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Protein

T-complex protein 1 subunit zeta-2

Gene

CCT6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein transporter activity Source: ProtInc
  • unfolded protein binding Source: ProtInc

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: ProtInc
  • protein folding Source: ProtInc
  • protein transport Source: GOC
  • spermatogenesis Source: ProtInc
  • toxin transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta-2
Short name:
TCP-1-zeta-2
Alternative name(s):
CCT-zeta-2
CCT-zeta-like
TCP-1-zeta-like
Testis-specific Tcp20
Testis-specific protein TSA303
Gene namesi
Name:CCT6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1621. CCT6B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26184.

Polymorphism and mutation databases

BioMutaiCCT6B.
DMDMi327478610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530T-complex protein 1 subunit zeta-2PRO_0000128363Add
BLAST

Proteomic databases

MaxQBiQ92526.
PaxDbiQ92526.
PRIDEiQ92526.

2D gel databases

REPRODUCTION-2DPAGEIPI00220656.

PTM databases

PhosphoSiteiQ92526.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ92526.
CleanExiHS_CCT6B.
ExpressionAtlasiQ92526. baseline and differential.
GenevestigatoriQ92526.

Organism-specific databases

HPAiHPA042996.
HPA045576.
HPA049949.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Protein-protein interaction databases

BioGridi115932. 60 interactions.
DIPiDIP-53269N.
IntActiQ92526. 2 interactions.
STRINGi9606.ENSP00000327191.

Structurei

3D structure databases

ProteinModelPortaliQ92526.
SMRiQ92526. Positions 4-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiCOG0459.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ92526.
KOiK09498.
OMAiHVESKQL.
OrthoDBiEOG7SN8C9.
PhylomeDBiQ92526.
TreeFamiTF106333.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92526-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIA EGFEAAKIKA LEVLEEVKVT KEMKRKILLD
160 170 180 190 200
VARTSLQTKV HAELADVLTE VVVDSVLAVR RPGYPIDLFM VEIMEMKHKL
210 220 230 240 250
GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE KTEVNSGFFY
260 270 280 290 300
KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF
310 320 330 340 350
SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV
360 370 380 390 400
YEYTLGEEKF TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN
410 420 430 440 450
AIEDGCMVPG AGAIEVAMAE ALVTYKNSIK GRARLGVQAF ADALLIIPKV
460 470 480 490 500
LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD LNTGEPMVAA DAGVWDNYCV
510 520 530
KKQLLHSCTV IATNILLVDE IMRAGMSSLK
Length:530
Mass (Da):57,821
Last modified:April 5, 2011 - v5
Checksum:iAE28A28E3826C196
GO
Isoform 2 (identifier: Q92526-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.

Note: No experimental confirmation available.

Show »
Length:485
Mass (Da):53,100
Checksum:iD8F1B077E65DE6A9
GO
Isoform 3 (identifier: Q92526-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-242: Missing.

Show »
Length:493
Mass (Da):53,586
Checksum:iCF7E2D93CFB23B14
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 3013AALAV…AARGL → QLWLSIYAPPRV in BAA11347 (PubMed:8812458).CuratedAdd
BLAST
Sequence conflicti86 – 861D → G in BAA11347 (PubMed:8812458).Curated
Sequence conflicti94 – 941S → T in BAA11347 (PubMed:8812458).Curated
Sequence conflicti176 – 1783VLA → LFP in BAA11347 (PubMed:8812458).Curated
Sequence conflicti183 – 1831G → P in BAA11347 (PubMed:8812458).Curated
Sequence conflicti529 – 5302LK → QMMIEFKINPSRR in BAA11347 (PubMed:8812458).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171R → Q.1 Publication
Corresponds to variant rs9635769 [ dbSNP | Ensembl ].
VAR_060297
Natural varianti48 – 481V → A.1 Publication
Corresponds to variant rs2230552 [ dbSNP | Ensembl ].
VAR_060298
Natural varianti247 – 2471G → A.1 Publication
Corresponds to variant rs2230553 [ dbSNP | Ensembl ].
VAR_057269

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 11245Missing in isoform 2. 1 PublicationVSP_043040Add
BLAST
Alternative sequencei206 – 24237Missing in isoform 3. 1 PublicationVSP_047129Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78333 mRNA. Translation: BAA11347.1.
AK301773 mRNA. Translation: BAG63232.1.
AK302344 mRNA. Translation: BAG63672.1.
AC022903 Genomic DNA. No translation available.
BC026125 mRNA. Translation: AAH26125.1.
BC027591 mRNA. Translation: AAH27591.1.
CCDSiCCDS32617.1. [Q92526-1]
CCDS54105.1. [Q92526-2]
CCDS54106.1. [Q92526-3]
RefSeqiNP_001180458.1. NM_001193529.2. [Q92526-3]
NP_001180459.1. NM_001193530.1. [Q92526-2]
NP_006575.2. NM_006584.3. [Q92526-1]
UniGeneiHs.73072.

Genome annotation databases

EnsembliENST00000314144; ENSP00000327191; ENSG00000132141. [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141. [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141. [Q92526-2]
GeneIDi10693.
KEGGihsa:10693.
UCSCiuc002hig.3. human. [Q92526-1]
uc010ctg.3. human.
uc010wcc.2. human. [Q92526-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78333 mRNA. Translation: BAA11347.1.
AK301773 mRNA. Translation: BAG63232.1.
AK302344 mRNA. Translation: BAG63672.1.
AC022903 Genomic DNA. No translation available.
BC026125 mRNA. Translation: AAH26125.1.
BC027591 mRNA. Translation: AAH27591.1.
CCDSiCCDS32617.1. [Q92526-1]
CCDS54105.1. [Q92526-2]
CCDS54106.1. [Q92526-3]
RefSeqiNP_001180458.1. NM_001193529.2. [Q92526-3]
NP_001180459.1. NM_001193530.1. [Q92526-2]
NP_006575.2. NM_006584.3. [Q92526-1]
UniGeneiHs.73072.

3D structure databases

ProteinModelPortaliQ92526.
SMRiQ92526. Positions 4-525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115932. 60 interactions.
DIPiDIP-53269N.
IntActiQ92526. 2 interactions.
STRINGi9606.ENSP00000327191.

PTM databases

PhosphoSiteiQ92526.

Polymorphism and mutation databases

BioMutaiCCT6B.
DMDMi327478610.

2D gel databases

REPRODUCTION-2DPAGEIPI00220656.

Proteomic databases

MaxQBiQ92526.
PaxDbiQ92526.
PRIDEiQ92526.

Protocols and materials databases

DNASUi10693.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314144; ENSP00000327191; ENSG00000132141. [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141. [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141. [Q92526-2]
GeneIDi10693.
KEGGihsa:10693.
UCSCiuc002hig.3. human. [Q92526-1]
uc010ctg.3. human.
uc010wcc.2. human. [Q92526-2]

Organism-specific databases

CTDi10693.
GeneCardsiGC17M033254.
H-InvDBHIX0013717.
HGNCiHGNC:1621. CCT6B.
HPAiHPA042996.
HPA045576.
HPA049949.
MIMi610730. gene.
neXtProtiNX_Q92526.
PharmGKBiPA26184.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0459.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ92526.
KOiK09498.
OMAiHVESKQL.
OrthoDBiEOG7SN8C9.
PhylomeDBiQ92526.
TreeFamiTF106333.

Miscellaneous databases

GenomeRNAii10693.
NextBioi40645.
PROiQ92526.
SOURCEiSearch...

Gene expression databases

BgeeiQ92526.
CleanExiHS_CCT6B.
ExpressionAtlasiQ92526. baseline and differential.
GenevestigatoriQ92526.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method."
    Ozaki K., Kuroki T., Hayashi S., Nakamura Y.
    Genomics 36:316-319(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-247.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Testis.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-17 AND ALA-48.
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTCPW_HUMAN
AccessioniPrimary (citable) accession number: Q92526
Secondary accession number(s): B4DX20, B4DYB0, Q8TC34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: April 29, 2015
This is version 138 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.