Reviewed, UniProtKB/Swiss-Prot Q924Y0 (BODG_MOUSE)

Names and origin

Protein names

Recommended name:
    Gamma-butyrobetaine dioxygenase
    EC=1.14.11.1
Alternative name(s):
    Gamma-butyrobetaine,2-oxoglutarate dioxygenase
    Gamma-butyrobetaine hydroxylase
      Short name=Gamma-BBH

Gene names

Name:

Bbox1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of L-carnitine from gamma-butyrobetaine By similarity.
Catalytic activity	4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.
Cofactor	Iron By similarity. Ascorbate By similarity.
Pathway	Amine and polyamine biosynthesis; carnitine biosynthesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the gamma-BBH/TMLD family.

Ontologies

Keywords
Biological process	Carnitine biosynthesis
Cellular component	Cytoplasm
Ligand	Iron
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	carnitine biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	gamma-butyrobetaine dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Gamma-butyrobetaine dioxygenase		PRO_0000207086

Sequences

	Sequence		Length	Mass (Da)
	Q924Y0-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 9F17F5F9CAE052BE	FASTA	387	44,699
	10 20 30 40 50 60 MHCAILKAEA VDGAHLMQIF WHDGAESLYP AVWLRDNCQC SDCYLHSAKA RKLLLEALDV 70 80 90 100 110 120 NIRIDDLTFD RKKVYITWPN DHYSEFEANW LKKRCFSQQA RARLQGELFL PECQYWGSEL 130 140 150 160 170 180 QLPTLNFEDV LNDDDHAYKW LSSLKKVGIV RLTGAADKRG EIIKLGKRIG FLYLTFYGHT 190 200 210 220 230 240 WQVQDKIDAN NVAYTTGKLS FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK 250 260 270 280 290 300 LKEKNPQAFH ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRVN FNNATRDTVF 310 320 330 340 350 360 DVPIERVQPF YAALKEFVDL MNSKEYKYTF KMNPGDVITF DNWRLLHGRR SYEAGTEISR 370 380 HLEGAYADWD VVMSRLRILR QRVTNGN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of mouse gamma-butyrobetaine hydroxylase cDNA." Vaz F.M., Ofman R., Wanders R.J.A. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: FVB/N.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY033514 mRNA. Translation: AAK54388.1. BC019406 mRNA. Translation: AAH19406.1.
IPI	IPI00126203.
RefSeq	NP_569719.1.
UniGene	Mm.27335
3D structure databases
SMR	Q924Y0. Positions 117-365.
ModBase	Search...
Protein-protein interaction databases
STRING	Q924Y0.
Proteomic databases
PRIDE	Q924Y0.
Genome annotation databases
Ensembl	ENSMUST00000046233; ENSMUSP00000046302; ENSMUSG00000041660; Mus musculus. [Genome view]
GeneID	170442.
KEGG	mmu:170442.
UCSC	uc008lmu.1. mouse.
Organism-specific databases
CTD	170442.
MGI	MGI:1891372. Bbox1.
Phylogenomic databases
HOGENOM	HBG715615.
HOVERGEN	Q924Y0.
InParanoid	Q924Y0.
OMA	PPGVQFL.
OrthoDB	EOG9MKR29.
PhylomeDB	Q924Y0.
Enzyme and pathway databases
BRENDA	1.14.11.1. 244.
Gene expression databases
ArrayExpress	Q924Y0.
Bgee	Q924Y0.
Genevestigator	Q924Y0.
GermOnline	ENSMUSG00000041660. Mus musculus.
Family and domain databases
InterPro	IPR012775. 2-oxoglut_dOase. IPR003819. Taurine_dOase. [Graphical view]
Pfam	PF02668. TauD. 1 hit. [Graphical view]
TIGRFAMs	TIGR02409. carnitine_bodg. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	370087.
SOURCE	Search...

Entry information

Entry name

BODG_MOUSE

Accession

Primary (citable) accession number: Q924Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	December 1, 2001
Last modified:	February 9, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)