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Q924W9

- RBTN1_MOUSE

UniProt

Q924W9 - RBTN1_MOUSE

Protein

Rhombotin-1

Gene

Lmo1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    2. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rhombotin-1
    Alternative name(s):
    Cysteine-rich protein TTG-1
    LIM domain only protein 1
    Short name:
    LMO-1
    T-cell translocation protein 1
    Gene namesi
    Name:Lmo1
    Synonyms:Rbtn1, Rhom1, Ttg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:102812. Lmo1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Rhombotin-1PRO_0000075895Add
    BLAST

    Proteomic databases

    PRIDEiQ924W9.

    PTM databases

    PhosphoSiteiQ924W9.

    Expressioni

    Tissue specificityi

    Expressed in the brain and not in the thymus.1 Publication

    Gene expression databases

    BgeeiQ924W9.
    CleanExiMM_LMO1.
    GenevestigatoriQ924W9.

    Interactioni

    Protein-protein interaction databases

    BioGridi224887. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924W9.
    SMRiQ924W9. Positions 24-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 8463LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini86 – 14863LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG288849.
    GeneTreeiENSGT00720000108603.
    HOGENOMiHOG000232175.
    HOVERGENiHBG054231.
    InParanoidiQ924W9.
    OMAiGSFETQV.
    OrthoDBiEOG75J0PF.
    PhylomeDBiQ924W9.
    TreeFamiTF351071.

    Family and domain databases

    Gene3Di2.10.110.10. 2 hits.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 2 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q924W9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK    50
    CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM 100
    VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQV DYEEGHLNGT 150
    FESQVQ 156
    Length:156
    Mass (Da):17,805
    Last modified:December 1, 2001 - v1
    Checksum:i7AAEB122870CCAAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ296304 Genomic DNA. Translation: CAC39310.1.
    BC053074 mRNA. Translation: AAH53074.1.
    CCDSiCCDS40080.1.
    RefSeqiNP_476514.1. NM_057173.2.
    XP_006507258.1. XM_006507195.1.
    UniGeneiMm.360145.

    Genome annotation databases

    EnsembliENSMUST00000036992; ENSMUSP00000037079; ENSMUSG00000036111.
    GeneIDi109594.
    KEGGimmu:109594.
    UCSCiuc009jdk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ296304 Genomic DNA. Translation: CAC39310.1 .
    BC053074 mRNA. Translation: AAH53074.1 .
    CCDSi CCDS40080.1.
    RefSeqi NP_476514.1. NM_057173.2.
    XP_006507258.1. XM_006507195.1.
    UniGenei Mm.360145.

    3D structure databases

    ProteinModelPortali Q924W9.
    SMRi Q924W9. Positions 24-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 224887. 4 interactions.

    PTM databases

    PhosphoSitei Q924W9.

    Proteomic databases

    PRIDEi Q924W9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036992 ; ENSMUSP00000037079 ; ENSMUSG00000036111 .
    GeneIDi 109594.
    KEGGi mmu:109594.
    UCSCi uc009jdk.1. mouse.

    Organism-specific databases

    CTDi 4004.
    MGIi MGI:102812. Lmo1.

    Phylogenomic databases

    eggNOGi NOG288849.
    GeneTreei ENSGT00720000108603.
    HOGENOMi HOG000232175.
    HOVERGENi HBG054231.
    InParanoidi Q924W9.
    OMAi GSFETQV.
    OrthoDBi EOG75J0PF.
    PhylomeDBi Q924W9.
    TreeFami TF351071.

    Miscellaneous databases

    NextBioi 362409.
    PROi Q924W9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q924W9.
    CleanExi MM_LMO1.
    Genevestigatori Q924W9.

    Family and domain databases

    Gene3Di 2.10.110.10. 2 hits.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 2 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."
      Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.
      Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells."
      McGuire E.A., Davis A.R., Korsmeyer S.J.
      Blood 77:599-606(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRBTN1_MOUSE
    AccessioniPrimary (citable) accession number: Q924W9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3