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Protein

KiSS-1 receptor

Gene

Kiss1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for metastin, a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.6 Publications

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: RGD
  • neuropeptide binding Source: RGD

GO - Biological processi

  • activation of MAPKK activity Source: RGD
  • arachidonic acid secretion Source: RGD
  • calcium-mediated signaling Source: RGD
  • G-protein coupled receptor signaling pathway Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of hormone secretion Source: RGD
  • positive regulation of stress fiber assembly Source: RGD
  • positive regulation of synaptic transmission Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
KiSS-1 receptor
Short name:
KiSS-1R
Alternative name(s):
G-protein coupled receptor 54
G-protein coupled receptor OT7T175
Short name:
rOT7T175
Kisspeptins receptor
Metastin receptor
Gene namesi
Name:Kiss1r
Synonyms:Gpr54
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70930. Kiss1r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 90CytoplasmicSequence analysisAdd BLAST23
Transmembranei91 – 111Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini112 – 120ExtracellularSequence analysis9
Transmembranei121 – 138Helical; Name=3Sequence analysisAdd BLAST18
Topological domaini139 – 159CytoplasmicSequence analysisAdd BLAST21
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 202ExtracellularSequence analysisAdd BLAST22
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 264CytoplasmicSequence analysisAdd BLAST41
Transmembranei265 – 285Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini286 – 305ExtracellularSequence analysisAdd BLAST20
Transmembranei306 – 326Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini327 – 396CytoplasmicSequence analysisAdd BLAST70

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: GOC
  • membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1169599.
GuidetoPHARMACOLOGYi266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696971 – 396KiSS-1 receptorAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi115 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924U1.
PRIDEiQ924U1.

PTM databases

PhosphoSitePlusiQ924U1.

Expressioni

Tissue specificityi

Highest expression levels in the cerebrum and cecum. Moderate expression in the ovary, colon and placenta. Low levels in the uterus, small intestine, and thymus. Expressed only moderately in the placenta. No expression in kidney tissues. Has a complex and abundant central nervous system expression pattern. Expressed in brain regions such as pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex, frontal cortex, and striatum. No expression in the cerebellum. Persistent expression is detected in hypothalamus throughout postnatal development, with maximum expression levels at puberty in both male and female. Hypothalamic expression changed throughout the estrus cycle and is significantly increased after gonadectomy, a rise that is prevented by sex steroid replacement both in males and females.4 Publications

Developmental stagei

Expression detected in trophoblast giant cells (TGCs), the placenta-derived cell lineage aligned at the boundary between the uterus and placenta, at embryonic days 12.5 (E12.5). However, expression is faint and only observed in some of these cells, and disappears by E15.5.1 Publication

Gene expression databases

BgeeiENSRNOG00000011954.

Interactioni

Protein-protein interaction databases

BioGridi249383. 1 interactor.
MINTiMINT-4997943.
STRINGi10116.ENSRNOP00000016395.

Chemistry databases

BindingDBiQ924U1.

Structurei

3D structure databases

ProteinModelPortaliQ924U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230487.
HOVERGENiHBG106952.
InParanoidiQ924U1.
KOiK08374.
PhylomeDBiQ924U1.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008103. KiSS_1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01728. KISS1RECEPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEATLGPN VSWWAPSNAS GCPGCGVNAS DGPGSAPRPL DAWLVPLFFA
60 70 80 90 100
ALMLLGLVGN SLVIFVICRH KHMQTVTNFY IANLAATDVT FLLCCVPFTA
110 120 130 140 150
LLYPLPTWVL GDFMCKFVNY IQQVSVQATC ATLTAMSVDR WYVTVFPLRA
160 170 180 190 200
LHRRTPRLAL TVSLSIWVGS AAVSAPVLAL HRLSPGPHTY CSEAFPSRAL
210 220 230 240 250
ERAFALYNLL ALYLLPLLAT CACYGAMLRH LGRAAVRPAP TDGALQGQLL
260 270 280 290 300
AQRAGAVRTK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP SGAWHPRSYA
310 320 330 340 350
AYALKIWAHC MSYSNSALNP LLYAFLGSHF RQAFCRVCPC GPQRQRRPHA
360 370 380 390
SAHSDRAAPH SVPHSRAAHP VRVRTPEPGN PVRRSPSVQD EHTAPL
Length:396
Mass (Da):42,889
Last modified:March 1, 2005 - v2
Checksum:iE68C680BC003B0F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289 – 300GPSGA…PRSYA → PLGGLAPSKLC in AAD19664 (PubMed:10100623).CuratedAdd BLAST12
Sequence conflicti383R → H (PubMed:10100623).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115516 mRNA. Translation: AAD19664.1.
AB051066 mRNA. Translation: BAB55447.1.
RefSeqiNP_076482.2. NM_023992.2.
UniGeneiRn.48681.

Genome annotation databases

GeneIDi78976.
KEGGirno:78976.
UCSCiRGD:70930. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115516 mRNA. Translation: AAD19664.1.
AB051066 mRNA. Translation: BAB55447.1.
RefSeqiNP_076482.2. NM_023992.2.
UniGeneiRn.48681.

3D structure databases

ProteinModelPortaliQ924U1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249383. 1 interactor.
MINTiMINT-4997943.
STRINGi10116.ENSRNOP00000016395.

Chemistry databases

BindingDBiQ924U1.
ChEMBLiCHEMBL1169599.
GuidetoPHARMACOLOGYi266.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ924U1.

Proteomic databases

PaxDbiQ924U1.
PRIDEiQ924U1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78976.
KEGGirno:78976.
UCSCiRGD:70930. rat.

Organism-specific databases

CTDi84634.
RGDi70930. Kiss1r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230487.
HOVERGENiHBG106952.
InParanoidiQ924U1.
KOiK08374.
PhylomeDBiQ924U1.
TreeFamiTF315737.

Miscellaneous databases

PROiQ924U1.

Gene expression databases

BgeeiENSRNOG00000011954.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008103. KiSS_1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01728. KISS1RECEPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKISSR_RAT
AccessioniPrimary (citable) accession number: Q924U1
Secondary accession number(s): Q9Z0T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.