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Protein

Tribbles homolog 2

Gene

TRIB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).By similarity

Miscellaneous

Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.

GO - Molecular functioni

  • mitogen-activated protein kinase kinase binding Source: GO_Central
  • protein kinase inhibitor activity Source: UniProtKB-KW
  • transcription factor binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL
  • ubiquitin-protein transferase regulator activity Source: BHF-UCL

GO - Biological processi

  • negative regulation of fat cell differentiation Source: BHF-UCL
  • negative regulation of interleukin-10 biosynthetic process Source: BHF-UCL
  • negative regulation of protein kinase activity Source: BHF-UCL
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  • regulation of MAP kinase activity Source: UniProtKB

Keywordsi

Molecular functionProtein kinase inhibitor

Enzyme and pathway databases

SignaLinkiQ92519.

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 2
Short name:
TRB-2
Gene namesi
Name:TRIB2Imported
Synonyms:TRB2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000071575.11.
HGNCiHGNC:30809. TRIB2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi28951.
OpenTargetsiENSG00000071575.
PharmGKBiPA128394647.

Polymorphism and mutation databases

BioMutaiTRIB2.
DMDMi74762638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001318631 – 343Tribbles homolog 2Add BLAST343

Proteomic databases

PaxDbiQ92519.
PeptideAtlasiQ92519.
PRIDEiQ92519.

PTM databases

iPTMnetiQ92519.
PhosphoSitePlusiQ92519.

Expressioni

Tissue specificityi

Highly expressed in peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000071575.
CleanExiHS_TRIB2.
ExpressionAtlasiQ92519. baseline and differential.
GenevisibleiQ92519. HS.

Organism-specific databases

HPAiHPA001305.

Interactioni

Subunit structurei

Interacts with RFWD2 (PubMed:27041596).1 Publication

GO - Molecular functioni

  • mitogen-activated protein kinase kinase binding Source: GO_Central
  • transcription factor binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi118779. 22 interactors.
IntActiQ92519. 11 interactors.
MINTiMINT-2812905.
STRINGi9606.ENSP00000155926.

Structurei

3D structure databases

ProteinModelPortaliQ92519.
SMRiQ92519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 308Protein kinasePROSITE-ProRule annotationAdd BLAST248

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00880000137914.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ92519.
KOiK08814.
OMAiAHCHDNG.
OrthoDBiEOG091G07JM.
PhylomeDBiQ92519.
TreeFamiTF329785.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
PANTHERiPTHR22961. PTHR22961. 1 hit.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE
60 70 80 90 100
TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES
110 120 130 140 150
LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE
160 170 180 190 200
EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY
210 220 230 240 250
ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG
260 270 280 290 300
RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ
310 320 330 340
EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN
Length:343
Mass (Da):38,801
Last modified:February 1, 1997 - v1
Checksum:iBF8B7366DACB84FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0423714H → R1 PublicationCorresponds to variant dbSNP:rs55813198Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87119 mRNA. Translation: BAA13250.1.
AY245544 mRNA. Translation: AAO89231.1.
AK313237 mRNA. Translation: BAG36048.1.
AC009486 Genomic DNA. Translation: AAY15015.1.
CH471053 Genomic DNA. Translation: EAX00907.1.
CH471053 Genomic DNA. Translation: EAX00908.1.
CH471053 Genomic DNA. Translation: EAX00909.1.
BC002637 mRNA. Translation: AAH02637.1.
CCDSiCCDS1683.1.
RefSeqiNP_067675.1. NM_021643.3.
UniGeneiHs.467751.

Genome annotation databases

EnsembliENST00000155926; ENSP00000155926; ENSG00000071575.
GeneIDi28951.
KEGGihsa:28951.
UCSCiuc002rbv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRIB2_HUMAN
AccessioniPrimary (citable) accession number: Q92519
Secondary accession number(s): B2R851, D6W510
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families