Q92520 (FAM3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM3C

Alternative name(s):
Interleukin-like EMT inducer

Gene names

Name:	FAM3C
Synonyms:	ILEI
ORF Names:	GS3786

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
Subcellular location	Secreted By similarity. Cytoplasmic vesicle. Note: Cytoplasmic in some cancer cells. Ref.7
Tissue specificity	Present in most secretory epithelia (at protein level). Ref.7
Miscellaneous	Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.
Sequence similarities	Belongs to the FAM3 family.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Secreted
Disease	Oncogene
Domain	Signal
Molecular function	Developmental protein
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Non-traceable author statement Ref.6. Source: UniProtKB
Molecular function	cytokine activity Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 227	203	Protein FAM3C		PRO_0000008752
Amino acid modifications
	Disulfide bond	58 ↔ 221		Potential
	Disulfide bond	64 ↔ 86		Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92520 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 6DC94B259052647F	FASTA	227	24,680
	10 20 30 40 50 60 MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS TKPPRYKCGI 70 80 90 100 110 120 SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINVALAN GKTGEVLDTK 130 140 150 160 170 180 YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY DDGATKLNDE ARRLIADLGS TSITNLGFRD 190 200 210 220 NWVFCGGKGI KTKSPFEQHI KNNKDTNKYE GWPEVVEMEG CIPQKQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cloning of a cDNA for novel genes expressed in human osteoblast." Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Duodenum and Muscle.
[6]	"Cloning, expression, and initial characterization of a novel cytokine-like gene family." Zhu Y., Xu G., Patel A., McLaughlin M.M., Silverman C., Knecht K.A., Sweitzer S., Li X., McDonnell P., Mirabile R., Zimmerman D., Boyce R., Tierney L.A., Hu E., Livi G.P., Wolf B.A., Abdel-Meguid S.S., Rose G.D. , Aurora R., Hensley P., Briggs M., Young P.R. Genomics 80:144-150(2002) [PubMed: 12160727] [Abstract] Cited for: IDENTIFICATION.
[7]	"ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells." Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A., Brabletz T., Schreiber M., Jechlinger M., Beug H. Cancer Cell 10:227-239(2006) [PubMed: 16959614] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, UP-REGULATION IN BREAST CANCER.
[8]	"ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression." Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D., van Zijl F., Huber H., Csiszar A., Beug H., Mikulits W. Oncogene 28:638-650(2009) [PubMed: 19015638] [Abstract] Cited for: UP-REGULATION IN BREAST CANCER.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D87120 mRNA. Translation: BAA13251.1. AK290682 mRNA. Translation: BAF83371.1. AK292731 mRNA. Translation: BAF85420.1. AC006364 Genomic DNA. Translation: AAQ96872.1. CH471070 Genomic DNA. Translation: EAW83558.1. BC024200 mRNA. Translation: AAH24200.1. BC046932 mRNA. Translation: AAH46932.1. BC068526 mRNA. Translation: AAH68526.1.
IPI	IPI00334282.
RefSeq	NP_001035109.1. NM_001040020.1. NP_055703.1. NM_014888.2.
UniGene	Hs.272375. Hs.434053.
3D structure databases
ProteinModelPortal	Q92520.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92520. 1 interaction.
STRING	Q92520.
Polymorphism databases
DMDM	3334194.
Proteomic databases
PeptideAtlas	Q92520.
PRIDE	Q92520.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359943; ENSP00000353025; ENSG00000196937. ENST00000455255; ENSP00000390160; ENSG00000196937.
GeneID	10447.
KEGG	hsa:10447.
UCSC	uc003vjx.1. human.
Organism-specific databases
CTD	10447.
GeneCards	GC07M120988.
H-InvDB	HIX0025328.
HGNC	HGNC:18664. FAM3C.
MIM	608618. gene.
neXtProt	NX_Q92520.
PharmGKB	PA38627.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07364.
GeneTree	ENSGT00530000063020.
HOGENOM	HBG714462.
HOVERGEN	HBG051544.
InParanoid	Q92520.
OMA	VGPKICV.
OrthoDB	EOG43R3NW.
PhylomeDB	Q92520.
Gene expression databases
ArrayExpress	Q92520.
Bgee	Q92520.
CleanEx	HS_FAM3C.
Genevestigator	Q92520.
GermOnline	ENSG00000196937. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	39599.
SOURCE	Search...

Entry information

Entry name

FAM3C_HUMAN

Accession

Primary (citable) accession number: Q92520
Secondary accession number(s): A6NDN2, A8K3R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.