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Q924T9

- CLTR2_RAT

UniProt

Q924T9 - CLTR2_RAT

Protein

Cysteinyl leukotriene receptor 2

Gene

Cysltr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.By similarity

    GO - Molecular functioni

    1. cysteinyl leukotriene receptor activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of angiogenesis Source: RGD
    2. positive regulation of cell death Source: RGD
    3. positive regulation of ERK1 and ERK2 cascade Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteinyl leukotriene receptor 2
    Short name:
    CysLTR2
    Alternative name(s):
    RSBPT32
    Gene namesi
    Name:Cysltr2
    Synonyms:Cyslt2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi619797. Cysltr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Cysteinyl leukotriene receptor 2PRO_0000069306Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 171PROSITE-ProRule annotation
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ924T9.
    PRIDEiQ924T9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ924T9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020187.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924T9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 569CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13718CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 18729ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 22921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 27121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119185.
    GeneTreeiENSGT00750000117402.
    HOGENOMiHOG000236328.
    HOVERGENiHBG099611.
    InParanoidiQ924T9.
    KOiK04323.
    OMAiVRFVAIV.
    OrthoDBiEOG74FF1B.
    PhylomeDBiQ924T9.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR013311. CLT2_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01903. CYSLT2RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q924T9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT    50
    YKKSTSVNVF MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY 100
    SLYVNMYTSI YFLTVLSIVR FLATAHPFQM LHITSVRSAW ILCGIIWVFI 150
    MASSGLLLKH GQEKKNNTTL CFELNLQKFK NLVILNYIAL GVGFLLPFFI 200
    LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF LLCFLPYHAL 250
    RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL 300
    RAIFSKDHL 309
    Length:309
    Mass (Da):35,507
    Last modified:December 1, 2001 - v1
    Checksum:iA122AC8177879D56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052661 mRNA. Translation: BAB60816.1.
    RefSeqiNP_596904.1. NM_133413.1.
    UniGeneiRn.74252.

    Genome annotation databases

    EnsembliENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042.
    GeneIDi170926.
    KEGGirno:170926.
    UCSCiRGD:619797. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052661 mRNA. Translation: BAB60816.1 .
    RefSeqi NP_596904.1. NM_133413.1.
    UniGenei Rn.74252.

    3D structure databases

    ProteinModelPortali Q924T9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020187.

    Chemistry

    GuidetoPHARMACOLOGYi 270.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi Q924T9.
    PRIDEi Q924T9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020186 ; ENSRNOP00000020187 ; ENSRNOG00000015042 .
    GeneIDi 170926.
    KEGGi rno:170926.
    UCSCi RGD:619797. rat.

    Organism-specific databases

    CTDi 57105.
    RGDi 619797. Cysltr2.

    Phylogenomic databases

    eggNOGi NOG119185.
    GeneTreei ENSGT00750000117402.
    HOGENOMi HOG000236328.
    HOVERGENi HBG099611.
    InParanoidi Q924T9.
    KOi K04323.
    OMAi VRFVAIV.
    OrthoDBi EOG74FF1B.
    PhylomeDBi Q924T9.
    TreeFami TF350009.

    Miscellaneous databases

    NextBioi 621439.
    PROi Q924T9.

    Gene expression databases

    Genevestigatori Q924T9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR013311. CLT2_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01903. CYSLT2RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the cloned rat and porcine cysteinyl leukotriene receptors."
      Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCLTR2_RAT
    AccessioniPrimary (citable) accession number: Q924T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3