Reviewed,
UniProtKB/Swiss-Prot Q924Y0 (BODG_MOUSE)
Last modified
November 25, 2008.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Gamma-butyrobetaine dioxygenase EC=1.14.11.1 Alternative name(s): Gamma-butyrobetaine,2-oxoglutarate dioxygenase Gamma-butyrobetaine hydroxylase Short name=Gamma-BBH | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 387 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the formation of L-carnitine from gamma-butyrobetaine By similarity. |
| Catalytic activity | 4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO(2). |
| Cofactor | Iron By similarity. Ascorbate By similarity. |
| Pathway | |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the gamma-BBH/TMLD family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Carnitine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Iron |
| Molecular function | Dioxygenase Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | carnitine biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | electron carrier activity Inferred from electronic annotation. Source: InterPro gamma-butyrobetaine dioxygenase activityInferred from sequence or structural similarity. Source: UniProtKB iron ion bindingInferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 387 | 387 | Gamma-butyrobetaine dioxygenase | PRO_0000207086 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of mouse gamma-butyrobetaine hydroxylase cDNA." Vaz F.M., Ofman R., Wanders R.J.A. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: FVB/N. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| AY033514 mRNA. Translation: AAK54388.1. BC019406 mRNA. Translation: AAH19406.1. | |
| RefSeq | NP_569719.1. |
| UniGene | Mm.27335 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000041660. Mus musculus. [Contig view] |
| GeneID | 170442. |
| KEGG | mmu:170442. |
Organism-specific databases | |
| MGI | MGI:1891372. Bbox1. |
Phylogenomic databases | |
| HOGENOM | Q924Y0. |
| HOVERGEN | Q924Y0. |
Gene expression databases | |
| ArrayExpress | Q924Y0. |
| GermOnline | ENSMUSG00000041660. Mus musculus. |
Family and domain databases | |
| InterPro | IPR012775. 2-oxoglut_dOase. IPR003819. Taurine_dOase. [Graphical view] |
| Pfam | PF02668. TauD. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02409. carnitine_bodg. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 370087. |
| SOURCE | Search... |
Entry information
| Entry name | BODG_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q924Y0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


