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Q924W9 (RBTN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rhombotin-1
Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name=LMO-1
T-cell translocation protein 1
Gene names
Name:Lmo1
Synonyms:Rbtn1, Rhom1, Ttg1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Ref.3

Subcellular location

Nucleus Ref.3.

Tissue specificity

Expressed in the brain and not in the thymus. Ref.3

Sequence similarities

Contains 2 LIM zinc-binding domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Rhombotin-1
PRO_0000075895

Regions

Domain22 – 8463LIM zinc-binding 1
Domain86 – 14863LIM zinc-binding 2

Sequences

Sequence LengthMass (Da)Tools
Q924W9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7AAEB122870CCAAC

FASTA15617,805
        10         20         30         40         50         60 
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE 

        70         80         90        100        110        120 
VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN 

       130        140        150 
QRFCVGDKFF LKNNMILCQV DYEEGHLNGT FESQVQ 

« Hide

References

« Hide 'large scale' references
[1]"Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."
Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.
Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells."
McGuire E.A., Davis A.R., Korsmeyer S.J.
Blood 77:599-606(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ296304 Genomic DNA. Translation: CAC39310.1.
BC053074 mRNA. Translation: AAH53074.1.
CCDSCCDS40080.1.
RefSeqNP_476514.1. NM_057173.2.
XP_006507258.1. XM_006507195.1.
UniGeneMm.360145.

3D structure databases

ProteinModelPortalQ924W9.
SMRQ924W9. Positions 24-144.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid224887. 4 interactions.

PTM databases

PhosphoSiteQ924W9.

Proteomic databases

PRIDEQ924W9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036992; ENSMUSP00000037079; ENSMUSG00000036111.
GeneID109594.
KEGGmmu:109594.
UCSCuc009jdk.1. mouse.

Organism-specific databases

CTD4004.
MGIMGI:102812. Lmo1.

Phylogenomic databases

eggNOGNOG288849.
GeneTreeENSGT00720000108603.
HOGENOMHOG000232175.
HOVERGENHBG054231.
InParanoidQ924W9.
OMAGSFETQV.
OrthoDBEOG75J0PF.
PhylomeDBQ924W9.
TreeFamTF351071.

Gene expression databases

BgeeQ924W9.
CleanExMM_LMO1.
GenevestigatorQ924W9.

Family and domain databases

Gene3D2.10.110.10. 2 hits.
InterProIPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00132. LIM. 2 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio362409.
PROQ924W9.
SOURCESearch...

Entry information

Entry nameRBTN1_MOUSE
AccessionPrimary (citable) accession number: Q924W9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot