Q924X4 (Q924X4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Parathyroid hormone-related protein EMBL CAC39218.1 Ensembl ENSMUSP00000051433

Gene names

Name:

Pthlh EMBL CAC39218.1 MGI 97800 Ensembl ENSMUSP00000051433

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Signal EMBL CAC39218.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endochondral ossification Inferred from mutant phenotype PubMed 8895385. Source: MGI endoderm development Inferred from direct assay PubMed 9921650. Source: MGI epithelial cell differentiation Inferred from mutant phenotype PubMed 15162506. Source: MGI lung alveolus development Inferred from mutant phenotype PubMed 15162506. Source: MGI mammary gland bud elongation Inferred from mutant phenotype PubMed 9477327. Source: MGI negative regulation of chondrocyte differentiation Inferred from direct assay PubMed 17328886. Source: MGI negative regulation of sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 17328886. Source: MGI nipple sheath formation Inferred from mutant phenotype PubMed 9477327. Source: MGI osteoblast development Inferred from mutant phenotype PubMed 9832460. Source: MGI positive regulation of cAMP biosynthetic process Inferred from sequence orthology PubMed 9008714. Source: MGI positive regulation of cell proliferation Inferred from direct assay PubMed 17328886. Source: MGI protein processing Inferred from direct assay PubMed 17328886. Source: MGI surfactant homeostasis Inferred from mutant phenotype PubMed 15162506. Source: MGI
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara extracellular space Traceable author statement PubMed 11606467. Source: MGI intracellular Inferred from direct assay PubMed 8895385. Source: MGI nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	hormone activity Traceable author statement PubMed 11606467. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 36	36	Potential EMBL CAC39218.1
	Chain	37 – 175	139	parathyroid hormone-related protein EMBL CAC39218.1		PRO_5000066089

Sequences

	Sequence		Length	Mass (Da)
	Q924X4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 6D22DBCC31900B45	FASTA	175	20,096
	10 20 30 40 50 60 MLRRLVQQWS VLVFLLSYSV PSRGRSVEGL GRRLKRAVSE HQLLHDKGKS IQDLRRRFFL 70 80 90 100 110 120 HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK 130 140 150 160 170 TPGKKKKGKP GKRREQEKKK RRTRSAWPST AASGLLEDPL PHTSRPSLEP SLRTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cancer modifier role for parathyroid hormone-related protein." Manenti G., Peissel B., Gariboldi M., Falvella F.S., Zaffaroni D., Allaria B., Pazzaglia S., Rebessi S., Covelli V., Saran A., Dragani T.A. Oncogene 19:5324-5328(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C3H/HeJ EMBL CAC39218.1. Tissue: Lung EMBL CAC39218.1.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000051433.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000051433.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC156278 Genomic DNA. No translation available. AJ278119 mRNA. Translation: CAC39218.1.
IPI	IPI00850394.
RefSeq	NP_032996.2. NM_008970.3.
UniGene	Mm.28440.
3D structure databases
HSSP	HSSP built from PDB template 1BZG based on UniProtKB P12272.
SMR	Q924X4. Positions 37-70.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000052296; ENSMUSP00000051433; ENSMUSG00000048776.
GeneID	19227.
KEGG	mmu:19227.
UCSC	uc009esx.2. mouse.
Organism-specific databases
CTD	5744.
MGI	MGI:97800. Pthlh.
Phylogenomic databases
GeneTree	ENSGT00390000004933.
HOVERGEN	HBG003236.
InParanoid	Q924X4.
OMA	PATNTKN.
Gene expression databases
Genevestigator	Q924X4.
Family and domain databases
InterPro	IPR003626. PTH-rel. IPR001415. PTH/PTH-rel. [Graphical view]
PANTHER	PTHR17223. PTHR17223. 1 hit.
Pfam	PF01279. Parathyroid. 1 hit. [Graphical view]
SMART	SM00087. PTH. 1 hit. [Graphical view]
PROSITE	PS00335. PARATHYROID. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	296020.
SOURCE	Search...

Entry information

Entry name

Q924X4_MOUSE

Accession

Primary (citable) accession number: Q924X4

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)