Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 15 member 3

Gene

Slc15a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.

GO - Molecular functioni

GO - Biological processi

  • protein catabolic process Source: RGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-427975. Proton/oligopeptide cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 3
Alternative name(s):
Peptide transporter 3
Peptide/histidine transporter 2
Gene namesi
Name:Slc15a3
Synonyms:Pht2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628663. Slc15a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei466 – 485HelicalSequence analysisAdd BLAST20
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959141 – 582Solute carrier family 15 member 3Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Glycosylationi357N-linked (GlcNAc...)Sequence analysis1
Glycosylationi440N-linked (GlcNAc...)Sequence analysis1
Glycosylationi575N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ924V4.
PRIDEiQ924V4.

Expressioni

Tissue specificityi

Abundant expression in lung, spleen and thymus, and detected faintly in brain, liver, adrenal gland and heart at protein level.1 Publication

Gene expression databases

BgeeiENSRNOG00000021644.
GenevisibleiQ924V4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034275.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi161 – 170Poly-Leu10

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ924V4.
KOiK14638.
OMAiIPNIFRT.
OrthoDBiEOG091G0GF9.
PhylomeDBiQ924V4.
TreeFamiTF330897.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALRAEQQP SRSGERQPLV AQGRWGPRRW RRTAAAAVLL VEMLERAAFF
60 70 80 90 100
GVTSNLVLYL NSLNFNWDGE HASRATLLFL GASYLLAPVG GWLADVYLGR
110 120 130 140 150
FLAISLSLLL YLAATGLLLT TITDDGRRSF CGEMPELPLK PACPSANCQG
160 170 180 190 200
SWSSPYCATT LYLVLLLLAL AASSVRSNLT SFGADQVMDL GRDATRRFFN
210 220 230 240 250
WFYWSINLGA ILSLLVVAFI EQNISFLQGY SIIVGLVGLA FFIFLIATPV
260 270 280 290 300
FITKPPTGSQ VSSMLNLAFQ NCCPGWQWWR RPSSRNSEGA HLLPDQRSNQ
310 320 330 340 350
PGPSPQEDMA NFQVLLKVLP VMVTLVPYWM VYFQMQSTYV LQGLHLHIPN
360 370 380 390 400
IFRTNPNISL PLRSDSSNYR IPEAWLLLAN VAVILILVPV KDHLIDPLLL
410 420 430 440 450
RCKLLPSALQ KMALGMFFGF TSIIVAGVLE KERLQYIAAN QTVPQLIGKD
460 470 480 490 500
LYYAAPLSIW WQIPQYLLIG ISEIFASIPG LEFAYSEAPR SMQGAIMGIF
510 520 530 540 550
FCLSGVGSLL GSGLVALLSL PGGWMYCPKD FGNINNCRMD LYFFLLAGIQ
560 570 580
AVTAVLFLWI AGRYERTRQD PDSQNSTSRV RG
Length:582
Mass (Da):64,593
Last modified:December 1, 2001 - v1
Checksum:i6E317638D95BE5FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026665 mRNA. Translation: BAB43942.1.
RefSeqiNP_647557.1. NM_139341.1.
XP_017444273.1. XM_017588784.1.
UniGeneiRn.17317.

Genome annotation databases

EnsembliENSRNOT00000029443; ENSRNOP00000034275; ENSRNOG00000021644.
GeneIDi246239.
KEGGirno:246239.
UCSCiRGD:628663. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026665 mRNA. Translation: BAB43942.1.
RefSeqiNP_647557.1. NM_139341.1.
XP_017444273.1. XM_017588784.1.
UniGeneiRn.17317.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034275.

Proteomic databases

PaxDbiQ924V4.
PRIDEiQ924V4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000029443; ENSRNOP00000034275; ENSRNOG00000021644.
GeneIDi246239.
KEGGirno:246239.
UCSCiRGD:628663. rat.

Organism-specific databases

CTDi51296.
RGDi628663. Slc15a3.

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ924V4.
KOiK14638.
OMAiIPNIFRT.
OrthoDBiEOG091G0GF9.
PhylomeDBiQ924V4.
TreeFamiTF330897.

Enzyme and pathway databases

ReactomeiR-RNO-427975. Proton/oligopeptide cotransporters.

Miscellaneous databases

PROiQ924V4.

Gene expression databases

BgeeiENSRNOG00000021644.
GenevisibleiQ924V4. RN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS15A3_RAT
AccessioniPrimary (citable) accession number: Q924V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.