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Q924T9

- CLTR2_RAT

UniProt

Q924T9 - CLTR2_RAT

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Protein

Cysteinyl leukotriene receptor 2

Gene

Cysltr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

  1. cysteinyl leukotriene receptor activity Source: Ensembl

GO - Biological processi

  1. positive regulation of angiogenesis Source: RGD
  2. positive regulation of cell death Source: RGD
  3. positive regulation of ERK1 and ERK2 cascade Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_231084. Leukotriene receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Alternative name(s):
RSBPT32
Gene namesi
Name:Cysltr2
Synonyms:Cyslt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi619797. Cysltr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 569CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13718CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 18729ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 22921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini251 – 27121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Cysteinyl leukotriene receptor 2PRO_0000069306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 171PROSITE-ProRule annotation
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924T9.
PRIDEiQ924T9.

Expressioni

Gene expression databases

GenevestigatoriQ924T9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020187.

Structurei

3D structure databases

ProteinModelPortaliQ924T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ924T9.
KOiK04323.
OMAiVRFVAIV.
OrthoDBiEOG74FF1B.
PhylomeDBiQ924T9.
TreeFamiTF350009.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924T9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT
60 70 80 90 100
YKKSTSVNVF MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY
110 120 130 140 150
SLYVNMYTSI YFLTVLSIVR FLATAHPFQM LHITSVRSAW ILCGIIWVFI
160 170 180 190 200
MASSGLLLKH GQEKKNNTTL CFELNLQKFK NLVILNYIAL GVGFLLPFFI
210 220 230 240 250
LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF LLCFLPYHAL
260 270 280 290 300
RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL

RAIFSKDHL
Length:309
Mass (Da):35,507
Last modified:December 1, 2001 - v1
Checksum:iA122AC8177879D56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052661 mRNA. Translation: BAB60816.1.
RefSeqiNP_596904.1. NM_133413.1.
XP_008769064.1. XM_008770842.1.
XP_008769065.1. XM_008770843.1.
XP_008769066.1. XM_008770844.1.
UniGeneiRn.74252.

Genome annotation databases

EnsembliENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042.
GeneIDi170926.
KEGGirno:170926.
UCSCiRGD:619797. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052661 mRNA. Translation: BAB60816.1 .
RefSeqi NP_596904.1. NM_133413.1.
XP_008769064.1. XM_008770842.1.
XP_008769065.1. XM_008770843.1.
XP_008769066.1. XM_008770844.1.
UniGenei Rn.74252.

3D structure databases

ProteinModelPortali Q924T9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000020187.

Chemistry

GuidetoPHARMACOLOGYi 270.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi Q924T9.
PRIDEi Q924T9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000020186 ; ENSRNOP00000020187 ; ENSRNOG00000015042 .
GeneIDi 170926.
KEGGi rno:170926.
UCSCi RGD:619797. rat.

Organism-specific databases

CTDi 57105.
RGDi 619797. Cysltr2.

Phylogenomic databases

eggNOGi NOG119185.
GeneTreei ENSGT00760000118784.
HOGENOMi HOG000236328.
HOVERGENi HBG099611.
InParanoidi Q924T9.
KOi K04323.
OMAi VRFVAIV.
OrthoDBi EOG74FF1B.
PhylomeDBi Q924T9.
TreeFami TF350009.

Enzyme and pathway databases

Reactomei REACT_231084. Leukotriene receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 621439.
PROi Q924T9.

Gene expression databases

Genevestigatori Q924T9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the cloned rat and porcine cysteinyl leukotriene receptors."
    Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCLTR2_RAT
AccessioniPrimary (citable) accession number: Q924T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3