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Q924W3

- Q924W3_RAT

UniProt

Q924W3 - Q924W3_RAT

Protein
Submitted name:

Integrin alpha 6 subchain

Gene

Itga6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. laminin binding Source: RGD
    2. protein complex binding Source: RGD

    GO - Biological processi

    1. brown fat cell differentiation Source: Ensembl
    2. cell adhesion mediated by integrin Source: Ensembl
    3. cell-matrix adhesion Source: Ensembl
    4. cellular response to extracellular stimulus Source: Ensembl
    5. cellular response to organic cyclic compound Source: RGD
    6. filopodium assembly Source: Ensembl
    7. integrin-mediated signaling pathway Source: UniProtKB-KW
    8. leukocyte migration Source: Ensembl
    9. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    10. odontogenesis of dentin-containing tooth Source: Ensembl
    11. positive regulation of apoptotic process Source: Ensembl
    12. positive regulation of cell-cell adhesion Source: Ensembl
    13. positive regulation of cell-substrate adhesion Source: RGD
    14. positive regulation of phosphorylation Source: Ensembl
    15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. single organismal cell-cell adhesion Source: RGD

    Keywords - Molecular functioni

    IntegrinImported

    Enzyme and pathway databases

    ReactomeiREACT_197259. Laminin interactions.
    REACT_199129. Assembly of collagen fibrils and other multimeric structures.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Integrin alpha 6 subchainImported
    Gene namesi
    Name:Itga6Imported
    Synonyms:inta6Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi621633. Itga6.

    Subcellular locationi

    GO - Cellular componenti

    1. basal plasma membrane Source: Ensembl
    2. basement membrane Source: Ensembl
    3. cell-cell adherens junction Source: RGD
    4. external side of plasma membrane Source: Ensembl
    5. filopodium Source: RGD
    6. hemidesmosome Source: Ensembl
    7. integrin alpha6-beta4 complex Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ924W3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ924W3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924W3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000015786.
    InParanoidiQ924W3.
    KOiK06485.

    Family and domain databases

    InterProiIPR013519. Int_alpha_beta-p.
    [Graphical view]
    SMARTiSM00191. Int_alpha. 1 hit.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q924W3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVAGQLCLL YLSAGLLARL STAFNLDTRE DNVIRKSGDP GSLFGFSLAM   50
    HWQLQPEDKR LLLVGAPRAE ALPLQKANRT GGLYSCDITS RGPCTRIVF 99
    Length:99
    Mass (Da):10,765
    Last modified:December 1, 2001 - v1
    Checksum:i3F0A90BB12E79CE1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei99 – 991Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ312933 mRNA. Translation: CAC38095.1.
    RefSeqiNP_446177.1. NM_053725.1.
    UniGeneiRn.22382.

    Genome annotation databases

    GeneIDi114517.
    KEGGirno:114517.
    UCSCiRGD:621633. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ312933 mRNA. Translation: CAC38095.1 .
    RefSeqi NP_446177.1. NM_053725.1.
    UniGenei Rn.22382.

    3D structure databases

    ProteinModelPortali Q924W3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q924W3. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 114517.
    KEGGi rno:114517.
    UCSCi RGD:621633. rat.

    Organism-specific databases

    CTDi 3655.
    RGDi 621633. Itga6.

    Phylogenomic databases

    HOGENOMi HOG000015786.
    InParanoidi Q924W3.
    KOi K06485.

    Enzyme and pathway databases

    Reactomei REACT_197259. Laminin interactions.
    REACT_199129. Assembly of collagen fibrils and other multimeric structures.

    Miscellaneous databases

    NextBioi 618643.

    Gene expression databases

    Genevestigatori Q924W3.

    Family and domain databases

    InterProi IPR013519. Int_alpha_beta-p.
    [Graphical view ]
    SMARTi SM00191. Int_alpha. 1 hit.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Herlevsen M.C.
      Thesis (2001), Department of Bio und Geowissenschaften, Univertsity of Karlsruhe, Karlsruhe, Germany
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation."
      Herlevsen M., Schmidt D.S., Miyazaki K., Zoller M.
      J. Cell Sci. 116:4373-4390(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ924W3_RAT
    AccessioniPrimary (citable) accession number: Q924W3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)