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Protein

Protein FAM3C

Gene

FAM3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Miscellaneous

Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3C
Alternative name(s):
Interleukin-like EMT inducer
Gene namesi
Name:FAM3C
Synonyms:ILEI
ORF Names:GS3786
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000196937.10.
HGNCiHGNC:18664. FAM3C.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNETi10447.
OpenTargetsiENSG00000196937.
PharmGKBiPA38627.

Polymorphism and mutation databases

BioMutaiFAM3C.
DMDMi3334194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000875225 – 227Protein FAM3CAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 86By similarity
Disulfide bondi64 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ92520.
MaxQBiQ92520.
PaxDbiQ92520.
PeptideAtlasiQ92520.
PRIDEiQ92520.
TopDownProteomicsiQ92520.

PTM databases

iPTMnetiQ92520.
PhosphoSitePlusiQ92520.
SwissPalmiQ92520.

Expressioni

Tissue specificityi

Present in most secretory epithelia (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000196937.
CleanExiHS_FAM3C.
ExpressionAtlasiQ92520. baseline and differential.
GenevisibleiQ92520. HS.

Organism-specific databases

HPAiHPA043376.
HPA050548.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA83EBI-2876774,EBI-6942903

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115712. 39 interactors.
IntActiQ92520. 13 interactors.
MINTiMINT-5003390.
STRINGi9606.ENSP00000353025.

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi57 – 59Combined sources3
Beta strandi66 – 74Combined sources9
Turni78 – 80Combined sources3
Beta strandi84 – 87Combined sources4
Beta strandi90 – 93Combined sources4
Turni95 – 98Combined sources4
Beta strandi102 – 109Combined sources8
Turni111 – 113Combined sources3
Beta strandi116 – 122Combined sources7
Turni124 – 126Combined sources3
Helixi130 – 137Combined sources8
Beta strandi144 – 151Combined sources8
Helixi159 – 166Combined sources8
Turni167 – 169Combined sources3
Helixi172 – 175Combined sources4
Beta strandi181 – 187Combined sources7
Beta strandi197 – 200Combined sources4
Turni204 – 206Combined sources3
Beta strandi208 – 212Combined sources5
Beta strandi217 – 223Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC2X-ray1.80A/B55-227[»]
ProteinModelPortaliQ92520.
SMRiQ92520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEGC. Eukaryota.
ENOG4111I9K. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ92520.
OMAiPKICVED.
OrthoDBiEOG091G0IGX.
PhylomeDBiQ92520.
TreeFamiTF353414.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS
60 70 80 90 100
TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV
110 120 130 140 150
GRGINVALAN GKTGEVLDTK YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY
160 170 180 190 200
DDGATKLNDE ARRLIADLGS TSITNLGFRD NWVFCGGKGI KTKSPFEQHI
210 220
KNNKDTNKYE GWPEVVEMEG CIPQKQD
Length:227
Mass (Da):24,680
Last modified:February 1, 1997 - v1
Checksum:i6DC94B259052647F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87120 mRNA. Translation: BAA13251.1.
AK290682 mRNA. Translation: BAF83371.1.
AK292731 mRNA. Translation: BAF85420.1.
AC006364 Genomic DNA. Translation: AAQ96872.1.
CH471070 Genomic DNA. Translation: EAW83558.1.
BC024200 mRNA. Translation: AAH24200.1.
BC046932 mRNA. Translation: AAH46932.1.
BC068526 mRNA. Translation: AAH68526.1.
CCDSiCCDS5782.1.
RefSeqiNP_001035109.1. NM_001040020.1.
NP_055703.1. NM_014888.2.
XP_011514038.1. XM_011515736.2.
XP_011514039.1. XM_011515737.2.
UniGeneiHs.272375.
Hs.434053.

Genome annotation databases

EnsembliENST00000359943; ENSP00000353025; ENSG00000196937.
GeneIDi10447.
KEGGihsa:10447.
UCSCiuc003vjx.4. human.

Similar proteinsi

Entry informationi

Entry nameiFAM3C_HUMAN
AccessioniPrimary (citable) accession number: Q92520
Secondary accession number(s): A6NDN2, A8K3R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 22, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families