Q92526 (TCPW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-complex protein 1 subunit zeta-2
Short name=TCP-1-zeta-2

Alternative name(s):
CCT-zeta-2
CCT-zeta-like
TCP-1-zeta-like
Testis-specific Tcp20
Testis-specific protein TSA303

Gene names

Name:

CCT6B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin By similarity.
Subunit structure	Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Subcellular location	Cytoplasm.
Tissue specificity	Testis specific.
Sequence similarities	Belongs to the TCP-1 chaperonin family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chaperone-mediated protein complex assembly Traceable author statement Ref.1. Source: ProtInc protein folding Traceable author statement Ref.1. Source: ProtInc spermatogenesis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein transporter activity Traceable author statement Ref.1. Source: ProtInc unfolded protein binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92526-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92526-2)

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	T-complex protein 1 subunit zeta-2		PRO_0000128363
Natural variations
	Alternative sequence	68 – 112	45	Missing in isoform 2.		VSP_043040
	Natural variant	17	1	R → Q. Ref.4 Corresponds to variant rs9635769 [ dbSNP | Ensembl ].		VAR_060297
	Natural variant	48	1	V → A. Ref.4 Corresponds to variant rs2230552 [ dbSNP | Ensembl ].		VAR_060298
	Natural variant	247	1	G → A. Ref.1 Corresponds to variant rs2230553 [ dbSNP | Ensembl ].		VAR_057269
Experimental info
	Sequence conflict	18 – 30	13	AALAV…AARGL → QLWLSIYAPPRV in BAA11347. Ref.1
	Sequence conflict	86	1	D → G in BAA11347. Ref.1
	Sequence conflict	94	1	S → T in BAA11347. Ref.1
	Sequence conflict	176 – 178	3	VLA → LFP in BAA11347. Ref.1
	Sequence conflict	183	1	G → P in BAA11347. Ref.1
	Sequence conflict	529 – 530	2	LK → QMMIEFKINPSRR in BAA11347. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 5. Checksum: AE28A28E3826C196	FASTA	530	57,821
	10 20 30 40 50 60 MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 70 80 90 100 110 120 NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIA 130 140 150 160 170 180 EGFEAAKIKA LEVLEEVKVT KEMKRKILLD VARTSLQTKV HAELADVLTE VVVDSVLAVR 190 200 210 220 230 240 RPGYPIDLFM VEIMEMKHKL GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE 250 260 270 280 290 300 KTEVNSGFFY KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF 310 320 330 340 350 360 SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV YEYTLGEEKF 370 380 390 400 410 420 TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN AIEDGCMVPG AGAIEVAMAE 430 440 450 460 470 480 ALVTYKNSIK GRARLGVQAF ADALLIIPKV LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD 490 500 510 520 530 LNTGEPMVAA DAGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK
	Isoform 2 [UniParc]. Checksum: D8F1B077E65DE6A9	FASTA	485	53,100
	10 20 30 40 50 60 MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 70 80 90 100 110 120 NVLLDEMGLH PRIIAEGFEA AKIKALEVLE EVKVTKEMKR KILLDVARTS LQTKVHAELA 130 140 150 160 170 180 DVLTEVVVDS VLAVRRPGYP IDLFMVEIME MKHKLGTDTK LIQGLVLDHG ARHPDMKKRV 190 200 210 220 230 240 EDAFILICNV SLEYEKTEVN SGFFYKTAEE KEKLVKAERK FIEDRVQKII DLKDKVCAQS 250 260 270 280 290 300 NKGFVVINQK GIDPFSLDSL AKHGIVALRR AKRRNMERLS LACGGMAVNS FEDLTVDCLG 310 320 330 340 350 360 HAGLVYEYTL GEEKFTFIEE CVNPCSVTLL VKGPNKHTLT QVKDAIRDGL RAIKNAIEDG 370 380 390 400 410 420 CMVPGAGAIE VAMAEALVTY KNSIKGRARL GVQAFADALL IIPKVLAQNA GYDPQETLVK 430 440 450 460 470 480 VQAEHVESKQ LVGVDLNTGE PMVAADAGVW DNYCVKKQLL HSCTVIATNI LLVDEIMRAG MSSLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method." Ozaki K., Kuroki T., Hayashi S., Nakamura Y. Genomics 36:316-319(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-247. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-17 AND ALA-48. Tissue: Testis.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D78333 mRNA. Translation: BAA11347.1. AK302344 mRNA. Translation: BAG63672.1. AC022903 Genomic DNA. No translation available. BC026125 mRNA. Translation: AAH26125.1. BC027591 mRNA. Translation: AAH27591.1.
IPI	IPI00220656. IPI00910226.
RefSeq	NP_001180459.1. NM_001193530.1. NP_006575.2. NM_006584.3.
UniGene	Hs.73072.
3D structure databases
ProteinModelPortal	Q92526.
SMR	Q92526. Positions 3-527.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92526. 2 interactions.
STRING	9606.ENSP00000327191.
PTM databases
PhosphoSite	Q92526.
Polymorphism databases
DMDM	22654293.
2D gel databases
REPRODUCTION-2DPAGE	IPI00220656.
Proteomic databases
PaxDb	Q92526.
PRIDE	Q92526.
Protocols and materials databases
DNASU	10693.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314144; ENSP00000327191; ENSG00000132141. ENST00000436961; ENSP00000400917; ENSG00000132141.
GeneID	10693.
KEGG	hsa:10693.
UCSC	uc002hig.3. human.
Organism-specific databases
CTD	10693.
GeneCards	GC17M033254.
H-InvDB	HIX0013717.
HGNC	HGNC:1621. CCT6B.
MIM	610730. gene.
neXtProt	NX_Q92526.
PharmGKB	PA26184.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0459.
HOGENOM	HOG000226733.
HOVERGEN	HBG103725.
InParanoid	Q92526.
KO	K09498.
OMA	IVEMKHK.
Gene expression databases
ArrayExpress	Q92526.
Bgee	Q92526.
CleanEx	HS_CCT6B.
Genevestigator	Q92526.
GermOnline	ENSG00000132141. Homo sapiens.
Family and domain databases
InterPro	IPR012722. Chap_CCT_zeta. IPR017998. Chaperone_TCP-1. IPR002194. Chaperonin_TCP-1_CS. IPR002423. Cpn60/TCP-1. [Graphical view]
PANTHER	PTHR11353. PTHR11353. 1 hit. PTHR11353:SF21. PTHR11353:SF21. 1 hit.
Pfam	PF00118. Cpn60_TCP1. 1 hit. [Graphical view]
PRINTS	PR00304. TCOMPLEXTCP1.
SUPFAM	SSF48592. GroEL-ATPase. 1 hit.
TIGRFAMs	TIGR02347. chap_CCT_zeta. 1 hit.
PROSITE	PS00750. TCP1_1. 1 hit. PS00751. TCP1_2. 1 hit. PS00995. TCP1_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10693.
NextBio	40645.
SOURCE	Search...

Entry information

Entry name

TCPW_HUMAN

Accession

Primary (citable) accession number: Q92526
Secondary accession number(s): B4DYB0, Q8TC34

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 5, 2011
Last modified:	April 3, 2013
This is version 119 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.