Reviewed,
UniProtKB/Swiss-Prot Q92519 (TRIB2_HUMAN)
Last modified
November 25, 2008.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tribbles homolog 2 Short name=TRB-2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 343 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity By similarity. |
| Subcellular location | CytoplasmBy similarity. Cytoplasm › cytoskeletonBy similarity. Note= May associate with the cytoskeleton By similarity. |
| Tissue specificity | Highly expressed in peripheral blood leukocytes. |
| Miscellaneous | Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis. |
| Sequence similarities | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton |
| Coding sequence diversity | Polymorphism |
| Molecular function | Protein kinase inhibitor |
Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro regulation of MAP kinase activityInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB cytoskeletonInferred from electronic annotation. Source: UniProtKB-KW nucleusInferred from direct assay. Source: HPA |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro protein kinase activityInferred from electronic annotation. Source: InterPro protein kinase inhibitor activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The cloning of a cDNA for putative serine/threonine kinase expressed in human osteoblast." Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cancellous bone. |
| [2] | Shan Y.X., Yu L. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus. |
| [5] | "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades." Kiss-Toth E., Bagstaff S.M., Sung H.Y., Jozsa V., Dempsey C., Caunt J.C., Oxley K.M., Wyllie D.H., Polgar T., Harte M., O'Neill L.A.J., Qwarnstrom E.E., Dower S.K. J. Biol. Chem. 279:42703-42708(2004) [PubMed: 15299019] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [6] | "Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display." Zhang Y., Davis J.L., Li W. Mol. Immunol. 42:1275-1281(2005) [PubMed: 15950723] [Abstract] Cited for: AUTOANTIBODIES. |
| [7] | "Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D87119 mRNA. Translation: BAA13250.1. AY245544 mRNA. Translation: AAO89231.1. AC009486 Genomic DNA. Translation: AAY15015.1. BC002637 mRNA. Translation: AAH02637.1. | |
| RefSeq | NP_067675.1. |
| UniGene | Hs.467751 Hs.696139 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q92519. |
PTM databases | |
| PhosphoSite | Q92519. |
Genome annotation databases | |
| Ensembl | ENSG00000071575. Homo sapiens. [Contig view] |
| GeneID | 28951. |
| KEGG | hsa:28951. |
Organism-specific databases | |
| H-InvDB | HIX0001835. |
| HGNC | HGNC:30809. TRIB2. |
| HPA | HPA001305. |
| MIM | 609462. gene. |
| PharmGKB | PA128394647. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q92519. |
| HOVERGEN | Q92519. |
Gene expression databases | |
| ArrayExpress | Q92519. |
| CleanEx | HS_TRIB2. |
| GermOnline | ENSG00000071575. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017442. Se/Thr_pkinase-rel. [Graphical view] |
| Pfam | PF00069. Pkinase. 2 hits. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 51761. |
| SOURCE | Search... |
Entry information
| Entry name | TRIB2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q92519 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


