Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SEC14-like protein 1

Gene

SEC14L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).2 Publications

GO - Molecular functioni

  • molecular function regulator Source: UniProtKB
  • RIG-I binding Source: UniProtKB

GO - Biological processi

  • choline transport Source: UniProtKB
  • innate immune response Source: UniProtKB-KW
  • negative regulation of RIG-I signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 1Curated
Gene namesi
Name:SEC14L1
Synonyms:SEC14L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10698. SEC14L1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35621.

Polymorphism and mutation databases

BioMutaiSEC14L1.
DMDMi313104180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715SEC14-like protein 1PRO_0000210753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92503.
MaxQBiQ92503.
PaxDbiQ92503.
PRIDEiQ92503.

PTM databases

iPTMnetiQ92503.
PhosphoSiteiQ92503.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ92503.
CleanExiHS_SEC14L1.
ExpressionAtlasiQ92503. baseline and differential.
GenevisibleiQ92503. HS.

Organism-specific databases

HPAiHPA021463.
HPA028703.

Interactioni

Subunit structurei

Interacts with DDX58 (via tandem CARD domain); the interaction is direct (PubMed:23843640). Interacts (via GOLD domain) with SLC18A3; the interaction is direct (PubMed:17092608). Interacts with SLC5A7 (via GOLD domain); the interaction is direct (PubMed:17092608).2 Publications

GO - Molecular functioni

  • RIG-I binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112297. 7 interactions.
IntActiQ92503. 3 interactions.
MINTiMINT-3048592.
STRINGi9606.ENSP00000376268.

Structurei

3D structure databases

ProteinModelPortaliQ92503.
SMRiQ92503. Positions 248-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 175175PRELI/MSF1PROSITE-ProRule annotationAdd
BLAST
Domaini319 – 495177CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Domaini521 – 674154GOLDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 510510Required for the interaction and inhibitory function toward DDX581 PublicationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation
Contains 1 PRELI/MSF1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000231147.
HOVERGENiHBG060237.
InParanoidiQ92503.
OMAiSGECMCE.
OrthoDBiEOG7RBZ8M.
PhylomeDBiQ92503.
TreeFamiTF313988.

Family and domain databases

Gene3Di3.40.525.10. 2 hits.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
IPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
PF04707. PRELI. 1 hit.
[Graphical view]
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
PS50904. PRELI_MSF1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92503-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQKYQSPVR VYKYPFELIM AAYERRFPTC PLIPMFVGSD TVNEFKSEDG
60 70 80 90 100
AIHVIERRCK LDVDAPRLLK KIAGVDYVYF VQKNSLNSRE RTLHIEAYNE
110 120 130 140 150
TFSNRVIINE HCCYTVHPEN EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK
160 170 180 190 200
QYTSNIKKGK EIIEYYLRQL EEEGITFVPR WSPPSITTSS ETSSSSSKKQ
210 220 230 240 250
AASMAVVIPE AALKEGLSGD ALSSPSAPEP VVGTPDDKLD ADYIKRYLGD
260 270 280 290 300
LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ
310 320 330 340 350
SLTWRKQHQV DYILETWTPP QVLQDYYAGG WHHHDKDGRP LYVLRLGQMD
360 370 380 390 400
TKGLVRALGE EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG
410 420 430 440 450
LNMRHLWRPG VKALLRIIEV VEANYPETLG RLLILRAPRV FPVLWTLVSP
460 470 480 490 500
FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK EIIPDFLSGE CMCEVPEGGL
510 520 530 540 550
VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI QIVDASSVIT
560 570 580 590 600
WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ
610 620 630 640 650
LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHS MPACAASSLP
660 670 680 690 700
RVDDVLASLQ VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA
710
TTSSSQSHSS SMISR
Length:715
Mass (Da):81,250
Last modified:November 30, 2010 - v2
Checksum:iA0B840F8FFF01D13
GO
Isoform 2 (identifier: Q92503-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     715-715: R → RWRFC

Show »
Length:719
Mass (Da):81,842
Checksum:iFEB0C5FA60B840F8
GO
Isoform 3 (identifier: Q92503-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Note: No experimental confirmation available.
Show »
Length:681
Mass (Da):77,132
Checksum:i08C9627F7417EFE8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431N → S in BAA11048 (PubMed:8697811).Curated
Sequence conflicti127 – 1271E → G in BAG56746 (PubMed:14702039).Curated
Sequence conflicti243 – 2431Y → H in BAA11048 (PubMed:8697811).Curated
Sequence conflicti370 – 3701I → V in BAA11048 (PubMed:8697811).Curated
Sequence conflicti374 – 3741G → R in BAA11048 (PubMed:8697811).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371V → M.
Corresponds to variant rs1049416 [ dbSNP | Ensembl ].
VAR_057173
Natural varianti97 – 971A → G.
Corresponds to variant rs1049422 [ dbSNP | Ensembl ].
VAR_060480
Natural varianti98 – 981Y → H.
Corresponds to variant rs1049423 [ dbSNP | Ensembl ].
VAR_060481
Natural varianti188 – 1881T → P.5 Publications
Corresponds to variant rs673918 [ dbSNP | Ensembl ].
VAR_060482

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3434Missing in isoform 3. 1 PublicationVSP_040117Add
BLAST
Alternative sequencei715 – 7151R → RWRFC in isoform 2. 2 PublicationsVSP_040118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67029 mRNA. Translation: BAA11048.1.
FM995495 mRNA. Translation: CAX33889.1.
FM995496 mRNA. Translation: CAX33890.1.
AK290913 mRNA. Translation: BAF83602.1.
AK293206 mRNA. Translation: BAG56746.1.
AC068594 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89469.1.
BC136523 mRNA. Translation: AAI36524.1.
BC136525 mRNA. Translation: AAI36526.1.
U79284 mRNA. Translation: AAB50220.1.
CCDSiCCDS11752.1. [Q92503-1]
CCDS42385.1. [Q92503-2]
CCDS45789.1. [Q92503-3]
RefSeqiNP_001034662.2. NM_001039573.2.
NP_001137470.1. NM_001143998.1.
NP_001137471.1. NM_001143999.1.
NP_001137473.1. NM_001144001.1.
NP_001191337.1. NM_001204408.1.
NP_001191339.1. NM_001204410.1.
NP_002994.3. NM_003003.3.
UniGeneiHs.464184.
Hs.720923.

Genome annotation databases

EnsembliENST00000392476; ENSP00000376268; ENSG00000129657. [Q92503-2]
ENST00000430767; ENSP00000408169; ENSG00000129657. [Q92503-1]
ENST00000431431; ENSP00000389838; ENSG00000129657. [Q92503-3]
ENST00000436233; ENSP00000390392; ENSG00000129657. [Q92503-1]
ENST00000443798; ENSP00000406030; ENSG00000129657. [Q92503-2]
ENST00000585618; ENSP00000466581; ENSG00000129657. [Q92503-1]
ENST00000591437; ENSP00000467934; ENSG00000129657. [Q92503-3]
GeneIDi6397.
KEGGihsa:6397.
UCSCiuc002jto.4. human. [Q92503-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D67029 mRNA. Translation: BAA11048.1.
FM995495 mRNA. Translation: CAX33889.1.
FM995496 mRNA. Translation: CAX33890.1.
AK290913 mRNA. Translation: BAF83602.1.
AK293206 mRNA. Translation: BAG56746.1.
AC068594 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89469.1.
BC136523 mRNA. Translation: AAI36524.1.
BC136525 mRNA. Translation: AAI36526.1.
U79284 mRNA. Translation: AAB50220.1.
CCDSiCCDS11752.1. [Q92503-1]
CCDS42385.1. [Q92503-2]
CCDS45789.1. [Q92503-3]
RefSeqiNP_001034662.2. NM_001039573.2.
NP_001137470.1. NM_001143998.1.
NP_001137471.1. NM_001143999.1.
NP_001137473.1. NM_001144001.1.
NP_001191337.1. NM_001204408.1.
NP_001191339.1. NM_001204410.1.
NP_002994.3. NM_003003.3.
UniGeneiHs.464184.
Hs.720923.

3D structure databases

ProteinModelPortaliQ92503.
SMRiQ92503. Positions 248-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112297. 7 interactions.
IntActiQ92503. 3 interactions.
MINTiMINT-3048592.
STRINGi9606.ENSP00000376268.

PTM databases

iPTMnetiQ92503.
PhosphoSiteiQ92503.

Polymorphism and mutation databases

BioMutaiSEC14L1.
DMDMi313104180.

Proteomic databases

EPDiQ92503.
MaxQBiQ92503.
PaxDbiQ92503.
PRIDEiQ92503.

Protocols and materials databases

DNASUi6397.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392476; ENSP00000376268; ENSG00000129657. [Q92503-2]
ENST00000430767; ENSP00000408169; ENSG00000129657. [Q92503-1]
ENST00000431431; ENSP00000389838; ENSG00000129657. [Q92503-3]
ENST00000436233; ENSP00000390392; ENSG00000129657. [Q92503-1]
ENST00000443798; ENSP00000406030; ENSG00000129657. [Q92503-2]
ENST00000585618; ENSP00000466581; ENSG00000129657. [Q92503-1]
ENST00000591437; ENSP00000467934; ENSG00000129657. [Q92503-3]
GeneIDi6397.
KEGGihsa:6397.
UCSCiuc002jto.4. human. [Q92503-1]

Organism-specific databases

CTDi6397.
GeneCardsiSEC14L1.
HGNCiHGNC:10698. SEC14L1.
HPAiHPA021463.
HPA028703.
MIMi601504. gene.
neXtProtiNX_Q92503.
PharmGKBiPA35621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000231147.
HOVERGENiHBG060237.
InParanoidiQ92503.
OMAiSGECMCE.
OrthoDBiEOG7RBZ8M.
PhylomeDBiQ92503.
TreeFamiTF313988.

Miscellaneous databases

ChiTaRSiSEC14L1. human.
GeneWikiiSEC14L1.
GenomeRNAii6397.
NextBioi24850.
PROiQ92503.
SOURCEiSearch...

Gene expression databases

BgeeiQ92503.
CleanExiHS_SEC14L1.
ExpressionAtlasiQ92503. baseline and differential.
GenevisibleiQ92503. HS.

Family and domain databases

Gene3Di3.40.525.10. 2 hits.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
IPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
PF04707. PRELI. 1 hit.
[Graphical view]
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
PS50904. PRELI_MSF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region."
    Chinen K., Takahashi E., Nakamura Y.
    Cytogenet. Cell Genet. 73:218-223(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-188, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "Alternative splice variants of SEC14L1."
    Matthes F., Hansmann I., Schlote D.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-188.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT PRO-188.
    Tissue: Adrenal gland.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-188.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-188.
    Tissue: Testis.
  7. "Large-scale concatenation cDNA sequencing."
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 423-715 (ISOFORM 2).
    Tissue: Brain.
  8. Cited for: FUNCTION, INTERACTION WITH SLC18A3 AND SLC5A7, SUBCELLULAR LOCATION.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1."
    Li M.T., Di W., Xu H., Yang Y.K., Chen H.W., Zhang F.X., Zhai Z.H., Chen D.Y.
    J. Virol. 87:10037-10046(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DDX58, SUBCELLULAR LOCATION, REGION.
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiS14L1_HUMAN
AccessioniPrimary (citable) accession number: Q92503
Secondary accession number(s): A8K4E8
, B4DDI5, D5G3K1, Q99780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 30, 2010
Last modified: April 13, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.