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Q92519

- TRIB2_HUMAN

UniProt

Q92519 - TRIB2_HUMAN

Protein

Tribbles homolog 2

Gene

TRIB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity By similarity.By similarity

    GO - Molecular functioni

    1. protein kinase inhibitor activity Source: UniProtKB-KW
    2. transcription factor binding Source: BHF-UCL
    3. transferase activity, transferring phosphorus-containing groups Source: InterPro
    4. ubiquitin protein ligase binding Source: BHF-UCL
    5. ubiquitin-protein transferase regulator activity Source: BHF-UCL

    GO - Biological processi

    1. negative regulation of fat cell differentiation Source: BHF-UCL
    2. negative regulation of interleukin-10 biosynthetic process Source: BHF-UCL
    3. negative regulation of protein kinase activity Source: BHF-UCL
    4. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    5. regulation of MAP kinase activity Source: UniProtKB

    Keywords - Molecular functioni

    Protein kinase inhibitor

    Enzyme and pathway databases

    SignaLinkiQ92519.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tribbles homolog 2
    Short name:
    TRB-2
    Gene namesi
    Name:TRIB2Imported
    Synonyms:TRB2Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:30809. TRIB2.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
    Note: May associate with the cytoskeleton.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394647.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Tribbles homolog 2PRO_0000131863Add
    BLAST

    Proteomic databases

    PaxDbiQ92519.
    PRIDEiQ92519.

    PTM databases

    PhosphoSiteiQ92519.

    Expressioni

    Tissue specificityi

    Highly expressed in peripheral blood leukocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ92519.
    BgeeiQ92519.
    CleanExiHS_TRIB2.
    GenevestigatoriQ92519.

    Organism-specific databases

    HPAiHPA001305.

    Interactioni

    Protein-protein interaction databases

    BioGridi118779. 8 interactions.
    IntActiQ92519. 4 interactions.
    MINTiMINT-2812905.
    STRINGi9606.ENSP00000155926.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92519.
    SMRiQ92519. Positions 61-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 308248Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000231872.
    HOVERGENiHBG067729.
    InParanoidiQ92519.
    KOiK08814.
    OMAiHCHDNGL.
    PhylomeDBiQ92519.
    TreeFamiTF329785.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR024104. Tribbles/Ser_Thr_kinase_40.
    [Graphical view]
    PANTHERiPTHR22961. PTHR22961. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92519-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE    50
    TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES 100
    LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE 150
    EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY 200
    ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG 250
    RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ 300
    EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN 343
    Length:343
    Mass (Da):38,801
    Last modified:February 1, 1997 - v1
    Checksum:iBF8B7366DACB84FA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41H → R.1 Publication
    Corresponds to variant rs55813198 [ dbSNP | Ensembl ].
    VAR_042371

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87119 mRNA. Translation: BAA13250.1.
    AY245544 mRNA. Translation: AAO89231.1.
    AK313237 mRNA. Translation: BAG36048.1.
    AC009486 Genomic DNA. Translation: AAY15015.1.
    CH471053 Genomic DNA. Translation: EAX00907.1.
    CH471053 Genomic DNA. Translation: EAX00908.1.
    CH471053 Genomic DNA. Translation: EAX00909.1.
    BC002637 mRNA. Translation: AAH02637.1.
    CCDSiCCDS1683.1.
    RefSeqiNP_067675.1. NM_021643.3.
    UniGeneiHs.467751.

    Genome annotation databases

    EnsembliENST00000155926; ENSP00000155926; ENSG00000071575.
    GeneIDi28951.
    KEGGihsa:28951.
    UCSCiuc002rbv.4. human.

    Polymorphism databases

    DMDMi74762638.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87119 mRNA. Translation: BAA13250.1 .
    AY245544 mRNA. Translation: AAO89231.1 .
    AK313237 mRNA. Translation: BAG36048.1 .
    AC009486 Genomic DNA. Translation: AAY15015.1 .
    CH471053 Genomic DNA. Translation: EAX00907.1 .
    CH471053 Genomic DNA. Translation: EAX00908.1 .
    CH471053 Genomic DNA. Translation: EAX00909.1 .
    BC002637 mRNA. Translation: AAH02637.1 .
    CCDSi CCDS1683.1.
    RefSeqi NP_067675.1. NM_021643.3.
    UniGenei Hs.467751.

    3D structure databases

    ProteinModelPortali Q92519.
    SMRi Q92519. Positions 61-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118779. 8 interactions.
    IntActi Q92519. 4 interactions.
    MINTi MINT-2812905.
    STRINGi 9606.ENSP00000155926.

    PTM databases

    PhosphoSitei Q92519.

    Polymorphism databases

    DMDMi 74762638.

    Proteomic databases

    PaxDbi Q92519.
    PRIDEi Q92519.

    Protocols and materials databases

    DNASUi 28951.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000155926 ; ENSP00000155926 ; ENSG00000071575 .
    GeneIDi 28951.
    KEGGi hsa:28951.
    UCSCi uc002rbv.4. human.

    Organism-specific databases

    CTDi 28951.
    GeneCardsi GC02P012856.
    HGNCi HGNC:30809. TRIB2.
    HPAi HPA001305.
    MIMi 609462. gene.
    neXtProti NX_Q92519.
    PharmGKBi PA128394647.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000231872.
    HOVERGENi HBG067729.
    InParanoidi Q92519.
    KOi K08814.
    OMAi HCHDNGL.
    PhylomeDBi Q92519.
    TreeFami TF329785.

    Enzyme and pathway databases

    SignaLinki Q92519.

    Miscellaneous databases

    GeneWikii TRIB2.
    GenomeRNAii 28951.
    NextBioi 51761.
    PROi Q92519.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92519.
    Bgeei Q92519.
    CleanExi HS_TRIB2.
    Genevestigatori Q92519.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR024104. Tribbles/Ser_Thr_kinase_40.
    [Graphical view ]
    PANTHERi PTHR22961. PTHR22961. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cloning of a cDNA for putative serine/threonine kinase expressed in human osteoblast."
      Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cancellous bone.
    2. Shan Y.X., Yu L.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: UterusImported.
    7. Cited for: TISSUE SPECIFICITY.
    8. "Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display."
      Zhang Y., Davis J.L., Li W.
      Mol. Immunol. 42:1275-1281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: AUTOANTIBODIES.
    9. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-4.

    Entry informationi

    Entry nameiTRIB2_HUMAN
    AccessioniPrimary (citable) accession number: Q92519
    Secondary accession number(s): B2R851, D6W510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3