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Protein

Cysteinyl leukotriene receptor 1

Gene

Cysltr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: GO_Central
  • leukotriene receptor activity Source: RGD

GO - Biological processi

  • inflammatory response Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of vasoconstriction Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391906 Leukotriene receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Gene namesi
Name:Cysltr1
Synonyms:Cyslt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi619796 Cysltr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 59CytoplasmicSequence analysis8
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 108ExtracellularSequence analysisAdd BLAST28
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 143CytoplasmicSequence analysisAdd BLAST14
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 195ExtracellularSequence analysisAdd BLAST31
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 232CytoplasmicSequence analysisAdd BLAST16
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 278ExtracellularSequence analysisAdd BLAST25
Transmembranei279 – 299Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini300 – 339CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075218

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693021 – 339Cysteinyl leukotriene receptor 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924T8

PTM databases

iPTMnetiQ924T8
PhosphoSitePlusiQ924T8

Expressioni

Gene expression databases

BgeeiENSRNOG00000037845
ExpressionAtlasiQ924T8 baseline and differential
GenevisibleiQ924T8 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040761

Chemistry databases

BindingDBiQ924T8

Structurei

3D structure databases

ProteinModelPortaliQ924T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK2 Eukaryota
ENOG410XRU6 LUCA
GeneTreeiENSGT00910000144002
HOGENOMiHOG000236328
HOVERGENiHBG099611
InParanoidiQ924T8
KOiK04322
OrthoDBiEOG091G0FE0
PhylomeDBiQ924T8

Family and domain databases

InterProiView protein in InterPro
IPR013310 CLT1_recept
IPR004071 Cyst_leuk_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01902 CYSLT1RECPTR
PR01533 CYSLTRECPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q924T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAENMTAS FSNNRCHDTI DEFRNQVYST MYSMISVVGF FGNSFVLYVL
60 70 80 90 100
IKTYHEKSAF QVYMINLAIA DLLCVCTLPL RVVYYVHKGK WFFGDFLCRL
110 120 130 140 150
TTYALYVNLY CSIFFMTAMS FFRCVAIVFP VQNINLVTQK KARFVCVGIW
160 170 180 190 200
IFVILTSSPF LLSKSYQDEK NNTKCFEPPQ DKQTKKYVLV LHYVSLIFGF
210 220 230 240 250
IIPFVTIIVC YTMIILTLLK NTMKKNLPSR RKAIGMIIVV TAAFLVSFMP
260 270 280 290 300
YHIQRAIHLH FLHSETRSCD SVLRMQKSVV ITLSLAASNC CFDPLLYFFS
310 320 330
GGNFRRRLST FRKHSLSSMT YIPKKKASLP EKGEEMCKE
Length:339
Mass (Da):39,143
Last modified:December 1, 2001 - v1
Checksum:i281B41DF050DF8EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052685 mRNA Translation: BAB60825.1
RefSeqiNP_446093.1, NM_053641.1
XP_006257220.1, XM_006257158.2
UniGeneiRn.74253

Genome annotation databases

EnsembliENSRNOT00000042799; ENSRNOP00000040761; ENSRNOG00000037845
GeneIDi114099
KEGGirno:114099
UCSCiRGD:619796 rat

Similar proteinsi

Entry informationi

Entry nameiCLTR1_RAT
AccessioniPrimary (citable) accession number: Q924T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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