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Protein

Cysteinyl leukotriene receptor 1

Gene

Cysltr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

  1. leukotriene receptor activity Source: RGD

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. chemotaxis Source: Ensembl
  3. inflammatory response Source: RGD
  4. positive regulation of angiogenesis Source: RGD
  5. positive regulation of vasoconstriction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_231084. Leukotriene receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Gene namesi
Name:Cysltr1
Synonyms:Cyslt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi619796. Cysltr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini52 – 598CytoplasmicSequence Analysis
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14314CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini165 – 19531ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini254 – 27825ExtracellularSequence AnalysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini300 – 33940CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Cysteinyl leukotriene receptor 1PRO_0000069302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924T8.

PTM databases

PhosphoSiteiQ924T8.

Expressioni

Gene expression databases

GenevestigatoriQ924T8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040761.

Structurei

3D structure databases

ProteinModelPortaliQ924T8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ924T8.
KOiK04322.
OMAiPQDNQAK.
OrthoDBiEOG7992R9.
PhylomeDBiQ924T8.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q924T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAENMTAS FSNNRCHDTI DEFRNQVYST MYSMISVVGF FGNSFVLYVL
60 70 80 90 100
IKTYHEKSAF QVYMINLAIA DLLCVCTLPL RVVYYVHKGK WFFGDFLCRL
110 120 130 140 150
TTYALYVNLY CSIFFMTAMS FFRCVAIVFP VQNINLVTQK KARFVCVGIW
160 170 180 190 200
IFVILTSSPF LLSKSYQDEK NNTKCFEPPQ DKQTKKYVLV LHYVSLIFGF
210 220 230 240 250
IIPFVTIIVC YTMIILTLLK NTMKKNLPSR RKAIGMIIVV TAAFLVSFMP
260 270 280 290 300
YHIQRAIHLH FLHSETRSCD SVLRMQKSVV ITLSLAASNC CFDPLLYFFS
310 320 330
GGNFRRRLST FRKHSLSSMT YIPKKKASLP EKGEEMCKE
Length:339
Mass (Da):39,143
Last modified:December 1, 2001 - v1
Checksum:i281B41DF050DF8EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052685 mRNA. Translation: BAB60825.1.
RefSeqiNP_446093.1. NM_053641.1.
XP_006257220.1. XM_006257158.2.
UniGeneiRn.74253.

Genome annotation databases

EnsembliENSRNOT00000042799; ENSRNOP00000040761; ENSRNOG00000037845.
GeneIDi114099.
KEGGirno:114099.
UCSCiRGD:619796. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052685 mRNA. Translation: BAB60825.1.
RefSeqiNP_446093.1. NM_053641.1.
XP_006257220.1. XM_006257158.2.
UniGeneiRn.74253.

3D structure databases

ProteinModelPortaliQ924T8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040761.

Chemistry

BindingDBiQ924T8.
ChEMBLiCHEMBL1075218.
GuidetoPHARMACOLOGYi269.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ924T8.

Proteomic databases

PaxDbiQ924T8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042799; ENSRNOP00000040761; ENSRNOG00000037845.
GeneIDi114099.
KEGGirno:114099.
UCSCiRGD:619796. rat.

Organism-specific databases

CTDi10800.
RGDi619796. Cysltr1.

Phylogenomic databases

eggNOGiNOG119185.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ924T8.
KOiK04322.
OMAiPQDNQAK.
OrthoDBiEOG7992R9.
PhylomeDBiQ924T8.

Enzyme and pathway databases

ReactomeiREACT_231084. Leukotriene receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi618253.
PROiQ924T8.

Gene expression databases

GenevestigatoriQ924T8.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of cloned rat and porcine cysteinyl leukotriene receptors."
    Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T., Soga T., Matsushime H., Furuichi K.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCLTR1_RAT
AccessioniPrimary (citable) accession number: Q924T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.