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Protein

Exportin-6

Gene

Xpo6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-6
Short name:
Exp6
Alternative name(s):
Ran-binding protein 20
Gene namesi
Name:Xpo6
Synonyms:Ranbp20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2429950. Xpo6.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 11251124Exportin-6PRO_0000235302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei199 – 1991PhosphoserineCombined sources
Modified residuei201 – 2011PhosphothreonineCombined sources
Modified residuei204 – 2041PhosphothreonineCombined sources
Modified residuei208 – 2081PhosphoserineCombined sources
Modified residuei224 – 2241PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ924Z6.
MaxQBiQ924Z6.
PaxDbiQ924Z6.
PRIDEiQ924Z6.

PTM databases

PhosphoSiteiQ924Z6.

Expressioni

Gene expression databases

BgeeiQ924Z6.
CleanExiMM_XPO6.
ExpressionAtlasiQ924Z6. baseline and differential.
GenevisibleiQ924Z6. MM.

Interactioni

Subunit structurei

Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009344.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9767Importin N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the exportin family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2020. Eukaryota.
COG5101. LUCA.
GeneTreeiENSGT00390000002810.
HOGENOMiHOG000220888.
HOVERGENiHBG054104.
InParanoidiQ924Z6.
OMAiWQRYLRQ.
OrthoDBiEOG76HQ0S.
PhylomeDBiQ924Z6.
TreeFamiTF323443.

Family and domain databases

Gene3Di1.25.10.10. 7 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q924Z6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QVGAWRFCLY
60 70 80 90 100
FLSSTRNDYV MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK
110 120 130 140 150
TLPYFIRNKL CKVIVDIGRQ DWPMFYHDFF TNILQLIQSP VTTPLGLIML
160 170 180 190 200
KTTSEELACP REDLSVARKE ELRKLLLDQV QTVLGLLTGI LETVWDKHSV
210 220 230 240 250
TAATPPPSPT SGESGDLLSN LLQSPSSAKL LHQPIPILDV ESEYVCSLAL
260 270 280 290 300
ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDTRARKMA SVNGSSQNCV
310 320 330 340 350
LGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD
360 370 380 390 400
NNAHTVKSRL EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL
410 420 430 440 450
LFKYTFHQPT HEGYFSCLDI WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL
460 470 480 490 500
VLLLTEVLNR IQFRYNQAQL EELDDETLDD DQQTEWQRYL RQSLEVVAKV
510 520 530 540 550
MELLPTHAFS TLFPVLQDNL EVYLGLQQFV VTSGSGHRLN ITAENDCRRL
560 570 580 590 600
HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI
610 620 630 640 650
KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCG EAHRQNTQQF
660 670 680 690 700
VTLISTTMDA ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ
710 720 730 740 750
KVFNSIIDAS AQRLTDKAQV LVCRALSNTL LLPWPNLPES EQQWPLRSIN
760 770 780 790 800
HASLISALSR DYHSLKPSAT APQRKVPLGD TKVIIHQTLS VLEDIVENIS
810 820 830 840 850
GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS FFLTLFRGLR
860 870 880 890 900
VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV
910 920 930 940 950
QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW
960 970 980 990 1000
RYFFKSTVLA SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL
1010 1020 1030 1040 1050
FYLETLNTKQ KLYHKKIFRT TMLFQFVNVL LQVLVHKSHD LLQEEIGIAI
1060 1070 1080 1090 1100
YNMASVDFDG FFAAFLPEFL TSCDGVDANQ KNVLGRNFKM DRDLPSFTQN
1110 1120
VHRLVNDLRY YRLCNDSLPP GTVKL
Length:1,125
Mass (Da):128,664
Last modified:May 16, 2006 - v2
Checksum:iCA808BDB172A84B9
GO
Isoform 2 (identifier: Q924Z6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-482: Missing.

Note: No experimental confirmation available.
Show »
Length:1,124
Mass (Da):128,536
Checksum:iDDB2EB30BD7A979B
GO
Isoform 3 (identifier: Q924Z6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-879: Missing.
     880-928: HEGSTGCRVV...MEQVYPIIAE → MAQGLLHGKW...RCSVVWISLQ

Note: No experimental confirmation available.
Show »
Length:246
Mass (Da):28,660
Checksum:iD84691A1141733C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti483 – 4831Missing in AAH58090 (PubMed:16141072).Curated
Sequence conflicti626 – 6261A → S in BAE32778 (PubMed:16141072).Curated
Sequence conflicti1072 – 10721S → R in BAE32778 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 879879Missing in isoform 3. 1 PublicationVSP_018466Add
BLAST
Alternative sequencei482 – 4821Missing in isoform 2. 1 PublicationVSP_018467
Alternative sequencei880 – 92849HEGST…PIIAE → MAQGLLHGKWQKCGWDMSTG YCLAPLRLLWWPPPSCMEGR CSVVWISLQ in isoform 3. 1 PublicationVSP_018468Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029528 mRNA. Translation: AAK40296.1.
AK011324 mRNA. Translation: BAB27545.1.
AK154709 mRNA. Translation: BAE32778.1.
BC058090 mRNA. Translation: AAH58090.1.
CCDSiCCDS52396.1. [Q924Z6-2]
CCDS80800.1. [Q924Z6-1]
RefSeqiNP_001298072.1. NM_001311143.1. [Q924Z6-1]
NP_083092.2. NM_028816.2. [Q924Z6-2]
UniGeneiMm.235663.

Genome annotation databases

EnsembliENSMUST00000009344; ENSMUSP00000009344; ENSMUSG00000000131. [Q924Z6-2]
ENSMUST00000168189; ENSMUSP00000130527; ENSMUSG00000000131. [Q924Z6-1]
GeneIDi74204.
KEGGimmu:74204.
UCSCiuc009jqq.1. mouse. [Q924Z6-1]
uc009jqr.1. mouse. [Q924Z6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029528 mRNA. Translation: AAK40296.1.
AK011324 mRNA. Translation: BAB27545.1.
AK154709 mRNA. Translation: BAE32778.1.
BC058090 mRNA. Translation: AAH58090.1.
CCDSiCCDS52396.1. [Q924Z6-2]
CCDS80800.1. [Q924Z6-1]
RefSeqiNP_001298072.1. NM_001311143.1. [Q924Z6-1]
NP_083092.2. NM_028816.2. [Q924Z6-2]
UniGeneiMm.235663.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009344.

PTM databases

PhosphoSiteiQ924Z6.

Proteomic databases

EPDiQ924Z6.
MaxQBiQ924Z6.
PaxDbiQ924Z6.
PRIDEiQ924Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009344; ENSMUSP00000009344; ENSMUSG00000000131. [Q924Z6-2]
ENSMUST00000168189; ENSMUSP00000130527; ENSMUSG00000000131. [Q924Z6-1]
GeneIDi74204.
KEGGimmu:74204.
UCSCiuc009jqq.1. mouse. [Q924Z6-1]
uc009jqr.1. mouse. [Q924Z6-2]

Organism-specific databases

CTDi23214.
MGIiMGI:2429950. Xpo6.

Phylogenomic databases

eggNOGiKOG2020. Eukaryota.
COG5101. LUCA.
GeneTreeiENSGT00390000002810.
HOGENOMiHOG000220888.
HOVERGENiHBG054104.
InParanoidiQ924Z6.
OMAiWQRYLRQ.
OrthoDBiEOG76HQ0S.
PhylomeDBiQ924Z6.
TreeFamiTF323443.

Miscellaneous databases

ChiTaRSiXpo6. mouse.
NextBioi340102.
PROiQ924Z6.
SOURCEiSearch...

Gene expression databases

BgeeiQ924Z6.
CleanExiMM_XPO6.
ExpressionAtlasiQ924Z6. baseline and differential.
GenevisibleiQ924Z6. MM.

Family and domain databases

Gene3Di1.25.10.10. 7 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hartmann E., Goerlich D.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199; THR-201; THR-204; SER-208 AND SER-224, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiXPO6_MOUSE
AccessioniPrimary (citable) accession number: Q924Z6
Secondary accession number(s): Q3U3K7, Q6PEF3, Q9D0K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: May 11, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.