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Protein

Ceramide synthase 2

Gene

Cers2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi67 – 12862HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • sphingosine N-acyltransferase activity Source: MGI

GO - Biological processi

  • ceramide biosynthetic process Source: MGI
  • sphingolipid biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BRENDAi2.3.1.24. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Chemistry

SwissLipidsiSLP:000000116.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase 2
Short name:
CerS2
Alternative name(s):
LAG1 longevity assurance homolog 2
Translocating chain-associating membrane protein homolog 3
Short name:
TRAM homolog 3
Gene namesi
Name:Cers2
Synonyms:Lass2, Trh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1924143. Cers2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040LumenalSequence analysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence analysisAdd
BLAST
Topological domaini62 – 13978CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Topological domaini161 – 17414LumenalSequence analysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Topological domaini196 – 20813CytoplasmicSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 26334LumenalSequence analysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Topological domaini285 – 30319CytoplasmicSequence analysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Topological domaini325 – 38056LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Ceramide synthase 2PRO_0000185510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)1 Publication
Modified residuei341 – 3411PhosphoserineCombined sources
Modified residuei346 – 3461PhosphothreonineCombined sources
Modified residuei348 – 3481PhosphoserineCombined sources
Modified residuei349 – 3491PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ924Z4.
MaxQBiQ924Z4.
PaxDbiQ924Z4.
PeptideAtlasiQ924Z4.
PRIDEiQ924Z4.

PTM databases

iPTMnetiQ924Z4.
PhosphoSiteiQ924Z4.
SwissPalmiQ924Z4.

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in liver and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000015714.
CleanExiMM_LASS2.
ExpressionAtlasiQ924Z4. baseline and differential.
GenevisibleiQ924Z4. MM.

Interactioni

Subunit structurei

Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1.By similarity

Protein-protein interaction databases

BioGridi218381. 31 interactions.
IntActiQ924Z4. 3 interactions.
MINTiMINT-1851988.
STRINGi10090.ENSMUSP00000015858.

Structurei

3D structure databases

ProteinModelPortaliQ924Z4.
SMRiQ924Z4. Positions 78-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 332202TLCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOVERGENiHBG052310.
InParanoidiQ924Z4.
KOiK04710.
OMAiGKQPKQA.
OrthoDBiEOG091G0BWM.
PhylomeDBiQ924Z4.
TreeFamiTF314319.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTLYDYFW WERLWLPVNL TWADLEDKDG RVYAKASDLY ITLPLALLFL
60 70 80 90 100
VIRYFFELYV ATPLAALLNV KEKTRLRAPP NATLEHFYQT SGKQPKQVEV
110 120 130 140 150
DLLSRQSGLS GRQVERWFRR RRNQDRPSLL KKFREASWRF TYYLIAFVAG
160 170 180 190 200
MAVTVDKPWF YDLRKVWEGY PIQSIIPSQY WYYMIELSFY WSLLFSIASD
210 220 230 240 250
VKRKDFKEQI IHHVATIILL CFSWFANYVR AGTLIMALHD ASDYLLESAK
260 270 280 290 300
MFNYAGWKNT CNNLFIVFAI VFIITRLVIM PFWILHCTMI YPLELYPAFF
310 320 330 340 350
GYYFFNFMMA VLQMLHIFWA YFILRMAHKF ITGKLIEDER SDREETESSE
360 370 380
GEETAAGAGA KSRLLANGHP ILNNNHPKND
Length:380
Mass (Da):45,024
Last modified:December 1, 2001 - v1
Checksum:iB6B5EB5397DB19FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029532 mRNA. Translation: AAK40300.1.
AK050161 mRNA. Translation: BAC34102.1.
AK159325 mRNA. Translation: BAE34991.1.
BC006847 mRNA. Translation: AAH06847.2.
CCDSiCCDS17612.1.
RefSeqiNP_001307421.1. NM_001320492.1.
NP_084065.1. NM_029789.2.
XP_006502323.1. XM_006502260.1.
UniGeneiMm.181009.

Genome annotation databases

EnsembliENSMUST00000015858; ENSMUSP00000015858; ENSMUSG00000015714.
GeneIDi76893.
KEGGimmu:76893.
UCSCiuc008qjj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029532 mRNA. Translation: AAK40300.1.
AK050161 mRNA. Translation: BAC34102.1.
AK159325 mRNA. Translation: BAE34991.1.
BC006847 mRNA. Translation: AAH06847.2.
CCDSiCCDS17612.1.
RefSeqiNP_001307421.1. NM_001320492.1.
NP_084065.1. NM_029789.2.
XP_006502323.1. XM_006502260.1.
UniGeneiMm.181009.

3D structure databases

ProteinModelPortaliQ924Z4.
SMRiQ924Z4. Positions 78-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218381. 31 interactions.
IntActiQ924Z4. 3 interactions.
MINTiMINT-1851988.
STRINGi10090.ENSMUSP00000015858.

Chemistry

SwissLipidsiSLP:000000116.

PTM databases

iPTMnetiQ924Z4.
PhosphoSiteiQ924Z4.
SwissPalmiQ924Z4.

Proteomic databases

EPDiQ924Z4.
MaxQBiQ924Z4.
PaxDbiQ924Z4.
PeptideAtlasiQ924Z4.
PRIDEiQ924Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015858; ENSMUSP00000015858; ENSMUSG00000015714.
GeneIDi76893.
KEGGimmu:76893.
UCSCiuc008qjj.1. mouse.

Organism-specific databases

CTDi29956.
MGIiMGI:1924143. Cers2.

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOVERGENiHBG052310.
InParanoidiQ924Z4.
KOiK04710.
OMAiGKQPKQA.
OrthoDBiEOG091G0BWM.
PhylomeDBiQ924Z4.
TreeFamiTF314319.

Enzyme and pathway databases

BRENDAi2.3.1.24. 3474.
ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSiCers2. mouse.
PROiQ924Z4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015714.
CleanExiMM_LASS2.
ExpressionAtlasiQ924Z4. baseline and differential.
GenevisibleiQ924Z4. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCERS2_MOUSE
AccessioniPrimary (citable) accession number: Q924Z4
Secondary accession number(s): Q3TXC5, Q9DCN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.