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Q92526 (TCPW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-complex protein 1 subunit zeta-2

Short name=TCP-1-zeta-2
Alternative name(s):
CCT-zeta-2
CCT-zeta-like
TCP-1-zeta-like
Testis-specific Tcp20
Testis-specific protein TSA303
Gene names
Name:CCT6B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin By similarity.

Subunit structure

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Subcellular location

Cytoplasm.

Tissue specificity

Testis specific.

Sequence similarities

Belongs to the TCP-1 chaperonin family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92526-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92526-2)

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q92526-3)

The sequence of this isoform differs from the canonical sequence as follows:
     206-242: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530T-complex protein 1 subunit zeta-2
PRO_0000128363

Natural variations

Alternative sequence68 – 11245Missing in isoform 2.
VSP_043040
Alternative sequence206 – 24237Missing in isoform 3.
VSP_047129
Natural variant171R → Q. Ref.4
Corresponds to variant rs9635769 [ dbSNP | Ensembl ].
VAR_060297
Natural variant481V → A. Ref.4
Corresponds to variant rs2230552 [ dbSNP | Ensembl ].
VAR_060298
Natural variant2471G → A. Ref.1
Corresponds to variant rs2230553 [ dbSNP | Ensembl ].
VAR_057269

Experimental info

Sequence conflict18 – 3013AALAV…AARGL → QLWLSIYAPPRV in BAA11347. Ref.1
Sequence conflict861D → G in BAA11347. Ref.1
Sequence conflict941S → T in BAA11347. Ref.1
Sequence conflict176 – 1783VLA → LFP in BAA11347. Ref.1
Sequence conflict1831G → P in BAA11347. Ref.1
Sequence conflict529 – 5302LK → QMMIEFKINPSRR in BAA11347. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 5, 2011. Version 5.
Checksum: AE28A28E3826C196

FASTA53057,821
        10         20         30         40         50         60 
MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 

        70         80         90        100        110        120 
NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIA 

       130        140        150        160        170        180 
EGFEAAKIKA LEVLEEVKVT KEMKRKILLD VARTSLQTKV HAELADVLTE VVVDSVLAVR 

       190        200        210        220        230        240 
RPGYPIDLFM VEIMEMKHKL GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE 

       250        260        270        280        290        300 
KTEVNSGFFY KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF 

       310        320        330        340        350        360 
SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV YEYTLGEEKF 

       370        380        390        400        410        420 
TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN AIEDGCMVPG AGAIEVAMAE 

       430        440        450        460        470        480 
ALVTYKNSIK GRARLGVQAF ADALLIIPKV LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD 

       490        500        510        520        530 
LNTGEPMVAA DAGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK 

« Hide

Isoform 2 [UniParc].

Checksum: D8F1B077E65DE6A9
Show »

FASTA48553,100
Isoform 3 [UniParc].

Checksum: CF7E2D93CFB23B14
Show »

FASTA49353,586

References

« Hide 'large scale' references
[1]"Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method."
Ozaki K., Kuroki T., Hayashi S., Nakamura Y.
Genomics 36:316-319(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-247.
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Testis.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-17 AND ALA-48.
Tissue: Testis.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D78333 mRNA. Translation: BAA11347.1.
AK301773 mRNA. Translation: BAG63232.1.
AK302344 mRNA. Translation: BAG63672.1.
AC022903 Genomic DNA. No translation available.
BC026125 mRNA. Translation: AAH26125.1.
BC027591 mRNA. Translation: AAH27591.1.
RefSeqNP_001180458.1. NM_001193529.1.
NP_001180459.1. NM_001193530.1.
NP_006575.2. NM_006584.3.
UniGeneHs.73072.

3D structure databases

ProteinModelPortalQ92526.
SMRQ92526. Positions 4-525.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115932. 15 interactions.
DIPDIP-53269N.
IntActQ92526. 2 interactions.
STRING9606.ENSP00000327191.

PTM databases

PhosphoSiteQ92526.

Polymorphism databases

DMDM327478610.

2D gel databases

REPRODUCTION-2DPAGEIPI00220656.

Proteomic databases

PaxDbQ92526.
PRIDEQ92526.

Protocols and materials databases

DNASU10693.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314144; ENSP00000327191; ENSG00000132141. [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141. [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141. [Q92526-2]
GeneID10693.
KEGGhsa:10693.
UCSCuc002hig.3. human. [Q92526-1]
uc010wcc.2. human. [Q92526-2]

Organism-specific databases

CTD10693.
GeneCardsGC17M033254.
H-InvDBHIX0013717.
HGNCHGNC:1621. CCT6B.
MIM610730. gene.
neXtProtNX_Q92526.
PharmGKBPA26184.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0459.
HOGENOMHOG000226733.
HOVERGENHBG103725.
InParanoidQ92526.
KOK09498.
OMAHVESKQL.
OrthoDBEOG7SN8C9.
PhylomeDBQ92526.
TreeFamTF106333.

Gene expression databases

ArrayExpressQ92526.
BgeeQ92526.
CleanExHS_CCT6B.
GenevestigatorQ92526.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERPTHR11353. PTHR11353. 1 hit.
PTHR11353:SF21. PTHR11353:SF21. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00304. TCOMPLEXTCP1.
SUPFAMSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10693.
NextBio40645.
PROQ92526.
SOURCESearch...

Entry information

Entry nameTCPW_HUMAN
AccessionPrimary (citable) accession number: Q92526
Secondary accession number(s): B4DX20, B4DYB0, Q8TC34
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 129 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM