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Q924X4

- Q924X4_MOUSE

UniProt

Q924X4 - Q924X4_MOUSE

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Protein
Submitted name:

Parathyroid hormone-related protein

Gene

Pthlh

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hormone activity Source: MGI

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. endochondral ossification Source: MGI
  3. endoderm development Source: MGI
  4. epithelial cell differentiation Source: MGI
  5. lung alveolus development Source: MGI
  6. mammary gland bud elongation Source: MGI
  7. negative regulation of chondrocyte differentiation Source: MGI
  8. negative regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  9. nipple sheath formation Source: MGI
  10. osteoblast development Source: MGI
  11. positive regulation of cAMP biosynthetic process Source: MGI
  12. positive regulation of cell proliferation Source: MGI
  13. protein processing Source: MGI
  14. regulation of gene expression Source: MGI
  15. skeletal system development Source: MGI
  16. surfactant homeostasis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_250061. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Submitted name:
Parathyroid hormone-related proteinImported
Gene namesi
Name:PthlhImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:97800. Pthlh.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. Golgi apparatus Source: Ensembl
  3. intracellular Source: MGI
  4. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636 PotentialImportedAdd
BLAST
Chaini37 – 175139parathyroid hormone-related proteinImportedPRO_5000066089Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ924X4.

Family & Domainsi

Keywords - Domaini

SignalImported

Phylogenomic databases

GeneTreeiENSGT00390000004933.
HOVERGENiHBG003236.
OMAiPATNTKN.
OrthoDBiEOG7FBRK8.
TreeFamiTF332953.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924X4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRRLVQQWS VLVFLLSYSV PSRGRSVEGL GRRLKRAVSE HQLLHDKGKS
60 70 80 90 100
IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE
110 120 130 140 150
GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRREQEKKK RRTRSAWPST
160 170
AASGLLEDPL PHTSRPSLEP SLRTH
Length:175
Mass (Da):20,096
Last modified:December 1, 2001 - v1
Checksum:i6D22DBCC31900B45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156278 Genomic DNA. No translation available.
AJ278119 mRNA. Translation: CAC39218.1.
RefSeqiNP_032996.2. NM_008970.3.
UniGeneiMm.28440.

Genome annotation databases

EnsembliENSMUST00000052296; ENSMUSP00000051433; ENSMUSG00000048776.
GeneIDi19227.
KEGGimmu:19227.
UCSCiuc009esx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156278 Genomic DNA. No translation available.
AJ278119 mRNA. Translation: CAC39218.1 .
RefSeqi NP_032996.2. NM_008970.3.
UniGenei Mm.28440.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052296 ; ENSMUSP00000051433 ; ENSMUSG00000048776 .
GeneIDi 19227.
KEGGi mmu:19227.
UCSCi uc009esx.2. mouse.

Organism-specific databases

CTDi 5744.
MGIi MGI:97800. Pthlh.

Phylogenomic databases

GeneTreei ENSGT00390000004933.
HOVERGENi HBG003236.
OMAi PATNTKN.
OrthoDBi EOG7FBRK8.
TreeFami TF332953.

Enzyme and pathway databases

Reactomei REACT_242871. G alpha (s) signalling events.
REACT_250061. Class B/2 (Secretin family receptors).

Miscellaneous databases

NextBioi 296020.
SOURCEi Search...

Gene expression databases

Genevestigatori Q924X4.

Family and domain databases

InterProi IPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view ]
PANTHERi PTHR17223. PTHR17223. 1 hit.
Pfami PF01279. Parathyroid. 1 hit.
[Graphical view ]
SMARTi SM00087. PTH. 1 hit.
[Graphical view ]
PROSITEi PS00335. PARATHYROID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/HeJImported.
    Tissue: LungImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ924X4_MOUSE
AccessioniPrimary (citable) accession number: Q924X4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3