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Q924W5 (SMC6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Structural maintenance of chromosomes protein 6

Short name=SMC protein 6
Short name=SMC-6
Short name=mSMC6
Gene names
Name:Smc6
Synonyms:Kiaa4103, Smc6l1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1097 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components By similarity.

Subunit structure

Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2 By similarity.

Subcellular location

Nucleus. Chromosome. Chromosometelomere By similarity. Note: Associates with chromatin. Ref.1

Domain

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer By similarity.

Post-translational modification

Phosphorylated By similarity.

Sumoylated by NSMCE2/MMS21 By similarity.

Ubiquitinated By similarity.

Sequence similarities

Belongs to the SMC family. SMC6 subfamily.

Sequence caution

The sequence BAB23051.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q924W5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q924W5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     323-326: RLND → LQAS
     327-1097: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10971097Structural maintenance of chromosomes protein 6
PRO_0000270957

Regions

Nucleotide binding82 – 898ATP Potential
Region458 – 667210Flexible hinge
Coiled coil232 – 348117 Potential
Coiled coil376 – 45782 Potential
Coiled coil668 – 920253 Potential
Compositional bias993 – 102836Ala/Asp-rich (DA-box)

Amino acid modifications

Modified residue6751Phosphoserine By similarity

Natural variations

Alternative sequence323 – 3264RLND → LQAS in isoform 2.
VSP_022254
Alternative sequence327 – 1097771Missing in isoform 2.
VSP_022255

Experimental info

Sequence conflict1201Q → W in BAD90287. Ref.4
Sequence conflict3511E → K in BAE22709. Ref.2
Sequence conflict4601E → A in AAH99955. Ref.3
Sequence conflict6281A → V in AAH99955. Ref.3
Sequence conflict9481K → E in BAB29353. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7329C25A85102DE5

FASTA1,097127,198
        10         20         30         40         50         60 
MAKRKEENFC SPENAKRPRQ EELEDFDKDG DEDECTISFT NGTSTLTAAE VGIIESIQLR 

        70         80         90        100        110        120 
NFMCHSMLGP FKFGSNVNFV VGNNGSGKSA VLTALIVGLG GKAVATNRGS SLKGFVKAGQ 

       130        140        150        160        170        180 
NSADISITLR NRGDDAFRAN VYGDSIVVQQ HISVDGSRSY KLKSEKGTVV STRKEELIAI 

       190        200        210        220        230        240 
LDHFNIQVDN PVSVLTQEMS KQFLQSKNEG DKYKFFMKAT QLEQMKEDYS YIMETKERTK 

       250        260        270        280        290        300 
EQINQGEERL TELKRQCLEK EERFQNIAGL STMKTNLEYL KHEMAWAVVN EIEKQLNAIR 

       310        320        330        340        350        360 
DNIKIGEERA AKLDRKMEEQ QVRLNDAEKK YKDIQDKLEK ISEETNARAP ECMALKTDVI 

       370        380        390        400        410        420 
ARTRAFNDAE VLYNRSLNEY KALKKDGEQL CKRIEELKKS TDQSLEPERL ERQKRICWLK 

       430        440        450        460        470        480 
EKVKALQDQE HTVNQEAEQF EQAIEKDKQE HGRVRKEDIE VRHALNYNQR QLKELKDSKT 

       490        500        510        520        530        540 
DRLKRFGPHV PALLEAIDDA YRRRQFTHKP IGPLGACIHL RDPELALAIE SCLKGLLQAY 

       550        560        570        580        590        600 
CCHNHADERV LQSLMKKFYP PGTSRPQIIV SEFRDEVYDV RLRAAYHPEF PTVLTALEID 

       610        620        630        640        650        660 
NAVVANSLID MRSIETVLLI KNNSVARAVM QSQKPPKNCR EAFTADGDQV FAGRYYSSES 

       670        680        690        700        710        720 
TRPKFLSRDV DSEISDLETE IENKKGHIIT LQQRLSALEK DIKRNEELLK RCQLHYKEIK 

       730        740        750        760        770        780 
MKIRKNISEI RELENIEEHQ SVDIATLEDE AEENKIKMQM VEKNMEQQKE NMENLKSLKI 

       790        800        810        820        830        840 
EAENKYDTIK LKINQLSELA DPLKDELNLA DSEVDSQKRG KQHYEDKQKE HLDTLNKKRR 

       850        860        870        880        890        900 
ELDMKEKELQ EKMSQARQIC PERIEVKKSA SILDKEINRL RQKIQAEHAS HGDREEIMKQ 

       910        920        930        940        950        960 
YQEARETYLD LDNKVRTLRR FIKLLEEIMT HRYKTYQQFR RCLTLRCKLY FDNLLSQRAY 

       970        980        990       1000       1010       1020 
CGKMNFDHKN ETLSITVQPG EGNKASFNDM RALSGGERSF STVCFILSLW SIAESPFRCL 

      1030       1040       1050       1060       1070       1080 
DEFDVYMDMV NRRIAMDMIL KMADSQRFRQ FILLTPQSMS SLPSSKLIRI LRMSDPERGQ 

      1090 
TTLPFRPVTQ EEDDSAS 

« Hide

Isoform 2 [UniParc].

Checksum: F4A36072831DA488
Show »

FASTA32636,744

References

« Hide 'large scale' references
[1]"Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex."
Taylor E.M., Moghraby J.S., Lees J.H., Smit B., Moens P.B., Lehmann A.R.
Mol. Biol. Cell 12:1583-1594(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-767 AND 797-1097 (ISOFORM 1).
Strain: C57BL/6J and NOD.
Tissue: Egg, Extraembryonic tissue, Liver, Pancreas, Placenta, Thymus and Tongue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6 and FVB/N.
Tissue: Brain, Colon and Egg.
[4]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-1097 (ISOFORM 1).
Tissue: Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ310552 mRNA. Translation: CAC39250.1.
AK003872 mRNA. Translation: BAB23051.1. Different initiation.
AK009009 mRNA. Translation: BAB26022.3.
AK011982 mRNA. Translation: BAB27956.1.
AK012626 mRNA. Translation: BAB28365.1.
AK014442 mRNA. Translation: BAB29353.2.
AK050341 mRNA. Translation: BAC34200.2.
AK088002 mRNA. Translation: BAC40087.2.
AK135873 mRNA. Translation: BAE22709.1.
AK148478 mRNA. Translation: BAE28576.1.
BC026429 mRNA. Translation: AAH26429.1.
BC048790 mRNA. Translation: AAH48790.1.
BC090630 mRNA. Translation: AAH90630.1.
BC099955 mRNA. Translation: AAH99955.1.
AK220488 mRNA. Translation: BAD90287.1.
RefSeqNP_079971.2. NM_025695.4.
UniGeneMm.173953.

3D structure databases

ProteinModelPortalQ924W5.
SMRQ924W5. Positions 53-201, 949-1088.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212040. 10 interactions.
IntActQ924W5. 9 interactions.

PTM databases

PhosphoSiteQ924W5.

Proteomic databases

PaxDbQ924W5.
PRIDEQ924W5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020931; ENSMUSP00000020931; ENSMUSG00000020608. [Q924W5-1]
GeneID67241.
KEGGmmu:67241.
UCSCuc007nax.1. mouse. [Q924W5-2]
uc007nay.1. mouse. [Q924W5-1]

Organism-specific databases

CTD79677.
MGIMGI:1914491. Smc6.
RougeSearch...

Phylogenomic databases

eggNOGCOG1196.
GeneTreeENSGT00550000074816.
HOVERGENHBG093964.
InParanoidQ924W5.
OMAELKXEDE.
OrthoDBEOG747PJ0.
PhylomeDBQ924W5.
TreeFamTF314520.

Gene expression databases

BgeeQ924W5.
CleanExMM_SMC6.
GenevestigatorQ924W5.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR027132. SMC6.
[Graphical view]
PANTHERPTHR19306:SF2. PTHR19306:SF2. 1 hit.
PfamPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
ProtoNetSearch...

Other

NextBio323984.
PROQ924W5.
SOURCESearch...

Entry information

Entry nameSMC6_MOUSE
AccessionPrimary (citable) accession number: Q924W5
Secondary accession number(s): Q3UFI5 expand/collapse secondary AC list , Q3UX54, Q499E1, Q5DTN2, Q8BFU9, Q8R0T4, Q9CSK7, Q9CV94, Q9CZZ5, Q9D169, Q9D6B2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot