Q924T9 (CLTR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteinyl leukotriene receptor 2
Short name=CysLTR2

Alternative name(s):
RSBPT32

Gene names

Name:	Cysltr2
Synonyms:	Cyslt2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of ERK1 and ERK2 cascade Inferred from mutant phenotype PubMed 21055410. Source: RGD positive regulation of angiogenesis Inferred from mutant phenotype PubMed 21105577. Source: RGD positive regulation of cell death Inferred from mutant phenotype PubMed 17910051. Source: RGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteinyl leukotriene receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Cysteinyl leukotriene receptor 2		PRO_0000069306
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 47	21	Helical; Name=1; Potential
	Topological domain	48 – 56	9	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 98	21	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Name=3; Potential
	Topological domain	120 – 137	18	Cytoplasmic Potential
	Transmembrane	138 – 158	21	Helical; Name=4; Potential
	Topological domain	159 – 187	29	Extracellular Potential
	Transmembrane	188 – 208	21	Helical; Name=5; Potential
	Topological domain	209 – 229	21	Cytoplasmic Potential
	Transmembrane	230 – 250	21	Helical; Name=6; Potential
	Topological domain	251 – 271	21	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 309	17	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	14	1	N-linked (GlcNAc...) Potential
	Glycosylation	166	1	N-linked (GlcNAc...) Potential
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 171		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q924T9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A122AC8177879D56	FASTA	309	35,507
	10 20 30 40 50 60 MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT YKKSTSVNVF 70 80 90 100 110 120 MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY SLYVNMYTSI YFLTVLSIVR 130 140 150 160 170 180 FLATAHPFQM LHITSVRSAW ILCGIIWVFI MASSGLLLKH GQEKKNNTTL CFELNLQKFK 190 200 210 220 230 240 NLVILNYIAL GVGFLLPFFI LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF 250 260 270 280 290 300 LLCFLPYHAL RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL RAIFSKDHL

References

[1]	"Characterization of the cloned rat and porcine cysteinyl leukotriene receptors." Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB052661 mRNA. Translation: BAB60816.1.
IPI	IPI00205103.
RefSeq	NP_596904.1. NM_133413.1.
UniGene	Rn.74252.
3D structure databases
ProteinModelPortal	Q924T9.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000020187.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	Q924T9.
PRIDE	Q924T9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042.
GeneID	170926.
KEGG	rno:170926.
UCSC	RGD:619797. rat.
Organism-specific databases
CTD	57105.
RGD	619797. Cysltr2.
Phylogenomic databases
eggNOG	NOG119185.
GeneTree	ENSGT00680000099512.
HOGENOM	HOG000236328.
HOVERGEN	HBG099611.
InParanoid	Q924T9.
KO	K04323.
OMA	HPFRLLH.
OrthoDB	EOG4PNXH8.
Gene expression databases
Genevestigator	Q924T9.
GermOnline	ENSRNOG00000015042. Rattus norvegicus.
Family and domain databases
InterPro	IPR013311. CLT2_recept. IPR004071. Cyst_leuk_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01903. CYSLT2RECPTR. PR01533. CYSLTRECPTR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	621439.

Entry information

Entry name

CLTR2_RAT

Accession

Primary (citable) accession number: Q924T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program