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Q924W9

- RBTN1_MOUSE

UniProt

Q924W9 - RBTN1_MOUSE

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Protein

Rhombotin-1

Gene
Lmo1, Rbtn1, Rhom1, Ttg1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rhombotin-1
Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name:
LMO-1
T-cell translocation protein 1
Gene namesi
Name:Lmo1
Synonyms:Rbtn1, Rhom1, Ttg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:102812. Lmo1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Rhombotin-1PRO_0000075895Add
BLAST

Proteomic databases

PRIDEiQ924W9.

PTM databases

PhosphoSiteiQ924W9.

Expressioni

Tissue specificityi

Expressed in the brain and not in the thymus.1 Publication

Gene expression databases

BgeeiQ924W9.
CleanExiMM_LMO1.
GenevestigatoriQ924W9.

Interactioni

Protein-protein interaction databases

BioGridi224887. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ924W9.
SMRiQ924W9. Positions 24-144.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 8463LIM zinc-binding 1Add
BLAST
Domaini86 – 14863LIM zinc-binding 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG288849.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiQ924W9.
OMAiGSFETQV.
OrthoDBiEOG75J0PF.
PhylomeDBiQ924W9.
TreeFamiTF351071.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924W9-1 [UniParc]FASTAAdd to Basket

« Hide

MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK    50
CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM 100
VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQV DYEEGHLNGT 150
FESQVQ 156
Length:156
Mass (Da):17,805
Last modified:December 1, 2001 - v1
Checksum:i7AAEB122870CCAAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ296304 Genomic DNA. Translation: CAC39310.1.
BC053074 mRNA. Translation: AAH53074.1.
CCDSiCCDS40080.1.
RefSeqiNP_476514.1. NM_057173.2.
XP_006507258.1. XM_006507195.1.
UniGeneiMm.360145.

Genome annotation databases

EnsembliENSMUST00000036992; ENSMUSP00000037079; ENSMUSG00000036111.
GeneIDi109594.
KEGGimmu:109594.
UCSCiuc009jdk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ296304 Genomic DNA. Translation: CAC39310.1 .
BC053074 mRNA. Translation: AAH53074.1 .
CCDSi CCDS40080.1.
RefSeqi NP_476514.1. NM_057173.2.
XP_006507258.1. XM_006507195.1.
UniGenei Mm.360145.

3D structure databases

ProteinModelPortali Q924W9.
SMRi Q924W9. Positions 24-144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 224887. 4 interactions.

PTM databases

PhosphoSitei Q924W9.

Proteomic databases

PRIDEi Q924W9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036992 ; ENSMUSP00000037079 ; ENSMUSG00000036111 .
GeneIDi 109594.
KEGGi mmu:109594.
UCSCi uc009jdk.1. mouse.

Organism-specific databases

CTDi 4004.
MGIi MGI:102812. Lmo1.

Phylogenomic databases

eggNOGi NOG288849.
GeneTreei ENSGT00720000108603.
HOGENOMi HOG000232175.
HOVERGENi HBG054231.
InParanoidi Q924W9.
OMAi GSFETQV.
OrthoDBi EOG75J0PF.
PhylomeDBi Q924W9.
TreeFami TF351071.

Miscellaneous databases

NextBioi 362409.
PROi Q924W9.
SOURCEi Search...

Gene expression databases

Bgeei Q924W9.
CleanExi MM_LMO1.
Genevestigatori Q924W9.

Family and domain databases

Gene3Di 2.10.110.10. 2 hits.
InterProi IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00132. LIM. 2 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."
    Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.
    Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells."
    McGuire E.A., Davis A.R., Korsmeyer S.J.
    Blood 77:599-606(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRBTN1_MOUSE
AccessioniPrimary (citable) accession number: Q924W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi