ID   FAM3C_HUMAN             Reviewed;         227 AA.
AC   Q92520; A6NDN2; A8K3R7;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-JAN-2012, entry version 91.
DE   RecName: Full=Protein FAM3C;
DE   AltName: Full=Interleukin-like EMT inducer;
DE   Flags: Precursor;
GN   Name=FAM3C; Synonyms=ILEI; ORFNames=GS3786;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone;
RA   Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K.;
RT   "The cloning of a cDNA for novel genes expressed in human
RT   osteoblast.";
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22737999; PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, Duodenum, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION.
RX   MEDLINE=22150867; PubMed=12160727; DOI=10.1006/geno.2002.6816;
RA   Zhu Y., Xu G., Patel A., McLaughlin M.M., Silverman C., Knecht K.A.,
RA   Sweitzer S., Li X., McDonnell P., Mirabile R., Zimmerman D., Boyce R.,
RA   Tierney L.A., Hu E., Livi G.P., Wolf B.A., Abdel-Meguid S.S.,
RA   Rose G.D., Aurora R., Hensley P., Briggs M., Young P.R.;
RT   "Cloning, expression, and initial characterization of a novel
RT   cytokine-like gene family.";
RL   Genomics 80:144-150(2002).
RN   [7]
RP   TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND UP-REGULATION IN BREAST
RP   CANCER.
RX   PubMed=16959614; DOI=10.1016/j.ccr.2006.07.020;
RA   Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A.,
RA   Brabletz T., Schreiber M., Jechlinger M., Beug H.;
RT   "ILEI: a cytokine essential for EMT, tumor formation, and late events
RT   in metastasis in epithelial cells.";
RL   Cancer Cell 10:227-239(2006).
RN   [8]
RP   UP-REGULATION IN BREAST CANCER.
RX   PubMed=19015638; DOI=10.1038/onc.2008.418;
RA   Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D.,
RA   van Zijl F., Huber H., Csiszar A., Beug H., Mikulits W.;
RT   "ILEI requires oncogenic Ras for the epithelial to mesenchymal
RT   transition of hepatocytes and liver carcinoma progression.";
RL   Oncogene 28:638-650(2009).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: May be involved in retinal laminar formation. Promotes
CC       epithelial to mesenchymal transition.
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity). Cytoplasmic
CC       vesicle. Note=Cytoplasmic in some cancer cells.
CC   -!- TISSUE SPECIFICITY: Present in most secretory epithelia (at
CC       protein level).
CC   -!- MISCELLANEOUS: Up-regulation and/or mislocalization in breast
CC       cancer and liver carcinoma cells is strongly correlated with
CC       metastasis formation and survival.
CC   -!- SIMILARITY: Belongs to the FAM3 family.
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DR   EMBL; D87120; BAA13251.1; -; mRNA.
DR   EMBL; AK290682; BAF83371.1; -; mRNA.
DR   EMBL; AK292731; BAF85420.1; -; mRNA.
DR   EMBL; AC006364; AAQ96872.1; -; Genomic_DNA.
DR   EMBL; CH471070; EAW83558.1; -; Genomic_DNA.
DR   EMBL; BC024200; AAH24200.1; -; mRNA.
DR   EMBL; BC046932; AAH46932.1; -; mRNA.
DR   EMBL; BC068526; AAH68526.1; -; mRNA.
DR   IPI; IPI00334282; -.
DR   RefSeq; NP_001035109.1; NM_001040020.1.
DR   RefSeq; NP_055703.1; NM_014888.2.
DR   UniGene; Hs.272375; -.
DR   UniGene; Hs.434053; -.
DR   ProteinModelPortal; Q92520; -.
DR   IntAct; Q92520; 1.
DR   STRING; Q92520; -.
DR   DMDM; 3334194; -.
DR   PeptideAtlas; Q92520; -.
DR   PRIDE; Q92520; -.
DR   Ensembl; ENST00000359943; ENSP00000353025; ENSG00000196937.
DR   Ensembl; ENST00000455255; ENSP00000390160; ENSG00000196937.
DR   GeneID; 10447; -.
DR   KEGG; hsa:10447; -.
DR   UCSC; uc003vjx.1; human.
DR   CTD; 10447; -.
DR   GeneCards; GC07M120988; -.
DR   H-InvDB; HIX0025328; -.
DR   HGNC; HGNC:18664; FAM3C.
DR   MIM; 608618; gene.
DR   neXtProt; NX_Q92520; -.
DR   PharmGKB; PA38627; -.
DR   eggNOG; prNOG07364; -.
DR   GeneTree; ENSGT00530000063020; -.
DR   HOGENOM; HBG714462; -.
DR   HOVERGEN; HBG051544; -.
DR   InParanoid; Q92520; -.
DR   OMA; VGPKICV; -.
DR   OrthoDB; EOG43R3NW; -.
DR   PhylomeDB; Q92520; -.
DR   NextBio; 39599; -.
DR   ArrayExpress; Q92520; -.
DR   Bgee; Q92520; -.
DR   CleanEx; HS_FAM3C; -.
DR   Genevestigator; Q92520; -.
DR   GermOnline; ENSG00000196937; Homo sapiens.
DR   GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; NAS:UniProtKB.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasmic vesicle; Developmental protein;
KW   Disulfide bond; Oncogene; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    227       Protein FAM3C.
FT                                /FTId=PRO_0000008752.
FT   DISULFID     58    221       Potential.
FT   DISULFID     64     86       Potential.
SQ   SEQUENCE   227 AA;  24680 MW;  6DC94B259052647F CRC64;
     MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS TKPPRYKCGI
     SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINVALAN GKTGEVLDTK
     YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY DDGATKLNDE ARRLIADLGS TSITNLGFRD
     NWVFCGGKGI KTKSPFEQHI KNNKDTNKYE GWPEVVEMEG CIPQKQD
//