220 230 240 250
GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE KTEVNSGFFY
260 270 280 290 300
KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF
310 320 330 340 350
SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV
360 370 380 390 400
YEYTLGEEKF TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN
410 420 430 440 450
AIEDGCMVPG AGAIEVAMAE ALVTYKNSIK GRARLGVQAF ADALLIIPKV
460 470 480 490 500
LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD LNTGEPMVAA DAGVWDNYCV
510 520 530
KKQLLHSCTV IATNILLVDE IMRAGMSSLK
Length:530
Mass (Da):57,821
Last modified:April 5, 2011 - v5
Checksum:iAE28A28E3826C196
GO
Isoform 2 (identifier: Q92526-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):53,100
Checksum:iD8F1B077E65DE6A9
GO
Isoform 3 (identifier: Q92526-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-242: Missing.

Show »
Length:493
Mass (Da):53,586
Checksum:iCF7E2D93CFB23B14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 30AALAV…AARGL → QLWLSIYAPPRV in BAA11347 (PubMed:8812458).CuratedAdd BLAST13
Sequence conflicti86D → G in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti94S → T in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti176 – 178VLA → LFP in BAA11347 (PubMed:8812458).Curated3
Sequence conflicti183G → P in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti529 – 530LK → QMMIEFKINPSRR in BAA11347 (PubMed:8812458).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06029717R → Q1 PublicationCorresponds to variant dbSNP:rs9635769Ensembl.1
Natural variantiVAR_06029848V → A1 PublicationCorresponds to variant dbSNP:rs2230552Ensembl.1
Natural variantiVAR_057269247G → A1 PublicationCorresponds to variant dbSNP:rs2230553Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04304068 – 112Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_047129206 – 242Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78333 mRNA Translation: BAA11347.1
AK301773 mRNA Translation: BAG63232.1
AK302344 mRNA Translation: BAG63672.1
AC022903 Genomic DNA No translation available.
BC026125 mRNA Translation: AAH26125.1
BC027591 mRNA Translation: AAH27591.1
CCDSiCCDS32617.1 [Q92526-1]
CCDS54105.1 [Q92526-2]
CCDS54106.1 [Q92526-3]
RefSeqiNP_001180458.1, NM_001193529.2 [Q92526-3]
NP_001180459.1, NM_001193530.1 [Q92526-2]
NP_006575.2, NM_006584.3 [Q92526-1]
UniGeneiHs.73072

Genome annotation databases

EnsembliENST00000314144; ENSP00000327191; ENSG00000132141 [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141 [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141 [Q92526-2]
GeneIDi10693
KEGGihsa:10693
UCSCiuc002hig.4 human [Q92526-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCPW_HUMAN
AccessioniPrimary (citable) accession number: Q92526
Secondary accession number(s): B4DX20, B4DYB0, Q8TC34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 164 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome