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Protein

Probable G-protein coupled receptor 149

Gene

Gpr149

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 149
Alternative name(s):
Induced early in differentiating astrocytes gene protein
Gene namesi
Name:Gpr149
Synonyms:Ieda
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619890. Gpr149.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 68CytoplasmicSequence analysisAdd BLAST13
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 108ExtracellularSequence analysisAdd BLAST19
Transmembranei109 – 131Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini132 – 148CytoplasmicSequence analysisAdd BLAST17
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 188ExtracellularSequence analysisAdd BLAST19
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 308CytoplasmicSequence analysisAdd BLAST99
Transmembranei309 – 329Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini330 – 340ExtracellularSequence analysisAdd BLAST11
Transmembranei341 – 361Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini362 – 730CytoplasmicSequence analysisAdd BLAST369

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696281 – 730Probable G-protein coupled receptor 149Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924Y8.
PRIDEiQ924Y8.

PTM databases

PhosphoSitePlusiQ924Y8.

Expressioni

Tissue specificityi

Expressed exclusively in brain and testis.1 Publication

Developmental stagei

Appeared in the brain of 16 days-old embryos and was maintained during the subsequent developmental stages.1 Publication

Inductioni

Expression increased during the early steps of astrocyte differentiation.

Gene expression databases

BgeeiENSRNOG00000014793.
GenevisibleiQ924Y8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019929.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi417 – 420Poly-Asp4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00390000003715.
HOGENOMiHOG000112771.
HOVERGENiHBG081566.
InParanoidiQ924Y8.
KOiK08433.
OMAiHEDYYDD.
OrthoDBiEOG091G02OC.
PhylomeDBiQ924Y8.
TreeFamiTF331679.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.
Isoform 1 (identifier: Q924Y8-1) [UniParc]FASTAAdd to basket
Also known as: Ieda-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFFLSNLTN DSRLWKVSHN STDLMNSPET LTLSLFCLIC LMTLVALVGS
60 70 80 90 100
IFSLVSLLTM QYRTVVSMLV TSWSVDDLLS VLSVAIFMVL QWPREAPGYF
110 120 130 140 150
QSLCTTSALL YMCQGLSSNL KATLIVFYNF YTMHRTVVSQ SSSWRSGQVL
160 170 180 190 200
GVALTVWAVS LLLASLPLCG WGVFVRTPWG CLTDCSSPYV LLLFAVYASA
210 220 230 240 250
FGLLAVLSVP LTHQLLCSEE PPRLHANYQE ISRGASTPGT PAAGGRVLCL
260 270 280 290 300
LPEDVEIPAL PGTGSSLSSD MVFAPGQPAA SSAGAGKREN LWTPRGSSSF
310 320 330 340 350
PVSLAQKRFA LILALTKVIL WLPMMIHMVV KHVVGFQSLP VDMLSFLLTL
360 370 380 390 400
LASTVTPVFV LSKRWAHLPC GCIINCQPDT YSVAFDGKKS KRKGFEFNLS
410 420 430 440 450
FQQSYGLYKM THADYYDDDD ENPISYHNPK KYECEATKEP REDNHGVFNT
460 470 480 490 500
ITVEISTTPP LDSATLTGVN KCTNTDIPEP KQAVSEEKGA FSIKTECAIN
510 520 530 540 550
YGEATSFEGP ERRLSHEETQ KPDLSDWEWC RSKSERTPRQ RSGGGLAIPI
560 570 580 590 600
CAFQGTVSLQ APTGKTLSLS TYEVSAEGQK ITPPSKKIEV YRSKSVGHEP
610 620 630 640 650
NSEESPSTFA DTNVKIHLEV LEICDNDEAL DTVSIISNIS QSSTKVRSPS
660 670 680 690 700
LRYSRKENRF VSCDLGETAS YSLFLPTSDP DGDINISIPD TVEAHRQNSR
710 720 730
RQHQDRDGYQ EEIQLLNKAY RKREAESKGN
Length:730
Mass (Da):80,524
Last modified:December 1, 2001 - v1
Checksum:iF15AA7C80C0EAB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY030276 mRNA. Translation: AAK51132.1.
RefSeqiNP_620246.1. NM_138891.1. [Q924Y8-1]
XP_017446091.1. XM_017590602.1. [Q924Y8-1]
UniGeneiRn.96392.

Genome annotation databases

EnsembliENSRNOT00000019929; ENSRNOP00000019929; ENSRNOG00000014793. [Q924Y8-1]
GeneIDi192251.
KEGGirno:192251.
UCSCiRGD:619890. rat. [Q924Y8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY030276 mRNA. Translation: AAK51132.1.
RefSeqiNP_620246.1. NM_138891.1. [Q924Y8-1]
XP_017446091.1. XM_017590602.1. [Q924Y8-1]
UniGeneiRn.96392.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019929.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ924Y8.

Proteomic databases

PaxDbiQ924Y8.
PRIDEiQ924Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019929; ENSRNOP00000019929; ENSRNOG00000014793. [Q924Y8-1]
GeneIDi192251.
KEGGirno:192251.
UCSCiRGD:619890. rat. [Q924Y8-1]

Organism-specific databases

CTDi344758.
RGDi619890. Gpr149.

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00390000003715.
HOGENOMiHOG000112771.
HOVERGENiHBG081566.
InParanoidiQ924Y8.
KOiK08433.
OMAiHEDYYDD.
OrthoDBiEOG091G02OC.
PhylomeDBiQ924Y8.
TreeFamiTF331679.

Miscellaneous databases

PROiQ924Y8.

Gene expression databases

BgeeiENSRNOG00000014793.
GenevisibleiQ924Y8. RN.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP149_RAT
AccessioniPrimary (citable) accession number: Q924Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.