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Protein
Submitted name:

Integrin alpha 6 subchain

Gene

Itga6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. laminin binding Source: RGD
  2. protein complex binding Source: RGD

GO - Biological processi

  1. amelogenesis Source: Ensembl
  2. brown fat cell differentiation Source: Ensembl
  3. cell adhesion mediated by integrin Source: Ensembl
  4. cell-matrix adhesion Source: Ensembl
  5. cellular response to extracellular stimulus Source: Ensembl
  6. cellular response to organic cyclic compound Source: RGD
  7. digestive tract development Source: Ensembl
  8. ectodermal cell differentiation Source: Ensembl
  9. filopodium assembly Source: Ensembl
  10. integrin-mediated signaling pathway Source: UniProtKB-KW
  11. leukocyte migration Source: Ensembl
  12. nail development Source: Ensembl
  13. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  14. positive regulation of apoptotic process Source: Ensembl
  15. positive regulation of cell-cell adhesion Source: Ensembl
  16. positive regulation of cell-substrate adhesion Source: RGD
  17. positive regulation of phosphorylation Source: Ensembl
  18. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  19. renal system development Source: Ensembl
  20. single organismal cell-cell adhesion Source: RGD
  21. skin development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

IntegrinImported

Enzyme and pathway databases

ReactomeiREACT_296405. Laminin interactions.
REACT_307069. Integrin cell surface interactions.
REACT_336327. Basigin interactions.
REACT_343914. Assembly of collagen fibrils and other multimeric structures.
REACT_345713. Type I hemidesmosome assembly.

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alpha 6 subchainImported
Gene namesi
Name:Itga6Imported
Synonyms:inta6Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621633. Itga6.

Subcellular locationi

GO - Cellular componenti

  1. basal plasma membrane Source: Ensembl
  2. basement membrane Source: Ensembl
  3. cell-cell adherens junction Source: RGD
  4. external side of plasma membrane Source: Ensembl
  5. filopodium Source: RGD
  6. focal adhesion Source: Ensembl
  7. hemidesmosome Source: Ensembl
  8. integrin alpha6-beta4 complex Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ924W3. baseline and differential.
GenevestigatoriQ924W3.

Interactioni

Protein-protein interaction databases

IntActiQ924W3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ924W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

HOGENOMiHOG000015786.
KOiK06485.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
[Graphical view]
SMARTiSM00191. Int_alpha. 1 hit.
[Graphical view]
PROSITEiPS51470. FG_GAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q924W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAGQLCLL YLSAGLLARL STAFNLDTRE DNVIRKSGDP GSLFGFSLAM
60 70 80 90
HWQLQPEDKR LLLVGAPRAE ALPLQKANRT GGLYSCDITS RGPCTRIVF
Length:99
Mass (Da):10,765
Last modified:November 30, 2001 - v1
Checksum:i3F0A90BB12E79CE1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei99 – 991Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312933 mRNA. Translation: CAC38095.1.
RefSeqiNP_446177.1. NM_053725.1.
UniGeneiRn.22382.

Genome annotation databases

GeneIDi114517.
KEGGirno:114517.
UCSCiRGD:621633. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312933 mRNA. Translation: CAC38095.1.
RefSeqiNP_446177.1. NM_053725.1.
UniGeneiRn.22382.

3D structure databases

ProteinModelPortaliQ924W3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ924W3. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114517.
KEGGirno:114517.
UCSCiRGD:621633. rat.

Organism-specific databases

CTDi3655.
RGDi621633. Itga6.

Phylogenomic databases

HOGENOMiHOG000015786.
KOiK06485.

Enzyme and pathway databases

ReactomeiREACT_296405. Laminin interactions.
REACT_307069. Integrin cell surface interactions.
REACT_336327. Basigin interactions.
REACT_343914. Assembly of collagen fibrils and other multimeric structures.
REACT_345713. Type I hemidesmosome assembly.

Miscellaneous databases

NextBioi618643.

Gene expression databases

ExpressionAtlasiQ924W3. baseline and differential.
GenevestigatoriQ924W3.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
[Graphical view]
SMARTiSM00191. Int_alpha. 1 hit.
[Graphical view]
PROSITEiPS51470. FG_GAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Herlevsen M.C.
    Thesis (2000), Department of Bio und Geowissenschaften, Univertsity of Karlsruhe, Karlsruhe, Germany
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation."
    Herlevsen M., Schmidt D.S., Miyazaki K., Zoller M.
    J. Cell Sci. 116:4373-4390(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ924W3_RAT
AccessioniPrimary (citable) accession number: Q924W3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 30, 2001
Last sequence update: November 30, 2001
Last modified: March 31, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.