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Q92526

- TCPW_HUMAN

UniProt

Q92526 - TCPW_HUMAN

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Protein

T-complex protein 1 subunit zeta-2

Gene

CCT6B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein transporter activity Source: ProtInc
  3. unfolded protein binding Source: ProtInc

GO - Biological processi

  1. chaperone-mediated protein complex assembly Source: ProtInc
  2. protein folding Source: ProtInc
  3. protein transport Source: GOC
  4. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta-2
Short name:
TCP-1-zeta-2
Alternative name(s):
CCT-zeta-2
CCT-zeta-like
TCP-1-zeta-like
Testis-specific Tcp20
Testis-specific protein TSA303
Gene namesi
Name:CCT6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:1621. CCT6B.

Subcellular locationi

GO - Cellular componenti

  1. chaperonin-containing T-complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530T-complex protein 1 subunit zeta-2PRO_0000128363Add
BLAST

Proteomic databases

MaxQBiQ92526.
PaxDbiQ92526.
PRIDEiQ92526.

2D gel databases

REPRODUCTION-2DPAGEIPI00220656.

PTM databases

PhosphoSiteiQ92526.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ92526.
CleanExiHS_CCT6B.
ExpressionAtlasiQ92526. baseline and differential.
GenevestigatoriQ92526.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Protein-protein interaction databases

BioGridi115932. 50 interactions.
DIPiDIP-53269N.
IntActiQ92526. 2 interactions.
STRINGi9606.ENSP00000327191.

Structurei

3D structure databases

ProteinModelPortaliQ92526.
SMRiQ92526. Positions 4-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiCOG0459.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ92526.
KOiK09498.
OMAiHVESKQL.
OrthoDBiEOG7SN8C9.
PhylomeDBiQ92526.
TreeFamiTF106333.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92526-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIA EGFEAAKIKA LEVLEEVKVT KEMKRKILLD
160 170 180 190 200
VARTSLQTKV HAELADVLTE VVVDSVLAVR RPGYPIDLFM VEIMEMKHKL
210 220 230 240 250
GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE KTEVNSGFFY
260 270 280 290 300
KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF
310 320 330 340 350
SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV
360 370 380 390 400
YEYTLGEEKF TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN
410 420 430 440 450
AIEDGCMVPG AGAIEVAMAE ALVTYKNSIK GRARLGVQAF ADALLIIPKV
460 470 480 490 500
LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD LNTGEPMVAA DAGVWDNYCV
510 520 530
KKQLLHSCTV IATNILLVDE IMRAGMSSLK
Length:530
Mass (Da):57,821
Last modified:April 5, 2011 - v5
Checksum:iAE28A28E3826C196
GO
Isoform 2 (identifier: Q92526-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.

Note: No experimental confirmation available.

Show »
Length:485
Mass (Da):53,100
Checksum:iD8F1B077E65DE6A9
GO
Isoform 3 (identifier: Q92526-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-242: Missing.

Show »
Length:493
Mass (Da):53,586
Checksum:iCF7E2D93CFB23B14
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 3013AALAV…AARGL → QLWLSIYAPPRV in BAA11347. (PubMed:8812458)CuratedAdd
BLAST
Sequence conflicti86 – 861D → G in BAA11347. (PubMed:8812458)Curated
Sequence conflicti94 – 941S → T in BAA11347. (PubMed:8812458)Curated
Sequence conflicti176 – 1783VLA → LFP in BAA11347. (PubMed:8812458)Curated
Sequence conflicti183 – 1831G → P in BAA11347. (PubMed:8812458)Curated
Sequence conflicti529 – 5302LK → QMMIEFKINPSRR in BAA11347. (PubMed:8812458)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171R → Q.1 Publication
Corresponds to variant rs9635769 [ dbSNP | Ensembl ].
VAR_060297
Natural varianti48 – 481V → A.1 Publication
Corresponds to variant rs2230552 [ dbSNP | Ensembl ].
VAR_060298
Natural varianti247 – 2471G → A.1 Publication
Corresponds to variant rs2230553 [ dbSNP | Ensembl ].
VAR_057269

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 11245Missing in isoform 2. 1 PublicationVSP_043040Add
BLAST
Alternative sequencei206 – 24237Missing in isoform 3. 1 PublicationVSP_047129Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78333 mRNA. Translation: BAA11347.1.
AK301773 mRNA. Translation: BAG63232.1.
AK302344 mRNA. Translation: BAG63672.1.
AC022903 Genomic DNA. No translation available.
BC026125 mRNA. Translation: AAH26125.1.
BC027591 mRNA. Translation: AAH27591.1.
CCDSiCCDS32617.1. [Q92526-1]
CCDS54105.1. [Q92526-2]
CCDS54106.1. [Q92526-3]
RefSeqiNP_001180458.1. NM_001193529.1. [Q92526-3]
NP_001180459.1. NM_001193530.1. [Q92526-2]
NP_006575.2. NM_006584.3. [Q92526-1]
UniGeneiHs.73072.

Genome annotation databases

EnsembliENST00000314144; ENSP00000327191; ENSG00000132141. [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141. [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141. [Q92526-2]
GeneIDi10693.
KEGGihsa:10693.
UCSCiuc002hig.3. human. [Q92526-1]
uc010ctg.3. human.
uc010wcc.2. human. [Q92526-2]

Polymorphism databases

DMDMi327478610.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78333 mRNA. Translation: BAA11347.1 .
AK301773 mRNA. Translation: BAG63232.1 .
AK302344 mRNA. Translation: BAG63672.1 .
AC022903 Genomic DNA. No translation available.
BC026125 mRNA. Translation: AAH26125.1 .
BC027591 mRNA. Translation: AAH27591.1 .
CCDSi CCDS32617.1. [Q92526-1 ]
CCDS54105.1. [Q92526-2 ]
CCDS54106.1. [Q92526-3 ]
RefSeqi NP_001180458.1. NM_001193529.1. [Q92526-3 ]
NP_001180459.1. NM_001193530.1. [Q92526-2 ]
NP_006575.2. NM_006584.3. [Q92526-1 ]
UniGenei Hs.73072.

3D structure databases

ProteinModelPortali Q92526.
SMRi Q92526. Positions 4-525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115932. 50 interactions.
DIPi DIP-53269N.
IntActi Q92526. 2 interactions.
STRINGi 9606.ENSP00000327191.

PTM databases

PhosphoSitei Q92526.

Polymorphism databases

DMDMi 327478610.

2D gel databases

REPRODUCTION-2DPAGE IPI00220656.

Proteomic databases

MaxQBi Q92526.
PaxDbi Q92526.
PRIDEi Q92526.

Protocols and materials databases

DNASUi 10693.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314144 ; ENSP00000327191 ; ENSG00000132141 . [Q92526-1 ]
ENST00000421975 ; ENSP00000398044 ; ENSG00000132141 . [Q92526-3 ]
ENST00000436961 ; ENSP00000400917 ; ENSG00000132141 . [Q92526-2 ]
GeneIDi 10693.
KEGGi hsa:10693.
UCSCi uc002hig.3. human. [Q92526-1 ]
uc010ctg.3. human.
uc010wcc.2. human. [Q92526-2 ]

Organism-specific databases

CTDi 10693.
GeneCardsi GC17M033254.
H-InvDB HIX0013717.
HGNCi HGNC:1621. CCT6B.
MIMi 610730. gene.
neXtProti NX_Q92526.
PharmGKBi PA26184.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0459.
GeneTreei ENSGT00550000074743.
HOGENOMi HOG000226733.
HOVERGENi HBG103725.
InParanoidi Q92526.
KOi K09498.
OMAi HVESKQL.
OrthoDBi EOG7SN8C9.
PhylomeDBi Q92526.
TreeFami TF106333.

Miscellaneous databases

GenomeRNAii 10693.
NextBioi 40645.
PROi Q92526.
SOURCEi Search...

Gene expression databases

Bgeei Q92526.
CleanExi HS_CCT6B.
ExpressionAtlasi Q92526. baseline and differential.
Genevestigatori Q92526.

Family and domain databases

Gene3Di 1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProi IPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view ]
PANTHERi PTHR11353. PTHR11353. 1 hit.
Pfami PF00118. Cpn60_TCP1. 1 hit.
[Graphical view ]
PRINTSi PR00304. TCOMPLEXTCP1.
SUPFAMi SSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsi TIGR02347. chap_CCT_zeta. 1 hit.
PROSITEi PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method."
    Ozaki K., Kuroki T., Hayashi S., Nakamura Y.
    Genomics 36:316-319(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-247.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Testis.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-17 AND ALA-48.
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTCPW_HUMAN
AccessioniPrimary (citable) accession number: Q92526
Secondary accession number(s): B4DX20, B4DYB0, Q8TC34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 134 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3