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Protein

SEC14-like protein 1

Gene

SEC14L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).2 Publications

GO - Molecular functioni

  • molecular function regulator Source: UniProtKB
  • RIG-I binding Source: UniProtKB

GO - Biological processi

  • choline transport Source: UniProtKB
  • innate immune response Source: UniProtKB-KW
  • negative regulation of RIG-I signaling pathway Source: UniProtKB

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 1Curated
Gene namesi
Name:SEC14L1
Synonyms:SEC14L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000129657.14
HGNCiHGNC:10698 SEC14L1
MIMi601504 gene
neXtProtiNX_Q92503

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6397
OpenTargetsiENSG00000129657
PharmGKBiPA35621

Polymorphism and mutation databases

BioMutaiSEC14L1
DMDMi313104180

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107531 – 715SEC14-like protein 1Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphothreonineCombined sources1
Modified residuei586PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92503
MaxQBiQ92503
PaxDbiQ92503
PeptideAtlasiQ92503
PRIDEiQ92503
ProteomicsDBi75272
75273 [Q92503-2]
75274 [Q92503-3]

PTM databases

iPTMnetiQ92503
PhosphoSitePlusiQ92503

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000129657
CleanExiHS_SEC14L1
ExpressionAtlasiQ92503 baseline and differential
GenevisibleiQ92503 HS

Organism-specific databases

HPAiHPA021463
HPA028703

Interactioni

Subunit structurei

Interacts with DDX58 (via tandem CARD domain); the interaction is direct (PubMed:23843640). Interacts (via GOLD domain) with SLC18A3; the interaction is direct (PubMed:17092608). Interacts with SLC5A7 (via GOLD domain); the interaction is direct (PubMed:17092608).2 Publications

GO - Molecular functioni

  • RIG-I binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112297, 7 interactors
IntActiQ92503, 4 interactors
MINTiQ92503
STRINGi9606.ENSP00000376268

Structurei

3D structure databases

ProteinModelPortaliQ92503
SMRiQ92503
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 175PRELI/MSF1PROSITE-ProRule annotationAdd BLAST175
Domaini319 – 495CRAL-TRIOPROSITE-ProRule annotationAdd BLAST177
Domaini521 – 674GOLDPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 510Required for interaction and inhibitory function toward DDX581 PublicationAdd BLAST510

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074580
HOGENOMiHOG000231147
HOVERGENiHBG060237
InParanoidiQ92503
OMAiAGGWHHH
OrthoDBiEOG091G0V9N
PhylomeDBiQ92503
TreeFamiTF313988

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR006797 PRELI/MSF1_dom
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
PF04707 PRELI, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit
PS50904 PRELI_MSF1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92503-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQKYQSPVR VYKYPFELIM AAYERRFPTC PLIPMFVGSD TVNEFKSEDG
60 70 80 90 100
AIHVIERRCK LDVDAPRLLK KIAGVDYVYF VQKNSLNSRE RTLHIEAYNE
110 120 130 140 150
TFSNRVIINE HCCYTVHPEN EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK
160 170 180 190 200
QYTSNIKKGK EIIEYYLRQL EEEGITFVPR WSPPSITTSS ETSSSSSKKQ
210 220 230 240 250
AASMAVVIPE AALKEGLSGD ALSSPSAPEP VVGTPDDKLD ADYIKRYLGD
260 270 280 290 300
LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ
310 320 330 340 350
SLTWRKQHQV DYILETWTPP QVLQDYYAGG WHHHDKDGRP LYVLRLGQMD
360 370 380 390 400
TKGLVRALGE EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG
410 420 430 440 450
LNMRHLWRPG VKALLRIIEV VEANYPETLG RLLILRAPRV FPVLWTLVSP
460 470 480 490 500
FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK EIIPDFLSGE CMCEVPEGGL
510 520 530 540 550
VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI QIVDASSVIT
560 570 580 590 600
WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ
610 620 630 640 650
LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHS MPACAASSLP
660 670 680 690 700
RVDDVLASLQ VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA
710
TTSSSQSHSS SMISR
Length:715
Mass (Da):81,250
Last modified:November 30, 2010 - v2
Checksum:iA0B840F8FFF01D13
GO
Isoform 2 (identifier: Q92503-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     715-715: R → RWRFC

Show »
Length:719
Mass (Da):81,842
Checksum:iFEB0C5FA60B840F8
GO
Isoform 3 (identifier: Q92503-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Note: No experimental confirmation available.
Show »
Length:681
Mass (Da):77,132
Checksum:i08C9627F7417EFE8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43N → S in BAA11048 (PubMed:8697811).Curated1
Sequence conflicti127E → G in BAG56746 (PubMed:14702039).Curated1
Sequence conflicti243Y → H in BAA11048 (PubMed:8697811).Curated1
Sequence conflicti370I → V in BAA11048 (PubMed:8697811).Curated1
Sequence conflicti374G → R in BAA11048 (PubMed:8697811).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05717337V → M. Corresponds to variant dbSNP:rs1049416Ensembl.1
Natural variantiVAR_06048097A → G. Corresponds to variant dbSNP:rs1049422Ensembl.1
Natural variantiVAR_06048198Y → H. Corresponds to variant dbSNP:rs1049423Ensembl.1
Natural variantiVAR_060482188T → P5 PublicationsCorresponds to variant dbSNP:rs673918Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0401171 – 34Missing in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_040118715R → RWRFC in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67029 mRNA Translation: BAA11048.1
FM995495 mRNA Translation: CAX33889.1
FM995496 mRNA Translation: CAX33890.1
AK290913 mRNA Translation: BAF83602.1
AK293206 mRNA Translation: BAG56746.1
AC068594 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89469.1
BC136523 mRNA Translation: AAI36524.1
BC136525 mRNA Translation: AAI36526.1
U79284 mRNA Translation: AAB50220.1
CCDSiCCDS11752.1 [Q92503-1]
CCDS42385.1 [Q92503-2]
CCDS45789.1 [Q92503-3]
RefSeqiNP_001034662.2, NM_001039573.2
NP_001137470.1, NM_001143998.1
NP_001137471.1, NM_001143999.1
NP_001137473.1, NM_001144001.1
NP_001191337.1, NM_001204408.1
NP_001191339.1, NM_001204410.1
NP_002994.3, NM_003003.3
UniGeneiHs.464184
Hs.720923

Genome annotation databases

EnsembliENST00000392476; ENSP00000376268; ENSG00000129657 [Q92503-2]
ENST00000430767; ENSP00000408169; ENSG00000129657 [Q92503-1]
ENST00000431431; ENSP00000389838; ENSG00000129657 [Q92503-3]
ENST00000436233; ENSP00000390392; ENSG00000129657 [Q92503-1]
ENST00000443798; ENSP00000406030; ENSG00000129657 [Q92503-2]
ENST00000585618; ENSP00000466581; ENSG00000129657 [Q92503-1]
ENST00000591437; ENSP00000467934; ENSG00000129657 [Q92503-3]
GeneIDi6397
KEGGihsa:6397
UCSCiuc002jto.4 human [Q92503-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS14L1_HUMAN
AccessioniPrimary (citable) accession number: Q92503
Secondary accession number(s): A8K4E8
, B4DDI5, D5G3K1, Q99780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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