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Q924W7

- ST5_MOUSE

UniProt

Q924W7 - ST5_MOUSE

Protein

Suppression of tumorigenicity 5 protein

Gene

St5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth By similarity.By similarity

    GO - Molecular functioni

    1. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    2. positive regulation of Rab GTPase activity Source: GOC

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Suppression of tumorigenicity 5 protein
    Alternative name(s):
    DENN domain-containing protein 2B
    Gene namesi
    Name:St5
    Synonyms:Dennd2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:108517. St5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11341134Suppression of tumorigenicity 5 proteinPRO_0000247449Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei619 – 6191PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ924W7.

    PTM databases

    PhosphoSiteiQ924W7.

    Expressioni

    Gene expression databases

    BgeeiQ924W7.
    CleanExiMM_ST5.
    GenevestigatoriQ924W7.

    Interactioni

    Subunit structurei

    Isoform 1 interacts with the SH3 domain of ABL1.By similarity

    Protein-protein interaction databases

    IntActiQ924W7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924W7.
    SMRiQ924W7. Positions 733-1086.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini706 – 78176UDENNAdd
    BLAST
    Domaini788 – 972185DENNPROSITE-ProRule annotationAdd
    BLAST
    Domaini1019 – 108668dDENNPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi368 – 43164Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 dDENN domain.PROSITE-ProRule annotation
    Contains 1 DENN domain.PROSITE-ProRule annotation
    Contains 1 uDENN domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG247048.
    GeneTreeiENSGT00730000110554.
    HOGENOMiHOG000273875.
    HOVERGENiHBG079980.
    InParanoidiQ924W7.
    OMAiDRKYNNP.
    OrthoDBiEOG79GT6H.
    PhylomeDBiQ924W7.
    TreeFamiTF320336.

    Family and domain databases

    InterProiIPR005112. dDENN_dom.
    IPR001194. DENN_dom.
    IPR005113. uDENN_dom.
    [Graphical view]
    PfamiPF03455. dDENN. 1 hit.
    PF02141. DENN. 1 hit.
    PF03456. uDENN. 1 hit.
    [Graphical view]
    SMARTiSM00801. dDENN. 1 hit.
    SM00799. DENN. 1 hit.
    SM00800. uDENN. 1 hit.
    [Graphical view]
    PROSITEiPS50947. DDENN. 1 hit.
    PS50211. DENN. 1 hit.
    PS50946. UDENN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: Q924W7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTMTANKNSS ITHGTGGTKA PRETLSRSQS VSPPPVLYPP RSPIYPLSDS     50
    ETSACRYPSH SKSQVLLKDR HSRNPSLLGQ DPSPETSPPI CTLKATSFSY 100
    LDRTPSLRKR EDQKETVQGA VQDVEGVAAC LPLAQSTPFL GAGSRSVLLS 150
    CTGTRAHSLG IREKISAWEG RREASPRMSL CGEKREGPGS EWSVSEGCPS 200
    VGCPSVVPSP CSSEKTFDFK GLRRMSRTFS ECSYPETEEE AEALPGRDSL 250
    YRLEKRPGRT EPSALLRGHG IRKESSAVLS RIQKIEQALK EQPGRGLPQL 300
    PSSCYSVDQG RRKTGTLGTL EEPTGTASVS PSSRAGGVAG VAGEAGPPLD 350
    REGSASMKSE TPGNSSSPQL LPPKSSPDPA VNPVPKPKRT FEYEADKNPK 400
    TKPSNGLPPS PTPAAPPPLP STPAPPVTRR PKKDMRGHRK SQNRKSFEFE 450
    DASSLQSLYP SSPTENGTES QPKFGSKSTL EENAYEDIVG GLPKENPYED 500
    VDLKNRRAGR KSQQLSENSL DSLHRMWSPQ DRKYNHPPMQ LSLKSNSQSL 550
    RSGNWSERKS HRLPRLPKRH SHDDMMLLAQ LSLPSSPSSL NEDSLSTTSE 600
    LLSSRRSRRI PKLVQRINSI YNAKRGKKRL KKLSMSSLET ASLRDENSES 650
    ESDSDDRFKA HTQRLVHIQS MLKRAPSYRT LELELLEWQE RELFEYFVVV 700
    SLKKKPSRNT YLPEVSYQFP KLDRPTKQMR EAEERLKAIP QFCFPDAKDW 750
    LPVSEYSSET FSFMLTGEDG SRRFGYCRRL LPSGKGPRLP EVYCVISRLG 800
    CFGLFSKVLD EVERRRGISA ALVYPFMRSL MESPFPAPGK TIKVKTFLPG 850
    AGNEVLELRR PMDSRLEHVD FECLFTCLSV RQLIRIFASL LLERRVIFVA 900
    DKLSTLSSCS HAVVALLYPF SWQHTFIPVL PASMIDIVCC PTPFLVGLLS 950
    SSLPKLKELP VEEALMVNLG SDRFIRQMDD EDTLLPRKLQ AALEQALERK 1000
    SELISQDSDS DSDDECNTLN GLVSEVFIRF FVETVGHYSL FLTHSEKGER 1050
    AFQREAFRKS VASKSIRRFL EVFMESQMFA GFIQDRELRK CRAKGLFEQR 1100
    VEQYLEELPD TEQSGMNKFL RGLGNKMKFL HKKN 1134

    Note: May be produced by alternative promoter usage. Alternative promoter usage has been proven in human.

    Length:1,134
    Mass (Da):126,861
    Last modified:December 1, 2001 - v1
    Checksum:i36F8404D63818579
    GO
    Isoform 2 (identifier: Q924W7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         28-444: Missing.

    Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.

    Show »
    Length:717
    Mass (Da):82,209
    Checksum:iB43472C85F50DE2A
    GO
    Isoform 3 (identifier: Q924W7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-525: Missing.

    Note: May be produced by alternative promoter usage. Alternative promoter usage has been proven in human.

    Show »
    Length:609
    Mass (Da):70,331
    Checksum:iFD013276C8A0CFE3
    GO

    Sequence cautioni

    The sequence AAH32266.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 525525Missing in isoform 3. 1 PublicationVSP_019989Add
    BLAST
    Alternative sequencei28 – 444417Missing in isoform 2. CuratedVSP_019990Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ307670 Genomic DNA. Translation: CAC38111.1.
    AJ307670 Genomic DNA. Translation: CAC38112.1.
    BC030391 mRNA. Translation: AAH30391.1.
    BC032266 mRNA. Translation: AAH32266.1. Different initiation.
    BC051034 mRNA. Translation: AAH51034.1.
    CCDSiCCDS21734.1. [Q924W7-1]
    CCDS21735.1. [Q924W7-2]
    RefSeqiNP_001001326.1. NM_001001326.1. [Q924W7-1]
    NP_084087.2. NM_029811.2. [Q924W7-2]
    XP_006508383.1. XM_006508320.1. [Q924W7-1]
    XP_006508384.1. XM_006508321.1. [Q924W7-1]
    XP_006508385.1. XM_006508322.1. [Q924W7-1]
    XP_006508386.1. XM_006508323.1. [Q924W7-1]
    XP_006508387.1. XM_006508324.1. [Q924W7-1]
    XP_006508388.1. XM_006508325.1. [Q924W7-1]
    UniGeneiMm.252009.

    Genome annotation databases

    EnsembliENSMUST00000077909; ENSMUSP00000077067; ENSMUSG00000031024. [Q924W7-1]
    ENSMUST00000079282; ENSMUSP00000078264; ENSMUSG00000031024. [Q924W7-1]
    ENSMUST00000084738; ENSMUSP00000081789; ENSMUSG00000031024. [Q924W7-2]
    ENSMUST00000168005; ENSMUSP00000130119; ENSMUSG00000031024. [Q924W7-2]
    GeneIDi76954.
    KEGGimmu:76954.
    UCSCiuc009jds.1. mouse. [Q924W7-1]
    uc009jdv.1. mouse. [Q924W7-2]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ307670 Genomic DNA. Translation: CAC38111.1 .
    AJ307670 Genomic DNA. Translation: CAC38112.1 .
    BC030391 mRNA. Translation: AAH30391.1 .
    BC032266 mRNA. Translation: AAH32266.1 . Different initiation.
    BC051034 mRNA. Translation: AAH51034.1 .
    CCDSi CCDS21734.1. [Q924W7-1 ]
    CCDS21735.1. [Q924W7-2 ]
    RefSeqi NP_001001326.1. NM_001001326.1. [Q924W7-1 ]
    NP_084087.2. NM_029811.2. [Q924W7-2 ]
    XP_006508383.1. XM_006508320.1. [Q924W7-1 ]
    XP_006508384.1. XM_006508321.1. [Q924W7-1 ]
    XP_006508385.1. XM_006508322.1. [Q924W7-1 ]
    XP_006508386.1. XM_006508323.1. [Q924W7-1 ]
    XP_006508387.1. XM_006508324.1. [Q924W7-1 ]
    XP_006508388.1. XM_006508325.1. [Q924W7-1 ]
    UniGenei Mm.252009.

    3D structure databases

    ProteinModelPortali Q924W7.
    SMRi Q924W7. Positions 733-1086.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q924W7. 1 interaction.

    PTM databases

    PhosphoSitei Q924W7.

    Proteomic databases

    PRIDEi Q924W7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077909 ; ENSMUSP00000077067 ; ENSMUSG00000031024 . [Q924W7-1 ]
    ENSMUST00000079282 ; ENSMUSP00000078264 ; ENSMUSG00000031024 . [Q924W7-1 ]
    ENSMUST00000084738 ; ENSMUSP00000081789 ; ENSMUSG00000031024 . [Q924W7-2 ]
    ENSMUST00000168005 ; ENSMUSP00000130119 ; ENSMUSG00000031024 . [Q924W7-2 ]
    GeneIDi 76954.
    KEGGi mmu:76954.
    UCSCi uc009jds.1. mouse. [Q924W7-1 ]
    uc009jdv.1. mouse. [Q924W7-2 ]

    Organism-specific databases

    CTDi 6764.
    MGIi MGI:108517. St5.

    Phylogenomic databases

    eggNOGi NOG247048.
    GeneTreei ENSGT00730000110554.
    HOGENOMi HOG000273875.
    HOVERGENi HBG079980.
    InParanoidi Q924W7.
    OMAi DRKYNNP.
    OrthoDBi EOG79GT6H.
    PhylomeDBi Q924W7.
    TreeFami TF320336.

    Miscellaneous databases

    NextBioi 346163.
    PROi Q924W7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q924W7.
    CleanExi MM_ST5.
    Genevestigatori Q924W7.

    Family and domain databases

    InterProi IPR005112. dDENN_dom.
    IPR001194. DENN_dom.
    IPR005113. uDENN_dom.
    [Graphical view ]
    Pfami PF03455. dDENN. 1 hit.
    PF02141. DENN. 1 hit.
    PF03456. uDENN. 1 hit.
    [Graphical view ]
    SMARTi SM00801. dDENN. 1 hit.
    SM00799. DENN. 1 hit.
    SM00800. uDENN. 1 hit.
    [Graphical view ]
    PROSITEi PS50947. DDENN. 1 hit.
    PS50211. DENN. 1 hit.
    PS50946. UDENN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
      Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
      Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: FVB/N.
      Tissue: Colon and Mammary tumor.

    Entry informationi

    Entry nameiST5_MOUSE
    AccessioniPrimary (citable) accession number: Q924W7
    Secondary accession number(s): Q05BD9
    , Q78H54, Q8K2P3, Q924W8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3