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Q924U5

- TESK2_RAT

UniProt

Q924U5 - TESK2_RAT

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Protein
Dual specificity testis-specific protein kinase 2
Gene
Tesk2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.
Manganese By similarity.

Enzyme regulationi

Activated by autophosphorylation on Ser-219 By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871ATP By similarity
Active sitei176 – 1761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 729ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB
  4. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
  5. protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: UniProtKB
  2. apoptotic process Source: UniProtKB
  3. focal adhesion assembly Source: UniProtKB
  4. intracellular signal transduction Source: UniProtKB
  5. protein phosphorylation Source: UniProtKB
  6. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity testis-specific protein kinase 2 (EC:2.7.12.1)
Alternative name(s):
Testicular protein kinase 2
Gene namesi
Name:Tesk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi619984. Tesk2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Dual specificity testis-specific protein kinase 2
PRO_0000086751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191Phosphoserine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

PTM databases

PhosphoSiteiQ924U5.

Expressioni

Tissue specificityi

Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.

Gene expression databases

GenevestigatoriQ924U5.

Structurei

3D structure databases

ProteinModelPortaliQ924U5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 313256Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063025.
HOGENOMiHOG000231415.
HOVERGENiHBG058204.
InParanoidiQ924U5.
KOiK08842.
OMAiNVLDPYY.
OrthoDBiEOG7V7664.
PhylomeDBiQ924U5.
TreeFamiTF318014.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924U5-1 [UniParc]FASTAAdd to Basket

« Hide

MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NTVQVGRVSS SSYRAIISAF    50
SRLTSLDDFT REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK 100
EMQLMNRLSH PNILRFMGVC VHQGQLHALT EYINSGNLEQ LLDSNLYLPW 150
TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK NCLIKRDENG YSAVVADFGL 200
AEKIPDASIG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF SYGIILCEII 250
ARIQADPDYL PRTENFGLDY DAFQHMVGDC PSDFLQLTFN CCNMDPKLRP 300
SFEEIGKTLE EIMSRLQEEE LERDRKLQPT AKGLLEKVPG GKRLSSLDDK 350
IPHKSPRPRR TIWLSRSQSD IFSRKPPRTV NVLDPYYQPR DGATHTPKVN 400
PFSARQDLKG GKVKFFDLPS KSVISLVFDL DAPGPGTVSL ADCQEPLAPS 450
SRRWRSLPGS PEFLHQACPF VGCEESLSDG PPPRLSSLKY RVREIPPFRT 500
SALSATSAHE AMDCSNPQEE NGFVPRPKGT SPCSGAASEE MEVEEERPRR 550
APVHFSISGI SLQTQGEQDG 570
Length:570
Mass (Da):63,559
Last modified:December 1, 2001 - v1
Checksum:iD20073AD93EE9F9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049402 mRNA. Translation: BAB62908.1.
BC128727 mRNA. Translation: AAI28728.1.
RefSeqiNP_596887.1. NM_133396.2.
XP_006238690.1. XM_006238628.1.
UniGeneiRn.144652.

Genome annotation databases

EnsembliENSRNOT00000023416; ENSRNOP00000023416; ENSRNOG00000017282.
GeneIDi170908.
KEGGirno:170908.
UCSCiRGD:619984. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049402 mRNA. Translation: BAB62908.1 .
BC128727 mRNA. Translation: AAI28728.1 .
RefSeqi NP_596887.1. NM_133396.2.
XP_006238690.1. XM_006238628.1.
UniGenei Rn.144652.

3D structure databases

ProteinModelPortali Q924U5.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q924U5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000023416 ; ENSRNOP00000023416 ; ENSRNOG00000017282 .
GeneIDi 170908.
KEGGi rno:170908.
UCSCi RGD:619984. rat.

Organism-specific databases

CTDi 10420.
RGDi 619984. Tesk2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00530000063025.
HOGENOMi HOG000231415.
HOVERGENi HBG058204.
InParanoidi Q924U5.
KOi K08842.
OMAi NVLDPYY.
OrthoDBi EOG7V7664.
PhylomeDBi Q924U5.
TreeFami TF318014.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 5301.

Miscellaneous databases

NextBioi 621355.
PROi Q924U5.

Gene expression databases

Genevestigatori Q924U5.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells."
    Toshima J., Toshima J.Y., Takeuchi K., Mori R., Mizuno K.
    J. Biol. Chem. 276:31449-31458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTESK2_RAT
AccessioniPrimary (citable) accession number: Q924U5
Secondary accession number(s): A1A5M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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