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Protein

Cysteinyl leukotriene receptor 2

Gene

Cysltr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell death Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_273914. Leukotriene receptors.
REACT_353304. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Alternative name(s):
RSBPT32
Gene namesi
Name:Cysltr2
Synonyms:Cyslt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi619797. Cysltr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 569CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13718CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 18729ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 22921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini251 – 27121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Cysteinyl leukotriene receptor 2PRO_0000069306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 171PROSITE-ProRule annotation
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924T9.
PRIDEiQ924T9.

Expressioni

Gene expression databases

GenevisibleiQ924T9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020187.

Structurei

3D structure databases

ProteinModelPortaliQ924T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ924T9.
KOiK04323.
OMAiVRFVAIV.
OrthoDBiEOG74FF1B.
PhylomeDBiQ924T9.
TreeFamiTF350009.

Family and domain databases

InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT
60 70 80 90 100
YKKSTSVNVF MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY
110 120 130 140 150
SLYVNMYTSI YFLTVLSIVR FLATAHPFQM LHITSVRSAW ILCGIIWVFI
160 170 180 190 200
MASSGLLLKH GQEKKNNTTL CFELNLQKFK NLVILNYIAL GVGFLLPFFI
210 220 230 240 250
LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF LLCFLPYHAL
260 270 280 290 300
RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL

RAIFSKDHL
Length:309
Mass (Da):35,507
Last modified:December 1, 2001 - v1
Checksum:iA122AC8177879D56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052661 mRNA. Translation: BAB60816.1.
RefSeqiNP_596904.1. NM_133413.1.
XP_008769064.1. XM_008770842.1.
XP_008769065.1. XM_008770843.1.
XP_008769066.1. XM_008770844.1.
UniGeneiRn.74252.

Genome annotation databases

EnsembliENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042.
GeneIDi170926.
KEGGirno:170926.
UCSCiRGD:619797. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052661 mRNA. Translation: BAB60816.1.
RefSeqiNP_596904.1. NM_133413.1.
XP_008769064.1. XM_008770842.1.
XP_008769065.1. XM_008770843.1.
XP_008769066.1. XM_008770844.1.
UniGeneiRn.74252.

3D structure databases

ProteinModelPortaliQ924T9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020187.

Chemistry

GuidetoPHARMACOLOGYi270.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ924T9.
PRIDEiQ924T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042.
GeneIDi170926.
KEGGirno:170926.
UCSCiRGD:619797. rat.

Organism-specific databases

CTDi57105.
RGDi619797. Cysltr2.

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ924T9.
KOiK04323.
OMAiVRFVAIV.
OrthoDBiEOG74FF1B.
PhylomeDBiQ924T9.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_273914. Leukotriene receptors.
REACT_353304. G alpha (q) signalling events.

Miscellaneous databases

NextBioi621439.
PROiQ924T9.

Gene expression databases

GenevisibleiQ924T9. RN.

Family and domain databases

InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the cloned rat and porcine cysteinyl leukotriene receptors."
    Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCLTR2_RAT
AccessioniPrimary (citable) accession number: Q924T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.