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Q924W5

- SMC6_MOUSE

UniProt

Q924W5 - SMC6_MOUSE

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Protein

Structural maintenance of chromosomes protein 6

Gene

Smc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 898ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular senescence Source: UniProtKB
  2. double-strand break repair via homologous recombination Source: InterPro
  3. telomere maintenance via recombination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 6
Short name:
SMC protein 6
Short name:
SMC-6
Short name:
mSMC6
Gene namesi
Name:Smc6
Synonyms:Kiaa4103, Smc6l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1914491. Smc6.

Subcellular locationi

Nucleus 1 Publication. Chromosome 1 Publication. Chromosometelomere By similarity
Note: Associates with chromatin.

GO - Cellular componenti

  1. chromosome, telomeric region Source: UniProtKB
  2. nucleolus Source: Ensembl
  3. PML body Source: UniProtKB
  4. Smc5-Smc6 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10971097Structural maintenance of chromosomes protein 6PRO_0000270957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei675 – 6751PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated.By similarity
Sumoylated by NSMCE2/MMS21.By similarity
Ubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ924W5.
PaxDbiQ924W5.
PRIDEiQ924W5.

PTM databases

PhosphoSiteiQ924W5.

Expressioni

Gene expression databases

BgeeiQ924W5.
CleanExiMM_SMC6.
GenevestigatoriQ924W5.

Interactioni

Subunit structurei

Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi212040. 10 interactions.
IntActiQ924W5. 9 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ924W5.
SMRiQ924W5. Positions 54-245, 991-1024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni458 – 667210Flexible hingeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili232 – 348117Sequence AnalysisAdd
BLAST
Coiled coili376 – 45782Sequence AnalysisAdd
BLAST
Coiled coili668 – 920253Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi993 – 102836Ala/Asp-rich (DA-box)Add
BLAST

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC6 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1196.
GeneTreeiENSGT00550000074816.
HOVERGENiHBG093964.
InParanoidiQ924W5.
OMAiDQENSVN.
OrthoDBiEOG747PJ0.
PhylomeDBiQ924W5.
TreeFamiTF314520.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR027132. SMC6.
[Graphical view]
PANTHERiPTHR19306:SF2. PTHR19306:SF2. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q924W5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKRKEENFC SPENAKRPRQ EELEDFDKDG DEDECTISFT NGTSTLTAAE
60 70 80 90 100
VGIIESIQLR NFMCHSMLGP FKFGSNVNFV VGNNGSGKSA VLTALIVGLG
110 120 130 140 150
GKAVATNRGS SLKGFVKAGQ NSADISITLR NRGDDAFRAN VYGDSIVVQQ
160 170 180 190 200
HISVDGSRSY KLKSEKGTVV STRKEELIAI LDHFNIQVDN PVSVLTQEMS
210 220 230 240 250
KQFLQSKNEG DKYKFFMKAT QLEQMKEDYS YIMETKERTK EQINQGEERL
260 270 280 290 300
TELKRQCLEK EERFQNIAGL STMKTNLEYL KHEMAWAVVN EIEKQLNAIR
310 320 330 340 350
DNIKIGEERA AKLDRKMEEQ QVRLNDAEKK YKDIQDKLEK ISEETNARAP
360 370 380 390 400
ECMALKTDVI ARTRAFNDAE VLYNRSLNEY KALKKDGEQL CKRIEELKKS
410 420 430 440 450
TDQSLEPERL ERQKRICWLK EKVKALQDQE HTVNQEAEQF EQAIEKDKQE
460 470 480 490 500
HGRVRKEDIE VRHALNYNQR QLKELKDSKT DRLKRFGPHV PALLEAIDDA
510 520 530 540 550
YRRRQFTHKP IGPLGACIHL RDPELALAIE SCLKGLLQAY CCHNHADERV
560 570 580 590 600
LQSLMKKFYP PGTSRPQIIV SEFRDEVYDV RLRAAYHPEF PTVLTALEID
610 620 630 640 650
NAVVANSLID MRSIETVLLI KNNSVARAVM QSQKPPKNCR EAFTADGDQV
660 670 680 690 700
FAGRYYSSES TRPKFLSRDV DSEISDLETE IENKKGHIIT LQQRLSALEK
710 720 730 740 750
DIKRNEELLK RCQLHYKEIK MKIRKNISEI RELENIEEHQ SVDIATLEDE
760 770 780 790 800
AEENKIKMQM VEKNMEQQKE NMENLKSLKI EAENKYDTIK LKINQLSELA
810 820 830 840 850
DPLKDELNLA DSEVDSQKRG KQHYEDKQKE HLDTLNKKRR ELDMKEKELQ
860 870 880 890 900
EKMSQARQIC PERIEVKKSA SILDKEINRL RQKIQAEHAS HGDREEIMKQ
910 920 930 940 950
YQEARETYLD LDNKVRTLRR FIKLLEEIMT HRYKTYQQFR RCLTLRCKLY
960 970 980 990 1000
FDNLLSQRAY CGKMNFDHKN ETLSITVQPG EGNKASFNDM RALSGGERSF
1010 1020 1030 1040 1050
STVCFILSLW SIAESPFRCL DEFDVYMDMV NRRIAMDMIL KMADSQRFRQ
1060 1070 1080 1090
FILLTPQSMS SLPSSKLIRI LRMSDPERGQ TTLPFRPVTQ EEDDSAS
Length:1,097
Mass (Da):127,198
Last modified:December 1, 2001 - v1
Checksum:i7329C25A85102DE5
GO
Isoform 2 (identifier: Q924W5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-326: RLND → LQAS
     327-1097: Missing.

Show »
Length:326
Mass (Da):36,744
Checksum:iF4A36072831DA488
GO

Sequence cautioni

The sequence BAB23051.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201Q → W in BAD90287. 1 PublicationCurated
Sequence conflicti351 – 3511E → K in BAE22709. (PubMed:16141072)Curated
Sequence conflicti460 – 4601E → A in AAH99955. (PubMed:15489334)Curated
Sequence conflicti628 – 6281A → V in AAH99955. (PubMed:15489334)Curated
Sequence conflicti948 – 9481K → E in BAB29353. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei323 – 3264RLND → LQAS in isoform 2. 2 PublicationsVSP_022254
Alternative sequencei327 – 1097771Missing in isoform 2. 2 PublicationsVSP_022255Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310552 mRNA. Translation: CAC39250.1.
AK003872 mRNA. Translation: BAB23051.1. Different initiation.
AK009009 mRNA. Translation: BAB26022.3.
AK011982 mRNA. Translation: BAB27956.1.
AK012626 mRNA. Translation: BAB28365.1.
AK014442 mRNA. Translation: BAB29353.2.
AK050341 mRNA. Translation: BAC34200.2.
AK088002 mRNA. Translation: BAC40087.2.
AK135873 mRNA. Translation: BAE22709.1.
AK148478 mRNA. Translation: BAE28576.1.
BC026429 mRNA. Translation: AAH26429.1.
BC048790 mRNA. Translation: AAH48790.1.
BC090630 mRNA. Translation: AAH90630.1.
BC099955 mRNA. Translation: AAH99955.1.
AK220488 mRNA. Translation: BAD90287.1.
CCDSiCCDS25815.1. [Q924W5-1]
RefSeqiNP_079971.2. NM_025695.4. [Q924W5-1]
UniGeneiMm.173953.

Genome annotation databases

EnsembliENSMUST00000020931; ENSMUSP00000020931; ENSMUSG00000020608. [Q924W5-1]
GeneIDi67241.
KEGGimmu:67241.
UCSCiuc007nax.1. mouse. [Q924W5-2]
uc007nay.1. mouse. [Q924W5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310552 mRNA. Translation: CAC39250.1 .
AK003872 mRNA. Translation: BAB23051.1 . Different initiation.
AK009009 mRNA. Translation: BAB26022.3 .
AK011982 mRNA. Translation: BAB27956.1 .
AK012626 mRNA. Translation: BAB28365.1 .
AK014442 mRNA. Translation: BAB29353.2 .
AK050341 mRNA. Translation: BAC34200.2 .
AK088002 mRNA. Translation: BAC40087.2 .
AK135873 mRNA. Translation: BAE22709.1 .
AK148478 mRNA. Translation: BAE28576.1 .
BC026429 mRNA. Translation: AAH26429.1 .
BC048790 mRNA. Translation: AAH48790.1 .
BC090630 mRNA. Translation: AAH90630.1 .
BC099955 mRNA. Translation: AAH99955.1 .
AK220488 mRNA. Translation: BAD90287.1 .
CCDSi CCDS25815.1. [Q924W5-1 ]
RefSeqi NP_079971.2. NM_025695.4. [Q924W5-1 ]
UniGenei Mm.173953.

3D structure databases

ProteinModelPortali Q924W5.
SMRi Q924W5. Positions 54-245, 991-1024.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212040. 10 interactions.
IntActi Q924W5. 9 interactions.

PTM databases

PhosphoSitei Q924W5.

Proteomic databases

MaxQBi Q924W5.
PaxDbi Q924W5.
PRIDEi Q924W5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020931 ; ENSMUSP00000020931 ; ENSMUSG00000020608 . [Q924W5-1 ]
GeneIDi 67241.
KEGGi mmu:67241.
UCSCi uc007nax.1. mouse. [Q924W5-2 ]
uc007nay.1. mouse. [Q924W5-1 ]

Organism-specific databases

CTDi 79677.
MGIi MGI:1914491. Smc6.
Rougei Search...

Phylogenomic databases

eggNOGi COG1196.
GeneTreei ENSGT00550000074816.
HOVERGENi HBG093964.
InParanoidi Q924W5.
OMAi DQENSVN.
OrthoDBi EOG747PJ0.
PhylomeDBi Q924W5.
TreeFami TF314520.

Miscellaneous databases

ChiTaRSi Smc6. mouse.
NextBioi 323984.
PROi Q924W5.
SOURCEi Search...

Gene expression databases

Bgeei Q924W5.
CleanExi MM_SMC6.
Genevestigatori Q924W5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR027132. SMC6.
[Graphical view ]
PANTHERi PTHR19306:SF2. PTHR19306:SF2. 1 hit.
Pfami PF02463. SMC_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex."
    Taylor E.M., Moghraby J.S., Lees J.H., Smit B., Moens P.B., Lehmann A.R.
    Mol. Biol. Cell 12:1583-1594(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-767 AND 797-1097 (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Egg, Extraembryonic tissue, Liver, Pancreas, Placenta, Thymus and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain, Colon and Egg.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-1097 (ISOFORM 1).
    Tissue: Fetal brain.

Entry informationi

Entry nameiSMC6_MOUSE
AccessioniPrimary (citable) accession number: Q924W5
Secondary accession number(s): Q3UFI5
, Q3UX54, Q499E1, Q5DTN2, Q8BFU9, Q8R0T4, Q9CSK7, Q9CV94, Q9CZZ5, Q9D169, Q9D6B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3