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Q924T8

- CLTR1_RAT

UniProt

Q924T8 - CLTR1_RAT

Protein

Cysteinyl leukotriene receptor 1

Gene

Cysltr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system By similarity.By similarity

    GO - Molecular functioni

    1. leukotriene receptor activity Source: RGD

    GO - Biological processi

    1. calcium ion transport Source: Ensembl
    2. chemotaxis Source: Ensembl
    3. inflammatory response Source: RGD
    4. positive regulation of angiogenesis Source: RGD
    5. positive regulation of vasoconstriction Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteinyl leukotriene receptor 1
    Short name:
    CysLTR1
    Gene namesi
    Name:Cysltr1
    Synonyms:Cyslt1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi619796. Cysltr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Cysteinyl leukotriene receptor 1PRO_0000069302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
    Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ924T8.

    PTM databases

    PhosphoSiteiQ924T8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ924T8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000040761.

    Structurei

    3D structure databases

    ProteinModelPortaliQ924T8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 598CytoplasmicSequence Analysis
    Topological domaini81 – 10828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 19531ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 27825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 33940CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119185.
    GeneTreeiENSGT00750000117402.
    HOGENOMiHOG000236328.
    HOVERGENiHBG099611.
    InParanoidiQ924T8.
    KOiK04322.
    OMAiPQDNQAK.
    OrthoDBiEOG7992R9.
    PhylomeDBiQ924T8.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR013310. CLT1_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01902. CYSLT1RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q924T8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGAENMTAS FSNNRCHDTI DEFRNQVYST MYSMISVVGF FGNSFVLYVL    50
    IKTYHEKSAF QVYMINLAIA DLLCVCTLPL RVVYYVHKGK WFFGDFLCRL 100
    TTYALYVNLY CSIFFMTAMS FFRCVAIVFP VQNINLVTQK KARFVCVGIW 150
    IFVILTSSPF LLSKSYQDEK NNTKCFEPPQ DKQTKKYVLV LHYVSLIFGF 200
    IIPFVTIIVC YTMIILTLLK NTMKKNLPSR RKAIGMIIVV TAAFLVSFMP 250
    YHIQRAIHLH FLHSETRSCD SVLRMQKSVV ITLSLAASNC CFDPLLYFFS 300
    GGNFRRRLST FRKHSLSSMT YIPKKKASLP EKGEEMCKE 339
    Length:339
    Mass (Da):39,143
    Last modified:December 1, 2001 - v1
    Checksum:i281B41DF050DF8EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052685 mRNA. Translation: BAB60825.1.
    RefSeqiNP_446093.1. NM_053641.1.
    XP_006257220.1. XM_006257158.1.
    UniGeneiRn.74253.

    Genome annotation databases

    EnsembliENSRNOT00000042799; ENSRNOP00000040761; ENSRNOG00000037845.
    GeneIDi114099.
    KEGGirno:114099.
    UCSCiRGD:619796. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052685 mRNA. Translation: BAB60825.1 .
    RefSeqi NP_446093.1. NM_053641.1.
    XP_006257220.1. XM_006257158.1.
    UniGenei Rn.74253.

    3D structure databases

    ProteinModelPortali Q924T8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000040761.

    Chemistry

    BindingDBi Q924T8.
    ChEMBLi CHEMBL1075218.
    GuidetoPHARMACOLOGYi 269.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q924T8.

    Proteomic databases

    PaxDbi Q924T8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000042799 ; ENSRNOP00000040761 ; ENSRNOG00000037845 .
    GeneIDi 114099.
    KEGGi rno:114099.
    UCSCi RGD:619796. rat.

    Organism-specific databases

    CTDi 10800.
    RGDi 619796. Cysltr1.

    Phylogenomic databases

    eggNOGi NOG119185.
    GeneTreei ENSGT00750000117402.
    HOGENOMi HOG000236328.
    HOVERGENi HBG099611.
    InParanoidi Q924T8.
    KOi K04322.
    OMAi PQDNQAK.
    OrthoDBi EOG7992R9.
    PhylomeDBi Q924T8.

    Miscellaneous databases

    NextBioi 618253.
    PROi Q924T8.

    Gene expression databases

    Genevestigatori Q924T8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR013310. CLT1_recept.
    IPR004071. Cyst_leuk_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01902. CYSLT1RECPTR.
    PR01533. CYSLTRECPTR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of cloned rat and porcine cysteinyl leukotriene receptors."
      Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCLTR1_RAT
    AccessioniPrimary (citable) accession number: Q924T8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3