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Protein

Gamma-butyrobetaine dioxygenase

Gene

Bbox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of L-carnitine from gamma-butyrobetaine.By similarity

Catalytic activityi

4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.

Cofactori

Protein has several cofactor binding sites:
  • Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
  • L-ascorbateBy similarity

Pathwayi: carnitine biosynthesis

This protein is involved in the pathway carnitine biosynthesis, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway carnitine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38ZincBy similarity1
Metal bindingi40ZincBy similarity1
Metal bindingi43ZincBy similarity1
Metal bindingi82ZincBy similarity1
Metal bindingi202Iron; catalyticBy similarity1
Metal bindingi204Iron; catalyticBy similarity1
Metal bindingi347Iron; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Carnitine biosynthesis

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-71262. Carnitine synthesis.
UniPathwayiUPA00118.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-butyrobetaine dioxygenase (EC:1.14.11.1)
Alternative name(s):
Gamma-butyrobetaine hydroxylase
Short name:
Gamma-BBH
Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Gene namesi
Name:Bbox1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1891372. Bbox1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002070861 – 387Gamma-butyrobetaine dioxygenaseAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ924Y0.
PaxDbiQ924Y0.
PRIDEiQ924Y0.

PTM databases

iPTMnetiQ924Y0.
PhosphoSitePlusiQ924Y0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041660.
ExpressionAtlasiQ924Y0. baseline and differential.
GenevisibleiQ924Y0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ924Y0. 1 interactor.
MINTiMINT-1856133.
STRINGi10090.ENSMUSP00000046302.

Structurei

3D structure databases

ProteinModelPortaliQ924Y0.
SMRiQ924Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-BBH/TMLD family.Curated

Phylogenomic databases

eggNOGiKOG3888. Eukaryota.
COG2175. LUCA.
GeneTreeiENSGT00530000063582.
HOGENOMiHOG000231427.
HOVERGENiHBG031125.
InParanoidiQ924Y0.
KOiK00471.
OMAiGMIKRTH.
OrthoDBiEOG091G062L.
PhylomeDBiQ924Y0.
TreeFamiTF313805.

Family and domain databases

InterProiIPR010376. DUF971.
IPR012775. GBBH.
IPR003819. TauD/TfdA-like.
[Graphical view]
PfamiPF06155. DUF971. 1 hit.
PF02668. TauD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02409. carnitine_bodg. 1 hit.

Sequencei

Sequence statusi: Complete.

Q924Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCAILKAEA VDGAHLMQIF WHDGAESLYP AVWLRDNCQC SDCYLHSAKA
60 70 80 90 100
RKLLLEALDV NIRIDDLTFD RKKVYITWPN DHYSEFEANW LKKRCFSQQA
110 120 130 140 150
RARLQGELFL PECQYWGSEL QLPTLNFEDV LNDDDHAYKW LSSLKKVGIV
160 170 180 190 200
RLTGAADKRG EIIKLGKRIG FLYLTFYGHT WQVQDKIDAN NVAYTTGKLS
210 220 230 240 250
FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK LKEKNPQAFH
260 270 280 290 300
ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRVN FNNATRDTVF
310 320 330 340 350
DVPIERVQPF YAALKEFVDL MNSKEYKYTF KMNPGDVITF DNWRLLHGRR
360 370 380
SYEAGTEISR HLEGAYADWD VVMSRLRILR QRVTNGN
Length:387
Mass (Da):44,699
Last modified:December 1, 2001 - v1
Checksum:i9F17F5F9CAE052BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033514 mRNA. Translation: AAK54388.1.
BC019406 mRNA. Translation: AAH19406.1.
CCDSiCCDS16510.1.
RefSeqiNP_569719.1. NM_130452.1.
XP_006498885.1. XM_006498822.3.
XP_006498886.1. XM_006498823.3.
UniGeneiMm.27335.

Genome annotation databases

EnsembliENSMUST00000046233; ENSMUSP00000046302; ENSMUSG00000041660.
GeneIDi170442.
KEGGimmu:170442.
UCSCiuc008lmu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033514 mRNA. Translation: AAK54388.1.
BC019406 mRNA. Translation: AAH19406.1.
CCDSiCCDS16510.1.
RefSeqiNP_569719.1. NM_130452.1.
XP_006498885.1. XM_006498822.3.
XP_006498886.1. XM_006498823.3.
UniGeneiMm.27335.

3D structure databases

ProteinModelPortaliQ924Y0.
SMRiQ924Y0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ924Y0. 1 interactor.
MINTiMINT-1856133.
STRINGi10090.ENSMUSP00000046302.

PTM databases

iPTMnetiQ924Y0.
PhosphoSitePlusiQ924Y0.

Proteomic databases

MaxQBiQ924Y0.
PaxDbiQ924Y0.
PRIDEiQ924Y0.

Protocols and materials databases

DNASUi170442.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046233; ENSMUSP00000046302; ENSMUSG00000041660.
GeneIDi170442.
KEGGimmu:170442.
UCSCiuc008lmu.1. mouse.

Organism-specific databases

CTDi8424.
MGIiMGI:1891372. Bbox1.

Phylogenomic databases

eggNOGiKOG3888. Eukaryota.
COG2175. LUCA.
GeneTreeiENSGT00530000063582.
HOGENOMiHOG000231427.
HOVERGENiHBG031125.
InParanoidiQ924Y0.
KOiK00471.
OMAiGMIKRTH.
OrthoDBiEOG091G062L.
PhylomeDBiQ924Y0.
TreeFamiTF313805.

Enzyme and pathway databases

UniPathwayiUPA00118.
ReactomeiR-MMU-71262. Carnitine synthesis.

Miscellaneous databases

PROiQ924Y0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041660.
ExpressionAtlasiQ924Y0. baseline and differential.
GenevisibleiQ924Y0. MM.

Family and domain databases

InterProiIPR010376. DUF971.
IPR012775. GBBH.
IPR003819. TauD/TfdA-like.
[Graphical view]
PfamiPF06155. DUF971. 1 hit.
PF02668. TauD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02409. carnitine_bodg. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBODG_MOUSE
AccessioniPrimary (citable) accession number: Q924Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.