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Protein

Tribbles homolog 2

Gene

TRIB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).By similarity

GO - Molecular functioni

  1. protein kinase inhibitor activity Source: UniProtKB-KW
  2. transcription factor binding Source: BHF-UCL
  3. transferase activity, transferring phosphorus-containing groups Source: InterPro
  4. ubiquitin protein ligase binding Source: BHF-UCL
  5. ubiquitin-protein transferase regulator activity Source: BHF-UCL

GO - Biological processi

  1. negative regulation of fat cell differentiation Source: BHF-UCL
  2. negative regulation of interleukin-10 biosynthetic process Source: BHF-UCL
  3. negative regulation of protein kinase activity Source: BHF-UCL
  4. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  5. regulation of MAP kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Enzyme and pathway databases

SignaLinkiQ92519.

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 2
Short name:
TRB-2
Gene namesi
Name:TRIB2Imported
Synonyms:TRB2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30809. TRIB2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
Note: May associate with the cytoskeleton.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Tribbles homolog 2PRO_0000131863Add
BLAST

Proteomic databases

PaxDbiQ92519.
PRIDEiQ92519.

PTM databases

PhosphoSiteiQ92519.

Expressioni

Tissue specificityi

Highly expressed in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiQ92519.
CleanExiHS_TRIB2.
ExpressionAtlasiQ92519. baseline and differential.
GenevestigatoriQ92519.

Organism-specific databases

HPAiHPA001305.

Interactioni

Protein-protein interaction databases

BioGridi118779. 9 interactions.
IntActiQ92519. 10 interactions.
MINTiMINT-2812905.
STRINGi9606.ENSP00000155926.

Structurei

3D structure databases

ProteinModelPortaliQ92519.
SMRiQ92519. Positions 61-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 308248Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121915.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ92519.
KOiK08814.
OMAiHCHDNGL.
PhylomeDBiQ92519.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE
60 70 80 90 100
TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES
110 120 130 140 150
LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE
160 170 180 190 200
EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY
210 220 230 240 250
ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG
260 270 280 290 300
RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ
310 320 330 340
EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN
Length:343
Mass (Da):38,801
Last modified:February 1, 1997 - v1
Checksum:iBF8B7366DACB84FA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41H → R.1 Publication
Corresponds to variant rs55813198 [ dbSNP | Ensembl ].
VAR_042371

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87119 mRNA. Translation: BAA13250.1.
AY245544 mRNA. Translation: AAO89231.1.
AK313237 mRNA. Translation: BAG36048.1.
AC009486 Genomic DNA. Translation: AAY15015.1.
CH471053 Genomic DNA. Translation: EAX00907.1.
CH471053 Genomic DNA. Translation: EAX00908.1.
CH471053 Genomic DNA. Translation: EAX00909.1.
BC002637 mRNA. Translation: AAH02637.1.
CCDSiCCDS1683.1.
RefSeqiNP_067675.1. NM_021643.3.
UniGeneiHs.467751.

Genome annotation databases

EnsembliENST00000155926; ENSP00000155926; ENSG00000071575.
GeneIDi28951.
KEGGihsa:28951.
UCSCiuc002rbv.4. human.

Polymorphism databases

DMDMi74762638.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87119 mRNA. Translation: BAA13250.1.
AY245544 mRNA. Translation: AAO89231.1.
AK313237 mRNA. Translation: BAG36048.1.
AC009486 Genomic DNA. Translation: AAY15015.1.
CH471053 Genomic DNA. Translation: EAX00907.1.
CH471053 Genomic DNA. Translation: EAX00908.1.
CH471053 Genomic DNA. Translation: EAX00909.1.
BC002637 mRNA. Translation: AAH02637.1.
CCDSiCCDS1683.1.
RefSeqiNP_067675.1. NM_021643.3.
UniGeneiHs.467751.

3D structure databases

ProteinModelPortaliQ92519.
SMRiQ92519. Positions 61-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118779. 9 interactions.
IntActiQ92519. 10 interactions.
MINTiMINT-2812905.
STRINGi9606.ENSP00000155926.

PTM databases

PhosphoSiteiQ92519.

Polymorphism databases

DMDMi74762638.

Proteomic databases

PaxDbiQ92519.
PRIDEiQ92519.

Protocols and materials databases

DNASUi28951.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000155926; ENSP00000155926; ENSG00000071575.
GeneIDi28951.
KEGGihsa:28951.
UCSCiuc002rbv.4. human.

Organism-specific databases

CTDi28951.
GeneCardsiGC02P012856.
HGNCiHGNC:30809. TRIB2.
HPAiHPA001305.
MIMi609462. gene.
neXtProtiNX_Q92519.
PharmGKBiPA128394647.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121915.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ92519.
KOiK08814.
OMAiHCHDNGL.
PhylomeDBiQ92519.
TreeFamiTF329785.

Enzyme and pathway databases

SignaLinkiQ92519.

Miscellaneous databases

GeneWikiiTRIB2.
GenomeRNAii28951.
NextBioi51761.
PROiQ92519.
SOURCEiSearch...

Gene expression databases

BgeeiQ92519.
CleanExiHS_TRIB2.
ExpressionAtlasiQ92519. baseline and differential.
GenevestigatoriQ92519.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cloning of a cDNA for putative serine/threonine kinase expressed in human osteoblast."
    Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cancellous bone.
  2. Shan Y.X., Yu L.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: UterusImported.
  7. Cited for: TISSUE SPECIFICITY.
  8. "Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display."
    Zhang Y., Davis J.L., Li W.
    Mol. Immunol. 42:1275-1281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: AUTOANTIBODIES.
  9. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-4.

Entry informationi

Entry nameiTRIB2_HUMAN
AccessioniPrimary (citable) accession number: Q92519
Secondary accession number(s): B2R851, D6W510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.