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Q924W7 (ST5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Suppression of tumorigenicity 5 protein
Alternative name(s):
DENN domain-containing protein 2B
Gene names
Name:St5
Synonyms:Dennd2b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1134 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth By similarity.

Subunit structure

Isoform 1 interacts with the SH3 domain of ABL1 By similarity.

Sequence similarities

Contains 1 dDENN domain.

Contains 1 DENN domain.

Contains 1 uDENN domain.

Sequence caution

The sequence AAH32266.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q924W7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: May be produced by alternative promoter usage. Alternative promoter usage has been proven in human.
Isoform 2 (identifier: Q924W7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     28-444: Missing.
Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.
Isoform 3 (identifier: Q924W7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-525: Missing.
Note: May be produced by alternative promoter usage. Alternative promoter usage has been proven in human.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11341134Suppression of tumorigenicity 5 protein
PRO_0000247449

Regions

Domain706 – 78176UDENN
Domain788 – 972185DENN
Domain1019 – 108668dDENN
Compositional bias368 – 43164Pro-rich

Amino acid modifications

Modified residue6191Phosphoserine By similarity

Natural variations

Alternative sequence1 – 525525Missing in isoform 3.
VSP_019989
Alternative sequence28 – 444417Missing in isoform 2.
VSP_019990

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 36F8404D63818579

FASTA1,134126,861
        10         20         30         40         50         60 
MTMTANKNSS ITHGTGGTKA PRETLSRSQS VSPPPVLYPP RSPIYPLSDS ETSACRYPSH 

        70         80         90        100        110        120 
SKSQVLLKDR HSRNPSLLGQ DPSPETSPPI CTLKATSFSY LDRTPSLRKR EDQKETVQGA 

       130        140        150        160        170        180 
VQDVEGVAAC LPLAQSTPFL GAGSRSVLLS CTGTRAHSLG IREKISAWEG RREASPRMSL 

       190        200        210        220        230        240 
CGEKREGPGS EWSVSEGCPS VGCPSVVPSP CSSEKTFDFK GLRRMSRTFS ECSYPETEEE 

       250        260        270        280        290        300 
AEALPGRDSL YRLEKRPGRT EPSALLRGHG IRKESSAVLS RIQKIEQALK EQPGRGLPQL 

       310        320        330        340        350        360 
PSSCYSVDQG RRKTGTLGTL EEPTGTASVS PSSRAGGVAG VAGEAGPPLD REGSASMKSE 

       370        380        390        400        410        420 
TPGNSSSPQL LPPKSSPDPA VNPVPKPKRT FEYEADKNPK TKPSNGLPPS PTPAAPPPLP 

       430        440        450        460        470        480 
STPAPPVTRR PKKDMRGHRK SQNRKSFEFE DASSLQSLYP SSPTENGTES QPKFGSKSTL 

       490        500        510        520        530        540 
EENAYEDIVG GLPKENPYED VDLKNRRAGR KSQQLSENSL DSLHRMWSPQ DRKYNHPPMQ 

       550        560        570        580        590        600 
LSLKSNSQSL RSGNWSERKS HRLPRLPKRH SHDDMMLLAQ LSLPSSPSSL NEDSLSTTSE 

       610        620        630        640        650        660 
LLSSRRSRRI PKLVQRINSI YNAKRGKKRL KKLSMSSLET ASLRDENSES ESDSDDRFKA 

       670        680        690        700        710        720 
HTQRLVHIQS MLKRAPSYRT LELELLEWQE RELFEYFVVV SLKKKPSRNT YLPEVSYQFP 

       730        740        750        760        770        780 
KLDRPTKQMR EAEERLKAIP QFCFPDAKDW LPVSEYSSET FSFMLTGEDG SRRFGYCRRL 

       790        800        810        820        830        840 
LPSGKGPRLP EVYCVISRLG CFGLFSKVLD EVERRRGISA ALVYPFMRSL MESPFPAPGK 

       850        860        870        880        890        900 
TIKVKTFLPG AGNEVLELRR PMDSRLEHVD FECLFTCLSV RQLIRIFASL LLERRVIFVA 

       910        920        930        940        950        960 
DKLSTLSSCS HAVVALLYPF SWQHTFIPVL PASMIDIVCC PTPFLVGLLS SSLPKLKELP 

       970        980        990       1000       1010       1020 
VEEALMVNLG SDRFIRQMDD EDTLLPRKLQ AALEQALERK SELISQDSDS DSDDECNTLN 

      1030       1040       1050       1060       1070       1080 
GLVSEVFIRF FVETVGHYSL FLTHSEKGER AFQREAFRKS VASKSIRRFL EVFMESQMFA 

      1090       1100       1110       1120       1130 
GFIQDRELRK CRAKGLFEQR VEQYLEELPD TEQSGMNKFL RGLGNKMKFL HKKN 

« Hide

Isoform 2 [UniParc].

Checksum: B43472C85F50DE2A
Show »

FASTA71782,209
Isoform 3 [UniParc].

Checksum: FD013276C8A0CFE3
Show »

FASTA60970,331

References

« Hide 'large scale' references
[1]"Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7."
Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A., Zabel B., Hankeln T., Schmidt E.R.
Cytogenet. Cell Genet. 93:284-290(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Strain: FVB/N.
Tissue: Colon and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ307670 Genomic DNA. Translation: CAC38111.1.
AJ307670 Genomic DNA. Translation: CAC38112.1.
BC030391 mRNA. Translation: AAH30391.1.
BC032266 mRNA. Translation: AAH32266.1. Different initiation.
BC051034 mRNA. Translation: AAH51034.1.
CCDSCCDS21734.1. [Q924W7-1]
CCDS21735.1. [Q924W7-2]
RefSeqNP_001001326.1. NM_001001326.1. [Q924W7-1]
NP_084087.2. NM_029811.2. [Q924W7-2]
XP_006508383.1. XM_006508320.1. [Q924W7-1]
XP_006508384.1. XM_006508321.1. [Q924W7-1]
XP_006508385.1. XM_006508322.1. [Q924W7-1]
XP_006508386.1. XM_006508323.1. [Q924W7-1]
XP_006508387.1. XM_006508324.1. [Q924W7-1]
XP_006508388.1. XM_006508325.1. [Q924W7-1]
UniGeneMm.252009.

3D structure databases

ProteinModelPortalQ924W7.
SMRQ924W7. Positions 733-1086.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ924W7. 1 interaction.

PTM databases

PhosphoSiteQ924W7.

Proteomic databases

PRIDEQ924W7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077909; ENSMUSP00000077067; ENSMUSG00000031024. [Q924W7-1]
ENSMUST00000079282; ENSMUSP00000078264; ENSMUSG00000031024. [Q924W7-1]
ENSMUST00000084738; ENSMUSP00000081789; ENSMUSG00000031024. [Q924W7-2]
ENSMUST00000168005; ENSMUSP00000130119; ENSMUSG00000031024. [Q924W7-2]
GeneID76954.
KEGGmmu:76954.
UCSCuc009jds.1. mouse. [Q924W7-1]
uc009jdv.1. mouse. [Q924W7-2]

Organism-specific databases

CTD6764.
MGIMGI:108517. St5.

Phylogenomic databases

eggNOGNOG247048.
GeneTreeENSGT00730000110554.
HOGENOMHOG000273875.
HOVERGENHBG079980.
InParanoidQ924W7.
OMADRKYNNP.
OrthoDBEOG79GT6H.
PhylomeDBQ924W7.
TreeFamTF320336.

Gene expression databases

BgeeQ924W7.
CleanExMM_ST5.
GenevestigatorQ924W7.

Family and domain databases

InterProIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
[Graphical view]
PfamPF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view]
SMARTSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view]
PROSITEPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio346163.
PROQ924W7.
SOURCESearch...

Entry information

Entry nameST5_MOUSE
AccessionPrimary (citable) accession number: Q924W7
Secondary accession number(s): Q05BD9 expand/collapse secondary AC list , Q78H54, Q8K2P3, Q924W8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot