ID   Q924X4_MOUSE            Unreviewed;       175 AA.
AC   Q924X4;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 150.
DE   RecName: Full=Parathyroid hormone-related protein {ECO:0000256|RuleBase:RU368098};
DE            Short=PTH-rP {ECO:0000256|RuleBase:RU368098};
DE            Short=PTHrP {ECO:0000256|RuleBase:RU368098};
DE   Contains:
DE     RecName: Full=Osteostatin {ECO:0000256|RuleBase:RU368098};
GN   Name=Pthlh {ECO:0000313|EMBL:CAC39218.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000051433.7, ECO:0000313|MGI:MGI:97800};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:CAC39218.1};
RN   [1] {ECO:0000313|EMBL:CAC39218.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C3H/HeJ {ECO:0000313|EMBL:CAC39218.1};
RC   TISSUE=Lung {ECO:0000313|EMBL:CAC39218.1};
RX   PubMed=11103933; DOI=10.1038/sj.onc.1203916;
RA   Manenti G., Peissel B., Gariboldi M., Falvella F.S., Zaffaroni D.,
RA   Allaria B., Pazzaglia S., Rebessi S., Covelli V., Saran A., Dragani T.A.;
RT   "A cancer modifier role for parathyroid hormone-related protein.";
RL   Oncogene 19:5324-5328(2000).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000051433.7, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000051433.7,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000051433.7}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000051433.7};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Neuroendocrine peptide which is a critical regulator of
CC       cellular and organ growth, development, migration, differentiation and
CC       survival and of epithelial calcium ion transport. Regulates
CC       endochondral bone development and epithelial-mesenchymal interactions
CC       during the formation of the mammary glands and teeth. Required for
CC       skeletal homeostasis. Promotes mammary mesenchyme differentiation and
CC       bud outgrowth by modulating mesenchymal cell responsiveness to BMPs.
CC       Up-regulates BMPR1A expression in the mammary mesenchyme and this
CC       increases the sensitivity of these cells to BMPs and allows them to
CC       respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling
CC       in the mesenchyme, in turn, triggers epithelial outgrowth and augments
CC       MSX2 expression, which causes the mammary mesenchyme to inhibit hair
CC       follicle formation within the nipple sheath.
CC       {ECO:0000256|RuleBase:RU368098}.
CC   -!- FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone
CC       resorption. {ECO:0000256|RuleBase:RU368098}.
CC   -!- SUBUNIT: PTHrP interacts with PTH1R (via N-terminal extracellular
CC       domain). {ECO:0000256|ARBA:ARBA00011816,
CC       ECO:0000256|RuleBase:RU368098}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368098}.
CC       Nucleus {ECO:0000256|RuleBase:RU368098}. Secreted
CC       {ECO:0000256|RuleBase:RU368098}.
CC   -!- PTM: There are several secretory forms, including osteostatin, arising
CC       from endoproteolytic cleavage of the initial translation product. Each
CC       of these secretory forms is believed to have one or more of its own
CC       receptors that mediates the normal paracrine, autocrine and endocrine
CC       actions. {ECO:0000256|RuleBase:RU368098}.
CC   -!- SIMILARITY: Belongs to the parathyroid hormone family.
CC       {ECO:0000256|ARBA:ARBA00006307, ECO:0000256|RuleBase:RU368098}.
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DR   EMBL; AJ278119; CAC39218.1; -; mRNA.
DR   RefSeq; NP_032996.2; NM_008970.4.
DR   Antibodypedia; 3662; 512 antibodies from 36 providers.
DR   DNASU; 19227; -.
DR   Ensembl; ENSMUST00000052296.9; ENSMUSP00000051433.7; ENSMUSG00000048776.9.
DR   Ensembl; ENSMUST00000204197.2; ENSMUSP00000145509.2; ENSMUSG00000048776.9.
DR   GeneID; 19227; -.
DR   KEGG; mmu:19227; -.
DR   UCSC; uc009esx.2; mouse.
DR   AGR; MGI:97800; -.
DR   CTD; 5744; -.
DR   MGI; MGI:97800; Pthlh.
DR   VEuPathDB; HostDB:ENSMUSG00000048776; -.
DR   GeneTree; ENSGT00390000004933; -.
DR   HOGENOM; CLU_095189_0_0_1; -.
DR   OMA; LQRWFFA; -.
DR   OrthoDB; 5317161at2759; -.
DR   TreeFam; TF332953; -.
DR   BioGRID-ORCS; 19227; 0 hits in 78 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 6.
DR   Bgee; ENSMUSG00000048776; Expressed in trophectoderm and 193 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051428; F:peptide hormone receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0030282; P:bone mineralization; IEA:InterPro.
DR   GO; GO:0061182; P:negative regulation of chondrocyte development; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR   InterPro; IPR003626; PTH-rel.
DR   InterPro; IPR001415; PTH/PTH-rel.
DR   PANTHER; PTHR17223; PARATHYROID HORMONE-RELATED; 1.
DR   PANTHER; PTHR17223:SF0; PARATHYROID HORMONE-RELATED PROTEIN; 1.
DR   Pfam; PF01279; Parathyroid; 1.
DR   SMART; SM00087; PTH; 1.
DR   PROSITE; PS00335; PARATHYROID; 1.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|RuleBase:RU368098};
KW   Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU368098};
KW   Cytoplasm {ECO:0000256|RuleBase:RU368098};
KW   Hormone {ECO:0000256|RuleBase:RU368098};
KW   Nucleus {ECO:0000256|RuleBase:RU368098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Secreted {ECO:0000256|RuleBase:RU368098};
KW   Signal {ECO:0000256|RuleBase:RU368098, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..175
FT                   /note="Parathyroid hormone-related protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015099525"
FT   REGION          74..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..140
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   175 AA;  20096 MW;  6D22DBCC31900B45 CRC64;
     MLRRLVQQWS VLVFLLSYSV PSRGRSVEGL GRRLKRAVSE HQLLHDKGKS IQDLRRRFFL
     HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK
     TPGKKKKGKP GKRREQEKKK RRTRSAWPST AASGLLEDPL PHTSRPSLEP SLRTH
//