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Protein

Protein FAM3C

Gene

FAM3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174028-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3C
Alternative name(s):
Interleukin-like EMT inducer
Gene namesi
Name:FAM3C
Synonyms:ILEI
ORF Names:GS3786
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18664. FAM3C.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • Golgi apparatus Source: HPA
  • platelet dense granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNETi10447.
OpenTargetsiENSG00000196937.
PharmGKBiPA38627.

Polymorphism and mutation databases

BioMutaiFAM3C.
DMDMi3334194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000875225 – 227Protein FAM3CAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 86By similarity
Disulfide bondi64 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ92520.
MaxQBiQ92520.
PaxDbiQ92520.
PeptideAtlasiQ92520.
PRIDEiQ92520.
TopDownProteomicsiQ92520.

PTM databases

iPTMnetiQ92520.
PhosphoSitePlusiQ92520.
SwissPalmiQ92520.

Expressioni

Tissue specificityi

Present in most secretory epithelia (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000196937.
CleanExiHS_FAM3C.
ExpressionAtlasiQ92520. baseline and differential.
GenevisibleiQ92520. HS.

Organism-specific databases

HPAiHPA043376.
HPA050548.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA83EBI-2876774,EBI-6942903

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115712. 32 interactors.
IntActiQ92520. 6 interactors.
MINTiMINT-5003390.
STRINGi9606.ENSP00000353025.

Structurei

3D structure databases

ProteinModelPortaliQ92520.
SMRiQ92520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEGC. Eukaryota.
ENOG4111I9K. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ92520.
OMAiPKICVED.
OrthoDBiEOG091G0IGX.
PhylomeDBiQ92520.
TreeFamiTF353414.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS
60 70 80 90 100
TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV
110 120 130 140 150
GRGINVALAN GKTGEVLDTK YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY
160 170 180 190 200
DDGATKLNDE ARRLIADLGS TSITNLGFRD NWVFCGGKGI KTKSPFEQHI
210 220
KNNKDTNKYE GWPEVVEMEG CIPQKQD
Length:227
Mass (Da):24,680
Last modified:February 1, 1997 - v1
Checksum:i6DC94B259052647F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87120 mRNA. Translation: BAA13251.1.
AK290682 mRNA. Translation: BAF83371.1.
AK292731 mRNA. Translation: BAF85420.1.
AC006364 Genomic DNA. Translation: AAQ96872.1.
CH471070 Genomic DNA. Translation: EAW83558.1.
BC024200 mRNA. Translation: AAH24200.1.
BC046932 mRNA. Translation: AAH46932.1.
BC068526 mRNA. Translation: AAH68526.1.
CCDSiCCDS5782.1.
RefSeqiNP_001035109.1. NM_001040020.1.
NP_055703.1. NM_014888.2.
XP_011514038.1. XM_011515736.2.
XP_011514039.1. XM_011515737.2.
UniGeneiHs.272375.
Hs.434053.

Genome annotation databases

EnsembliENST00000359943; ENSP00000353025; ENSG00000196937.
GeneIDi10447.
KEGGihsa:10447.
UCSCiuc003vjx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87120 mRNA. Translation: BAA13251.1.
AK290682 mRNA. Translation: BAF83371.1.
AK292731 mRNA. Translation: BAF85420.1.
AC006364 Genomic DNA. Translation: AAQ96872.1.
CH471070 Genomic DNA. Translation: EAW83558.1.
BC024200 mRNA. Translation: AAH24200.1.
BC046932 mRNA. Translation: AAH46932.1.
BC068526 mRNA. Translation: AAH68526.1.
CCDSiCCDS5782.1.
RefSeqiNP_001035109.1. NM_001040020.1.
NP_055703.1. NM_014888.2.
XP_011514038.1. XM_011515736.2.
XP_011514039.1. XM_011515737.2.
UniGeneiHs.272375.
Hs.434053.

3D structure databases

ProteinModelPortaliQ92520.
SMRiQ92520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115712. 32 interactors.
IntActiQ92520. 6 interactors.
MINTiMINT-5003390.
STRINGi9606.ENSP00000353025.

PTM databases

iPTMnetiQ92520.
PhosphoSitePlusiQ92520.
SwissPalmiQ92520.

Polymorphism and mutation databases

BioMutaiFAM3C.
DMDMi3334194.

Proteomic databases

EPDiQ92520.
MaxQBiQ92520.
PaxDbiQ92520.
PeptideAtlasiQ92520.
PRIDEiQ92520.
TopDownProteomicsiQ92520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359943; ENSP00000353025; ENSG00000196937.
GeneIDi10447.
KEGGihsa:10447.
UCSCiuc003vjx.4. human.

Organism-specific databases

CTDi10447.
DisGeNETi10447.
GeneCardsiFAM3C.
HGNCiHGNC:18664. FAM3C.
HPAiHPA043376.
HPA050548.
MIMi608618. gene.
neXtProtiNX_Q92520.
OpenTargetsiENSG00000196937.
PharmGKBiPA38627.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGC. Eukaryota.
ENOG4111I9K. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ92520.
OMAiPKICVED.
OrthoDBiEOG091G0IGX.
PhylomeDBiQ92520.
TreeFamiTF353414.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174028-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiFAM3C. human.
GeneWikiiFAM3C.
GenomeRNAii10447.
PROiQ92520.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196937.
CleanExiHS_FAM3C.
ExpressionAtlasiQ92520. baseline and differential.
GenevisibleiQ92520. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiFAM3C_HUMAN
AccessioniPrimary (citable) accession number: Q92520
Secondary accession number(s): A6NDN2, A8K3R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.