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Protein

Ceramide synthase 2

Gene

Cers2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi67 – 128HomeoboxPROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • sphingosine N-acyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BRENDAi2.3.1.24. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Chemistry databases

SwissLipidsiSLP:000000116.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase 2
Short name:
CerS2
Alternative name(s):
LAG1 longevity assurance homolog 2
Translocating chain-associating membrane protein homolog 3
Short name:
TRAM homolog 3
Gene namesi
Name:Cers2
Synonyms:Lass2, Trh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1924143. Cers2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40LumenalSequence analysisAdd BLAST40
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 139CytoplasmicSequence analysisAdd BLAST78
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 174LumenalSequence analysisAdd BLAST14
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 208CytoplasmicSequence analysisAdd BLAST13
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 263LumenalSequence analysisAdd BLAST34
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 303CytoplasmicSequence analysisAdd BLAST19
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 380LumenalSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855101 – 380Ceramide synthase 2Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)1 Publication1
Modified residuei341PhosphoserineCombined sources1
Modified residuei346PhosphothreonineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ924Z4.
MaxQBiQ924Z4.
PaxDbiQ924Z4.
PeptideAtlasiQ924Z4.
PRIDEiQ924Z4.

PTM databases

iPTMnetiQ924Z4.
PhosphoSitePlusiQ924Z4.
SwissPalmiQ924Z4.

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in liver and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000015714.
CleanExiMM_LASS2.
ExpressionAtlasiQ924Z4. baseline and differential.
GenevisibleiQ924Z4. MM.

Interactioni

Subunit structurei

Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1.By similarity

Protein-protein interaction databases

BioGridi218381. 31 interactors.
IntActiQ924Z4. 3 interactors.
MINTiMINT-1851988.
STRINGi10090.ENSMUSP00000015858.

Structurei

3D structure databases

ProteinModelPortaliQ924Z4.
SMRiQ924Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 332TLCPROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOVERGENiHBG052310.
InParanoidiQ924Z4.
KOiK04710.
OMAiGKQPKQA.
OrthoDBiEOG091G0BWM.
PhylomeDBiQ924Z4.
TreeFamiTF314319.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTLYDYFW WERLWLPVNL TWADLEDKDG RVYAKASDLY ITLPLALLFL
60 70 80 90 100
VIRYFFELYV ATPLAALLNV KEKTRLRAPP NATLEHFYQT SGKQPKQVEV
110 120 130 140 150
DLLSRQSGLS GRQVERWFRR RRNQDRPSLL KKFREASWRF TYYLIAFVAG
160 170 180 190 200
MAVTVDKPWF YDLRKVWEGY PIQSIIPSQY WYYMIELSFY WSLLFSIASD
210 220 230 240 250
VKRKDFKEQI IHHVATIILL CFSWFANYVR AGTLIMALHD ASDYLLESAK
260 270 280 290 300
MFNYAGWKNT CNNLFIVFAI VFIITRLVIM PFWILHCTMI YPLELYPAFF
310 320 330 340 350
GYYFFNFMMA VLQMLHIFWA YFILRMAHKF ITGKLIEDER SDREETESSE
360 370 380
GEETAAGAGA KSRLLANGHP ILNNNHPKND
Length:380
Mass (Da):45,024
Last modified:December 1, 2001 - v1
Checksum:iB6B5EB5397DB19FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029532 mRNA. Translation: AAK40300.1.
AK050161 mRNA. Translation: BAC34102.1.
AK159325 mRNA. Translation: BAE34991.1.
BC006847 mRNA. Translation: AAH06847.2.
CCDSiCCDS17612.1.
RefSeqiNP_001307421.1. NM_001320492.1.
NP_084065.1. NM_029789.2.
XP_006502323.1. XM_006502260.1.
UniGeneiMm.181009.

Genome annotation databases

EnsembliENSMUST00000015858; ENSMUSP00000015858; ENSMUSG00000015714.
GeneIDi76893.
KEGGimmu:76893.
UCSCiuc008qjj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029532 mRNA. Translation: AAK40300.1.
AK050161 mRNA. Translation: BAC34102.1.
AK159325 mRNA. Translation: BAE34991.1.
BC006847 mRNA. Translation: AAH06847.2.
CCDSiCCDS17612.1.
RefSeqiNP_001307421.1. NM_001320492.1.
NP_084065.1. NM_029789.2.
XP_006502323.1. XM_006502260.1.
UniGeneiMm.181009.

3D structure databases

ProteinModelPortaliQ924Z4.
SMRiQ924Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218381. 31 interactors.
IntActiQ924Z4. 3 interactors.
MINTiMINT-1851988.
STRINGi10090.ENSMUSP00000015858.

Chemistry databases

SwissLipidsiSLP:000000116.

PTM databases

iPTMnetiQ924Z4.
PhosphoSitePlusiQ924Z4.
SwissPalmiQ924Z4.

Proteomic databases

EPDiQ924Z4.
MaxQBiQ924Z4.
PaxDbiQ924Z4.
PeptideAtlasiQ924Z4.
PRIDEiQ924Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015858; ENSMUSP00000015858; ENSMUSG00000015714.
GeneIDi76893.
KEGGimmu:76893.
UCSCiuc008qjj.1. mouse.

Organism-specific databases

CTDi29956.
MGIiMGI:1924143. Cers2.

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOVERGENiHBG052310.
InParanoidiQ924Z4.
KOiK04710.
OMAiGKQPKQA.
OrthoDBiEOG091G0BWM.
PhylomeDBiQ924Z4.
TreeFamiTF314319.

Enzyme and pathway databases

BRENDAi2.3.1.24. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSiCers2. mouse.
PROiQ924Z4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015714.
CleanExiMM_LASS2.
ExpressionAtlasiQ924Z4. baseline and differential.
GenevisibleiQ924Z4. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCERS2_MOUSE
AccessioniPrimary (citable) accession number: Q924Z4
Secondary accession number(s): Q3TXC5, Q9DCN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.