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Protein

Cysteinyl leukotriene receptor 2

Gene

Cysltr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • neuropeptide signaling pathway Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell death Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391906. Leukotriene receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Alternative name(s):
RSBPT32
Gene namesi
Name:Cysltr2
Synonyms:Cyslt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi619797. Cysltr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 56CytoplasmicSequence analysis9
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 137CytoplasmicSequence analysisAdd BLAST18
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 187ExtracellularSequence analysisAdd BLAST29
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 229CytoplasmicSequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 271ExtracellularSequence analysisAdd BLAST21
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693061 – 309Cysteinyl leukotriene receptor 2Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 171PROSITE-ProRule annotation
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924T9.
PRIDEiQ924T9.

PTM databases

PhosphoSitePlusiQ924T9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015042.
GenevisibleiQ924T9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020187.

Structurei

3D structure databases

ProteinModelPortaliQ924T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGJM. Eukaryota.
ENOG410YDV0. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ924T9.
KOiK04323.
OMAiAANSCFN.
OrthoDBiEOG091G0EA7.
PhylomeDBiQ924T9.
TreeFamiTF350009.

Family and domain databases

InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT
60 70 80 90 100
YKKSTSVNVF MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY
110 120 130 140 150
SLYVNMYTSI YFLTVLSIVR FLATAHPFQM LHITSVRSAW ILCGIIWVFI
160 170 180 190 200
MASSGLLLKH GQEKKNNTTL CFELNLQKFK NLVILNYIAL GVGFLLPFFI
210 220 230 240 250
LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF LLCFLPYHAL
260 270 280 290 300
RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL

RAIFSKDHL
Length:309
Mass (Da):35,507
Last modified:December 1, 2001 - v1
Checksum:iA122AC8177879D56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052661 mRNA. Translation: BAB60816.1.
RefSeqiNP_596904.1. NM_133413.1.
XP_008769065.1. XM_008770843.2.
UniGeneiRn.220881.
Rn.74252.

Genome annotation databases

EnsembliENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042.
GeneIDi170926.
KEGGirno:170926.
UCSCiRGD:619797. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052661 mRNA. Translation: BAB60816.1.
RefSeqiNP_596904.1. NM_133413.1.
XP_008769065.1. XM_008770843.2.
UniGeneiRn.220881.
Rn.74252.

3D structure databases

ProteinModelPortaliQ924T9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020187.

Chemistry databases

GuidetoPHARMACOLOGYi270.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ924T9.

Proteomic databases

PaxDbiQ924T9.
PRIDEiQ924T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042.
GeneIDi170926.
KEGGirno:170926.
UCSCiRGD:619797. rat.

Organism-specific databases

CTDi57105.
RGDi619797. Cysltr2.

Phylogenomic databases

eggNOGiENOG410IGJM. Eukaryota.
ENOG410YDV0. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ924T9.
KOiK04323.
OMAiAANSCFN.
OrthoDBiEOG091G0EA7.
PhylomeDBiQ924T9.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-RNO-391906. Leukotriene receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ924T9.

Gene expression databases

BgeeiENSRNOG00000015042.
GenevisibleiQ924T9. RN.

Family and domain databases

InterProiIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLTR2_RAT
AccessioniPrimary (citable) accession number: Q924T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.