Q92502 (STAR8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
StAR-related lipid transfer protein 8

Alternative name(s):
Deleted in liver cancer 3 protein
Short name=DLC-3
START domain-containing protein 8
Short name=StARD8
START-GAP3

Gene names

Name:	STARD8
Synonyms:	DLC3, KIAA0189

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1023 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. Ref.7
Subunit structure	Binds both the SH2 and PTB domains of TNS1.
Subcellular location	Cell junction › focal adhesion Ref.7.
Tissue specificity	Widely expressed with highest levels in kidney, lung and placenta. Ref.8
Sequence similarities	Contains 1 Rho-GAP domain. Contains 1 START domain.
Sequence caution	The sequence BAA11506.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92502-1)

Also known as: DLC3beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92502-2)

Also known as: DLC3alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPLLDVFWSC...SLGALCRRLM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1023	1023	StAR-related lipid transfer protein 8		PRO_0000220676
Regions
	Domain	573 – 777	205	Rho-GAP
	Domain	809 – 1017	209	START
	Compositional bias	24 – 27	4	Poly-Glu
	Compositional bias	338 – 342	5	Poly-Glu
Amino acid modifications
	Modified residue	238	1	Phosphoserine By similarity
	Modified residue	481	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1	1	M → MPLLDVFWSCFRKVKCFPLL QVKKNAEAEAKRACEWLQAT GFPQYVQLFEEGSFPLDIGS VKKNHGFLDEDSLGALCRRL M in isoform 2.		VSP_032984
	Natural variant	188	1	G → S in a breast cancer sample; somatic mutation. Ref.10		VAR_036588
	Natural variant	242	1	E → K in a breast cancer sample; somatic mutation. Ref.10		VAR_036589
	Natural variant	327	1	R → Q. Corresponds to variant rs55962426 [ dbSNP | Ensembl ].		VAR_061816
Experimental info
	Mutagenesis	608	1	R → E: No effect on cell morphology when overexpressed. Ref.7
	Sequence conflict	466	1	P → S in BAA11506. Ref.1
Isoform 2:
	Sequence conflict	71	1	D → G in CAH18253. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (DLC3beta) [UniParc]. Last modified March 21, 2006. Version 2. Checksum: F93804B352450DE2	FASTA	1,023	112,601
	10 20 30 40 50 60 MTLNNCASMK LEVHFQSKQN EDSEEEEQCT ISSHWAFQQE SKCWSPMGSS DLLAPPSPGL 70 80 90 100 110 120 PATSSCESVL TELSATSLPV ITVSLPPEPA DLPLPGRAPS SSDRPLLSPT QGQEGPQDKA 130 140 150 160 170 180 KKRHRNRSFL KHLESLRRKE KSGSQQAEPK HSPATSEKVS KASSFRSCRG FLSAGFYRAK 190 200 210 220 230 240 NWAATSAGGS GANTRKAWEA WPVASFRHPQ WTHRGDCLVH VPGDHKPGTF PRSLSIESLC 250 260 270 280 290 300 PEDGHRLADW QPGRRWGCEG RRGSCGSTGS HASTYDNLPE LYPAEPVMVG AEAEDEDDEE 310 320 330 340 350 360 SGGSYAHLDD ILQHVWGLQQ RVELWSRAMY PDLGPGDEEE EEATSSVEIA TVEVKCQAEA 370 380 390 400 410 420 LSQMEVPAHG ESPAWAQAEV QPAVLAPAQA PAEAEPVAQE EAEAPAPAPA PAPAQDSEQE 430 440 450 460 470 480 AHSGGEPTFA SSLSVEEGHS ISDTVASSSE LDSSGNSMNE AEAAGPLAGL QASMPRERRD 490 500 510 520 530 540 SGVGASLTRP CRKLRWHSFQ NSHRPSLNSE SLEINRQFAG QINLLHKGSL LRLTAFMEKY 550 560 570 580 590 600 TVPHKQGWVW SMPKFMRRNK TPDYRGQHVF GVPPLIHVQR TGQPLPQSIQ QAMRYLRSQC 610 620 630 640 650 660 LDQVGIFRKS GVKSRIQNLR QMNETSPDNV CYEGQSAYDV ADLLKQYFRD LPEPIFTSKL 670 680 690 700 710 720 TTTFLQIYQL LPKDQWLAAA QAATLLLPDE NREVLQTLLY FLSDIASAEE NQMTAGNLAV 730 740 750 760 770 780 CLAPSIFHLN VSKKDSPSPR IKSKRSLIGR PGPRDLSDNM AATQGLSHMI SDCKKLFQVP 790 800 810 820 830 840 QDMVLQLCSS YSAAELSPPG PALAELRQAQ AAGVSLSLYM EENIQDLLRD AAERFKGWMS 850 860 870 880 890 900 VPGPQHTELA CRKAPDGHPL RLWKASTEVA APPAVVLHRV LRERALWDED LLRAQVLEAL 910 920 930 940 950 960 MPGVELYHYV TDSMAPHPCR DFVVLRMWRS DLPRGGCLLV SQSLDPEQPV PESGVRALML 970 980 990 1000 1010 1020 TSQYLMEPCG LGRSRLTHIC RADLRGRSPD WYNKVFGHLC AMEVAKIRDS FPTLQAAGPE TKL
	Isoform 2 (DLC3alpha) [UniParc]. Checksum: 2BA1262D4C925551	FASTA	1,103	121,749
	10 20 30 40 50 60 MPLLDVFWSC FRKVKCFPLL QVKKNAEAEA KRACEWLQAT GFPQYVQLFE EGSFPLDIGS 70 80 90 100 110 120 VKKNHGFLDE DSLGALCRRL MTLNNCASMK LEVHFQSKQN EDSEEEEQCT ISSHWAFQQE 130 140 150 160 170 180 SKCWSPMGSS DLLAPPSPGL PATSSCESVL TELSATSLPV ITVSLPPEPA DLPLPGRAPS 190 200 210 220 230 240 SSDRPLLSPT QGQEGPQDKA KKRHRNRSFL KHLESLRRKE KSGSQQAEPK HSPATSEKVS 250 260 270 280 290 300 KASSFRSCRG FLSAGFYRAK NWAATSAGGS GANTRKAWEA WPVASFRHPQ WTHRGDCLVH 310 320 330 340 350 360 VPGDHKPGTF PRSLSIESLC PEDGHRLADW QPGRRWGCEG RRGSCGSTGS HASTYDNLPE 370 380 390 400 410 420 LYPAEPVMVG AEAEDEDDEE SGGSYAHLDD ILQHVWGLQQ RVELWSRAMY PDLGPGDEEE 430 440 450 460 470 480 EEATSSVEIA TVEVKCQAEA LSQMEVPAHG ESPAWAQAEV QPAVLAPAQA PAEAEPVAQE 490 500 510 520 530 540 EAEAPAPAPA PAPAQDSEQE AHSGGEPTFA SSLSVEEGHS ISDTVASSSE LDSSGNSMNE 550 560 570 580 590 600 AEAAGPLAGL QASMPRERRD SGVGASLTRP CRKLRWHSFQ NSHRPSLNSE SLEINRQFAG 610 620 630 640 650 660 QINLLHKGSL LRLTAFMEKY TVPHKQGWVW SMPKFMRRNK TPDYRGQHVF GVPPLIHVQR 670 680 690 700 710 720 TGQPLPQSIQ QAMRYLRSQC LDQVGIFRKS GVKSRIQNLR QMNETSPDNV CYEGQSAYDV 730 740 750 760 770 780 ADLLKQYFRD LPEPIFTSKL TTTFLQIYQL LPKDQWLAAA QAATLLLPDE NREVLQTLLY 790 800 810 820 830 840 FLSDIASAEE NQMTAGNLAV CLAPSIFHLN VSKKDSPSPR IKSKRSLIGR PGPRDLSDNM 850 860 870 880 890 900 AATQGLSHMI SDCKKLFQVP QDMVLQLCSS YSAAELSPPG PALAELRQAQ AAGVSLSLYM 910 920 930 940 950 960 EENIQDLLRD AAERFKGWMS VPGPQHTELA CRKAPDGHPL RLWKASTEVA APPAVVLHRV 970 980 990 1000 1010 1020 LRERALWDED LLRAQVLEAL MPGVELYHYV TDSMAPHPCR DFVVLRMWRS DLPRGGCLLV 1030 1040 1050 1060 1070 1080 SQSLDPEQPV PESGVRALML TSQYLMEPCG LGRSRLTHIC RADLRGRSPD WYNKVFGHLC 1090 1100 AMEVAKIRDS FPTLQAAGPE TKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Endometrial tumor.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
[7]	"START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology." Kawai K., Kiyota M., Seike J., Deki Y., Yagisawa H. Biochem. Biophys. Res. Commun. 364:783-789(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-608.
[8]	"Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth." Durkin M.E., Ullmannova V., Guan M., Popescu N.C. Oncogene 26:4580-4589(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities." Qian X., Li G., Asmussen H.K., Asnaghi L., Vass W.C., Braverman R., Yamada K.M., Popescu N.C., Papageorge A.G., Lowy D.R. Proc. Natl. Acad. Sci. U.S.A. 104:9012-9017(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TNS1.
[10]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-188 AND LYS-242.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D80011 mRNA. Translation: BAA11506.2. Different initiation. AK291747 mRNA. Translation: BAF84436.1. CR749411 mRNA. Translation: CAH18253.1. AL360076 Genomic DNA. Translation: CAI41586.1. CH471132 Genomic DNA. Translation: EAX05374.1. CH471132 Genomic DNA. Translation: EAX05375.1. BC035587 mRNA. Translation: AAH35587.1.
IPI	IPI00293887. IPI00742801.
PIR	B59430.
RefSeq	NP_001135975.1. NM_001142503.2. NP_001135976.1. NM_001142504.2. NP_055540.2. NM_014725.4.
UniGene	Hs.95140.
3D structure databases
ProteinModelPortal	Q92502.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363727.
PTM databases
PhosphoSite	Q92502.
Polymorphism databases
DMDM	90110072.
Proteomic databases
PaxDb	Q92502.
PRIDE	Q92502.
Protocols and materials databases
DNASU	9754.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252336; ENSP00000252336; ENSG00000130052. ENST00000374597; ENSP00000363725; ENSG00000130052. ENST00000374599; ENSP00000363727; ENSG00000130052.
GeneID	9754.
KEGG	hsa:9754.
UCSC	uc004dxa.3. human. uc004dxb.3. human.
Organism-specific databases
CTD	9754.
GeneCards	GC0XP067867.
HGNC	HGNC:19161. STARD8.
MIM	300689. gene.
neXtProt	NX_Q92502.
PharmGKB	PA38804.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG236923.
HOGENOM	HOG000039960.
HOVERGEN	HBG055955.
InParanoid	Q92502.
OMA	RKAPDGH.
OrthoDB	EOG4JDH7M.
PhylomeDB	Q92502.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q92502.
Bgee	Q92502.
CleanEx	HS_STARD8.
Genevestigator	Q92502.
GermOnline	ENSG00000130052. Homo sapiens.
Family and domain databases
Gene3D	1.10.555.10. 1 hit. 3.30.530.20. 1 hit.
InterPro	IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. IPR023393. START-like_dom. IPR002913. START_lipid-bd_dom. [Graphical view]
Pfam	PF00620. RhoGAP. 1 hit. PF01852. START. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. SM00234. START. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50238. RHOGAP. 1 hit. PS50848. START. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9754.
NextBio	36716.
SOURCE	Search...

Entry information

Entry name

STAR8_HUMAN

Accession

Primary (citable) accession number: Q92502
Secondary accession number(s): A8K6T2 , D3DVT9, Q5JST0, Q68DG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.