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Protein

Rhombotin-1

Gene

Lmo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rhombotin-1
Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name:
LMO-1
T-cell translocation protein 1
Gene namesi
Name:Lmo1
Synonyms:Rbtn1, Rhom1, Ttg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:102812. Lmo1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Rhombotin-1PRO_0000075895Add
BLAST

Proteomic databases

MaxQBiQ924W9.
PRIDEiQ924W9.

PTM databases

PhosphoSiteiQ924W9.

Expressioni

Tissue specificityi

Expressed in the brain and not in the thymus.1 Publication

Gene expression databases

BgeeiQ924W9.
CleanExiMM_LMO1.
ExpressionAtlasiQ924W9. baseline and differential.
GenevisibleiQ924W9. MM.

Interactioni

Protein-protein interaction databases

BioGridi224887. 4 interactions.
STRINGi10090.ENSMUSP00000037079.

Structurei

3D structure databases

ProteinModelPortaliQ924W9.
SMRiQ924W9. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 8463LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini86 – 14863LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG288849.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiQ924W9.
OMAiCPRTGRP.
OrthoDBiEOG75J0PF.
PhylomeDBiQ924W9.
TreeFamiTF351071.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK
60 70 80 90 100
CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM
110 120 130 140 150
VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQV DYEEGHLNGT

FESQVQ
Length:156
Mass (Da):17,805
Last modified:December 1, 2001 - v1
Checksum:i7AAEB122870CCAAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296304 Genomic DNA. Translation: CAC39310.1.
BC053074 mRNA. Translation: AAH53074.1.
CCDSiCCDS40080.1.
RefSeqiNP_001289134.1. NM_001302205.1.
NP_001289135.1. NM_001302206.1.
NP_476514.1. NM_057173.3.
XP_006507258.1. XM_006507195.2.
UniGeneiMm.360145.

Genome annotation databases

EnsembliENSMUST00000036992; ENSMUSP00000037079; ENSMUSG00000036111.
GeneIDi109594.
KEGGimmu:109594.
UCSCiuc009jdk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296304 Genomic DNA. Translation: CAC39310.1.
BC053074 mRNA. Translation: AAH53074.1.
CCDSiCCDS40080.1.
RefSeqiNP_001289134.1. NM_001302205.1.
NP_001289135.1. NM_001302206.1.
NP_476514.1. NM_057173.3.
XP_006507258.1. XM_006507195.2.
UniGeneiMm.360145.

3D structure databases

ProteinModelPortaliQ924W9.
SMRiQ924W9. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224887. 4 interactions.
STRINGi10090.ENSMUSP00000037079.

PTM databases

PhosphoSiteiQ924W9.

Proteomic databases

MaxQBiQ924W9.
PRIDEiQ924W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036992; ENSMUSP00000037079; ENSMUSG00000036111.
GeneIDi109594.
KEGGimmu:109594.
UCSCiuc009jdk.2. mouse.

Organism-specific databases

CTDi4004.
MGIiMGI:102812. Lmo1.

Phylogenomic databases

eggNOGiNOG288849.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiQ924W9.
OMAiCPRTGRP.
OrthoDBiEOG75J0PF.
PhylomeDBiQ924W9.
TreeFamiTF351071.

Miscellaneous databases

NextBioi362409.
PROiQ924W9.
SOURCEiSearch...

Gene expression databases

BgeeiQ924W9.
CleanExiMM_LMO1.
ExpressionAtlasiQ924W9. baseline and differential.
GenevisibleiQ924W9. MM.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."
    Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.
    Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells."
    McGuire E.A., Davis A.R., Korsmeyer S.J.
    Blood 77:599-606(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRBTN1_MOUSE
AccessioniPrimary (citable) accession number: Q924W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.