SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q92521

- PIGB_HUMAN

UniProt

Q92521 - PIGB_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
GPI mannosyltransferase 3
Gene
PIGB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.1 Publication

Pathwayi

GO - Molecular functioni

  1. mannosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. C-terminal protein lipidation Source: Reactome
  2. GPI anchor biosynthetic process Source: UniProtKB
  3. cellular protein metabolic process Source: Reactome
  4. mannosylation Source: GOC
  5. post-translational protein modification Source: Reactome
  6. preassembly of GPI anchor in ER membrane Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiREACT_952. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 3 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase III
Short name:
GPI-MT-III
Phosphatidylinositol-glycan biosynthesis class B protein
Short name:
PIG-B
Gene namesi
Name:PIGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:8959. PIGB.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8321Helical; Reviewed prediction
Add
BLAST
Transmembranei136 – 15621Helical; Reviewed prediction
Add
BLAST
Transmembranei192 – 21221Helical; Reviewed prediction
Add
BLAST
Transmembranei224 – 24421Helical; Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST
Transmembranei315 – 33521Helical; Reviewed prediction
Add
BLAST
Transmembranei340 – 36021Helical; Reviewed prediction
Add
BLAST
Transmembranei362 – 38221Helical; Reviewed prediction
Add
BLAST
Transmembranei387 – 40721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554GPI mannosyltransferase 3
PRO_0000246251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi427 – 4271N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ92521.
PaxDbiQ92521.
PRIDEiQ92521.

PTM databases

PhosphoSiteiQ92521.

Expressioni

Gene expression databases

ArrayExpressiQ92521.
BgeeiQ92521.
CleanExiHS_PIGB.
GenevestigatoriQ92521.

Organism-specific databases

HPAiHPA039929.

Interactioni

Protein-protein interaction databases

BioGridi114870. 1 interaction.
STRINGi9606.ENSP00000164305.

Structurei

3D structure databases

ProteinModelPortaliQ92521.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276773.
HOGENOMiHOG000189846.
HOVERGENiHBG082136.
InParanoidiQ92521.
KOiK05286.
OMAiFLQCPPN.
OrthoDBiEOG761BV9.
PhylomeDBiQ92521.
TreeFamiTF313518.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92521-1 [UniParc]FASTAAdd to Basket

« Hide

MRRPLSKCGM EPGGGDASLT LHGLQNRSHG KIKLRKRKST LYFNTQEKSA    50
RRRGDLLGEN IYLLLFTIAL RILNCFLVQT SFVPDEYWQS LEVSHHMVFN 100
YGYLTWEWTE RLRSYTYPLI FASIYKILHL LGKDSVQLLI WIPRLAQALL 150
SAVADVRLYS LMKQLENQEV ARWVFFCQLC SWFTWYCCTR TLTNTMETVL 200
TIIALFYYPL EGSKSMNSVK YSSLVALAFI IRPTAVILWT PLLFRHFCQE 250
PRKLDLILHH FLPVGFVTLS LSLMIDRIFF GQWTLVQFNF LKFNVLQNWG 300
TFYGSHPWHW YFSQGFPVIL GTHLPFFIHG CYLAPKRYRI LLVTVLWTLL 350
VYSMLSHKEF RFIYPVLPFC MVFCGYSLTH LKTWKKPALS FLFLSNLFLA 400
LYTGLVHQRG TLDVMSHIQK VCYNNPNKSS ASIFIMMPCH STPYYSHVHC 450
PLPMRFLQCP PDLTGKSHYL DEADVFYLNP LNWLHREFHD DASLPTHLIT 500
FSILEEEISA FLISSNYKRT AVFFHTHLPE GRIGSHIYVY ERKLKGKFNM 550
KMKF 554
Length:554
Mass (Da):65,056
Last modified:February 1, 1997 - v1
Checksum:iB2AF87D13ADF90B3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681I → L.1 Publication
Corresponds to variant rs17851556 [ dbSNP | Ensembl ].
VAR_027027
Natural varianti162 – 1621M → T.
Corresponds to variant rs2290344 [ dbSNP | Ensembl ].
VAR_027028
Natural varianti299 – 2991W → L.2 Publications
Corresponds to variant rs678892 [ dbSNP | Ensembl ].
VAR_027029
Natural varianti484 – 4841L → S.1 Publication
Corresponds to variant rs17851554 [ dbSNP | Ensembl ].
VAR_027030
Natural varianti502 – 5021S → G.
Corresponds to variant rs652397 [ dbSNP | Ensembl ].
VAR_049224
Natural varianti551 – 5511K → T.
Corresponds to variant rs2444042 [ dbSNP | Ensembl ].
VAR_027031

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981T → I in BAD97050. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42138 mRNA. Translation: BAA07709.1.
AK223330 mRNA. Translation: BAD97050.1.
BC017711 mRNA. Translation: AAH17711.1.
CCDSiCCDS61641.1.
PIRiS71751.
RefSeqiNP_004846.4. NM_004855.4.
UniGeneiHs.612814.

Genome annotation databases

EnsembliENST00000164305; ENSP00000164305; ENSG00000069943.
GeneIDi9488.
KEGGihsa:9488.
UCSCiuc002act.3. human.

Polymorphism databases

DMDMi74716597.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42138 mRNA. Translation: BAA07709.1 .
AK223330 mRNA. Translation: BAD97050.1 .
BC017711 mRNA. Translation: AAH17711.1 .
CCDSi CCDS61641.1.
PIRi S71751.
RefSeqi NP_004846.4. NM_004855.4.
UniGenei Hs.612814.

3D structure databases

ProteinModelPortali Q92521.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114870. 1 interaction.
STRINGi 9606.ENSP00000164305.

Protein family/group databases

CAZyi GT22. Glycosyltransferase Family 22.

PTM databases

PhosphoSitei Q92521.

Polymorphism databases

DMDMi 74716597.

Proteomic databases

MaxQBi Q92521.
PaxDbi Q92521.
PRIDEi Q92521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000164305 ; ENSP00000164305 ; ENSG00000069943 .
GeneIDi 9488.
KEGGi hsa:9488.
UCSCi uc002act.3. human.

Organism-specific databases

CTDi 9488.
GeneCardsi GC15P055611.
HGNCi HGNC:8959. PIGB.
HPAi HPA039929.
MIMi 604122. gene.
neXtProti NX_Q92521.
PharmGKBi PA33290.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276773.
HOGENOMi HOG000189846.
HOVERGENi HBG082136.
InParanoidi Q92521.
KOi K05286.
OMAi FLQCPPN.
OrthoDBi EOG761BV9.
PhylomeDBi Q92521.
TreeFami TF313518.

Enzyme and pathway databases

UniPathwayi UPA00196 .
Reactomei REACT_952. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

GeneWikii PIGB.
GenomeRNAii 9488.
NextBioi 35552.
PROi Q92521.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92521.
Bgeei Q92521.
CleanExi HS_PIGB.
Genevestigatori Q92521.

Family and domain databases

InterProi IPR005599. GPI_mannosylTrfase.
[Graphical view ]
PANTHERi PTHR22760. PTHR22760. 1 hit.
Pfami PF03901. Glyco_transf_22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor."
    Takahashi M., Inoue N., Ohishi K., Maeda Y., Nakamura N., Endo Y., Fujita T., Takeda J., Kinoshita T.
    EMBO J. 15:4254-4261(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LEU-68; LEU-299 AND SER-484.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-299.
    Tissue: Prostate.
  4. "Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants."
    Mohney R.P., Knez J.J., Ravi L., Sevlever D., Rosenberry T.L., Hirose S., Medof M.E.
    J. Biol. Chem. 269:6536-6542(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiPIGB_HUMAN
AccessioniPrimary (citable) accession number: Q92521
Secondary accession number(s): Q53FF9, Q8WVN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi