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Protein

Protein FAM3C

Gene

FAM3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

GO - Molecular functioni

  1. cytokine activity Source: UniProtKB

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3C
Alternative name(s):
Interleukin-like EMT inducer
Gene namesi
Name:FAM3C
Synonyms:ILEI
ORF Names:GS3786
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18664. FAM3C.

Subcellular locationi

Secreted By similarity. Cytoplasmic vesicle 1 Publication
Note: Cytoplasmic in some cancer cells.

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProtKB
  4. Golgi apparatus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Organism-specific databases

PharmGKBiPA38627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 227203Protein FAM3CPRO_0000008752Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 86By similarity
Disulfide bondi64 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ92520.
PaxDbiQ92520.
PeptideAtlasiQ92520.
PRIDEiQ92520.

PTM databases

PhosphoSiteiQ92520.

Expressioni

Tissue specificityi

Present in most secretory epithelia (at protein level).1 Publication

Gene expression databases

BgeeiQ92520.
CleanExiHS_FAM3C.
ExpressionAtlasiQ92520. baseline and differential.
GenevestigatoriQ92520.

Organism-specific databases

HPAiHPA043376.
HPA050548.

Interactioni

Protein-protein interaction databases

BioGridi115712. 26 interactions.
IntActiQ92520. 2 interactions.
MINTiMINT-5003390.

Structurei

3D structure databases

ProteinModelPortaliQ92520.
SMRiQ92520. Positions 53-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG79275.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ92520.
OMAiPKICVED.
PhylomeDBiQ92520.
TreeFamiTF353414.

Family and domain databases

InterProiIPR026101. FAM3.
[Graphical view]
PANTHERiPTHR14592. PTHR14592. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS
60 70 80 90 100
TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV
110 120 130 140 150
GRGINVALAN GKTGEVLDTK YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY
160 170 180 190 200
DDGATKLNDE ARRLIADLGS TSITNLGFRD NWVFCGGKGI KTKSPFEQHI
210 220
KNNKDTNKYE GWPEVVEMEG CIPQKQD
Length:227
Mass (Da):24,680
Last modified:February 1, 1997 - v1
Checksum:i6DC94B259052647F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87120 mRNA. Translation: BAA13251.1.
AK290682 mRNA. Translation: BAF83371.1.
AK292731 mRNA. Translation: BAF85420.1.
AC006364 Genomic DNA. Translation: AAQ96872.1.
CH471070 Genomic DNA. Translation: EAW83558.1.
BC024200 mRNA. Translation: AAH24200.1.
BC046932 mRNA. Translation: AAH46932.1.
BC068526 mRNA. Translation: AAH68526.1.
CCDSiCCDS5782.1.
RefSeqiNP_001035109.1. NM_001040020.1.
NP_055703.1. NM_014888.2.
UniGeneiHs.272375.
Hs.434053.

Genome annotation databases

EnsembliENST00000359943; ENSP00000353025; ENSG00000196937.
GeneIDi10447.
KEGGihsa:10447.
UCSCiuc003vjx.3. human.

Polymorphism databases

DMDMi3334194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87120 mRNA. Translation: BAA13251.1.
AK290682 mRNA. Translation: BAF83371.1.
AK292731 mRNA. Translation: BAF85420.1.
AC006364 Genomic DNA. Translation: AAQ96872.1.
CH471070 Genomic DNA. Translation: EAW83558.1.
BC024200 mRNA. Translation: AAH24200.1.
BC046932 mRNA. Translation: AAH46932.1.
BC068526 mRNA. Translation: AAH68526.1.
CCDSiCCDS5782.1.
RefSeqiNP_001035109.1. NM_001040020.1.
NP_055703.1. NM_014888.2.
UniGeneiHs.272375.
Hs.434053.

3D structure databases

ProteinModelPortaliQ92520.
SMRiQ92520. Positions 53-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115712. 26 interactions.
IntActiQ92520. 2 interactions.
MINTiMINT-5003390.

PTM databases

PhosphoSiteiQ92520.

Polymorphism databases

DMDMi3334194.

Proteomic databases

MaxQBiQ92520.
PaxDbiQ92520.
PeptideAtlasiQ92520.
PRIDEiQ92520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359943; ENSP00000353025; ENSG00000196937.
GeneIDi10447.
KEGGihsa:10447.
UCSCiuc003vjx.3. human.

Organism-specific databases

CTDi10447.
GeneCardsiGC07M120988.
HGNCiHGNC:18664. FAM3C.
HPAiHPA043376.
HPA050548.
MIMi608618. gene.
neXtProtiNX_Q92520.
PharmGKBiPA38627.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79275.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ92520.
OMAiPKICVED.
PhylomeDBiQ92520.
TreeFamiTF353414.

Miscellaneous databases

ChiTaRSiFAM3C. human.
GeneWikiiFAM3C.
GenomeRNAii10447.
NextBioi39599.
PROiQ92520.
SOURCEiSearch...

Gene expression databases

BgeeiQ92520.
CleanExiHS_FAM3C.
ExpressionAtlasiQ92520. baseline and differential.
GenevestigatoriQ92520.

Family and domain databases

InterProiIPR026101. FAM3.
[Graphical view]
PANTHERiPTHR14592. PTHR14592. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning of a cDNA for novel genes expressed in human osteoblast."
    Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Duodenum and Muscle.
  6. Cited for: IDENTIFICATION.
  7. "ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells."
    Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A., Brabletz T., Schreiber M., Jechlinger M., Beug H.
    Cancer Cell 10:227-239(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, UP-REGULATION IN BREAST CANCER.
  8. "ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression."
    Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D., van Zijl F., Huber H., Csiszar A., Beug H., Mikulits W.
    Oncogene 28:638-650(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UP-REGULATION IN BREAST CANCER.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFAM3C_HUMAN
AccessioniPrimary (citable) accession number: Q92520
Secondary accession number(s): A6NDN2, A8K3R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.