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Q924T9 (CLTR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteinyl leukotriene receptor 2

Short name=CysLTR2
Alternative name(s):
RSBPT32
Gene names
Name:Cysltr2
Synonyms:Cyslt2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Cysteinyl leukotriene receptor 2
PRO_0000069306

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 569Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13718Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 18729Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 22921Cytoplasmic Potential
Transmembrane230 – 25021Helical; Name=6; Potential
Topological domain251 – 27121Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 30917Cytoplasmic Potential

Amino acid modifications

Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation1661N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 171 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q924T9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A122AC8177879D56

FASTA30935,507
        10         20         30         40         50         60 
MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT YKKSTSVNVF 

        70         80         90        100        110        120 
MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY SLYVNMYTSI YFLTVLSIVR 

       130        140        150        160        170        180 
FLATAHPFQM LHITSVRSAW ILCGIIWVFI MASSGLLLKH GQEKKNNTTL CFELNLQKFK 

       190        200        210        220        230        240 
NLVILNYIAL GVGFLLPFFI LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF 

       250        260        270        280        290        300 
LLCFLPYHAL RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL 


RAIFSKDHL 

« Hide

References

[1]"Characterization of the cloned rat and porcine cysteinyl leukotriene receptors."
Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T., Soga T., Matsushime H., Furuichi K.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB052661 mRNA. Translation: BAB60816.1.
RefSeqNP_596904.1. NM_133413.1.
UniGeneRn.74252.

3D structure databases

ProteinModelPortalQ924T9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000020187.

Chemistry

GuidetoPHARMACOLOGY270.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbQ924T9.
PRIDEQ924T9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042.
GeneID170926.
KEGGrno:170926.
UCSCRGD:619797. rat.

Organism-specific databases

CTD57105.
RGD619797. Cysltr2.

Phylogenomic databases

eggNOGNOG119185.
GeneTreeENSGT00750000117402.
HOGENOMHOG000236328.
HOVERGENHBG099611.
InParanoidQ924T9.
KOK04323.
OMAVRFVAIV.
OrthoDBEOG74FF1B.
PhylomeDBQ924T9.
TreeFamTF350009.

Gene expression databases

GenevestigatorQ924T9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR013311. CLT2_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01903. CYSLT2RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio621439.
PROQ924T9.

Entry information

Entry nameCLTR2_RAT
AccessionPrimary (citable) accession number: Q924T9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries