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Q924T8 (CLTR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cysteinyl leukotriene receptor 1

Short name=CysLTR1
Gene names
Name:Cysltr1
Synonyms:Cyslt1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Cysteinyl leukotriene receptor 1
PRO_0000069302

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 598Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 10828Extracellular Potential
Transmembrane109 – 12921Helical; Name=3; Potential
Topological domain130 – 14314Cytoplasmic Potential
Transmembrane144 – 16421Helical; Name=4; Potential
Topological domain165 – 19531Extracellular Potential
Transmembrane196 – 21621Helical; Name=5; Potential
Topological domain217 – 23216Cytoplasmic Potential
Transmembrane233 – 25321Helical; Name=6; Potential
Topological domain254 – 27825Extracellular Potential
Transmembrane279 – 29921Helical; Name=7; Potential
Topological domain300 – 33940Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation1711N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 175 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q924T8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 281B41DF050DF8EA

FASTA33939,143
        10         20         30         40         50         60 
MVGAENMTAS FSNNRCHDTI DEFRNQVYST MYSMISVVGF FGNSFVLYVL IKTYHEKSAF 

        70         80         90        100        110        120 
QVYMINLAIA DLLCVCTLPL RVVYYVHKGK WFFGDFLCRL TTYALYVNLY CSIFFMTAMS 

       130        140        150        160        170        180 
FFRCVAIVFP VQNINLVTQK KARFVCVGIW IFVILTSSPF LLSKSYQDEK NNTKCFEPPQ 

       190        200        210        220        230        240 
DKQTKKYVLV LHYVSLIFGF IIPFVTIIVC YTMIILTLLK NTMKKNLPSR RKAIGMIIVV 

       250        260        270        280        290        300 
TAAFLVSFMP YHIQRAIHLH FLHSETRSCD SVLRMQKSVV ITLSLAASNC CFDPLLYFFS 

       310        320        330 
GGNFRRRLST FRKHSLSSMT YIPKKKASLP EKGEEMCKE 

« Hide

References

[1]"Characterization of cloned rat and porcine cysteinyl leukotriene receptors."
Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB052685 mRNA. Translation: BAB60825.1.
RefSeqNP_446093.1. NM_053641.1.
XP_006257220.1. XM_006257158.1.
UniGeneRn.74253.

3D structure databases

ProteinModelPortalQ924T8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000040761.

Chemistry

BindingDBQ924T8.
ChEMBLCHEMBL1075218.
GuidetoPHARMACOLOGY269.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ924T8.

Proteomic databases

PaxDbQ924T8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000042799; ENSRNOP00000040761; ENSRNOG00000037845.
GeneID114099.
KEGGrno:114099.
UCSCRGD:619796. rat.

Organism-specific databases

CTD10800.
RGD619796. Cysltr1.

Phylogenomic databases

eggNOGNOG119185.
GeneTreeENSGT00750000117402.
HOGENOMHOG000236328.
HOVERGENHBG099611.
InParanoidQ924T8.
KOK04322.
OMAPQDNQAK.
OrthoDBEOG7992R9.
PhylomeDBQ924T8.

Gene expression databases

GenevestigatorQ924T8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio618253.
PROQ924T8.

Entry information

Entry nameCLTR1_RAT
AccessionPrimary (citable) accession number: Q924T8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries