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Protein

GPI mannosyltransferase 3

Gene

PIGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.1 Publication

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

  • glycolipid mannosyltransferase activity Source: Reactome
  • mannosyltransferase activity Source: UniProtKB

GO - Biological processi

  • GPI anchor biosynthetic process Source: UniProtKB
  • preassembly of GPI anchor in ER membrane Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-162710. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 3 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase III
Short name:
GPI-MT-III
Phosphatidylinositol-glycan biosynthesis class B protein
Short name:
PIG-B
Gene namesi
Name:PIGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:8959. PIGB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9488.
OpenTargetsiENSG00000069943.
PharmGKBiPA33290.

Polymorphism and mutation databases

BioMutaiPIGB.
DMDMi74716597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002462511 – 554GPI mannosyltransferase 3Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi427N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ92521.
MaxQBiQ92521.
PaxDbiQ92521.
PeptideAtlasiQ92521.
PRIDEiQ92521.

PTM databases

iPTMnetiQ92521.
PhosphoSitePlusiQ92521.

Expressioni

Gene expression databases

BgeeiENSG00000069943.
CleanExiHS_PIGB.
ExpressionAtlasiQ92521. baseline and differential.
GenevisibleiQ92521. HS.

Organism-specific databases

HPAiHPA039929.

Interactioni

Protein-protein interaction databases

BioGridi114870. 7 interactors.
STRINGi9606.ENSP00000164305.

Structurei

3D structure databases

ProteinModelPortaliQ92521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1771. Eukaryota.
ENOG410XYK9. LUCA.
GeneTreeiENSGT00550000075012.
HOGENOMiHOG000189846.
HOVERGENiHBG082136.
InParanoidiQ92521.
KOiK05286.
PhylomeDBiQ92521.
TreeFamiTF313518.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRPLSKCGM EPGGGDASLT LHGLQNRSHG KIKLRKRKST LYFNTQEKSA
60 70 80 90 100
RRRGDLLGEN IYLLLFTIAL RILNCFLVQT SFVPDEYWQS LEVSHHMVFN
110 120 130 140 150
YGYLTWEWTE RLRSYTYPLI FASIYKILHL LGKDSVQLLI WIPRLAQALL
160 170 180 190 200
SAVADVRLYS LMKQLENQEV ARWVFFCQLC SWFTWYCCTR TLTNTMETVL
210 220 230 240 250
TIIALFYYPL EGSKSMNSVK YSSLVALAFI IRPTAVILWT PLLFRHFCQE
260 270 280 290 300
PRKLDLILHH FLPVGFVTLS LSLMIDRIFF GQWTLVQFNF LKFNVLQNWG
310 320 330 340 350
TFYGSHPWHW YFSQGFPVIL GTHLPFFIHG CYLAPKRYRI LLVTVLWTLL
360 370 380 390 400
VYSMLSHKEF RFIYPVLPFC MVFCGYSLTH LKTWKKPALS FLFLSNLFLA
410 420 430 440 450
LYTGLVHQRG TLDVMSHIQK VCYNNPNKSS ASIFIMMPCH STPYYSHVHC
460 470 480 490 500
PLPMRFLQCP PDLTGKSHYL DEADVFYLNP LNWLHREFHD DASLPTHLIT
510 520 530 540 550
FSILEEEISA FLISSNYKRT AVFFHTHLPE GRIGSHIYVY ERKLKGKFNM

KMKF
Length:554
Mass (Da):65,056
Last modified:February 1, 1997 - v1
Checksum:iB2AF87D13ADF90B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198T → I in BAD97050 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02702768I → L.1 PublicationCorresponds to variant rs17851556dbSNPEnsembl.1
Natural variantiVAR_027028162M → T.Corresponds to variant rs2290344dbSNPEnsembl.1
Natural variantiVAR_027029299W → L.2 PublicationsCorresponds to variant rs678892dbSNPEnsembl.1
Natural variantiVAR_027030484L → S.1 PublicationCorresponds to variant rs17851554dbSNPEnsembl.1
Natural variantiVAR_049224502S → G.Corresponds to variant rs652397dbSNPEnsembl.1
Natural variantiVAR_027031551K → T.Corresponds to variant rs2444042dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42138 mRNA. Translation: BAA07709.1.
AK223330 mRNA. Translation: BAD97050.1.
BC017711 mRNA. Translation: AAH17711.1.
CCDSiCCDS61641.1.
PIRiS71751.
RefSeqiNP_004846.4. NM_004855.4.
UniGeneiHs.612814.

Genome annotation databases

EnsembliENST00000164305; ENSP00000164305; ENSG00000069943.
GeneIDi9488.
KEGGihsa:9488.
UCSCiuc002act.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42138 mRNA. Translation: BAA07709.1.
AK223330 mRNA. Translation: BAD97050.1.
BC017711 mRNA. Translation: AAH17711.1.
CCDSiCCDS61641.1.
PIRiS71751.
RefSeqiNP_004846.4. NM_004855.4.
UniGeneiHs.612814.

3D structure databases

ProteinModelPortaliQ92521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114870. 7 interactors.
STRINGi9606.ENSP00000164305.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

PTM databases

iPTMnetiQ92521.
PhosphoSitePlusiQ92521.

Polymorphism and mutation databases

BioMutaiPIGB.
DMDMi74716597.

Proteomic databases

EPDiQ92521.
MaxQBiQ92521.
PaxDbiQ92521.
PeptideAtlasiQ92521.
PRIDEiQ92521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000164305; ENSP00000164305; ENSG00000069943.
GeneIDi9488.
KEGGihsa:9488.
UCSCiuc002act.4. human.

Organism-specific databases

CTDi9488.
DisGeNETi9488.
GeneCardsiPIGB.
HGNCiHGNC:8959. PIGB.
HPAiHPA039929.
MIMi604122. gene.
neXtProtiNX_Q92521.
OpenTargetsiENSG00000069943.
PharmGKBiPA33290.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1771. Eukaryota.
ENOG410XYK9. LUCA.
GeneTreeiENSGT00550000075012.
HOGENOMiHOG000189846.
HOVERGENiHBG082136.
InParanoidiQ92521.
KOiK05286.
PhylomeDBiQ92521.
TreeFamiTF313518.

Enzyme and pathway databases

UniPathwayiUPA00196.
ReactomeiR-HSA-162710. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

ChiTaRSiPIGB. human.
GeneWikiiPIGB.
GenomeRNAii9488.
PROiQ92521.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069943.
CleanExiHS_PIGB.
ExpressionAtlasiQ92521. baseline and differential.
GenevisibleiQ92521. HS.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGB_HUMAN
AccessioniPrimary (citable) accession number: Q92521
Secondary accession number(s): Q53FF9, Q8WVN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.