ID CLTR2_RAT Reviewed; 309 AA. AC Q924T9; DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 27-MAR-2024, entry version 133. DE RecName: Full=Cysteinyl leukotriene receptor 2; DE Short=CysLTR2; DE AltName: Full=RSBPT32; GN Name=Cysltr2; Synonyms=Cyslt2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., RA Soga T., Matsushime H., Furuichi K.; RT "Characterization of the cloned rat and porcine cysteinyl leukotriene RT receptors."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for cysteinyl leukotrienes. The response is mediated CC via a G-protein that activates a phosphatidylinositol-calcium second CC messenger system (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB052661; BAB60816.1; -; mRNA. DR RefSeq; NP_596904.1; NM_133413.1. DR RefSeq; XP_008769065.1; XM_008770843.2. DR AlphaFoldDB; Q924T9; -. DR SMR; Q924T9; -. DR STRING; 10116.ENSRNOP00000020187; -. DR GuidetoPHARMACOLOGY; 270; -. DR GlyCosmos; Q924T9; 3 sites, No reported glycans. DR GlyGen; Q924T9; 3 sites. DR PhosphoSitePlus; Q924T9; -. DR PaxDb; 10116-ENSRNOP00000020187; -. DR Ensembl; ENSRNOT00000101826.1; ENSRNOP00000095936.1; ENSRNOG00000067464.1. DR Ensembl; ENSRNOT00000102995.1; ENSRNOP00000083658.1; ENSRNOG00000067464.1. DR Ensembl; ENSRNOT00000105845.1; ENSRNOP00000091083.1; ENSRNOG00000067464.1. DR Ensembl; ENSRNOT00000112031.1; ENSRNOP00000083081.1; ENSRNOG00000067464.1. DR Ensembl; ENSRNOT00000115019.1; ENSRNOP00000087467.1; ENSRNOG00000067464.1. DR Ensembl; ENSRNOT00055025188; ENSRNOP00055020594; ENSRNOG00055014686. DR Ensembl; ENSRNOT00055025195; ENSRNOP00055020599; ENSRNOG00055014686. DR Ensembl; ENSRNOT00055025200; ENSRNOP00055020603; ENSRNOG00055014686. DR Ensembl; ENSRNOT00055025204; ENSRNOP00055020607; ENSRNOG00055014686. DR Ensembl; ENSRNOT00055025207; ENSRNOP00055020609; ENSRNOG00055014686. DR Ensembl; ENSRNOT00055025212; ENSRNOP00055020612; ENSRNOG00055014686. DR Ensembl; ENSRNOT00060031588; ENSRNOP00060025655; ENSRNOG00060018408. DR Ensembl; ENSRNOT00060031614; ENSRNOP00060025679; ENSRNOG00060018408. DR Ensembl; ENSRNOT00060031619; ENSRNOP00060025684; ENSRNOG00060018408. DR Ensembl; ENSRNOT00060031632; ENSRNOP00060025697; ENSRNOG00060018408. DR Ensembl; ENSRNOT00060031638; ENSRNOP00060025703; ENSRNOG00060018408. DR Ensembl; ENSRNOT00060031642; ENSRNOP00060025707; ENSRNOG00060018408. DR Ensembl; ENSRNOT00065029298; ENSRNOP00065023245; ENSRNOG00065017529. DR Ensembl; ENSRNOT00065029302; ENSRNOP00065023249; ENSRNOG00065017529. DR Ensembl; ENSRNOT00065029310; ENSRNOP00065023257; ENSRNOG00065017529. DR Ensembl; ENSRNOT00065029316; ENSRNOP00065023262; ENSRNOG00065017529. DR Ensembl; ENSRNOT00065029321; ENSRNOP00065023267; ENSRNOG00065017529. DR Ensembl; ENSRNOT00065029328; ENSRNOP00065023274; ENSRNOG00065017529. DR Ensembl; ENSRNOT00065029331; ENSRNOP00065023277; ENSRNOG00065017529. DR GeneID; 170926; -. DR KEGG; rno:170926; -. DR UCSC; RGD:619797; rat. DR AGR; RGD:619797; -. DR CTD; 57105; -. DR RGD; 619797; Cysltr2. DR eggNOG; ENOG502RX8K; Eukaryota. DR GeneTree; ENSGT00990000203619; -. DR HOGENOM; CLU_009579_8_2_1; -. DR InParanoid; Q924T9; -. DR OMA; FCTIIVC; -. DR OrthoDB; 2875155at2759; -. DR PhylomeDB; Q924T9; -. DR TreeFam; TF350009; -. DR Reactome; R-RNO-391906; Leukotriene receptors. DR Reactome; R-RNO-416476; G alpha (q) signalling events. DR PRO; PR:Q924T9; -. DR Proteomes; UP000002494; Chromosome 15. DR Bgee; ENSRNOG00000015042; Expressed in thymus and 10 other cell types or tissues. DR GO; GO:0016020; C:membrane; ISO:RGD. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0001631; F:cysteinyl leukotriene receptor activity; ISO:RGD. DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central. DR GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD. DR GO; GO:0060253; P:negative regulation of glial cell proliferation; IMP:RGD. DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central. DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:RGD. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:RGD. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR013311; CLT2_recept. DR InterPro; IPR004071; Cyst_leuk_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24231:SF48; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR24231; PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR01903; CYSLT2RECPTR. DR PRINTS; PR01533; CYSLTRECPTR. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; Q924T9; RN. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..309 FT /note="Cysteinyl leukotriene receptor 2" FT /id="PRO_0000069306" FT TOPO_DOM 1..26 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 27..47 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 48..56 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 57..77 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 78..98 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 99..119 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 120..137 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 138..158 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 159..187 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 188..208 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 209..229 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 230..250 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 251..271 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 272..292 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 293..309 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 14 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 166 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 167 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 95..171 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 309 AA; 35507 MW; A122AC8177879D56 CRC64; MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT YKKSTSVNVF MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY SLYVNMYTSI YFLTVLSIVR FLATAHPFQM LHITSVRSAW ILCGIIWVFI MASSGLLLKH GQEKKNNTTL CFELNLQKFK NLVILNYIAL GVGFLLPFFI LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF LLCFLPYHAL RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL RAIFSKDHL //