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Q92523

- CPT1B_HUMAN

UniProt

Q92523 - CPT1B_HUMAN

Protein

Carnitine O-palmitoyltransferase 1, muscle isoform

Gene

CPT1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei473 – 4731Proton acceptorBy similarity
    Binding sitei589 – 5891CarnitineBy similarity
    Binding sitei602 – 6021CarnitineBy similarity

    GO - Molecular functioni

    1. carnitine O-palmitoyltransferase activity Source: ProtInc

    GO - Biological processi

    1. carnitine shuttle Source: Reactome
    2. cellular lipid metabolic process Source: Reactome
    3. fatty acid beta-oxidation Source: ProtInc
    4. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER66-34409.
    BRENDAi2.3.1.21. 2681.
    ReactomeiREACT_11082. Import of palmitoyl-CoA into the mitochondrial matrix.
    SABIO-RKQ92523.
    UniPathwayiUPA00659.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carnitine O-palmitoyltransferase 1, muscle isoform (EC:2.3.1.21)
    Short name:
    CPT1-M
    Alternative name(s):
    Carnitine O-palmitoyltransferase I, muscle isoform
    Short name:
    CPT I
    Short name:
    CPTI-M
    Carnitine palmitoyltransferase 1B
    Carnitine palmitoyltransferase I-like protein
    Gene namesi
    Name:CPT1B
    Synonyms:KIAA1670
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:2329. CPT1B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: Reactome
    3. mitochondrion Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26848.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 772772Carnitine O-palmitoyltransferase 1, muscle isoformPRO_0000210162Add
    BLAST

    Proteomic databases

    MaxQBiQ92523.
    PaxDbiQ92523.
    PRIDEiQ92523.

    PTM databases

    PhosphoSiteiQ92523.

    Expressioni

    Tissue specificityi

    Strong expression in heart and skeletal muscle. No expression in liver and kidney.

    Gene expression databases

    BgeeiQ92523.
    CleanExiHS_CPT1B.
    GenevestigatoriQ92523.

    Organism-specific databases

    HPAiHPA029583.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000312189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92523.
    SMRiQ92523. Positions 1-42, 171-764.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini74 – 10229Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini123 – 772650CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 7326HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12220HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni555 – 56713Coenzyme A bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70127.
    HOGENOMiHOG000233542.
    HOVERGENiHBG003458.
    InParanoidiQ92523.
    KOiK08765.
    OMAiRDRGKFC.
    OrthoDBiEOG7J17ZQ.
    PhylomeDBiQ92523.
    TreeFamiTF313836.

    Family and domain databases

    InterProiIPR000542. Carn_acyl_trans.
    [Graphical view]
    PANTHERiPTHR22589. PTHR22589. 1 hit.
    PfamiPF00755. Carn_acyltransf. 1 hit.
    [Graphical view]
    PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
    PS00440. ACYLTRANSF_C_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92523-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEAHQAVAF QFTVTPDGVD FRLSREALKH VYLSGINSWK KRLIRIKNGI    50
    LRGVYPGSPT SWLVVIMATV GSSFCNVDIS LGLVSCIQRC LPQGCGPYQT 100
    PQTRALLSMA IFSTGVWVTG IFFFRQTLKL LLCYHGWMFE MHGKTSNLTR 150
    IWAMCIRLLS SRHPMLYSFQ TSLPKLPVPR VSATIQRYLE SVRPLLDDEE 200
    YYRMELLAKE FQDKTAPRLQ KYLVLKSWWA SNYVSDWWEE YIYLRGRSPL 250
    MVNSNYYVMD LVLIKNTDVQ AARLGNIIHA MIMYRRKLDR EEIKPVMALG 300
    IVPMCSYQME RMFNTTRIPG KDTDVLQHLS DSRHVAVYHK GRFFKLWLYE 350
    GARLLKPQDL EMQFQRILDD PSPPQPGEEK LAALTAGGRV EWAQARQAFF 400
    SSGKNKAALE AIERAAFFVA LDEESYSYDP EDEASLSLYG KALLHGNCYN 450
    RWFDKSFTLI SFKNGQLGLN AEHAWADAPI IGHLWEFVLG TDSFHLGYTE 500
    TGHCLGKPNP ALAPPTRLQW DIPKQCQAVI ESSYQVAKAL ADDVELYCFQ 550
    FLPFGKGLIK KCRTSPDAFV QIALQLAHFR DRGKFCLTYE ASMTRMFREG 600
    RTETVRSCTS ESTAFVQAMM EGSHTKADLR DLFQKAAKKH QNMYRLAMTG 650
    AGIDRHLFCL YLVSKYLGVS SPFLAEVLSE PWRLSTSQIP QSQIRMFDPE 700
    QHPNHLGAGG GFGPVADDGY GVSYMIAGEN TIFFHISSKF SSSETNAQRF 750
    GNHIRKALLD IADLFQVPKA YS 772
    Length:772
    Mass (Da):87,801
    Last modified:November 1, 1997 - v2
    Checksum:iF7E3ED40643DFC81
    GO
    Isoform 2 (identifier: Q92523-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         581-581: D → G
         582-772: Missing.

    Show »
    Length:581
    Mass (Da):66,384
    Checksum:i3814222A5BDBF724
    GO
    Isoform 3 (identifier: Q92523-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         154-187: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:738
    Mass (Da):83,891
    Checksum:i24F7EAC9FFEE3D31
    GO
    Isoform 4 (identifier: Q92523-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         355-435: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:691
    Mass (Da):78,844
    Checksum:iED1E1029F325C8F4
    GO

    Sequence cautioni

    The sequence BAB33340.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751C → S in BAH13024. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661I → V.
    Corresponds to variant rs3213445 [ dbSNP | Ensembl ].
    VAR_020029
    Natural varianti320 – 3201G → D.
    Corresponds to variant rs2269383 [ dbSNP | Ensembl ].
    VAR_021854
    Natural varianti427 – 4271S → C.
    Corresponds to variant rs8142477 [ dbSNP | Ensembl ].
    VAR_024188
    Natural varianti531 – 5311E → K.2 Publications
    Corresponds to variant rs470117 [ dbSNP | Ensembl ].
    VAR_011739
    Natural varianti664 – 6641S → Y.
    Corresponds to variant rs1804702 [ dbSNP | Ensembl ].
    VAR_011740

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei154 – 18734Missing in isoform 3. 1 PublicationVSP_043184Add
    BLAST
    Alternative sequencei355 – 43581Missing in isoform 4. 1 PublicationVSP_044451Add
    BLAST
    Alternative sequencei581 – 5811D → G in isoform 2. 1 PublicationVSP_034246
    Alternative sequencei582 – 772191Missing in isoform 2. 1 PublicationVSP_034247Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87812 mRNA. Translation: BAA13461.1.
    U66828 mRNA. Translation: AAB40651.1.
    U62733 mRNA. Translation: AAC51122.1.
    Y08682 mRNA. Translation: CAA69938.1.
    Y08683 mRNA. Translation: CAA69939.1.
    AB003286 Genomic DNA. Translation: BAA21492.1.
    AB051457 mRNA. Translation: BAB33340.1. Different initiation.
    AK297866 mRNA. Translation: BAH12680.1.
    AK299395 mRNA. Translation: BAH13024.1.
    U62317 Genomic DNA. Translation: AAB03343.1.
    CCDSiCCDS14098.1. [Q92523-1]
    CCDS46734.1. [Q92523-3]
    CCDS46735.1. [Q92523-4]
    PIRiG02860.
    RefSeqiNP_001138606.1. NM_001145134.1. [Q92523-3]
    NP_001138607.1. NM_001145135.1. [Q92523-1]
    NP_001138608.1. NM_001145136.1. [Q92523-4]
    NP_001138609.1. NM_001145137.1. [Q92523-1]
    NP_004368.1. NM_004377.3. [Q92523-1]
    NP_689451.1. NM_152245.2. [Q92523-1]
    NP_689452.1. NM_152246.2. [Q92523-1]
    UniGeneiHs.439777.
    Hs.609867.

    Genome annotation databases

    EnsembliENST00000312108; ENSP00000312189; ENSG00000205560. [Q92523-1]
    ENST00000360719; ENSP00000353945; ENSG00000205560. [Q92523-1]
    ENST00000395650; ENSP00000379011; ENSG00000205560. [Q92523-1]
    ENST00000405237; ENSP00000385486; ENSG00000205560. [Q92523-1]
    ENST00000457250; ENSP00000409342; ENSG00000205560. [Q92523-3]
    GeneIDi1375.
    KEGGihsa:1375.
    UCSCiuc003bmk.4. human. [Q92523-1]
    uc011asa.2. human. [Q92523-3]
    uc011asb.2. human. [Q92523-4]

    Polymorphism databases

    DMDMi2493497.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87812 mRNA. Translation: BAA13461.1 .
    U66828 mRNA. Translation: AAB40651.1 .
    U62733 mRNA. Translation: AAC51122.1 .
    Y08682 mRNA. Translation: CAA69938.1 .
    Y08683 mRNA. Translation: CAA69939.1 .
    AB003286 Genomic DNA. Translation: BAA21492.1 .
    AB051457 mRNA. Translation: BAB33340.1 . Different initiation.
    AK297866 mRNA. Translation: BAH12680.1 .
    AK299395 mRNA. Translation: BAH13024.1 .
    U62317 Genomic DNA. Translation: AAB03343.1 .
    CCDSi CCDS14098.1. [Q92523-1 ]
    CCDS46734.1. [Q92523-3 ]
    CCDS46735.1. [Q92523-4 ]
    PIRi G02860.
    RefSeqi NP_001138606.1. NM_001145134.1. [Q92523-3 ]
    NP_001138607.1. NM_001145135.1. [Q92523-1 ]
    NP_001138608.1. NM_001145136.1. [Q92523-4 ]
    NP_001138609.1. NM_001145137.1. [Q92523-1 ]
    NP_004368.1. NM_004377.3. [Q92523-1 ]
    NP_689451.1. NM_152245.2. [Q92523-1 ]
    NP_689452.1. NM_152246.2. [Q92523-1 ]
    UniGenei Hs.439777.
    Hs.609867.

    3D structure databases

    ProteinModelPortali Q92523.
    SMRi Q92523. Positions 1-42, 171-764.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000312189.

    Chemistry

    ChEMBLi CHEMBL2216739.

    PTM databases

    PhosphoSitei Q92523.

    Polymorphism databases

    DMDMi 2493497.

    Proteomic databases

    MaxQBi Q92523.
    PaxDbi Q92523.
    PRIDEi Q92523.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312108 ; ENSP00000312189 ; ENSG00000205560 . [Q92523-1 ]
    ENST00000360719 ; ENSP00000353945 ; ENSG00000205560 . [Q92523-1 ]
    ENST00000395650 ; ENSP00000379011 ; ENSG00000205560 . [Q92523-1 ]
    ENST00000405237 ; ENSP00000385486 ; ENSG00000205560 . [Q92523-1 ]
    ENST00000457250 ; ENSP00000409342 ; ENSG00000205560 . [Q92523-3 ]
    GeneIDi 1375.
    KEGGi hsa:1375.
    UCSCi uc003bmk.4. human. [Q92523-1 ]
    uc011asa.2. human. [Q92523-3 ]
    uc011asb.2. human. [Q92523-4 ]

    Organism-specific databases

    CTDi 1375.
    GeneCardsi GC22M051008.
    HGNCi HGNC:2329. CPT1B.
    HPAi HPA029583.
    MIMi 601987. gene.
    neXtProti NX_Q92523.
    PharmGKBi PA26848.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70127.
    HOGENOMi HOG000233542.
    HOVERGENi HBG003458.
    InParanoidi Q92523.
    KOi K08765.
    OMAi RDRGKFC.
    OrthoDBi EOG7J17ZQ.
    PhylomeDBi Q92523.
    TreeFami TF313836.

    Enzyme and pathway databases

    UniPathwayi UPA00659 .
    BioCyci MetaCyc:MONOMER66-34409.
    BRENDAi 2.3.1.21. 2681.
    Reactomei REACT_11082. Import of palmitoyl-CoA into the mitochondrial matrix.
    SABIO-RK Q92523.

    Miscellaneous databases

    ChiTaRSi CPT1B. human.
    GenomeRNAii 1375.
    NextBioi 5575.
    PROi Q92523.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92523.
    CleanExi HS_CPT1B.
    Genevestigatori Q92523.

    Family and domain databases

    InterProi IPR000542. Carn_acyl_trans.
    [Graphical view ]
    PANTHERi PTHR22589. PTHR22589. 1 hit.
    Pfami PF00755. Carn_acyltransf. 1 hit.
    [Graphical view ]
    PROSITEi PS00439. ACYLTRANSF_C_1. 1 hit.
    PS00440. ACYLTRANSF_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I."
      Yamazaki N., Shinohara Y., Shima A., Yamanaka Y., Terada H.
      Biochim. Biophys. Acta 1307:157-161(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    2. "Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I."
      Zhu H., Shi J., de Vries Y., Arvidson D.N., Cregg J.M., Woldegiorgis G.
      Arch. Biochem. Biophys. 347:53-61(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B)."
      Britton C.H., Mackey D.W., Esser V., Foster D.W., Burns D.K., Yarnall D.P., Froguel P., McGarry J.D.
      Genomics 40:209-211(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    4. "Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I."
      van der Leij F.R., Takens J., van der Veen A.Y., Terpstra P., Kuipers J.R.G.
      Biochim. Biophys. Acta 1352:123-128(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    5. "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I."
      Yamazaki N., Yamanaka Y., Hashimoto Y., Shinohara Y., Shima A., Terada H.
      FEBS Lett. 409:401-406(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    6. "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping."
      Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.
      DNA Res. 8:1-9(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LYS-531.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT LYS-531.
      Tissue: Heart and Tongue.
    8. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCPT1B_HUMAN
    AccessioniPrimary (citable) accession number: Q92523
    Secondary accession number(s): B7Z4U4
    , B7Z5T8, E9PCP2, Q13389, Q99655, Q9BY90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This protein is produced by a bicistronic gene which also produces the CHKB protein from a non-overlapping reading frame.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3