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Protein

Histone H1x

Gene

H1FX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1x
Gene namesi
Name:H1FX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000184897.5
HGNCiHGNC:4722 H1FX
MIMi602785 gene
neXtProtiNX_Q92522

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8971
OpenTargetsiENSG00000184897
PharmGKBiPA29099

Polymorphism and mutation databases

BioMutaiH1FX
DMDMi6016184

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001959122 – 213Histone H1xAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei47N6-acetyllysineCombined sources1
Modified residuei62CitrullineBy similarity1

Post-translational modificationi

Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiQ92522
MaxQBiQ92522
PaxDbiQ92522
PeptideAtlasiQ92522
PRIDEiQ92522
ProteomicsDBi75281
TopDownProteomicsiQ92522

PTM databases

iPTMnetiQ92522
PhosphoSitePlusiQ92522

Expressioni

Tissue specificityi

Expressed ubiquitously.

Gene expression databases

BgeeiENSG00000184897
CleanExiHS_H1FX
GenevisibleiQ92522 HS

Organism-specific databases

HPAiCAB012235
HPA040099

Interactioni

Subunit structurei

Interacts with RRP1B.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114461, 65 interactors
CORUMiQ92522
DIPiDIP-36358N
IntActiQ92522, 44 interactors
MINTiQ92522
STRINGi9606.ENSP00000329662

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 59Combined sources13
Helixi67 – 74Combined sources8
Turni82 – 84Combined sources3
Helixi85 – 98Combined sources14
Beta strandi101 – 105Combined sources5
Beta strandi107 – 109Combined sources3
Beta strandi111 – 116Combined sources6
Turni120 – 122Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LSONMR-A44-123[»]
ProteinModelPortaliQ92522
SMRiQ92522
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 118H15PROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00730000111536
HOGENOMiHOG000112842
HOVERGENiHBG009035
InParanoidiQ92522
KOiK11275
OMAiARKVAWF
OrthoDBiEOG091G167M
PhylomeDBiQ92522
TreeFamiTF313664

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVELEEALP VTTAEGMAKK VTKAGGSAAL SPSKKRKNSK KKNQPGKYSQ
60 70 80 90 100
LVVETIRRLG ERNGSSLAKI YTEAKKVPWF DQQNGRTYLK YSIKALVQND
110 120 130 140 150
TLLQVKGTGA NGSFKLNRKK LEGGGERRGA PAAATAPAPT AHKAKKAAPG
160 170 180 190 200
AAGSRRADKK PARGQKPEQR SHKKGAGAKK DKGGKAKKTA AAGGKKVKKA
210
AKPSVPKVPK GRK
Length:213
Mass (Da):22,487
Last modified:February 1, 1997 - v1
Checksum:i11548D85C5448FF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64142 mRNA Translation: BAA11018.1
BC000426 mRNA Translation: AAH00426.1
BC010435 mRNA Translation: AAH10435.1
CCDSiCCDS3057.1
PIRiJC4928
RefSeqiNP_006017.1, NM_006026.3
UniGeneiHs.75307

Genome annotation databases

EnsembliENST00000333762; ENSP00000329662; ENSG00000184897
GeneIDi8971
KEGGihsa:8971
UCSCiuc003elx.3 human

Similar proteinsi

Entry informationi

Entry nameiH1X_HUMAN
AccessioniPrimary (citable) accession number: Q92522
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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