Q924Y0 (BODG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-butyrobetaine dioxygenase
EC=1.14.11.1

Alternative name(s):
Gamma-butyrobetaine hydroxylase
Short name=Gamma-BBH
Gamma-butyrobetaine,2-oxoglutarate dioxygenase

Gene names

Name:

Bbox1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of L-carnitine from gamma-butyrobetaine By similarity.
Catalytic activity	4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.
Cofactor	Binds 1 Fe2+ ion per subunit By similarity. Ascorbate By similarity.
Pathway	Amine and polyamine biosynthesis; carnitine biosynthesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the gamma-BBH/TMLD family.

Ontologies

Keywords
Biological process	Carnitine biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carnitine biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	gamma-butyrobetaine dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB iron ion binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Gamma-butyrobetaine dioxygenase		PRO_0000207086
Sites
	Metal binding	38	1	Zinc By similarity
	Metal binding	40	1	Zinc By similarity
	Metal binding	43	1	Zinc By similarity
	Metal binding	82	1	Zinc By similarity
	Metal binding	202	1	Iron; catalytic By similarity
	Metal binding	204	1	Iron; catalytic By similarity
	Metal binding	347	1	Iron; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q924Y0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 9F17F5F9CAE052BE	FASTA	387	44,699
	10 20 30 40 50 60 MHCAILKAEA VDGAHLMQIF WHDGAESLYP AVWLRDNCQC SDCYLHSAKA RKLLLEALDV 70 80 90 100 110 120 NIRIDDLTFD RKKVYITWPN DHYSEFEANW LKKRCFSQQA RARLQGELFL PECQYWGSEL 130 140 150 160 170 180 QLPTLNFEDV LNDDDHAYKW LSSLKKVGIV RLTGAADKRG EIIKLGKRIG FLYLTFYGHT 190 200 210 220 230 240 WQVQDKIDAN NVAYTTGKLS FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK 250 260 270 280 290 300 LKEKNPQAFH ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRVN FNNATRDTVF 310 320 330 340 350 360 DVPIERVQPF YAALKEFVDL MNSKEYKYTF KMNPGDVITF DNWRLLHGRR SYEAGTEISR 370 380 HLEGAYADWD VVMSRLRILR QRVTNGN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of mouse gamma-butyrobetaine hydroxylase cDNA." Vaz F.M., Ofman R., Wanders R.J.A. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: FVB/N.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY033514 mRNA. Translation: AAK54388.1. BC019406 mRNA. Translation: AAH19406.1.
IPI	IPI00126203.
RefSeq	NP_569719.1. NM_130452.1.
UniGene	Mm.27335.
3D structure databases
ProteinModelPortal	Q924Y0.
SMR	Q924Y0. Positions 1-385.
ModBase	Search...
Protein-protein interaction databases
STRING	Q924Y0.
PTM databases
PhosphoSite	Q924Y0.
Proteomic databases
PRIDE	Q924Y0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000046233; ENSMUSP00000046302; ENSMUSG00000041660.
GeneID	170442.
KEGG	mmu:170442.
Organism-specific databases
CTD	8424.
MGI	MGI:1891372. Bbox1.
Phylogenomic databases
GeneTree	ENSGT00530000063582.
HOGENOM	HBG715615.
HOVERGEN	HBG031125.
InParanoid	Q924Y0.
OMA	IQKAEVL.
OrthoDB	EOG4SXNCM.
PhylomeDB	Q924Y0.
Gene expression databases
ArrayExpress	Q924Y0.
Bgee	Q924Y0.
Genevestigator	Q924Y0.
GermOnline	ENSMUSG00000041660. Mus musculus.
Family and domain databases
InterPro	IPR012775. 2-oxoglut_dOase. IPR010376. DUF971. IPR003819. Taurine_dOase. [Graphical view]
KO	K00471.
Pfam	PF06155. DUF971. 1 hit. PF02668. TauD. 1 hit. [Graphical view]
TIGRFAMs	TIGR02409. Carnitine_bodg. 1 hit.
ProtoNet	Search...
Other
NextBio	370087.
SOURCE	Search...

Entry information

Entry name

BODG_MOUSE

Accession

Primary (citable) accession number: Q924Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program