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Q924W7

- ST5_MOUSE

UniProt

Q924W7 - ST5_MOUSE

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Protein
Suppression of tumorigenicity 5 protein
Gene
St5, Dennd2b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth By similarity.

GO - Molecular functioni

  1. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  2. regulation of Rab GTPase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Suppression of tumorigenicity 5 protein
Alternative name(s):
DENN domain-containing protein 2B
Gene namesi
Name:St5
Synonyms:Dennd2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:108517. St5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11341134Suppression of tumorigenicity 5 protein
PRO_0000247449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei619 – 6191Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ924W7.

PTM databases

PhosphoSiteiQ924W7.

Expressioni

Gene expression databases

BgeeiQ924W7.
CleanExiMM_ST5.
GenevestigatoriQ924W7.

Interactioni

Subunit structurei

Isoform 1 interacts with the SH3 domain of ABL1 By similarity.

Protein-protein interaction databases

IntActiQ924W7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ924W7.
SMRiQ924W7. Positions 733-1086.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini706 – 78176UDENN
Add
BLAST
Domaini788 – 972185DENN
Add
BLAST
Domaini1019 – 108668dDENN
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi368 – 43164Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 dDENN domain.
Contains 1 DENN domain.
Contains 1 uDENN domain.

Phylogenomic databases

eggNOGiNOG247048.
GeneTreeiENSGT00730000110554.
HOGENOMiHOG000273875.
HOVERGENiHBG079980.
InParanoidiQ924W7.
OMAiDRKYNNP.
OrthoDBiEOG79GT6H.
PhylomeDBiQ924W7.
TreeFamiTF320336.

Family and domain databases

InterProiIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
[Graphical view]
PfamiPF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view]
SMARTiSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view]
PROSITEiPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: Q924W7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTMTANKNSS ITHGTGGTKA PRETLSRSQS VSPPPVLYPP RSPIYPLSDS     50
ETSACRYPSH SKSQVLLKDR HSRNPSLLGQ DPSPETSPPI CTLKATSFSY 100
LDRTPSLRKR EDQKETVQGA VQDVEGVAAC LPLAQSTPFL GAGSRSVLLS 150
CTGTRAHSLG IREKISAWEG RREASPRMSL CGEKREGPGS EWSVSEGCPS 200
VGCPSVVPSP CSSEKTFDFK GLRRMSRTFS ECSYPETEEE AEALPGRDSL 250
YRLEKRPGRT EPSALLRGHG IRKESSAVLS RIQKIEQALK EQPGRGLPQL 300
PSSCYSVDQG RRKTGTLGTL EEPTGTASVS PSSRAGGVAG VAGEAGPPLD 350
REGSASMKSE TPGNSSSPQL LPPKSSPDPA VNPVPKPKRT FEYEADKNPK 400
TKPSNGLPPS PTPAAPPPLP STPAPPVTRR PKKDMRGHRK SQNRKSFEFE 450
DASSLQSLYP SSPTENGTES QPKFGSKSTL EENAYEDIVG GLPKENPYED 500
VDLKNRRAGR KSQQLSENSL DSLHRMWSPQ DRKYNHPPMQ LSLKSNSQSL 550
RSGNWSERKS HRLPRLPKRH SHDDMMLLAQ LSLPSSPSSL NEDSLSTTSE 600
LLSSRRSRRI PKLVQRINSI YNAKRGKKRL KKLSMSSLET ASLRDENSES 650
ESDSDDRFKA HTQRLVHIQS MLKRAPSYRT LELELLEWQE RELFEYFVVV 700
SLKKKPSRNT YLPEVSYQFP KLDRPTKQMR EAEERLKAIP QFCFPDAKDW 750
LPVSEYSSET FSFMLTGEDG SRRFGYCRRL LPSGKGPRLP EVYCVISRLG 800
CFGLFSKVLD EVERRRGISA ALVYPFMRSL MESPFPAPGK TIKVKTFLPG 850
AGNEVLELRR PMDSRLEHVD FECLFTCLSV RQLIRIFASL LLERRVIFVA 900
DKLSTLSSCS HAVVALLYPF SWQHTFIPVL PASMIDIVCC PTPFLVGLLS 950
SSLPKLKELP VEEALMVNLG SDRFIRQMDD EDTLLPRKLQ AALEQALERK 1000
SELISQDSDS DSDDECNTLN GLVSEVFIRF FVETVGHYSL FLTHSEKGER 1050
AFQREAFRKS VASKSIRRFL EVFMESQMFA GFIQDRELRK CRAKGLFEQR 1100
VEQYLEELPD TEQSGMNKFL RGLGNKMKFL HKKN 1134

Note: May be produced by alternative promoter usage. Alternative promoter usage has been proven in human.

Length:1,134
Mass (Da):126,861
Last modified:December 1, 2001 - v1
Checksum:i36F8404D63818579
GO
Isoform 2 (identifier: Q924W7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-444: Missing.

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.

Show »
Length:717
Mass (Da):82,209
Checksum:iB43472C85F50DE2A
GO
Isoform 3 (identifier: Q924W7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-525: Missing.

Note: May be produced by alternative promoter usage. Alternative promoter usage has been proven in human.

Show »
Length:609
Mass (Da):70,331
Checksum:iFD013276C8A0CFE3
GO

Sequence cautioni

The sequence AAH32266.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 525525Missing in isoform 3.
VSP_019989Add
BLAST
Alternative sequencei28 – 444417Missing in isoform 2.
VSP_019990Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ307670 Genomic DNA. Translation: CAC38111.1.
AJ307670 Genomic DNA. Translation: CAC38112.1.
BC030391 mRNA. Translation: AAH30391.1.
BC032266 mRNA. Translation: AAH32266.1. Different initiation.
BC051034 mRNA. Translation: AAH51034.1.
CCDSiCCDS21734.1. [Q924W7-1]
CCDS21735.1. [Q924W7-2]
RefSeqiNP_001001326.1. NM_001001326.1. [Q924W7-1]
NP_084087.2. NM_029811.2. [Q924W7-2]
XP_006508383.1. XM_006508320.1. [Q924W7-1]
XP_006508384.1. XM_006508321.1. [Q924W7-1]
XP_006508385.1. XM_006508322.1. [Q924W7-1]
XP_006508386.1. XM_006508323.1. [Q924W7-1]
XP_006508387.1. XM_006508324.1. [Q924W7-1]
XP_006508388.1. XM_006508325.1. [Q924W7-1]
UniGeneiMm.252009.

Genome annotation databases

EnsembliENSMUST00000077909; ENSMUSP00000077067; ENSMUSG00000031024. [Q924W7-1]
ENSMUST00000079282; ENSMUSP00000078264; ENSMUSG00000031024. [Q924W7-1]
ENSMUST00000084738; ENSMUSP00000081789; ENSMUSG00000031024. [Q924W7-2]
ENSMUST00000168005; ENSMUSP00000130119; ENSMUSG00000031024. [Q924W7-2]
GeneIDi76954.
KEGGimmu:76954.
UCSCiuc009jds.1. mouse. [Q924W7-1]
uc009jdv.1. mouse. [Q924W7-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ307670 Genomic DNA. Translation: CAC38111.1 .
AJ307670 Genomic DNA. Translation: CAC38112.1 .
BC030391 mRNA. Translation: AAH30391.1 .
BC032266 mRNA. Translation: AAH32266.1 . Different initiation.
BC051034 mRNA. Translation: AAH51034.1 .
CCDSi CCDS21734.1. [Q924W7-1 ]
CCDS21735.1. [Q924W7-2 ]
RefSeqi NP_001001326.1. NM_001001326.1. [Q924W7-1 ]
NP_084087.2. NM_029811.2. [Q924W7-2 ]
XP_006508383.1. XM_006508320.1. [Q924W7-1 ]
XP_006508384.1. XM_006508321.1. [Q924W7-1 ]
XP_006508385.1. XM_006508322.1. [Q924W7-1 ]
XP_006508386.1. XM_006508323.1. [Q924W7-1 ]
XP_006508387.1. XM_006508324.1. [Q924W7-1 ]
XP_006508388.1. XM_006508325.1. [Q924W7-1 ]
UniGenei Mm.252009.

3D structure databases

ProteinModelPortali Q924W7.
SMRi Q924W7. Positions 733-1086.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q924W7. 1 interaction.

PTM databases

PhosphoSitei Q924W7.

Proteomic databases

PRIDEi Q924W7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077909 ; ENSMUSP00000077067 ; ENSMUSG00000031024 . [Q924W7-1 ]
ENSMUST00000079282 ; ENSMUSP00000078264 ; ENSMUSG00000031024 . [Q924W7-1 ]
ENSMUST00000084738 ; ENSMUSP00000081789 ; ENSMUSG00000031024 . [Q924W7-2 ]
ENSMUST00000168005 ; ENSMUSP00000130119 ; ENSMUSG00000031024 . [Q924W7-2 ]
GeneIDi 76954.
KEGGi mmu:76954.
UCSCi uc009jds.1. mouse. [Q924W7-1 ]
uc009jdv.1. mouse. [Q924W7-2 ]

Organism-specific databases

CTDi 6764.
MGIi MGI:108517. St5.

Phylogenomic databases

eggNOGi NOG247048.
GeneTreei ENSGT00730000110554.
HOGENOMi HOG000273875.
HOVERGENi HBG079980.
InParanoidi Q924W7.
OMAi DRKYNNP.
OrthoDBi EOG79GT6H.
PhylomeDBi Q924W7.
TreeFami TF320336.

Miscellaneous databases

NextBioi 346163.
PROi Q924W7.
SOURCEi Search...

Gene expression databases

Bgeei Q924W7.
CleanExi MM_ST5.
Genevestigatori Q924W7.

Family and domain databases

InterProi IPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
[Graphical view ]
Pfami PF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view ]
SMARTi SM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view ]
PROSITEi PS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
    Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
    Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.

Entry informationi

Entry nameiST5_MOUSE
AccessioniPrimary (citable) accession number: Q924W7
Secondary accession number(s): Q05BD9
, Q78H54, Q8K2P3, Q924W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi