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Q92504

- S39A7_HUMAN

UniProt

Q92504 - S39A7_HUMAN

Protein

Zinc transporter SLC39A7

Gene

SLC39A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca2+, as well as by exogenous Zn2+.3 Publications

    GO - Molecular functioni

    1. metal ion transmembrane transporter activity Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. transmembrane transport Source: Reactome
    2. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

    Protein family/group databases

    TCDBi2.A.5.4.3. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter SLC39A7
    Alternative name(s):
    Histidine-rich membrane protein Ke4
    Really interesting new gene 5 protein
    Solute carrier family 39 member 7
    Zrt-, Irt-like protein 7
    Short name:
    ZIP7
    Gene namesi
    Name:SLC39A7
    Synonyms:HKE4, RING5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4927. SLC39A7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: ProtInc

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi275 – 2751S → A: Loss of phosphorylation in response to Zn(2+) treatment and of cytosolic Zn(2+) release; when associated with A-276. 1 Publication
    Mutagenesisi276 – 2761S → A: Loss of phosphorylation in response to Zn(2+) treatment and of cytosolic Zn(2+) release; when associated with A-275. 1 Publication

    Organism-specific databases

    PharmGKBiPA29305.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Zinc transporter SLC39A7PRO_0000213688Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei275 – 2751Phosphoserine; by CK22 Publications
    Modified residuei276 – 2761Phosphoserine; by CK22 Publications
    Cross-linki310 – 310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Post-translational modificationi

    Rapidly phosphorylated by CK2 following Zn2+ treatment. This phosphorylation is required for efficient cytosolic Zn2+ release.2 Publications

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ92504.
    PaxDbiQ92504.
    PRIDEiQ92504.

    PTM databases

    PhosphoSiteiQ92504.

    Expressioni

    Tissue specificityi

    Widely expressed.2 Publications

    Inductioni

    Down-regulated by Zn(+2).1 Publication

    Gene expression databases

    ArrayExpressiQ92504.
    BgeeiQ92504.
    CleanExiHS_SLC39A7.
    GenevestigatoriQ92504.

    Organism-specific databases

    HPAiHPA053999.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CSNK2A1P684004EBI-1051105,EBI-347804

    Protein-protein interaction databases

    BioGridi113652. 8 interactions.
    IntActiQ92504. 5 interactions.
    STRINGi9606.ENSP00000391735.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92504.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43620HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 11485His-richAdd
    BLAST
    Compositional biasi238 – 26326His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    HOGENOMiHOG000185308.
    HOVERGENiHBG001037.
    InParanoidiQ92504.
    KOiK14713.
    OMAiFYISSVP.
    PhylomeDBiQ92504.
    TreeFamiTF318470.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92504-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGLGAPHW VAVGLLTWAT LGLLVAGLGG HDDLHDDLQE DFHGHSHRHS    50
    HEDFHHGHSH AHGHGHTHES IWHGHTHDHD HGHSHEDLHH GHSHGYSHES 100
    LYHRGHGHDH EHSHGGYGES GAPGIKQDLD AVTLWAYALG ATVLISAAPF 150
    FVLFLIPVES NSPRHRSLLQ ILLSFASGGL LGDAFLHLIP HALEPHSHHT 200
    LEQPGHGHSH SGQGPILSVG LWVLSGIVAF LVVEKFVRHV KGGHGHSHGH 250
    GHAHSHTRGS HGHGRQERST KEKQSSEEEE KETRGVQKRR GGSTVPKDGP 300
    VRPQNAEEEK RGLDLRVSGY LNLAADLAHN FTDGLAIGAS FRGGRGLGIL 350
    TTMTVLLHEV PHEVGDFAIL VQSGCSKKQA MRLQLLTAVG ALAGTACALL 400
    TEGGAVGSEI AGGAGPGWVL PFTAGGFIYV ATVSVLPELL REASPLQSLL 450
    EVLGLLGGVI MMVLIAHLE 469
    Length:469
    Mass (Da):50,118
    Last modified:January 24, 2001 - v2
    Checksum:i6504A1EF5AA6A5B9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71A → G in BAA11528. (PubMed:8812499)Curated
    Sequence conflicti7 – 71A → G in AAD12305. 1 PublicationCurated
    Sequence conflicti376 – 3761S → T in BAA11528. (PubMed:8812499)Curated
    Sequence conflicti376 – 3761S → T in AAD12305. 1 PublicationCurated
    Sequence conflicti397 – 46973CALLT…IAHLE → VPFSLKEEQWTVKLQVVQVL AGSCHLLQVALST in BAA11528. (PubMed:8812499)CuratedAdd
    BLAST
    Sequence conflicti397 – 46973CALLT…IAHLE → VPFSLKEEQWTVKLQVVQVL AGSCHLLQVALST in AAD12305. 1 PublicationCuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871D → N.
    Corresponds to variant rs34211188 [ dbSNP | Ensembl ].
    VAR_050034
    Natural varianti124 – 1241G → R.
    Corresponds to variant rs35690712 [ dbSNP | Ensembl ].
    VAR_050035
    Natural varianti280 – 2801E → G.2 Publications
    Corresponds to variant rs1048778 [ dbSNP | Ensembl ].
    VAR_050036

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82060 mRNA. Translation: BAA11528.1.
    AF117221 Genomic DNA. Translation: AAD12305.1.
    AL031228 Genomic DNA. Translation: CAA20238.1.
    AL645940 Genomic DNA. Translation: CAI18067.1.
    AL662824 Genomic DNA. Translation: CAI17615.1.
    AL844527 Genomic DNA. Translation: CAI41839.1.
    CR759786, CR936877 Genomic DNA. Translation: CAQ08249.1.
    CR936877, CR759786 Genomic DNA. Translation: CAQ09067.1.
    CR759733 Genomic DNA. Translation: CAQ10301.1.
    CR354565 Genomic DNA. Translation: CAQ11085.1.
    CH471081 Genomic DNA. Translation: EAX03680.1.
    BC000645 mRNA. Translation: AAH00645.1.
    CCDSiCCDS43453.1.
    RefSeqiNP_001070984.1. NM_001077516.1.
    NP_001275706.1. NM_001288777.1.
    NP_008910.2. NM_006979.2.
    UniGeneiHs.631995.

    Genome annotation databases

    EnsembliENST00000374675; ENSP00000363807; ENSG00000112473.
    ENST00000374677; ENSP00000363809; ENSG00000112473.
    ENST00000383213; ENSP00000372700; ENSG00000206288.
    ENST00000383214; ENSP00000372701; ENSG00000206288.
    ENST00000416369; ENSP00000403583; ENSG00000229802.
    ENST00000418477; ENSP00000416439; ENSG00000226614.
    ENST00000423043; ENSP00000389623; ENSG00000226614.
    ENST00000431735; ENSP00000410656; ENSG00000224399.
    ENST00000441854; ENSP00000391735; ENSG00000229802.
    ENST00000441953; ENSP00000413027; ENSG00000224399.
    ENST00000443773; ENSP00000407093; ENSG00000227402.
    ENST00000456261; ENSP00000414145; ENSG00000227402.
    GeneIDi7922.
    KEGGihsa:7922.
    UCSCiuc003odf.3. human.

    Polymorphism databases

    DMDMi12643344.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82060 mRNA. Translation: BAA11528.1 .
    AF117221 Genomic DNA. Translation: AAD12305.1 .
    AL031228 Genomic DNA. Translation: CAA20238.1 .
    AL645940 Genomic DNA. Translation: CAI18067.1 .
    AL662824 Genomic DNA. Translation: CAI17615.1 .
    AL844527 Genomic DNA. Translation: CAI41839.1 .
    CR759786 , CR936877 Genomic DNA. Translation: CAQ08249.1 .
    CR936877 , CR759786 Genomic DNA. Translation: CAQ09067.1 .
    CR759733 Genomic DNA. Translation: CAQ10301.1 .
    CR354565 Genomic DNA. Translation: CAQ11085.1 .
    CH471081 Genomic DNA. Translation: EAX03680.1 .
    BC000645 mRNA. Translation: AAH00645.1 .
    CCDSi CCDS43453.1.
    RefSeqi NP_001070984.1. NM_001077516.1.
    NP_001275706.1. NM_001288777.1.
    NP_008910.2. NM_006979.2.
    UniGenei Hs.631995.

    3D structure databases

    ProteinModelPortali Q92504.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113652. 8 interactions.
    IntActi Q92504. 5 interactions.
    STRINGi 9606.ENSP00000391735.

    Protein family/group databases

    TCDBi 2.A.5.4.3. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    PTM databases

    PhosphoSitei Q92504.

    Polymorphism databases

    DMDMi 12643344.

    Proteomic databases

    MaxQBi Q92504.
    PaxDbi Q92504.
    PRIDEi Q92504.

    Protocols and materials databases

    DNASUi 7922.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374675 ; ENSP00000363807 ; ENSG00000112473 .
    ENST00000374677 ; ENSP00000363809 ; ENSG00000112473 .
    ENST00000383213 ; ENSP00000372700 ; ENSG00000206288 .
    ENST00000383214 ; ENSP00000372701 ; ENSG00000206288 .
    ENST00000416369 ; ENSP00000403583 ; ENSG00000229802 .
    ENST00000418477 ; ENSP00000416439 ; ENSG00000226614 .
    ENST00000423043 ; ENSP00000389623 ; ENSG00000226614 .
    ENST00000431735 ; ENSP00000410656 ; ENSG00000224399 .
    ENST00000441854 ; ENSP00000391735 ; ENSG00000229802 .
    ENST00000441953 ; ENSP00000413027 ; ENSG00000224399 .
    ENST00000443773 ; ENSP00000407093 ; ENSG00000227402 .
    ENST00000456261 ; ENSP00000414145 ; ENSG00000227402 .
    GeneIDi 7922.
    KEGGi hsa:7922.
    UCSCi uc003odf.3. human.

    Organism-specific databases

    CTDi 7922.
    GeneCardsi GC06P033168.
    GC06Pj33090.
    GC06Pk33146.
    GC06Pl33322.
    GC06Pm33338.
    GC06Pn33097.
    HGNCi HGNC:4927. SLC39A7.
    HPAi HPA053999.
    MIMi 601416. gene.
    neXtProti NX_Q92504.
    PharmGKBi PA29305.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0428.
    HOGENOMi HOG000185308.
    HOVERGENi HBG001037.
    InParanoidi Q92504.
    KOi K14713.
    OMAi FYISSVP.
    PhylomeDBi Q92504.
    TreeFami TF318470.

    Enzyme and pathway databases

    Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    ChiTaRSi SLC39A7. human.
    GeneWikii SLC39A7.
    GenomeRNAii 7922.
    NextBioi 30416.
    PROi Q92504.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92504.
    Bgeei Q92504.
    CleanExi HS_SLC39A7.
    Genevestigatori Q92504.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region."
      Ando A., Kikuti Y.Y., Shigenari A., Kawata H., Okamoto N., Shiina T., Chen L., Ikemura T., Abe K., Kimura M., Inoko H.
      Genomics 35:600-602(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-280.
      Tissue: Kidney.
    2. "Molecular cloning and characterization of the human KE4 gene and 5' flanking region."
      Vergara A., Lana I., Corella A., de Miguel C., Migliaccio M., Encio I.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-280.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters."
      Taylor K.M., Morgan H.E., Johnson A., Nicholson R.I.
      Biochem. J. 377:131-139(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus."
      Huang L., Kirschke C.P., Zhang Y., Yu Y.Y.
      J. Biol. Chem. 280:15456-15463(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275 AND SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7."
      Taylor K.M., Hiscox S., Nicholson R.I., Hogstrand C., Kille P.
      Sci. Signal. 5:RA11-RA11(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-275 AND SER-276, MUTAGENESIS OF SER-275 AND SER-276.

    Entry informationi

    Entry nameiS39A7_HUMAN
    AccessioniPrimary (citable) accession number: Q92504
    Secondary accession number(s): B0UXF6, Q5STP8, Q9UIQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3