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Q924X4

- Q924X4_MOUSE

UniProt

Q924X4 - Q924X4_MOUSE

Protein
Submitted name:

Parathyroid hormone-related protein

Gene

Pthlh

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. hormone activity Source: MGI

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. endochondral ossification Source: MGI
    3. endoderm development Source: MGI
    4. epithelial cell differentiation Source: MGI
    5. lung alveolus development Source: MGI
    6. mammary gland bud elongation Source: MGI
    7. negative regulation of chondrocyte differentiation Source: MGI
    8. negative regulation of sequence-specific DNA binding transcription factor activity Source: MGI
    9. nipple sheath formation Source: MGI
    10. osteoblast development Source: MGI
    11. positive regulation of cAMP biosynthetic process Source: MGI
    12. positive regulation of cell proliferation Source: MGI
    13. protein processing Source: MGI
    14. regulation of gene expression Source: MGI
    15. skeletal system development Source: MGI
    16. surfactant homeostasis Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Parathyroid hormone-related proteinImported
    Gene namesi
    Name:PthlhImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:97800. Pthlh.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. Golgi apparatus Source: Ensembl
    3. intracellular Source: MGI
    4. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636 PotentialImportedAdd
    BLAST
    Chaini37 – 175139parathyroid hormone-related proteinImportedPRO_5000066089Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ924X4.

    Family & Domainsi

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    GeneTreeiENSGT00390000004933.
    HOVERGENiHBG003236.
    InParanoidiQ924X4.
    OMAiPATNTKN.
    OrthoDBiEOG7FBRK8.
    TreeFamiTF332953.

    Family and domain databases

    InterProiIPR003626. PTH-rel.
    IPR001415. PTH/PTH-rel.
    [Graphical view]
    PANTHERiPTHR17223. PTHR17223. 1 hit.
    PfamiPF01279. Parathyroid. 1 hit.
    [Graphical view]
    SMARTiSM00087. PTH. 1 hit.
    [Graphical view]
    PROSITEiPS00335. PARATHYROID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q924X4-1 [UniParc]FASTAAdd to Basket

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    MLRRLVQQWS VLVFLLSYSV PSRGRSVEGL GRRLKRAVSE HQLLHDKGKS    50
    IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE 100
    GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRREQEKKK RRTRSAWPST 150
    AASGLLEDPL PHTSRPSLEP SLRTH 175
    Length:175
    Mass (Da):20,096
    Last modified:December 1, 2001 - v1
    Checksum:i6D22DBCC31900B45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC156278 Genomic DNA. No translation available.
    AJ278119 mRNA. Translation: CAC39218.1.
    RefSeqiNP_032996.2. NM_008970.3.
    UniGeneiMm.28440.

    Genome annotation databases

    EnsembliENSMUST00000052296; ENSMUSP00000051433; ENSMUSG00000048776.
    GeneIDi19227.
    KEGGimmu:19227.
    UCSCiuc009esx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC156278 Genomic DNA. No translation available.
    AJ278119 mRNA. Translation: CAC39218.1 .
    RefSeqi NP_032996.2. NM_008970.3.
    UniGenei Mm.28440.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052296 ; ENSMUSP00000051433 ; ENSMUSG00000048776 .
    GeneIDi 19227.
    KEGGi mmu:19227.
    UCSCi uc009esx.2. mouse.

    Organism-specific databases

    CTDi 5744.
    MGIi MGI:97800. Pthlh.

    Phylogenomic databases

    GeneTreei ENSGT00390000004933.
    HOVERGENi HBG003236.
    InParanoidi Q924X4.
    OMAi PATNTKN.
    OrthoDBi EOG7FBRK8.
    TreeFami TF332953.

    Miscellaneous databases

    NextBioi 296020.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q924X4.

    Family and domain databases

    InterProi IPR003626. PTH-rel.
    IPR001415. PTH/PTH-rel.
    [Graphical view ]
    PANTHERi PTHR17223. PTHR17223. 1 hit.
    Pfami PF01279. Parathyroid. 1 hit.
    [Graphical view ]
    SMARTi SM00087. PTH. 1 hit.
    [Graphical view ]
    PROSITEi PS00335. PARATHYROID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C3H/HeJImported.
      Tissue: LungImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ924X4_MOUSE
    AccessioniPrimary (citable) accession number: Q924X4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3