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Protein

Leukotriene B4 receptor 2

Gene

Ltb4r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391906. Leukotriene receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 2
Short name:
LTB4-R 2
Short name:
LTB4-R2
Alternative name(s):
LTB4 receptor JULF2
Gene namesi
Name:Ltb4r2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi621029. Ltb4r2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 60CytoplasmicSequence analysisAdd BLAST15
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 96ExtracellularSequence analysisAdd BLAST15
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 140CytoplasmicSequence analysisAdd BLAST23
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 185ExtracellularSequence analysisAdd BLAST24
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 225CytoplasmicSequence analysisAdd BLAST19
Transmembranei226 – 246Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini247 – 275ExtracellularSequence analysisAdd BLAST29
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 358CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697131 – 358Leukotriene B4 receptor 2Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ924U0.

PTM databases

PhosphoSitePlusiQ924U0.

Expressioni

Gene expression databases

GenevisibleiQ924U0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027619.

Structurei

3D structure databases

ProteinModelPortaliQ924U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ924U0.
KOiK04297.
OMAiSREGTME.
OrthoDBiEOG091G0G5V.
PhylomeDBiQ924U0.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003982. Leukotriene_B4_typ-2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01478. LTB2RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCYRPPGN ETLLSWKGSR ATGTAFLLLA ALLGLPGNGF VVWSLAGWRP
60 70 80 90 100
TAGRPLAATL VLHLALADGA VLLLTPLFVA FLSRQAWPLG QVGCKAVYYV
110 120 130 140 150
CALSMYASVL LTGLLSLQRC LAVTRPFLAP RLRSPALARR LLLGVWLAAL
160 170 180 190 200
VLAVPAAVYR HLWGDRVCQL CHPSAVHAAA HLSLETLTAF VLPFGTVLGC
210 220 230 240 250
YGVTLARLRG ARWGSGRQGT RVGRLVSAIV LAFGLLWAPY HAVNLLQAVA
260 270 280 290 300
ALAPPEGPLA RLGGAGQAAR AGTTALAFFS SSVNPVLYVF TAGDLLPRAG
310 320 330 340 350
PRFLTRLFEG SGEARVGSRS REGTMELRTT PRLKVVGQGR GYGDPGGGGR

MEKDSQEW
Length:358
Mass (Da):37,899
Last modified:December 1, 2001 - v1
Checksum:i4CD35D009D39319A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052660 mRNA. Translation: BAB60815.1.
RefSeqiNP_446092.1. NM_053640.1.
XP_008768880.1. XM_008770658.2.
UniGeneiRn.74251.

Genome annotation databases

EnsembliENSRNOT00000027619; ENSRNOP00000027619; ENSRNOG00000020382.
GeneIDi114098.
KEGGirno:114098.
UCSCiRGD:621029. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052660 mRNA. Translation: BAB60815.1.
RefSeqiNP_446092.1. NM_053640.1.
XP_008768880.1. XM_008770658.2.
UniGeneiRn.74251.

3D structure databases

ProteinModelPortaliQ924U0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027619.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ924U0.

Proteomic databases

PaxDbiQ924U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027619; ENSRNOP00000027619; ENSRNOG00000020382.
GeneIDi114098.
KEGGirno:114098.
UCSCiRGD:621029. rat.

Organism-specific databases

CTDi56413.
RGDi621029. Ltb4r2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiQ924U0.
KOiK04297.
OMAiSREGTME.
OrthoDBiEOG091G0G5V.
PhylomeDBiQ924U0.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-RNO-391906. Leukotriene receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ924U0.

Gene expression databases

GenevisibleiQ924U0. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003982. Leukotriene_B4_typ-2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01478. LTB2RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLT4R2_RAT
AccessioniPrimary (citable) accession number: Q924U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.