Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Epigen

Gene

Epgn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: HGNC
  • growth factor activity Source: HGNC

GO - Biological processi

  • activation of MAPK activity Source: HGNC
  • angiogenesis Source: HGNC
  • MAPK cascade Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epidermal growth factor-activated receptor activity Source: HGNC
  • positive regulation of epithelial cell proliferation Source: HGNC
  • positive regulation of MAP kinase activity Source: HGNC
  • positive regulation of mitotic nuclear division Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Epigen
Alternative name(s):
Epithelial mitogen
Short name:
EPG
Gene namesi
Name:Epgn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919170. Epgn.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 10991ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Topological domaini131 – 15222CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 152134EpigenPRO_0000045463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi67 ↔ 83PROSITE-ProRule annotation
Disulfide bondi85 ↔ 94PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924X1.
PRIDEiQ924X1.

PTM databases

iPTMnetiQ924X1.
PhosphoSiteiQ924X1.

Expressioni

Tissue specificityi

Expressed at low levels in testis, heart and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000035020.
CleanExiMM_EPGN.
ExpressionAtlasiQ924X1. baseline and differential.
GenevisibleiQ924X1. MM.

Interactioni

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: HGNC
  • growth factor activity Source: HGNC

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046987.

Structurei

3D structure databases

ProteinModelPortaliQ924X1.
SMRiQ924X1. Positions 59-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 9541EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVWD. Eukaryota.
ENOG410Y2CI. LUCA.
GeneTreeiENSGT00510000048556.
HOGENOMiHOG000041330.
HOVERGENiHBG079616.
InParanoidiQ924X1.
OMAiSNWTVNK.
OrthoDBiEOG091G0RK4.
PhylomeDBiQ924X1.
TreeFamiTF335931.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGVLIAVC LLFKAMKAAL SEEAEVIPPS TAQQSNWTFN NTEADYIEEP
60 70 80 90 100
VALKFSHPCL EDHNSYCING ACAFHHELKQ AICRCFTGYT GQRCEHLTLT
110 120 130 140 150
SYAVDSYEKY IAIGIGVGLL ISAFLAVFYC YIRKRCINLK SPYIICSGGS

PL
Length:152
Mass (Da):16,799
Last modified:December 1, 2001 - v1
Checksum:i3302888CFFEA558E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171K → E in BAC25281 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291391 mRNA. Translation: CAC39435.1.
AK010136 mRNA. Translation: BAC25281.1.
CCDSiCCDS19419.1.
RefSeqiNP_444317.1. NM_053087.2.
UniGeneiMm.197319.

Genome annotation databases

EnsembliENSMUST00000041516; ENSMUSP00000046987; ENSMUSG00000035020.
GeneIDi71920.
KEGGimmu:71920.
UCSCiuc008ybq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291391 mRNA. Translation: CAC39435.1.
AK010136 mRNA. Translation: BAC25281.1.
CCDSiCCDS19419.1.
RefSeqiNP_444317.1. NM_053087.2.
UniGeneiMm.197319.

3D structure databases

ProteinModelPortaliQ924X1.
SMRiQ924X1. Positions 59-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046987.

PTM databases

iPTMnetiQ924X1.
PhosphoSiteiQ924X1.

Proteomic databases

PaxDbiQ924X1.
PRIDEiQ924X1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041516; ENSMUSP00000046987; ENSMUSG00000035020.
GeneIDi71920.
KEGGimmu:71920.
UCSCiuc008ybq.1. mouse.

Organism-specific databases

CTDi255324.
MGIiMGI:1919170. Epgn.

Phylogenomic databases

eggNOGiENOG410IVWD. Eukaryota.
ENOG410Y2CI. LUCA.
GeneTreeiENSGT00510000048556.
HOGENOMiHOG000041330.
HOVERGENiHBG079616.
InParanoidiQ924X1.
OMAiSNWTVNK.
OrthoDBiEOG091G0RK4.
PhylomeDBiQ924X1.
TreeFamiTF335931.

Miscellaneous databases

PROiQ924X1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035020.
CleanExiMM_EPGN.
ExpressionAtlasiQ924X1. baseline and differential.
GenevisibleiQ924X1. MM.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPGN_MOUSE
AccessioniPrimary (citable) accession number: Q924X1
Secondary accession number(s): Q8CEX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.