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Protein

T-complex protein 1 subunit zeta-2

Gene

CCT6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein transporter activity Source: ProtInc
  • unfolded protein binding Source: ProtInc

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: ProtInc
  • protein folding Source: ProtInc
  • spermatogenesis Source: ProtInc
  • toxin transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132141-MONOMER.
ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.
R-HSA-389960. Formation of tubulin folding intermediates by CCT/TriC.
R-HSA-390450. Folding of actin by CCT/TriC.
R-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta-2
Short name:
TCP-1-zeta-2
Alternative name(s):
CCT-zeta-2
CCT-zeta-like
TCP-1-zeta-like
Testis-specific Tcp20
Testis-specific protein TSA303
Gene namesi
Name:CCT6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1621. CCT6B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10693.
OpenTargetsiENSG00000132141.
PharmGKBiPA26184.

Polymorphism and mutation databases

BioMutaiCCT6B.
DMDMi327478610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283631 – 530T-complex protein 1 subunit zeta-2Add BLAST530

Proteomic databases

EPDiQ92526.
MaxQBiQ92526.
PaxDbiQ92526.
PeptideAtlasiQ92526.
PRIDEiQ92526.

2D gel databases

REPRODUCTION-2DPAGEIPI00220656.

PTM databases

iPTMnetiQ92526.
PhosphoSitePlusiQ92526.
SwissPalmiQ92526.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000132141.
CleanExiHS_CCT6B.
ExpressionAtlasiQ92526. baseline and differential.
GenevisibleiQ92526. HS.

Organism-specific databases

HPAiHPA042996.
HPA045576.
HPA049949.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

  • unfolded protein binding Source: ProtInc

Protein-protein interaction databases

BioGridi115932. 106 interactors.
DIPiDIP-53269N.
IntActiQ92526. 6 interactors.
STRINGi9606.ENSP00000327191.

Structurei

3D structure databases

ProteinModelPortaliQ92526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ92526.
KOiK09498.
OMAiIVEMKHK.
OrthoDBiEOG091G07CE.
PhylomeDBiQ92526.
TreeFamiTF106333.

Family and domain databases

CDDicd03342. TCP1_zeta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92526-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIA EGFEAAKIKA LEVLEEVKVT KEMKRKILLD
160 170 180 190 200
VARTSLQTKV HAELADVLTE VVVDSVLAVR RPGYPIDLFM VEIMEMKHKL
210 220 230 240 250
GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE KTEVNSGFFY
260 270 280 290 300
KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF
310 320 330 340 350
SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV
360 370 380 390 400
YEYTLGEEKF TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN
410 420 430 440 450
AIEDGCMVPG AGAIEVAMAE ALVTYKNSIK GRARLGVQAF ADALLIIPKV
460 470 480 490 500
LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD LNTGEPMVAA DAGVWDNYCV
510 520 530
KKQLLHSCTV IATNILLVDE IMRAGMSSLK
Length:530
Mass (Da):57,821
Last modified:April 5, 2011 - v5
Checksum:iAE28A28E3826C196
GO
Isoform 2 (identifier: Q92526-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):53,100
Checksum:iD8F1B077E65DE6A9
GO
Isoform 3 (identifier: Q92526-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-242: Missing.

Show »
Length:493
Mass (Da):53,586
Checksum:iCF7E2D93CFB23B14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 30AALAV…AARGL → QLWLSIYAPPRV in BAA11347 (PubMed:8812458).CuratedAdd BLAST13
Sequence conflicti86D → G in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti94S → T in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti176 – 178VLA → LFP in BAA11347 (PubMed:8812458).Curated3
Sequence conflicti183G → P in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti529 – 530LK → QMMIEFKINPSRR in BAA11347 (PubMed:8812458).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06029717R → Q.1 PublicationCorresponds to variant rs9635769dbSNPEnsembl.1
Natural variantiVAR_06029848V → A.1 PublicationCorresponds to variant rs2230552dbSNPEnsembl.1
Natural variantiVAR_057269247G → A.1 PublicationCorresponds to variant rs2230553dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04304068 – 112Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_047129206 – 242Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78333 mRNA. Translation: BAA11347.1.
AK301773 mRNA. Translation: BAG63232.1.
AK302344 mRNA. Translation: BAG63672.1.
AC022903 Genomic DNA. No translation available.
BC026125 mRNA. Translation: AAH26125.1.
BC027591 mRNA. Translation: AAH27591.1.
CCDSiCCDS32617.1. [Q92526-1]
CCDS54105.1. [Q92526-2]
CCDS54106.1. [Q92526-3]
RefSeqiNP_001180458.1. NM_001193529.2. [Q92526-3]
NP_001180459.1. NM_001193530.1. [Q92526-2]
NP_006575.2. NM_006584.3. [Q92526-1]
UniGeneiHs.73072.

Genome annotation databases

EnsembliENST00000314144; ENSP00000327191; ENSG00000132141. [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141. [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141. [Q92526-2]
GeneIDi10693.
KEGGihsa:10693.
UCSCiuc002hig.4. human. [Q92526-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78333 mRNA. Translation: BAA11347.1.
AK301773 mRNA. Translation: BAG63232.1.
AK302344 mRNA. Translation: BAG63672.1.
AC022903 Genomic DNA. No translation available.
BC026125 mRNA. Translation: AAH26125.1.
BC027591 mRNA. Translation: AAH27591.1.
CCDSiCCDS32617.1. [Q92526-1]
CCDS54105.1. [Q92526-2]
CCDS54106.1. [Q92526-3]
RefSeqiNP_001180458.1. NM_001193529.2. [Q92526-3]
NP_001180459.1. NM_001193530.1. [Q92526-2]
NP_006575.2. NM_006584.3. [Q92526-1]
UniGeneiHs.73072.

3D structure databases

ProteinModelPortaliQ92526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115932. 106 interactors.
DIPiDIP-53269N.
IntActiQ92526. 6 interactors.
STRINGi9606.ENSP00000327191.

PTM databases

iPTMnetiQ92526.
PhosphoSitePlusiQ92526.
SwissPalmiQ92526.

Polymorphism and mutation databases

BioMutaiCCT6B.
DMDMi327478610.

2D gel databases

REPRODUCTION-2DPAGEIPI00220656.

Proteomic databases

EPDiQ92526.
MaxQBiQ92526.
PaxDbiQ92526.
PeptideAtlasiQ92526.
PRIDEiQ92526.

Protocols and materials databases

DNASUi10693.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314144; ENSP00000327191; ENSG00000132141. [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141. [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141. [Q92526-2]
GeneIDi10693.
KEGGihsa:10693.
UCSCiuc002hig.4. human. [Q92526-1]

Organism-specific databases

CTDi10693.
DisGeNETi10693.
GeneCardsiCCT6B.
H-InvDBHIX0013717.
HGNCiHGNC:1621. CCT6B.
HPAiHPA042996.
HPA045576.
HPA049949.
MIMi610730. gene.
neXtProtiNX_Q92526.
OpenTargetsiENSG00000132141.
PharmGKBiPA26184.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ92526.
KOiK09498.
OMAiIVEMKHK.
OrthoDBiEOG091G07CE.
PhylomeDBiQ92526.
TreeFamiTF106333.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132141-MONOMER.
ReactomeiR-HSA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.
R-HSA-389960. Formation of tubulin folding intermediates by CCT/TriC.
R-HSA-390450. Folding of actin by CCT/TriC.
R-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

GenomeRNAii10693.
PROiQ92526.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132141.
CleanExiHS_CCT6B.
ExpressionAtlasiQ92526. baseline and differential.
GenevisibleiQ92526. HS.

Family and domain databases

CDDicd03342. TCP1_zeta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPW_HUMAN
AccessioniPrimary (citable) accession number: Q92526
Secondary accession number(s): B4DX20, B4DYB0, Q8TC34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 152 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.