Reviewed,
UniProtKB/Swiss-Prot Q924U5 (TESK2_RAT)
Last modified
November 3, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dual specificity testis-specific protein kinase 2 EC=2.7.12.1 Alternative name(s): Testicular protein kinase 2 | ||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 570 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Cofactor | Magnesium By similarity. Manganese By similarity. |
| Enzyme regulation | Activated by autophosphorylation on Ser-219 By similarity. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 1 protein kinase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 570 | 570 | Dual specificity testis-specific protein kinase 2 | PRO_0000086751 | |||||
Regions | |||||||||
| Domain | 58 – 313 | 256 | Protein kinase | ||||||
| Nucleotide binding | 64 – 72 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 176 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 87 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 219 | 1 | Phosphoserine; by autocatalysis By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells." Toshima J., Toshima J.Y., Takeuchi K., Mori R., Mizuno K. J. Biol. Chem. 276:31449-31458(2001) [PubMed: 11418599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB049402 mRNA. Translation: BAB62908.1. BC128727 mRNA. Translation: AAI28728.1. | |
| IPI | IPI00205126. |
| RefSeq | NP_596887.1. |
| UniGene | Rn.144652 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q924U5. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000023416; ENSRNOP00000023416; ENSRNOG00000017282; Rattus norvegicus. [Genome view] |
| GeneID | 170908. |
| KEGG | rno:170908. |
| UCSC | NM_133396. rat. |
Organism-specific databases | |
| CTD | 170908. |
| RGD | 619984. Tesk2. |
Phylogenomic databases | |
| HOVERGEN | Q924U5. |
| OMA | RRWRSLP. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.2. 248. 2.7.12.1. 248. |
Gene expression databases | |
| ArrayExpress | Q924U5. |
| Genevestigator | Q924U5. |
| GermOnline | ENSRNOG00000017282. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| PRINTS | PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 621355. |
Entry information
| Entry name | TESK2_RAT | ||||||||
| Accession | Primary (citable) accession number: Q924U5 Secondary accession number(s): A1A5M5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


