Q92519 (TRIB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tribbles homolog 2
Short name=TRB-2

Gene names

Name:	TRIB2
Synonyms:	TRB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity By similarity. UniProtKB Q28283 UniProtKB Q96RU8
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Note: May associate with the cytoskeleton By similarity.
Tissue specificity	Highly expressed in peripheral blood leukocytes. Ref.7
Domain	The protein kinase domain is predicted to be catalytically inactive.
Miscellaneous	Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Molecular function	Protein kinase inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of fat cell differentiation Inferred from sequence or structural similarity PubMed 17576771. Source: BHF-UCL negative regulation of interleukin-10 biosynthetic process Inferred from mutant phenotype PubMed 18643775. Source: BHF-UCL negative regulation of protein kinase activity Non-traceable author statement PubMed 12791994. Source: BHF-UCL positive regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from sequence or structural similarity PubMed 20410507. Source: BHF-UCL regulation of MAP kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA
Molecular_function	protein kinase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW transcription factor binding Inferred from sequence or structural similarity PubMed 17576771. Source: BHF-UCL transferase activity, transferring phosphorus-containing groups Inferred from electronic annotation. Source: InterPro ubiquitin protein ligase binding Inferred from sequence or structural similarity PubMed 20410507. Source: BHF-UCL ubiquitin-protein ligase regulator activity Inferred from sequence or structural similarity PubMed 20410507. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Tribbles homolog 2		PRO_0000131863
Regions
	Domain	61 – 308	248	Protein kinase
Natural variations
	Natural variant	4	1	H → R. Ref.9 Corresponds to variant rs55813198 [ dbSNP | Ensembl ].		VAR_042371

Sequences

	Sequence		Length	Mass (Da)
	Q92519 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: BF8B7366DACB84FA	FASTA	343	38,801
	10 20 30 40 50 60 MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC 70 80 90 100 110 120 IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII 130 140 150 160 170 180 LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK 190 200 210 220 230 240 FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL 250 260 270 280 290 300 GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ 310 320 330 340 EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cloning of a cDNA for putative serine/threonine kinase expressed in human osteoblast." Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cancellous bone.
[2]	Shan Y.X., Yu L. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[7]	"Human tribbles, a protein family controlling mitogen-activated protein kinase cascades." Kiss-Toth E., Bagstaff S.M., Sung H.Y., Jozsa V., Dempsey C., Caunt J.C., Oxley K.M., Wyllie D.H., Polgar T., Harte M., O'Neill L.A.J., Qwarnstrom E.E., Dower S.K. J. Biol. Chem. 279:42703-42708(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display." Zhang Y., Davis J.L., Li W. Mol. Immunol. 42:1275-1281(2005) [PubMed] [Europe PMC] [Abstract] Cited for: AUTOANTIBODIES.
[9]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D87119 mRNA. Translation: BAA13250.1. AY245544 mRNA. Translation: AAO89231.1. AK313237 mRNA. Translation: BAG36048.1. AC009486 Genomic DNA. Translation: AAY15015.1. CH471053 Genomic DNA. Translation: EAX00907.1. CH471053 Genomic DNA. Translation: EAX00908.1. CH471053 Genomic DNA. Translation: EAX00909.1. BC002637 mRNA. Translation: AAH02637.1.
IPI	IPI00012516.
RefSeq	NP_067675.1. NM_021643.3.
UniGene	Hs.467751.
3D structure databases
ProteinModelPortal	Q92519.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92519. 2 interactions.
MINT	MINT-2812905.
STRING	9606.ENSP00000155926.
PTM databases
PhosphoSite	Q92519.
Polymorphism databases
DMDM	74762638.
Proteomic databases
PaxDb	Q92519.
PRIDE	Q92519.
Protocols and materials databases
DNASU	28951.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000155926; ENSP00000155926; ENSG00000071575.
GeneID	28951.
KEGG	hsa:28951.
UCSC	uc002rbv.4. human.
Organism-specific databases
CTD	28951.
GeneCards	GC02P012807.
HGNC	HGNC:30809. TRIB2.
HPA	HPA001305.
MIM	609462. gene.
neXtProt	NX_Q92519.
PharmGKB	PA128394647.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000231872.
HOVERGEN	HBG067729.
InParanoid	Q92519.
KO	K08814.
OMA	HCHDNGL.
OrthoDB	EOG4WSW9Z.
PhylomeDB	Q92519.
Enzyme and pathway databases
SignaLink	Q92519.
Gene expression databases
ArrayExpress	Q92519.
Bgee	Q92519.
CleanEx	HS_TRIB2.
Genevestigator	Q92519.
GermOnline	ENSG00000071575. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR024104. Tribbles/Ser_Thr_kinase_40. [Graphical view]
PANTHER	PTHR22961. PTHR22961. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	28951.
NextBio	51761.
SOURCE	Search...

Entry information

Entry name

TRIB2_HUMAN

Accession

Primary (citable) accession number: Q92519
Secondary accession number(s): B2R851, D6W510

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	February 1, 1997
Last modified:	May 29, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.