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Q92526

- TCPW_HUMAN

UniProt

Q92526 - TCPW_HUMAN

Protein

T-complex protein 1 subunit zeta-2

Gene

CCT6B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 5 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein transporter activity Source: ProtInc
    3. unfolded protein binding Source: ProtInc

    GO - Biological processi

    1. chaperone-mediated protein complex assembly Source: ProtInc
    2. protein folding Source: ProtInc
    3. protein transport Source: GOC
    4. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-complex protein 1 subunit zeta-2
    Short name:
    TCP-1-zeta-2
    Alternative name(s):
    CCT-zeta-2
    CCT-zeta-like
    TCP-1-zeta-like
    Testis-specific Tcp20
    Testis-specific protein TSA303
    Gene namesi
    Name:CCT6B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1621. CCT6B.

    Subcellular locationi

    GO - Cellular componenti

    1. chaperonin-containing T-complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26184.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530T-complex protein 1 subunit zeta-2PRO_0000128363Add
    BLAST

    Proteomic databases

    MaxQBiQ92526.
    PaxDbiQ92526.
    PRIDEiQ92526.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00220656.

    PTM databases

    PhosphoSiteiQ92526.

    Expressioni

    Tissue specificityi

    Testis specific.

    Gene expression databases

    ArrayExpressiQ92526.
    BgeeiQ92526.
    CleanExiHS_CCT6B.
    GenevestigatoriQ92526.

    Interactioni

    Subunit structurei

    Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

    Protein-protein interaction databases

    BioGridi115932. 15 interactions.
    DIPiDIP-53269N.
    IntActiQ92526. 2 interactions.
    STRINGi9606.ENSP00000327191.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92526.
    SMRiQ92526. Positions 4-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCP-1 chaperonin family.Curated

    Phylogenomic databases

    eggNOGiCOG0459.
    HOGENOMiHOG000226733.
    HOVERGENiHBG103725.
    InParanoidiQ92526.
    KOiK09498.
    OMAiHVESKQL.
    OrthoDBiEOG7SN8C9.
    PhylomeDBiQ92526.
    TreeFamiTF106333.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProiIPR012722. Chap_CCT_zeta.
    IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00304. TCOMPLEXTCP1.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
    PROSITEiPS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92526-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG    50
    AGDIKLTKDG NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG 100
    ELLKQADLYI SEGLHPRIIA EGFEAAKIKA LEVLEEVKVT KEMKRKILLD 150
    VARTSLQTKV HAELADVLTE VVVDSVLAVR RPGYPIDLFM VEIMEMKHKL 200
    GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE KTEVNSGFFY 250
    KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF 300
    SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV 350
    YEYTLGEEKF TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN 400
    AIEDGCMVPG AGAIEVAMAE ALVTYKNSIK GRARLGVQAF ADALLIIPKV 450
    LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD LNTGEPMVAA DAGVWDNYCV 500
    KKQLLHSCTV IATNILLVDE IMRAGMSSLK 530
    Length:530
    Mass (Da):57,821
    Last modified:April 5, 2011 - v5
    Checksum:iAE28A28E3826C196
    GO
    Isoform 2 (identifier: Q92526-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         68-112: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:485
    Mass (Da):53,100
    Checksum:iD8F1B077E65DE6A9
    GO
    Isoform 3 (identifier: Q92526-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         206-242: Missing.

    Show »
    Length:493
    Mass (Da):53,586
    Checksum:iCF7E2D93CFB23B14
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 3013AALAV…AARGL → QLWLSIYAPPRV in BAA11347. (PubMed:8812458)CuratedAdd
    BLAST
    Sequence conflicti86 – 861D → G in BAA11347. (PubMed:8812458)Curated
    Sequence conflicti94 – 941S → T in BAA11347. (PubMed:8812458)Curated
    Sequence conflicti176 – 1783VLA → LFP in BAA11347. (PubMed:8812458)Curated
    Sequence conflicti183 – 1831G → P in BAA11347. (PubMed:8812458)Curated
    Sequence conflicti529 – 5302LK → QMMIEFKINPSRR in BAA11347. (PubMed:8812458)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171R → Q.1 Publication
    Corresponds to variant rs9635769 [ dbSNP | Ensembl ].
    VAR_060297
    Natural varianti48 – 481V → A.1 Publication
    Corresponds to variant rs2230552 [ dbSNP | Ensembl ].
    VAR_060298
    Natural varianti247 – 2471G → A.1 Publication
    Corresponds to variant rs2230553 [ dbSNP | Ensembl ].
    VAR_057269

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei68 – 11245Missing in isoform 2. 1 PublicationVSP_043040Add
    BLAST
    Alternative sequencei206 – 24237Missing in isoform 3. 1 PublicationVSP_047129Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78333 mRNA. Translation: BAA11347.1.
    AK301773 mRNA. Translation: BAG63232.1.
    AK302344 mRNA. Translation: BAG63672.1.
    AC022903 Genomic DNA. No translation available.
    BC026125 mRNA. Translation: AAH26125.1.
    BC027591 mRNA. Translation: AAH27591.1.
    CCDSiCCDS32617.1. [Q92526-1]
    CCDS54105.1. [Q92526-2]
    CCDS54106.1. [Q92526-3]
    RefSeqiNP_001180458.1. NM_001193529.1. [Q92526-3]
    NP_001180459.1. NM_001193530.1. [Q92526-2]
    NP_006575.2. NM_006584.3. [Q92526-1]
    UniGeneiHs.73072.

    Genome annotation databases

    EnsembliENST00000314144; ENSP00000327191; ENSG00000132141. [Q92526-1]
    ENST00000421975; ENSP00000398044; ENSG00000132141. [Q92526-3]
    ENST00000436961; ENSP00000400917; ENSG00000132141. [Q92526-2]
    GeneIDi10693.
    KEGGihsa:10693.
    UCSCiuc002hig.3. human. [Q92526-1]
    uc010wcc.2. human. [Q92526-2]

    Polymorphism databases

    DMDMi327478610.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78333 mRNA. Translation: BAA11347.1 .
    AK301773 mRNA. Translation: BAG63232.1 .
    AK302344 mRNA. Translation: BAG63672.1 .
    AC022903 Genomic DNA. No translation available.
    BC026125 mRNA. Translation: AAH26125.1 .
    BC027591 mRNA. Translation: AAH27591.1 .
    CCDSi CCDS32617.1. [Q92526-1 ]
    CCDS54105.1. [Q92526-2 ]
    CCDS54106.1. [Q92526-3 ]
    RefSeqi NP_001180458.1. NM_001193529.1. [Q92526-3 ]
    NP_001180459.1. NM_001193530.1. [Q92526-2 ]
    NP_006575.2. NM_006584.3. [Q92526-1 ]
    UniGenei Hs.73072.

    3D structure databases

    ProteinModelPortali Q92526.
    SMRi Q92526. Positions 4-525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115932. 15 interactions.
    DIPi DIP-53269N.
    IntActi Q92526. 2 interactions.
    STRINGi 9606.ENSP00000327191.

    PTM databases

    PhosphoSitei Q92526.

    Polymorphism databases

    DMDMi 327478610.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00220656.

    Proteomic databases

    MaxQBi Q92526.
    PaxDbi Q92526.
    PRIDEi Q92526.

    Protocols and materials databases

    DNASUi 10693.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314144 ; ENSP00000327191 ; ENSG00000132141 . [Q92526-1 ]
    ENST00000421975 ; ENSP00000398044 ; ENSG00000132141 . [Q92526-3 ]
    ENST00000436961 ; ENSP00000400917 ; ENSG00000132141 . [Q92526-2 ]
    GeneIDi 10693.
    KEGGi hsa:10693.
    UCSCi uc002hig.3. human. [Q92526-1 ]
    uc010wcc.2. human. [Q92526-2 ]

    Organism-specific databases

    CTDi 10693.
    GeneCardsi GC17M033254.
    H-InvDB HIX0013717.
    HGNCi HGNC:1621. CCT6B.
    MIMi 610730. gene.
    neXtProti NX_Q92526.
    PharmGKBi PA26184.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0459.
    HOGENOMi HOG000226733.
    HOVERGENi HBG103725.
    InParanoidi Q92526.
    KOi K09498.
    OMAi HVESKQL.
    OrthoDBi EOG7SN8C9.
    PhylomeDBi Q92526.
    TreeFami TF106333.

    Miscellaneous databases

    GenomeRNAii 10693.
    NextBioi 40645.
    PROi Q92526.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92526.
    Bgeei Q92526.
    CleanExi HS_CCT6B.
    Genevestigatori Q92526.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProi IPR012722. Chap_CCT_zeta.
    IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00304. TCOMPLEXTCP1.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02347. chap_CCT_zeta. 1 hit.
    PROSITEi PS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method."
      Ozaki K., Kuroki T., Hayashi S., Nakamura Y.
      Genomics 36:316-319(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-247.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Testis.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-17 AND ALA-48.
      Tissue: Testis.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTCPW_HUMAN
    AccessioniPrimary (citable) accession number: Q92526
    Secondary accession number(s): B4DX20, B4DYB0, Q8TC34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3