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Q92520

- FAM3C_HUMAN

UniProt

Q92520 - FAM3C_HUMAN

Protein

Protein FAM3C

Gene

FAM3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

    GO - Molecular functioni

    1. cytokine activity Source: UniProtKB

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM3C
    Alternative name(s):
    Interleukin-like EMT inducer
    Gene namesi
    Name:FAM3C
    Synonyms:ILEI
    ORF Names:GS3786
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:18664. FAM3C.

    Subcellular locationi

    Secreted By similarity. Cytoplasmic vesicle 1 Publication
    Note: Cytoplasmic in some cancer cells.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi apparatus Source: HPA

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    Organism-specific databases

    PharmGKBiPA38627.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 227203Protein FAM3CPRO_0000008752Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 86By similarity
    Disulfide bondi64 ↔ 221By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ92520.
    PaxDbiQ92520.
    PeptideAtlasiQ92520.
    PRIDEiQ92520.

    PTM databases

    PhosphoSiteiQ92520.

    Expressioni

    Tissue specificityi

    Present in most secretory epithelia (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ92520.
    BgeeiQ92520.
    CleanExiHS_FAM3C.
    GenevestigatoriQ92520.

    Organism-specific databases

    HPAiHPA043376.
    HPA050548.

    Interactioni

    Protein-protein interaction databases

    BioGridi115712. 17 interactions.
    IntActiQ92520. 2 interactions.
    MINTiMINT-5003390.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92520.
    SMRiQ92520. Positions 53-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM3 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG79275.
    HOGENOMiHOG000285992.
    HOVERGENiHBG051544.
    InParanoidiQ92520.
    OMAiPKICVED.
    PhylomeDBiQ92520.
    TreeFamiTF353414.

    Family and domain databases

    InterProiIPR026101. FAM3.
    [Graphical view]
    PANTHERiPTHR14592. PTHR14592. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92520-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS    50
    TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV 100
    GRGINVALAN GKTGEVLDTK YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY 150
    DDGATKLNDE ARRLIADLGS TSITNLGFRD NWVFCGGKGI KTKSPFEQHI 200
    KNNKDTNKYE GWPEVVEMEG CIPQKQD 227
    Length:227
    Mass (Da):24,680
    Last modified:February 1, 1997 - v1
    Checksum:i6DC94B259052647F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87120 mRNA. Translation: BAA13251.1.
    AK290682 mRNA. Translation: BAF83371.1.
    AK292731 mRNA. Translation: BAF85420.1.
    AC006364 Genomic DNA. Translation: AAQ96872.1.
    CH471070 Genomic DNA. Translation: EAW83558.1.
    BC024200 mRNA. Translation: AAH24200.1.
    BC046932 mRNA. Translation: AAH46932.1.
    BC068526 mRNA. Translation: AAH68526.1.
    CCDSiCCDS5782.1.
    RefSeqiNP_001035109.1. NM_001040020.1.
    NP_055703.1. NM_014888.2.
    UniGeneiHs.272375.
    Hs.434053.

    Genome annotation databases

    EnsembliENST00000359943; ENSP00000353025; ENSG00000196937.
    GeneIDi10447.
    KEGGihsa:10447.
    UCSCiuc003vjx.3. human.

    Polymorphism databases

    DMDMi3334194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87120 mRNA. Translation: BAA13251.1 .
    AK290682 mRNA. Translation: BAF83371.1 .
    AK292731 mRNA. Translation: BAF85420.1 .
    AC006364 Genomic DNA. Translation: AAQ96872.1 .
    CH471070 Genomic DNA. Translation: EAW83558.1 .
    BC024200 mRNA. Translation: AAH24200.1 .
    BC046932 mRNA. Translation: AAH46932.1 .
    BC068526 mRNA. Translation: AAH68526.1 .
    CCDSi CCDS5782.1.
    RefSeqi NP_001035109.1. NM_001040020.1.
    NP_055703.1. NM_014888.2.
    UniGenei Hs.272375.
    Hs.434053.

    3D structure databases

    ProteinModelPortali Q92520.
    SMRi Q92520. Positions 53-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115712. 17 interactions.
    IntActi Q92520. 2 interactions.
    MINTi MINT-5003390.

    PTM databases

    PhosphoSitei Q92520.

    Polymorphism databases

    DMDMi 3334194.

    Proteomic databases

    MaxQBi Q92520.
    PaxDbi Q92520.
    PeptideAtlasi Q92520.
    PRIDEi Q92520.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359943 ; ENSP00000353025 ; ENSG00000196937 .
    GeneIDi 10447.
    KEGGi hsa:10447.
    UCSCi uc003vjx.3. human.

    Organism-specific databases

    CTDi 10447.
    GeneCardsi GC07M120988.
    HGNCi HGNC:18664. FAM3C.
    HPAi HPA043376.
    HPA050548.
    MIMi 608618. gene.
    neXtProti NX_Q92520.
    PharmGKBi PA38627.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79275.
    HOGENOMi HOG000285992.
    HOVERGENi HBG051544.
    InParanoidi Q92520.
    OMAi PKICVED.
    PhylomeDBi Q92520.
    TreeFami TF353414.

    Miscellaneous databases

    ChiTaRSi FAM3C. human.
    GeneWikii FAM3C.
    GenomeRNAii 10447.
    NextBioi 39599.
    PROi Q92520.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92520.
    Bgeei Q92520.
    CleanExi HS_FAM3C.
    Genevestigatori Q92520.

    Family and domain databases

    InterProi IPR026101. FAM3.
    [Graphical view ]
    PANTHERi PTHR14592. PTHR14592. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The cloning of a cDNA for novel genes expressed in human osteoblast."
      Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Duodenum and Muscle.
    6. Cited for: IDENTIFICATION.
    7. "ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells."
      Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A., Brabletz T., Schreiber M., Jechlinger M., Beug H.
      Cancer Cell 10:227-239(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, UP-REGULATION IN BREAST CANCER.
    8. "ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression."
      Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D., van Zijl F., Huber H., Csiszar A., Beug H., Mikulits W.
      Oncogene 28:638-650(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: UP-REGULATION IN BREAST CANCER.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFAM3C_HUMAN
    AccessioniPrimary (citable) accession number: Q92520
    Secondary accession number(s): A6NDN2, A8K3R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3