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Protein

Gamma-butyrobetaine dioxygenase

Gene

Bbox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of L-carnitine from gamma-butyrobetaine.By similarity

Catalytic activityi

4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2.

Cofactori

Protein has several cofactor binding sites:
  • Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
  • L-ascorbateBy similarity

Pathwayi: carnitine biosynthesis

This protein is involved in the pathway carnitine biosynthesis, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway carnitine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38ZincBy similarity1
Metal bindingi40ZincBy similarity1
Metal bindingi43ZincBy similarity1
Metal bindingi82ZincBy similarity1
Metal bindingi202Iron; catalyticBy similarity1
Metal bindingi204Iron; catalyticBy similarity1
Metal bindingi347Iron; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processCarnitine biosynthesis
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-71262 Carnitine synthesis
UniPathwayiUPA00118

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-butyrobetaine dioxygenase (EC:1.14.11.1)
Alternative name(s):
Gamma-butyrobetaine hydroxylase
Short name:
Gamma-BBH
Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Gene namesi
Name:Bbox1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1891372 Bbox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002070861 – 387Gamma-butyrobetaine dioxygenaseAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ924Y0
PaxDbiQ924Y0
PRIDEiQ924Y0

PTM databases

iPTMnetiQ924Y0
PhosphoSitePlusiQ924Y0

Expressioni

Gene expression databases

BgeeiENSMUSG00000041660
ExpressionAtlasiQ924Y0 baseline and differential
GenevisibleiQ924Y0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ924Y0, 1 interactor
MINTiQ924Y0
STRINGi10090.ENSMUSP00000046302

Structurei

3D structure databases

ProteinModelPortaliQ924Y0
SMRiQ924Y0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-BBH/TMLD family.Curated

Phylogenomic databases

eggNOGiKOG3888 Eukaryota
COG2175 LUCA
GeneTreeiENSGT00530000063582
HOGENOMiHOG000231427
HOVERGENiHBG031125
InParanoidiQ924Y0
KOiK00471
OMAiYINDGHH
OrthoDBiEOG091G062L
PhylomeDBiQ924Y0
TreeFamiTF313805

Family and domain databases

Gene3Di3.30.2020.30, 1 hit
InterProiView protein in InterPro
IPR012775 GBBH
IPR038492 GBBH-like_N_sf
IPR010376 GBH-like_N
IPR003819 TauD/TfdA-like
PfamiView protein in Pfam
PF06155 DUF971, 1 hit
PF02668 TauD, 1 hit
TIGRFAMsiTIGR02409 carnitine_bodg, 1 hit

Sequencei

Sequence statusi: Complete.

Q924Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCAILKAEA VDGAHLMQIF WHDGAESLYP AVWLRDNCQC SDCYLHSAKA
60 70 80 90 100
RKLLLEALDV NIRIDDLTFD RKKVYITWPN DHYSEFEANW LKKRCFSQQA
110 120 130 140 150
RARLQGELFL PECQYWGSEL QLPTLNFEDV LNDDDHAYKW LSSLKKVGIV
160 170 180 190 200
RLTGAADKRG EIIKLGKRIG FLYLTFYGHT WQVQDKIDAN NVAYTTGKLS
210 220 230 240 250
FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK LKEKNPQAFH
260 270 280 290 300
ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRVN FNNATRDTVF
310 320 330 340 350
DVPIERVQPF YAALKEFVDL MNSKEYKYTF KMNPGDVITF DNWRLLHGRR
360 370 380
SYEAGTEISR HLEGAYADWD VVMSRLRILR QRVTNGN
Length:387
Mass (Da):44,699
Last modified:December 1, 2001 - v1
Checksum:i9F17F5F9CAE052BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033514 mRNA Translation: AAK54388.1
BC019406 mRNA Translation: AAH19406.1
CCDSiCCDS16510.1
RefSeqiNP_569719.1, NM_130452.1
XP_006498885.1, XM_006498822.3
XP_006498886.1, XM_006498823.3
UniGeneiMm.27335

Genome annotation databases

EnsembliENSMUST00000046233; ENSMUSP00000046302; ENSMUSG00000041660
GeneIDi170442
KEGGimmu:170442
UCSCiuc008lmu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBODG_MOUSE
AccessioniPrimary (citable) accession number: Q924Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health