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Protein

Endothelial transcription factor GATA-2

Gene

Gata2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Phagocytosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial transcription factor GATA-2
Alternative name(s):
GATA-binding protein 2
Gene namesi
Name:Gata2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2664. Gata2.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
  • protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Endothelial transcription factor GATA-2PRO_0000083405Add
BLAST

Proteomic databases

PaxDbiQ924Y4.

PTM databases

PhosphoSiteiQ924Y4.

Expressioni

Gene expression databases

ExpressionAtlasiQ924Y4. baseline and differential.
GenevisibleiQ924Y4. RN.

Interactioni

Subunit structurei

Interacts with BRD3. Interacts with AR and CCAR1.By similarity

Protein-protein interaction databases

BioGridi247224. 1 interaction.
STRINGi10116.ENSRNOP00000017240.

Structurei

3D structure databases

ProteinModelPortaliQ924Y4.
SMRiQ924Y4. Positions 290-334, 343-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri295 – 31925GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37325GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiQ924Y4.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG7CCBRF.
PhylomeDBiQ924Y4.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG
110 120 130 140 150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG
160 170 180 190 200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASPSAGG
210 220 230 240 250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP ATHHPIPTYP
260 270 280 290 300
SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
310 320 330 340 350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA
360 370 380 390 400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM
410 420 430 440 450
SSKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG
460 470 480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Length:480
Mass (Da):50,464
Last modified:December 1, 2001 - v1
Checksum:i80FBA84AA4258EAD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti347 – 3471T → S in AAL57180 (PubMed:12933836).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032734 mRNA. Translation: AAK51128.1.
AF345897 mRNA. Translation: AAL57180.1.
BC061745 mRNA. Translation: AAH61745.1.
RefSeqiNP_254277.1. NM_033442.1.
UniGeneiRn.34322.

Genome annotation databases

EnsembliENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347.
GeneIDi25159.
KEGGirno:25159.
UCSCiRGD:2664. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032734 mRNA. Translation: AAK51128.1.
AF345897 mRNA. Translation: AAL57180.1.
BC061745 mRNA. Translation: AAH61745.1.
RefSeqiNP_254277.1. NM_033442.1.
UniGeneiRn.34322.

3D structure databases

ProteinModelPortaliQ924Y4.
SMRiQ924Y4. Positions 290-334, 343-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247224. 1 interaction.
STRINGi10116.ENSRNOP00000017240.

PTM databases

PhosphoSiteiQ924Y4.

Proteomic databases

PaxDbiQ924Y4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347.
GeneIDi25159.
KEGGirno:25159.
UCSCiRGD:2664. rat.

Organism-specific databases

CTDi2624.
RGDi2664. Gata2.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiQ924Y4.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG7CCBRF.
PhylomeDBiQ924Y4.
TreeFamiTF315391.

Enzyme and pathway databases

ReactomeiR-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ924Y4.

Gene expression databases

ExpressionAtlasiQ924Y4. baseline and differential.
GenevisibleiQ924Y4. RN.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Itoh T., Itoh A., Pleasure D.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-DawleyImported.
  2. "Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts."
    Lasbury M.E., Tang X., Durant P.J., Lee C.-H.
    Infect. Immun. 71:4943-4952(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN PHAGOCYTOSIS.
    Strain: Sprague-DawleyImported.
    Tissue: Lung1 Publication.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.

Entry informationi

Entry nameiGATA2_RAT
AccessioniPrimary (citable) accession number: Q924Y4
Secondary accession number(s): Q8VHY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.