Reviewed, UniProtKB/Swiss-Prot Q92519 (TRIB2_HUMAN)

Names and origin

Protein names

Recommended name:
    Tribbles homolog 2
      Short name=TRB-2

Gene names

Name:	TRIB2
Synonyms:	TRB2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity By similarity.
Subcellular location	CytoplasmBy similarity. Cytoplasm › cytoskeletonBy similarity. Note= May associate with the cytoskeleton By similarity.
Tissue specificity	Highly expressed in peripheral blood leukocytes.
Miscellaneous	Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Molecular function	Protein kinase inhibitor
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro regulation of MAP kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: HPA
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein kinase activity Inferred from electronic annotation. Source: InterPro protein kinase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Tribbles homolog 2		PRO_0000131863
Regions
	Domain	61 – 308	248	Protein kinase
Natural variations
	Natural variant	4	1	H → R		VAR_042371

Sequences

	Sequence		Length	Mass (Da)
	Q92519-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: BF8B7366DACB84FA	FASTA	343	38,801
	10 20 30 40 50 60 MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC 70 80 90 100 110 120 IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII 130 140 150 160 170 180 LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK 190 200 210 220 230 240 FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL 250 260 270 280 290 300 GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ 310 320 330 340 EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cloning of a cDNA for putative serine/threonine kinase expressed in human osteoblast." Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cancellous bone.
[2]	Shan Y.X., Yu L. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	"Human tribbles, a protein family controlling mitogen-activated protein kinase cascades." Kiss-Toth E., Bagstaff S.M., Sung H.Y., Jozsa V., Dempsey C., Caunt J.C., Oxley K.M., Wyllie D.H., Polgar T., Harte M., O'Neill L.A.J., Qwarnstrom E.E., Dower S.K. J. Biol. Chem. 279:42703-42708(2004) [PubMed: 15299019] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display." Zhang Y., Davis J.L., Li W. Mol. Immunol. 42:1275-1281(2005) [PubMed: 15950723] [Abstract] Cited for: AUTOANTIBODIES.
[7]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D87119 mRNA. Translation: BAA13250.1. AY245544 mRNA. Translation: AAO89231.1. AC009486 Genomic DNA. Translation: AAY15015.1. BC002637 mRNA. Translation: AAH02637.1.
RefSeq	NP_067675.1.
UniGene	Hs.467751 Hs.696139
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92519.
PTM databases
PhosphoSite	Q92519.
Genome annotation databases
Ensembl	ENSG00000071575. Homo sapiens. [Contig view]
GeneID	28951.
KEGG	hsa:28951.
Organism-specific databases
H-InvDB	HIX0001835.
HGNC	HGNC:30809. TRIB2.
HPA	HPA001305.
MIM	609462. gene.
PharmGKB	PA128394647.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q92519.
HOVERGEN	Q92519.
Gene expression databases
ArrayExpress	Q92519.
CleanEx	HS_TRIB2.
GermOnline	ENSG00000071575. Homo sapiens.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017442. Se/Thr_pkinase-rel. [Graphical view]
Pfam	PF00069. Pkinase. 2 hits. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	51761.
SOURCE	Search...

Entry information

Entry name

TRIB2_HUMAN

Accession

Primary (citable) accession number: Q92519

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	February 1, 1997
Last modified:	November 25, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)